REV3L (REV3 like, DNA directed polymerase zeta catalytic subunit)

Gene

• Entrez ID: 5980
• Gene name: REV3 like, DNA directed polymerase zeta catalytic subunit
• Gene symbol: REV3L
• Synonyms: POLZ, REV3
• Chromosome: 6
• Chromosome location: 6q21
• Summary: The protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause o

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1057519367	T>A	Likely-pathogenic	Non coding transcript variant, coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019556	hsa-miR-340-5p	Sequencing	20371350
MIRT025031	hsa-miR-183-5p	Sequencing	20371350
MIRT028057	hsa-miR-93-5p	Sequencing	20371350
MIRT030718	hsa-miR-21-5p	Microarray	18591254
MIRT054928	hsa-miR-25-3p	Luciferase reporter assay	22349819
MIRT054929	hsa-miR-32-5p	Luciferase reporter assay	22349819
MIRT566049	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT054928	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT054929	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT566048	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT566047	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT566046	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT098316	hsa-miR-4282	PAR-CLIP	20371350
MIRT566045	hsa-miR-548av-5p	PAR-CLIP	20371350
MIRT566044	hsa-miR-548k	PAR-CLIP	20371350
MIRT566042	hsa-miR-8054	PAR-CLIP	20371350
MIRT566043	hsa-miR-548l	PAR-CLIP	20371350
MIRT566040	hsa-miR-4694-3p	PAR-CLIP	20371350
MIRT566041	hsa-miR-3163	PAR-CLIP	20371350
MIRT566039	hsa-miR-6505-5p	PAR-CLIP	20371350
MIRT566038	hsa-miR-4470	PAR-CLIP	20371350
MIRT566037	hsa-miR-124-5p	PAR-CLIP	20371350
MIRT566036	hsa-miR-2113	PAR-CLIP	20371350
MIRT566035	hsa-miR-5010-3p	PAR-CLIP	20371350
MIRT439783	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439783	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT726769	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT726768	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT726767	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT726766	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT726765	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT566046	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT566049	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT054929	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT566049	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT054928	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT054929	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT566048	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT566047	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT566046	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT098316	hsa-miR-4282	PAR-CLIP	20371350
MIRT566045	hsa-miR-548av-5p	PAR-CLIP	20371350
MIRT566044	hsa-miR-548k	PAR-CLIP	20371350
MIRT566042	hsa-miR-8054	PAR-CLIP	20371350
MIRT566043	hsa-miR-548l	PAR-CLIP	20371350
