RARRES1 (retinoic acid receptor responder 1)

Gene

• Entrez ID: 5918
• Gene name: Retinoic acid receptor responder 1
• Gene symbol: RARRES1
• Synonyms: LXNL, PERG-1, TIG1
• Chromosome: 3
• Chromosome location: 3q25.32
• Summary: This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be dow

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1291725	hsa-miR-186	CLIP-seq
MIRT1291726	hsa-miR-567	CLIP-seq
MIRT2608088	hsa-miR-125a-5p	CLIP-seq
MIRT2608089	hsa-miR-125b	CLIP-seq
MIRT2608090	hsa-miR-1284	CLIP-seq
MIRT2608091	hsa-miR-134	CLIP-seq
MIRT2608092	hsa-miR-138	CLIP-seq
MIRT2608093	hsa-miR-2054	CLIP-seq
MIRT2608094	hsa-miR-2115	CLIP-seq
MIRT2608095	hsa-miR-28-3p	CLIP-seq
MIRT2608096	hsa-miR-3118	CLIP-seq
MIRT2608097	hsa-miR-3144-3p	CLIP-seq
MIRT2608098	hsa-miR-3146	CLIP-seq
MIRT2608099	hsa-miR-3180-5p	CLIP-seq
MIRT2608100	hsa-miR-33a	CLIP-seq
MIRT2608101	hsa-miR-33b	CLIP-seq
MIRT2608102	hsa-miR-3613-3p	CLIP-seq
MIRT2608103	hsa-miR-370	CLIP-seq
MIRT2608104	hsa-miR-3914	CLIP-seq
MIRT2608105	hsa-miR-3915	CLIP-seq
MIRT2608106	hsa-miR-3928	CLIP-seq
MIRT2608107	hsa-miR-4276	CLIP-seq
MIRT2608108	hsa-miR-4299	CLIP-seq
MIRT2608109	hsa-miR-4302	CLIP-seq
MIRT2608110	hsa-miR-4303	CLIP-seq
MIRT2608111	hsa-miR-4319	CLIP-seq
MIRT2608112	hsa-miR-4446-5p	CLIP-seq
MIRT2608113	hsa-miR-4464	CLIP-seq
MIRT2608114	hsa-miR-4468	CLIP-seq
MIRT2608115	hsa-miR-452	CLIP-seq
MIRT2608116	hsa-miR-4676-3p	CLIP-seq
MIRT2608117	hsa-miR-4682	CLIP-seq
MIRT2608118	hsa-miR-4748	CLIP-seq
MIRT2608119	hsa-miR-4762-3p	CLIP-seq
MIRT2608120	hsa-miR-4796-5p	CLIP-seq
MIRT2608121	hsa-miR-491-3p	CLIP-seq
MIRT2608122	hsa-miR-520a-5p	CLIP-seq
MIRT2608123	hsa-miR-525-5p	CLIP-seq
MIRT2608124	hsa-miR-539	CLIP-seq
MIRT2608125	hsa-miR-544b	CLIP-seq
MIRT2608126	hsa-miR-548aa	CLIP-seq
MIRT2608127	hsa-miR-548ac	CLIP-seq
MIRT2608128	hsa-miR-548d-3p	CLIP-seq
MIRT2608129	hsa-miR-548z	CLIP-seq
MIRT2608130	hsa-miR-648	CLIP-seq
MIRT2608131	hsa-miR-875-5p	CLIP-seq
MIRT2608132	hsa-miR-943	CLIP-seq
MIRT2608133	hsa-miR-944	CLIP-seq
MIRT2608088	hsa-miR-125a-5p	CLIP-seq
MIRT2608089	hsa-miR-125b	CLIP-seq
MIRT2608090	hsa-miR-1284	CLIP-seq
MIRT2608091	hsa-miR-134	CLIP-seq
MIRT2608092	hsa-miR-138	CLIP-seq
MIRT2608093	hsa-miR-2054	CLIP-seq
MIRT2608094	hsa-miR-2115	CLIP-seq
MIRT2608095	hsa-miR-28-3p	CLIP-seq
MIRT2608096	hsa-miR-3118	CLIP-seq
MIRT2608097	hsa-miR-3144-3p	CLIP-seq
MIRT2608098	hsa-miR-3146	CLIP-seq
MIRT2608099	hsa-miR-3180-5p	CLIP-seq
MIRT2608100	hsa-miR-33a	CLIP-seq
MIRT2608101	hsa-miR-33b	CLIP-seq
MIRT2608102	hsa-miR-3613-3p	CLIP-seq
MIRT2608103	hsa-miR-370	CLIP-seq
MIRT2608104	hsa-miR-3914	CLIP-seq
MIRT2608105	hsa-miR-3915	CLIP-seq
MIRT2608106	hsa-miR-3928	CLIP-seq
MIRT2608107	hsa-miR-4276	CLIP-seq
MIRT2608108	hsa-miR-4299	CLIP-seq
MIRT2608109	hsa-miR-4302	CLIP-seq
MIRT2608110	hsa-miR-4303	CLIP-seq
MIRT2608111	hsa-miR-4319	CLIP-seq
MIRT2608112	hsa-miR-4446-5p	CLIP-seq
MIRT2608113	hsa-miR-4464	CLIP-seq
MIRT2608114	hsa-miR-4468	CLIP-seq
MIRT2608115	hsa-miR-452	CLIP-seq
MIRT2608116	hsa-miR-4676-3p	CLIP-seq
MIRT2608117	hsa-miR-4682	CLIP-seq
MIRT2608118	hsa-miR-4748	CLIP-seq
MIRT2608119	hsa-miR-4762-3p	CLIP-seq
MIRT2608120	hsa-miR-4796-5p	CLIP-seq
MIRT2608121	hsa-miR-491-3p	CLIP-seq
MIRT2608122	hsa-miR-520a-5p	CLIP-seq
MIRT2608123	hsa-miR-525-5p	CLIP-seq
MIRT2608124	hsa-miR-539	CLIP-seq
MIRT2608125	hsa-miR-544b	CLIP-seq
MIRT2608126	hsa-miR-548aa	CLIP-seq
MIRT2608127	hsa-miR-548ac	CLIP-seq
MIRT2608128	hsa-miR-548d-3p	CLIP-seq
MIRT2608129	hsa-miR-548z	CLIP-seq
MIRT2608130	hsa-miR-648	CLIP-seq
MIRT2608131	hsa-miR-875-5p	CLIP-seq
MIRT2608132	hsa-miR-943	CLIP-seq
MIRT2608133	hsa-miR-944	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CTCF	Activation	22615834

