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RAP2A (RAP2A, member of RAS oncogene family)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5911
Gene nameGene Name - the full gene name approved by the HGNC.
RAP2A, member of RAS oncogene family
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
RAP2A
SynonymsGene synonyms aliases
K-REV, KREV, RAP2, RbBP-30
ChromosomeChromosome number
13
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q32.1
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT047381 hsa-miR-34a-5p CLASH 23622248
MIRT054331 hsa-miR-1225-3p Microarray, qRT-PCR 23593351
MIRT054342 hsa-miR-376a-5p Immunoblot, qRT-PCR, Western blot 23093778
MIRT249192 hsa-miR-10a-5p Microarray, qRT-PCR 22815788
MIRT385269 hsa-miR-6865-3p HITS-CLIP 19536157
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IMP 9312017, 10591105
GO:0001934 Process Positive regulation of protein phosphorylation IMP 22797597
GO:0003924 Function GTPase activity IBA 21873635
GO:0003924 Function GTPase activity IDA 1900290
GO:0005515 Function Protein binding IPI 14966141, 15342639, 20159449, 30614533, 32296183
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P10114
Protein name Ras-related protein Rap-2a (EC 3.6.5.2) (RbBP-30)
Protein function Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form (PubMed:14966141, PubMed:15342639, PubMed:16246175, PubMed:16540189, PubMed:18930710, PubMed:20159449, PubMed:35293963). In its active form interacts
PDB 1KAO , 2RAP , 3RAP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras
5 166
Ras family
Domain
Sequence
Sequence length 183
Interactions View interactions
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Rheumatoid arthritis Rheumatoid Arthritis rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212 12833524

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