MIRT566040	hsa-miR-4694-3p	PAR-CLIP	20371350
MIRT566041	hsa-miR-3163	PAR-CLIP	20371350
MIRT566039	hsa-miR-6505-5p	PAR-CLIP	20371350
MIRT566038	hsa-miR-4470	PAR-CLIP	20371350
MIRT566037	hsa-miR-124-5p	PAR-CLIP	20371350
MIRT566036	hsa-miR-2113	PAR-CLIP	20371350
MIRT566035	hsa-miR-5010-3p	PAR-CLIP	20371350
MIRT1301135	hsa-miR-105	CLIP-seq
MIRT1301136	hsa-miR-106a	CLIP-seq
MIRT1301137	hsa-miR-106b	CLIP-seq
MIRT1301138	hsa-miR-1243	CLIP-seq
MIRT1301139	hsa-miR-1257	CLIP-seq
MIRT1301140	hsa-miR-1264	CLIP-seq
MIRT1301141	hsa-miR-1284	CLIP-seq
MIRT1301142	hsa-miR-1324	CLIP-seq
MIRT1301143	hsa-miR-142-5p	CLIP-seq
MIRT1301144	hsa-miR-145	CLIP-seq
MIRT1301145	hsa-miR-148a	CLIP-seq
MIRT1301146	hsa-miR-148b	CLIP-seq
MIRT1301147	hsa-miR-152	CLIP-seq
MIRT1301148	hsa-miR-17	CLIP-seq
MIRT1301149	hsa-miR-194	CLIP-seq
MIRT1301150	hsa-miR-20a	CLIP-seq
MIRT1301151	hsa-miR-20b	CLIP-seq
MIRT1301152	hsa-miR-25	CLIP-seq
MIRT1301153	hsa-miR-29a	CLIP-seq
MIRT1301154	hsa-miR-29b	CLIP-seq
MIRT1301155	hsa-miR-29c	CLIP-seq
MIRT1301156	hsa-miR-300	CLIP-seq
MIRT1301157	hsa-miR-30a	CLIP-seq
MIRT1301158	hsa-miR-30b	CLIP-seq
MIRT1301159	hsa-miR-30c	CLIP-seq
MIRT1301160	hsa-miR-30d	CLIP-seq
MIRT1301161	hsa-miR-30e	CLIP-seq
MIRT1301162	hsa-miR-3125	CLIP-seq
MIRT1301163	hsa-miR-3140-3p	CLIP-seq
MIRT1301164	hsa-miR-3180-5p	CLIP-seq
MIRT1301165	hsa-miR-3189-5p	CLIP-seq
MIRT1301166	hsa-miR-32	CLIP-seq
MIRT1301167	hsa-miR-3201	CLIP-seq
MIRT1301168	hsa-miR-340	CLIP-seq
MIRT1301169	hsa-miR-3609	CLIP-seq
MIRT1301170	hsa-miR-362-5p	CLIP-seq
MIRT1301171	hsa-miR-363	CLIP-seq
MIRT1301172	hsa-miR-3646	CLIP-seq
MIRT1301173	hsa-miR-3647-3p	CLIP-seq
MIRT1301174	hsa-miR-365	CLIP-seq
MIRT1301175	hsa-miR-3654	CLIP-seq
MIRT1301176	hsa-miR-3658	CLIP-seq
MIRT1301177	hsa-miR-3662	CLIP-seq
MIRT1301178	hsa-miR-3667-3p	CLIP-seq
MIRT1301179	hsa-miR-367	CLIP-seq
MIRT1301180	hsa-miR-376a	CLIP-seq
MIRT1301181	hsa-miR-376b	CLIP-seq
MIRT1301182	hsa-miR-381	CLIP-seq
MIRT1301183	hsa-miR-3916	CLIP-seq
MIRT1301184	hsa-miR-3942-3p	CLIP-seq
MIRT1301185	hsa-miR-4268	CLIP-seq
MIRT1301186	hsa-miR-4276	CLIP-seq
MIRT1301187	hsa-miR-4326	CLIP-seq
MIRT1301188	hsa-miR-4422	CLIP-seq
MIRT1301189	hsa-miR-4426	CLIP-seq
MIRT1301190	hsa-miR-4436b-5p	CLIP-seq
MIRT1301191	hsa-miR-4448	CLIP-seq
MIRT1301192	hsa-miR-4464	CLIP-seq
MIRT1301193	hsa-miR-450b-5p	CLIP-seq
MIRT1301194	hsa-miR-4528	CLIP-seq
MIRT1301195	hsa-miR-4646-5p	CLIP-seq
MIRT1301196	hsa-miR-4647	CLIP-seq
MIRT1301197	hsa-miR-4662b	CLIP-seq
MIRT1301198	hsa-miR-4666-3p	CLIP-seq
MIRT1301199	hsa-miR-4698	CLIP-seq
MIRT1301200	hsa-miR-4699-3p	CLIP-seq
MIRT1301201	hsa-miR-4719	CLIP-seq
MIRT1301202	hsa-miR-4747-5p	CLIP-seq
MIRT1301203	hsa-miR-4748	CLIP-seq
MIRT1301204	hsa-miR-4758-3p	CLIP-seq
MIRT1301205	hsa-miR-4790-3p	CLIP-seq
MIRT1301206	hsa-miR-4791	CLIP-seq
MIRT1301207	hsa-miR-4796-3p	CLIP-seq
MIRT1301208	hsa-miR-4796-5p	CLIP-seq