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	31886233
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0008191	Function	Metalloendopeptidase inhibitor activity	IBA	21873635
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0010951	Process	Negative regulation of endopeptidase activity	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0070062	Component	Extracellular exosome	HDA	19199708

Other IDs

• MIM: 605090
• HGNC: 9867
• e!Ensembl: ENSG00000118849

Protein

• UniProt ID: P49788
• Protein name: Retinoic acid receptor responder protein 1 (Phorbol ester-induced gene 1 protein) (PERG-1) (RAR-responsive protein TIG1) (Tazarotene-induced gene 1 protein)
• Protein function: Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06907	Latexin	52 → 274	Latexin	Family

• Sequence:

  MQPRRQRLPAPWSGPRGPRPTAPLLALLLLLAPVAAPAGSGDPDDPGQPQDAGVPRRLLQ
  QAARAALHFFNFRSGSPSALRVLAEVQEGRAWINPKEGCKVHVVFSTERYNPESLLQEGE
  GRLGKCSARVFFKNQKPRPTINVTCTRLIEKKKRQQEDYLLYKQMKQLKNPLEIVSIPDN
  HGHIDPSLRLIWDLAFLGSSYVMWEMTTQVSHYYLAQLTSVRQWKTNDDTIDFDYTVLLH
  ELSTQEIIPCRIHLVWYPGKPLKVKYHCQELQTPEEASGTEEGSAVVPTELSNF

• Sequence length: 294

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	16134180

Unknown
Disease name	Disease term	dbSNP ID	References
Stomach neoplasms	Malignant neoplasm of stomach, Stomach Neoplasms		16134180