MIRT1301209	hsa-miR-495	CLIP-seq
MIRT1301210	hsa-miR-500b	CLIP-seq
MIRT1301211	hsa-miR-507	CLIP-seq
MIRT1301212	hsa-miR-511	CLIP-seq
MIRT1301213	hsa-miR-519d	CLIP-seq
MIRT1301214	hsa-miR-520d-5p	CLIP-seq
MIRT1301215	hsa-miR-524-5p	CLIP-seq
MIRT1301216	hsa-miR-548a-5p	CLIP-seq
MIRT1301217	hsa-miR-548ab	CLIP-seq
MIRT1301218	hsa-miR-548ah	CLIP-seq
MIRT1301219	hsa-miR-548ak	CLIP-seq
MIRT1301220	hsa-miR-548b-5p	CLIP-seq
MIRT1301221	hsa-miR-548c-5p	CLIP-seq
MIRT1301222	hsa-miR-548d-5p	CLIP-seq
MIRT1301223	hsa-miR-548h	CLIP-seq
MIRT1301224	hsa-miR-548i	CLIP-seq
MIRT1301225	hsa-miR-548j	CLIP-seq
MIRT1301226	hsa-miR-548w	CLIP-seq
MIRT1301227	hsa-miR-548y	CLIP-seq
MIRT1301228	hsa-miR-557	CLIP-seq
MIRT1301229	hsa-miR-559	CLIP-seq
MIRT1301230	hsa-miR-570	CLIP-seq
MIRT1301231	hsa-miR-579	CLIP-seq
MIRT1301232	hsa-miR-633	CLIP-seq
MIRT1301233	hsa-miR-767-5p	CLIP-seq
MIRT1301234	hsa-miR-802	CLIP-seq
MIRT1301235	hsa-miR-877	CLIP-seq
MIRT1301236	hsa-miR-888	CLIP-seq
MIRT1301237	hsa-miR-92a	CLIP-seq
MIRT1301238	hsa-miR-92b	CLIP-seq
MIRT1301239	hsa-miR-93	CLIP-seq
MIRT2089445	hsa-miR-101	CLIP-seq
MIRT1301136	hsa-miR-106a	CLIP-seq
MIRT1301137	hsa-miR-106b	CLIP-seq
MIRT1301139	hsa-miR-1257	CLIP-seq
MIRT1301143	hsa-miR-142-5p	CLIP-seq
MIRT2089446	hsa-miR-144	CLIP-seq
MIRT1301144	hsa-miR-145	CLIP-seq
MIRT1301148	hsa-miR-17	CLIP-seq
MIRT1301150	hsa-miR-20a	CLIP-seq
MIRT1301151	hsa-miR-20b	CLIP-seq
MIRT1301153	hsa-miR-29a	CLIP-seq
MIRT1301154	hsa-miR-29b	CLIP-seq
MIRT1301155	hsa-miR-29c	CLIP-seq
MIRT1301162	hsa-miR-3125	CLIP-seq
MIRT1301164	hsa-miR-3180-5p	CLIP-seq
MIRT1301167	hsa-miR-3201	CLIP-seq
MIRT1301168	hsa-miR-340	CLIP-seq
MIRT1301169	hsa-miR-3609	CLIP-seq
MIRT1301183	hsa-miR-3916	CLIP-seq
MIRT1301193	hsa-miR-450b-5p	CLIP-seq
MIRT1301199	hsa-miR-4698	CLIP-seq
MIRT1301205	hsa-miR-4790-3p	CLIP-seq
MIRT1301206	hsa-miR-4791	CLIP-seq
MIRT1301207	hsa-miR-4796-3p	CLIP-seq
MIRT1301211	hsa-miR-507	CLIP-seq
MIRT1301213	hsa-miR-519d	CLIP-seq
MIRT1301218	hsa-miR-548ah	CLIP-seq
MIRT2089447	hsa-miR-548p	CLIP-seq
MIRT1301228	hsa-miR-557	CLIP-seq
MIRT1301235	hsa-miR-877	CLIP-seq
MIRT1301239	hsa-miR-93	CLIP-seq
MIRT2089445	hsa-miR-101	CLIP-seq
MIRT1301135	hsa-miR-105	CLIP-seq
MIRT1301136	hsa-miR-106a	CLIP-seq
MIRT1301137	hsa-miR-106b	CLIP-seq
MIRT1301139	hsa-miR-1257	CLIP-seq
MIRT1301140	hsa-miR-1264	CLIP-seq
MIRT1301142	hsa-miR-1324	CLIP-seq
MIRT2314353	hsa-miR-140-5p	CLIP-seq
MIRT1301143	hsa-miR-142-5p	CLIP-seq
MIRT2089446	hsa-miR-144	CLIP-seq
MIRT1301148	hsa-miR-17	CLIP-seq
MIRT2314354	hsa-miR-200b	CLIP-seq
MIRT2314355	hsa-miR-200c	CLIP-seq
MIRT2314356	hsa-miR-2054	CLIP-seq
MIRT1301150	hsa-miR-20a	CLIP-seq
MIRT1301151	hsa-miR-20b	CLIP-seq
MIRT1301152	hsa-miR-25	CLIP-seq
MIRT1301153	hsa-miR-29a	CLIP-seq
MIRT1301154	hsa-miR-29b	CLIP-seq
MIRT1301155	hsa-miR-29c	CLIP-seq
MIRT1301157	hsa-miR-30a	CLIP-seq
MIRT1301158	hsa-miR-30b	CLIP-seq
MIRT1301159	hsa-miR-30c	CLIP-seq
MIRT1301160	hsa-miR-30d	CLIP-seq
MIRT1301161	hsa-miR-30e	CLIP-seq
MIRT1301162	hsa-miR-3125	CLIP-seq
MIRT2314357	hsa-miR-3145-3p	CLIP-seq
MIRT1301165	hsa-miR-3189-5p	CLIP-seq
MIRT1301166	hsa-miR-32	CLIP-seq
MIRT1301167	hsa-miR-3201	CLIP-seq
MIRT1301168	hsa-miR-340	CLIP-seq
MIRT2314358	hsa-miR-3545-5p	CLIP-seq
MIRT2314359	hsa-miR-3591-5p	CLIP-seq
MIRT1301169	hsa-miR-3609	CLIP-seq
MIRT1301170	hsa-miR-362-5p	CLIP-seq
MIRT1301171	hsa-miR-363	CLIP-seq
MIRT1301174	hsa-miR-365	CLIP-seq
MIRT1301178	hsa-miR-3667-3p	CLIP-seq
MIRT1301179	hsa-miR-367	CLIP-seq
MIRT2314360	hsa-miR-3689a-5p	CLIP-seq
MIRT2314361	hsa-miR-3689b	CLIP-seq
MIRT2314362	hsa-miR-3689e	CLIP-seq
MIRT2314363	hsa-miR-3689f	CLIP-seq
MIRT1301180	hsa-miR-376a	CLIP-seq
MIRT1301181	hsa-miR-376b	CLIP-seq
MIRT1301183	hsa-miR-3916	CLIP-seq
MIRT1301184	hsa-miR-3942-3p	CLIP-seq
MIRT1301185	hsa-miR-4268	CLIP-seq
MIRT2314364	hsa-miR-429	CLIP-seq
MIRT2314365	hsa-miR-4310	CLIP-seq
MIRT2314366	hsa-miR-4318	CLIP-seq
MIRT1301187	hsa-miR-4326	CLIP-seq
MIRT1301188	hsa-miR-4422	CLIP-seq
MIRT1301190	hsa-miR-4436b-5p	CLIP-seq
MIRT1301191	hsa-miR-4448	CLIP-seq
MIRT2314367	hsa-miR-4460	CLIP-seq
MIRT1301193	hsa-miR-450b-5p	CLIP-seq
MIRT2314368	hsa-miR-4517	CLIP-seq
MIRT2314369	hsa-miR-451b	CLIP-seq
MIRT1301194	hsa-miR-4528	CLIP-seq
MIRT1301195	hsa-miR-4646-5p	CLIP-seq
MIRT2314370	hsa-miR-466	CLIP-seq
MIRT2314371	hsa-miR-4679	CLIP-seq
MIRT2314372	hsa-miR-4693-5p	CLIP-seq
MIRT2314373	hsa-miR-4696	CLIP-seq
MIRT1301199	hsa-miR-4698	CLIP-seq
MIRT2314374	hsa-miR-4709-5p	CLIP-seq
MIRT2314375	hsa-miR-4727-3p	CLIP-seq
MIRT1301202	hsa-miR-4747-5p	CLIP-seq
MIRT1301204	hsa-miR-4758-3p	CLIP-seq
MIRT1301205	hsa-miR-4790-3p	CLIP-seq
MIRT1301206	hsa-miR-4791	CLIP-seq
MIRT1301207	hsa-miR-4796-3p	CLIP-seq
MIRT1301210	hsa-miR-500b	CLIP-seq
MIRT1301211	hsa-miR-507	CLIP-seq
MIRT1301213	hsa-miR-519d	CLIP-seq
MIRT1301216	hsa-miR-548a-5p	CLIP-seq
MIRT1301217	hsa-miR-548ab	CLIP-seq
MIRT1301218	hsa-miR-548ah	CLIP-seq
MIRT1301219	hsa-miR-548ak	CLIP-seq
MIRT1301220	hsa-miR-548b-5p	CLIP-seq
MIRT1301221	hsa-miR-548c-5p	CLIP-seq
MIRT1301222	hsa-miR-548d-5p	CLIP-seq
MIRT1301223	hsa-miR-548h	CLIP-seq
MIRT1301224	hsa-miR-548i	CLIP-seq
MIRT1301225	hsa-miR-548j	CLIP-seq
MIRT2089447	hsa-miR-548p	CLIP-seq
MIRT1301226	hsa-miR-548w	CLIP-seq
MIRT1301227	hsa-miR-548y	CLIP-seq
MIRT1301228	hsa-miR-557	CLIP-seq
MIRT1301229	hsa-miR-559	CLIP-seq
MIRT2314376	hsa-miR-584	CLIP-seq
MIRT2314377	hsa-miR-590-3p	CLIP-seq
MIRT2314378	hsa-miR-627	CLIP-seq
MIRT1301232	hsa-miR-633	CLIP-seq
MIRT1301233	hsa-miR-767-5p	CLIP-seq
MIRT1301234	hsa-miR-802	CLIP-seq
MIRT1301235	hsa-miR-877	CLIP-seq
MIRT2314379	hsa-miR-889	CLIP-seq
MIRT2314380	hsa-miR-892a	CLIP-seq
MIRT1301237	hsa-miR-92a	CLIP-seq
MIRT1301238	hsa-miR-92b	CLIP-seq
MIRT1301239	hsa-miR-93	CLIP-seq
MIRT1301142	hsa-miR-1324	CLIP-seq
MIRT1301174	hsa-miR-365	CLIP-seq
MIRT1301187	hsa-miR-4326	CLIP-seq
MIRT2089445	hsa-miR-101	CLIP-seq
MIRT2089446	hsa-miR-144	CLIP-seq
MIRT1301153	hsa-miR-29a	CLIP-seq
MIRT1301154	hsa-miR-29b	CLIP-seq
MIRT1301155	hsa-miR-29c	CLIP-seq
MIRT1301156	hsa-miR-300	CLIP-seq
MIRT1301182	hsa-miR-381	CLIP-seq
MIRT2432677	hsa-miR-3941	CLIP-seq
MIRT2432678	hsa-miR-452	CLIP-seq
MIRT2314370	hsa-miR-466	CLIP-seq
MIRT1301198	hsa-miR-4666-3p	CLIP-seq
MIRT2432679	hsa-miR-4672	CLIP-seq
MIRT2432680	hsa-miR-4676-3p	CLIP-seq
MIRT1301199	hsa-miR-4698	CLIP-seq
MIRT2432681	hsa-miR-4789-5p	CLIP-seq
MIRT1301211	hsa-miR-507	CLIP-seq
MIRT1301228	hsa-miR-557	CLIP-seq
MIRT2314353	hsa-miR-140-5p	CLIP-seq
MIRT2314354	hsa-miR-200b	CLIP-seq
MIRT2314355	hsa-miR-200c	CLIP-seq
MIRT2314356	hsa-miR-2054	CLIP-seq
MIRT1301153	hsa-miR-29a	CLIP-seq
MIRT1301154	hsa-miR-29b	CLIP-seq
MIRT1301155	hsa-miR-29c	CLIP-seq
MIRT2314357	hsa-miR-3145-3p	CLIP-seq
MIRT2314358	hsa-miR-3545-5p	CLIP-seq
MIRT2314359	hsa-miR-3591-5p	CLIP-seq
MIRT2314360	hsa-miR-3689a-5p	CLIP-seq
MIRT2314361	hsa-miR-3689b	CLIP-seq
MIRT2314362	hsa-miR-3689e	CLIP-seq
MIRT2314363	hsa-miR-3689f	CLIP-seq
MIRT2314364	hsa-miR-429	CLIP-seq
MIRT2314366	hsa-miR-4318	CLIP-seq
MIRT2314367	hsa-miR-4460	CLIP-seq
MIRT2314371	hsa-miR-4679	CLIP-seq
MIRT2314372	hsa-miR-4693-5p	CLIP-seq
MIRT2314374	hsa-miR-4709-5p	CLIP-seq
MIRT2314375	hsa-miR-4727-3p	CLIP-seq
MIRT1301233	hsa-miR-767-5p	CLIP-seq
MIRT2314380	hsa-miR-892a	CLIP-seq
MIRT2314354	hsa-miR-200b	CLIP-seq
MIRT2314355	hsa-miR-200c	CLIP-seq
MIRT2314356	hsa-miR-2054	CLIP-seq
MIRT1301153	hsa-miR-29a	CLIP-seq
MIRT1301154	hsa-miR-29b	CLIP-seq
MIRT1301155	hsa-miR-29c	CLIP-seq
MIRT2314359	hsa-miR-3591-5p	CLIP-seq
MIRT2314364	hsa-miR-429	CLIP-seq
MIRT2314366	hsa-miR-4318	CLIP-seq
MIRT2314367	hsa-miR-4460	CLIP-seq
MIRT2314371	hsa-miR-4679	CLIP-seq
MIRT2314372	hsa-miR-4693-5p	CLIP-seq
MIRT2314374	hsa-miR-4709-5p	CLIP-seq
MIRT2314375	hsa-miR-4727-3p	CLIP-seq
MIRT1301233	hsa-miR-767-5p	CLIP-seq
MIRT2314380	hsa-miR-892a	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000724	Process	Double-strand break repair via homologous recombination	IBA	21873635
GO:0003677	Function	DNA binding	IEA
GO:0003887	Function	DNA-directed DNA polymerase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	22828282
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IEA
GO:0006261	Process	DNA-dependent DNA replication	TAS	9618506
GO:0008408	Function	3'-5' exonuclease activity	IBA	21873635
GO:0016035	Component	Zeta DNA polymerase complex	IBA	21873635
GO:0016035	Component	Zeta DNA polymerase complex	IDA	20164194, 22465957
GO:0042276	Process	Error-prone translesion synthesis	IBA	21873635
GO:0042276	Process	Error-prone translesion synthesis	TAS
GO:0046872	Function	Metal ion binding	IEA
GO:0051539	Function	4 iron, 4 sulfur cluster binding	IEA
GO:0090305	Process	Nucleic acid phosphodiester bond hydrolysis	IEA

Other IDs

• MIM: 602776
• HGNC: 9968
• e!Ensembl: ENSG00000009413

Protein

• UniProt ID: O60673
• Protein name: DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3)
• Protein function: Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.
• PDB: 3ABD, 3ABE, 3VU7, 4EXT, 4GK0, 4GK5, 5O8K, 6BC8, 6BCD, 6BI7, 6EKM, 6KEA, 6WS0, 6WS5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03104	DNA_pol_B_exo1	43 → 203	DNA polymerase family B, exonuclease domain	Family
  PF15735	DUF4683	746 → 1133	Domain of unknown function (DUF4683)	Family
  PF03104	DNA_pol_B_exo1	2221 → 2484	DNA polymerase family B, exonuclease domain	Family
  PF00136	DNA_pol_B	2549 → 3001	DNA polymerase family B	Family
  PF14260	zf-C4pol	3042 → 3110	C4-type zinc-finger of DNA polymerase delta	Domain

• Sequence:

  MFSVRIVTADYYMASPLQGLDTCQSPLTQAPVKKVPVVRVFGATPAGQKTCLHLHGIFPY
  LYVPYDGYGQQPESYLSQMAFSIDRALNVALGNPSSTAQHVFKVSLVSGMPFYGYHEKER
  HFMKIYLYNPTMVKRICELLQSGAIMNKFYQPHEAHIPYLLQLFIDYNLYGMNLINLAAV
  KFRKARRKSNTLHATGSCKNHLSGNSLADTLFRWEQDEIPSSLILEGVEPQSTCELEVDA
  VAADILNRLDIEAQIGGNPGLQAIWEDEKQRRRNRNETSQMSQPESQDHRFVPATESEKK
  FQKRLQEILKQNDFSVTLSGSVDYSDGSQEFSAELTLHSEVLSPEMLQCTPANMVEVHKD
  KESSKGHTRHKVEEALINEEAILNLMENSQTFQPLTQRLSESPVFMDSSPDEALVHLLAG
  LESDGYRGERNRMPSPCRSFGNNKYPQNSDDEENEPQIEKEEMELSLVMSQRWDSNIEEH
  CAKKRSLCRNTHRSSTEDDDSSSGEEMEWSDNSLLLASLSIPQLDGTADENSDNPLNNEN
  SRTHSSVIATSKLSVKPSIFHKDAATLEPSSSAKITFQCKHTSALSSHVLNKEDLIEDLS
  QTNKNTEKGLDNSVTSFTNESTYSMKYPGSLSSTVHSENSHKENSKKEILPVSSCESSIF
  DYEEDIPSVTRQVPSRKYTNIRKIEKDSPFIHMHRHPNENTLGKNSFNFSDLNHSKNKVS
  SEGNEKGNSTALSSLFPSSFTENCELLSCSGENRTMVHSLNSTADESGLNKLKIRYEEFQ
  EHKTEKPSLSQQAAHYMFFPSVVLSNCLTRPQKLSPVTYKLQPGNKPSRLKLNKRKLAGH
  QETSTKSSETGSTKDNFIQNNPCNSNPEKDNALASDLTKTTRGAFENKTPTDGFIDCHFG
  DGTLETEQSFGLYGNKYTLRAKRKVNYETEDSESSFVTHNSKISLPHPMEIGESLDGTLK
  SRKRRKMSKKLPPVIIKYIIINRFRGRKNMLVKLGKIDSKEKQVILTEEKMELYKKLAPL
  KDFWPKVPDSPATKYPIYPLTPKKSHRRKSKHKSAKKKTGKQQRTNNENIKRTLSFRKKR
  SHAILSPPSPSYNAETEDCDLNYSDVMSKLGFLSERSTSPINSSPPRCWSPTDPRAEEIM
  AAAEKEAMLFKGPNVYKKTVNSRIGKTSRARAQIKKSKAKLANPSIVTKKRNKRNQTNKL
  VDDGKKKPRAKQKTNEKGTSRKHTTLKDEKIKSQSGAEVKFVLKHQNVSEFASSSGGSQL
  LFKQKDMPLMGSAVDHPLSASLPTGINAQQKLSGCFSSFLESKKSVDLQTFPSSRDDLHP
  SVVCNSIGPGVSKINVQRPHNQSAMFTLKESTLIQKNIFDLSNHLSQVAQNTQISSGMSS
  KIEDNANNIQRNYLSSIGKLSEYRNSLESKLDQAYTPNFLHCKDSQQQIVCIAEQSKHSE
  TCSPGNTASEESQMPNNCFVTSLRSPIKQIAWEQKQRGFILDMSNFKPERVKPRSLSEAI
  SQTKALSQCKNRNVSTPSAFGEGQSGLAVLKELLQKRQQKAQNANTTQDPLSNKHQPNKN
  ISGSLEHNKANKRTRSVTSPRKPRTPRSTKQKEKIPKLLKVDSLNLQNSSQLDNSVSDDS
  PIFFSDPGFESCYSLEDSLSPEHNYNFDINTIGQTGFCSFYSGSQFVPADQNLPQKFLSD
  AVQDLFPGQAIEKNEFLSHDNQKCDEDKHHTTDSASWIRSGTLSPEIFEKSTIDSNENRR
  HNQWKNSFHPLTTRSNSIMDSFCVQQAEDCLSEKSRLNRSSVSKEVFLSLPQPNNSDWIQ
  GHTRKEMGQSLDSANTSFTAILSSPDGELVDVACEDLELYVSRNNDMLTPTPDSSPRSTS
  SPSQSKNGSFTPRTANILKPLMSPPSREEIMATLLDHDLSETIYQEPFCSNPSDVPEKPR
  EIGGRLLMVETRLANDLAEFEGDFSLEGLRLWKTAFSAMTQNPRPGSPLRSGQGVVNKGS
  SNSPKMVEDKKIVIMPCKCAPSRQLVQVWLQAKEEYERSKKLPKTKPTGVVKSAENFSSS
  VNPDDKPVVPPKMDVSPCILPTTAHTKEDVDNSQIALQAPTTGCSQTASESQMLPPVASA
  SDPEKDEDDDDNYYISYSSPDSPVIPPWQQPISPDSKALNGDDRPSSPVEELPSLAFENF
  LKPIKDGIQKSPCSEPQEPLVISPINTRARTGKCESLCFHSTPIIQRKLLERLPEAPGLS
  PLSTEPKTQKLSNKKGSNTDTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGFKV
  SIQNLQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSDTPLPDTEKT
  ELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGLEVTYAADEKALFHEIANIIKRYDPDI
  LLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDKIENRFAAERDEYGSYTMSEINIVG
  RITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVDHY
  VSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYIPVT
  PSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVENL
  GKYDEFKFGCTSLRVPPDLLYQVRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKTRFMV
  KQSMKAYKQDRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETL
  ERAIKLVNDTKKWGARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKF
  EKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFET
  RDISLIKQYVQRQCMKLLEGKASIQDFIFAKEYRGSFSYKPGACVPALELTRKMLTYDRR
  SEPQVGERVPYVIIYGTPGVPLIQLVRRPVEVLQDPTLRLNATYYITKQILPPLARIFSL
  IGIDVFSWYHELPRIHKATSSSRSEPEGRKGTISQYFTTLHCPVCDDLTQHGICSKCRSQ
  PQHVAVILNQEIRELERQQEQLVKICKNCTGCFDRHIPCVSLNCPVLFKLSRVNRELSKA
  PYLRQLLDQF

• Sequence length: 3130

Pathways

KEGG:

Platinum drug resistance
Fanconi anemia pathway

Reactome:

Translesion synthesis by REV1
Translesion synthesis by POLK
Translesion synthesis by POLI

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Arthrogryposis multiplex congenita	Arthrogryposis	rs1586285494, rs80358233, rs137853305, rs1559154278, rs398124167, rs398124172, rs587780399, rs786204576, rs786204430, rs769345284, rs749355583, rs793888524, rs793888525, rs878854368, rs555445835, rs758105619, rs886041851, rs794727136, rs755239192, rs760715690, rs773952935, rs112610938, rs1057516676, rs1057516996, rs780022652, rs1057517399, rs1057517360, rs1057518353, rs1057517977, rs1064796311, rs779232987, rs775997446, rs1064797093, rs1064797094, rs1064797095, rs755500591, rs754272530, rs758247804, rs200731870, rs747179265, rs1553740233, rs776569219, rs375628303, rs775631800, rs781667543, rs1553548666, rs928945364, rs763364977, rs1458048713, rs1553883480, rs1472403020, rs1336053002, rs202048855, rs1197561990, rs755531536, rs1554112524, rs762133567, rs1553555882, rs934111355, rs1255744452, rs1366269616, rs1555734932, rs1553548207, rs752582527, rs1257495033, rs113525641, rs755863625, rs374929094, rs539819851, rs1366853918, rs1218073575, rs1553537512, rs1553552384, rs747564597, rs776059611, rs756726488, rs1357811155, rs1553939600, rs772009599, rs1255445731, rs1011425121, rs1553561697, rs1553551748, rs1553552413, rs760935667, rs1553603400, rs1302373559, rs1389892619, rs1553710982, rs757157808, rs1180339426, rs761964375, rs1235589246, rs1443738549, rs1553934586, rs1553934597, rs1553603437, rs749452641, rs1553904694, rs754369875, rs112517981, rs774495973, rs1428597732, rs746999970, rs113091511, rs1553603958, rs1553469502, rs770797137, rs1553608621, rs1159756073, rs776167256, rs778593702, rs1553601066, rs1553689774, rs760768475, rs1559296376, rs201636991, rs1559039815, rs748922882, rs772366030, rs1207534366, rs1259297878, rs762780413, rs1559360386, rs1559940778, rs760200697, rs1344099907, rs750900690, rs1559168230, rs746177326, rs761067911, rs1323364980, rs537560378, rs1319778592, rs1340063197, rs1577833924, rs750585238, rs1600470099, rs1575714905, rs1576203853, rs779909544, rs760124743, rs2096362304, rs1212374733, rs1490309743, rs767709270, rs1374971806, rs2096491549, rs2097886912, rs2099021112, rs2097758221, rs1474341248, rs925947627
Autism	Autistic Disorder	rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634
Brachydactyly	Brachydactyly	rs121908949, rs28937580, rs121909082, rs104894122, rs863223289, rs863223290, rs104894121, rs1587657302, rs863223292, rs74315386, rs74315387, rs28936397, rs753691079, rs121909348, rs121917852, rs121917853, rs121917854, rs121917855, rs121917859, rs121917861, rs267606873, rs267606872, rs267606985, rs267606986, rs267606987, rs267606988, rs28933082, rs397514519, rs869025613, rs869025614, rs886039878, rs1553540620, rs1057518333, rs1948841937, rs1948868228, rs1948842030, rs1948842142
Cafe-au-lait spot	Cafe au lait spots, multiple	rs1057518792, rs1555613206, rs1555608663
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs1801155, rs121908380, rs121908702, rs267606674, rs4939827, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553149467, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208	27165003
Hypogonadotropic hypogonadism	Hypogonadotropic hypogonadism	rs104894702, rs104893836, rs104893837, rs104893842, rs121909628, rs138249161, rs1601946139
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	20953190, 25574825, 25903422

Unknown
Disease name	Disease term	dbSNP ID	References
Camptodactyly of fingers	Clinodactyly of the 5th finger
Breast aplasia	Congenital absence of breast
Congenital clubfoot	Congenital clubfoot
Congenital epicanthus	Congenital Epicanthus
Dysphagia	Deglutition Disorders
Facial paralysis	Facial paralysis
High palate	Byzanthine arch palate
Microdontia	Microdontia (disorder)
Micrognathism	Micrognathism
Mobius syndrome	Mobius Syndrome, Mobius II syndrome		26068067
Moebius syndrome	Moebius syndrome
Motor delay	Clumsiness - motor delay
Psoriatic arthritis	Arthritis, Psoriatic		30552173
Ptosis	Blepharoptosis, Ptosis	rs139920573
Strabismus	Strabismus
Syndactyly of fingers	Syndactyly of fingers