RAP1GAP (RAP1 GTPase activating protein)

Gene

• Entrez ID: 5909
• Gene name: RAP1 GTPase activating protein
• Gene symbol: RAP1GAP
• Synonyms: RAP1GA1, RAP1GAP1, RAP1GAPII, RAPGAP
• Chromosome: 1
• Chromosome location: 1p36.12
• Summary: This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this g

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024590	hsa-miR-215-5p	Microarray	19074876
MIRT026546	hsa-miR-192-5p	Microarray	19074876
MIRT734048	hsa-miR-3121-3p	Luciferase reporter assay, qRT-PCR, Western blotting	33178761
MIRT1290114	hsa-miR-1913	CLIP-seq
MIRT1290115	hsa-miR-2682	CLIP-seq
MIRT1290116	hsa-miR-3138	CLIP-seq
MIRT1290117	hsa-miR-3189-5p	CLIP-seq
MIRT1290118	hsa-miR-324-3p	CLIP-seq
MIRT1290119	hsa-miR-34a	CLIP-seq
MIRT1290120	hsa-miR-34c-5p	CLIP-seq
MIRT1290121	hsa-miR-3607-5p	CLIP-seq
MIRT1290122	hsa-miR-449a	CLIP-seq
MIRT1290123	hsa-miR-449b	CLIP-seq
MIRT1290124	hsa-miR-449c	CLIP-seq
MIRT1290125	hsa-miR-4520a-3p	CLIP-seq
MIRT1290126	hsa-miR-4690-3p	CLIP-seq
MIRT1290127	hsa-miR-4758-3p	CLIP-seq
MIRT1290128	hsa-miR-4761-3p	CLIP-seq
MIRT1290129	hsa-miR-940	CLIP-seq
MIRT1290114	hsa-miR-1913	CLIP-seq
MIRT1290115	hsa-miR-2682	CLIP-seq
MIRT1290116	hsa-miR-3138	CLIP-seq
MIRT1290118	hsa-miR-324-3p	CLIP-seq
MIRT1290119	hsa-miR-34a	CLIP-seq
MIRT1290120	hsa-miR-34c-5p	CLIP-seq
MIRT1290121	hsa-miR-3607-5p	CLIP-seq
MIRT1290122	hsa-miR-449a	CLIP-seq
MIRT1290123	hsa-miR-449b	CLIP-seq
MIRT1290124	hsa-miR-449c	CLIP-seq
MIRT1290125	hsa-miR-4520a-3p	CLIP-seq
MIRT1290126	hsa-miR-4690-3p	CLIP-seq
MIRT1290130	hsa-miR-4749-3p	CLIP-seq
MIRT1290128	hsa-miR-4761-3p	CLIP-seq
MIRT1290129	hsa-miR-940	CLIP-seq
MIRT1290131	hsa-miR-146b-3p	CLIP-seq
MIRT1290132	hsa-miR-2467-3p	CLIP-seq
MIRT1290133	hsa-miR-3158-5p	CLIP-seq
MIRT1290134	hsa-miR-3173-5p	CLIP-seq
MIRT1290135	hsa-miR-3678-3p	CLIP-seq
MIRT1290126	hsa-miR-4690-3p	CLIP-seq
MIRT1290136	hsa-miR-874	CLIP-seq
MIRT1556950	hsa-miR-1202	CLIP-seq
MIRT1556951	hsa-miR-125a-5p	CLIP-seq
MIRT1556952	hsa-miR-125b	CLIP-seq
MIRT1556953	hsa-miR-3194-5p	CLIP-seq
MIRT1556954	hsa-miR-3972	CLIP-seq
MIRT1556955	hsa-miR-4319	CLIP-seq
MIRT1556956	hsa-miR-4530	CLIP-seq
MIRT1556957	hsa-miR-4732-3p	CLIP-seq
MIRT1556958	hsa-miR-646	CLIP-seq
MIRT1556959	hsa-miR-670	CLIP-seq
MIRT1556956	hsa-miR-4530	CLIP-seq
MIRT1290126	hsa-miR-4690-3p	CLIP-seq
MIRT1556958	hsa-miR-646	CLIP-seq
MIRT1290114	hsa-miR-1913	CLIP-seq
MIRT1290118	hsa-miR-324-3p	CLIP-seq
MIRT2311392	hsa-miR-4257	CLIP-seq
MIRT2311393	hsa-miR-4328	CLIP-seq
MIRT1290126	hsa-miR-4690-3p	CLIP-seq
MIRT1290130	hsa-miR-4749-3p	CLIP-seq
MIRT2311394	hsa-miR-5096	CLIP-seq
MIRT2311395	hsa-miR-767-3p	CLIP-seq
MIRT2393471	hsa-miR-1321	CLIP-seq
MIRT1290114	hsa-miR-1913	CLIP-seq
MIRT2393472	hsa-miR-1915	CLIP-seq
MIRT2393473	hsa-miR-3134	CLIP-seq
MIRT1290118	hsa-miR-324-3p	CLIP-seq
MIRT2393474	hsa-miR-3612	CLIP-seq
MIRT2393475	hsa-miR-4270	CLIP-seq
MIRT2393476	hsa-miR-4441	CLIP-seq
MIRT2393477	hsa-miR-4443	CLIP-seq
MIRT2393478	hsa-miR-4534	CLIP-seq
MIRT1290126	hsa-miR-4690-3p	CLIP-seq
MIRT2393479	hsa-miR-4739	CLIP-seq
MIRT1290130	hsa-miR-4749-3p	CLIP-seq
MIRT2393480	hsa-miR-4756-5p	CLIP-seq
MIRT2393481	hsa-miR-4802-5p	CLIP-seq
MIRT2393482	hsa-miR-650	CLIP-seq
MIRT2457743	hsa-miR-1285	CLIP-seq
MIRT2457744	hsa-miR-3187-5p	CLIP-seq
MIRT2393474	hsa-miR-3612	CLIP-seq
MIRT2457745	hsa-miR-4459	CLIP-seq
MIRT2457746	hsa-miR-4695-5p	CLIP-seq
MIRT2457747	hsa-miR-612	CLIP-seq
MIRT2393482	hsa-miR-650	CLIP-seq
MIRT2457748	hsa-miR-665	CLIP-seq
MIRT2607726	hsa-miR-3649	CLIP-seq
MIRT2607727	hsa-miR-4283	CLIP-seq
MIRT2607728	hsa-miR-4489	CLIP-seq
MIRT2607729	hsa-miR-4685-5p	CLIP-seq
MIRT2607726	hsa-miR-3649	CLIP-seq
MIRT2607727	hsa-miR-4283	CLIP-seq
MIRT2607728	hsa-miR-4489	CLIP-seq
MIRT2607729	hsa-miR-4685-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0003924	Function	GTPase activity	NAS	10476970
GO:0005096	Function	GTPase activator activity	IBA	21873635
GO:0005096	Function	GTPase activator activity	IDA	15141215
GO:0005515	Function	Protein binding	IPI	18309292, 20877310, 32814053
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005829	Component	Cytosol	IDA	10476970
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	NAS	10476970
GO:0007411	Process	Axon guidance	TAS
GO:0016020	Component	Membrane	IBA	21873635
GO:0016020	Component	Membrane	IDA	10476970
GO:0031267	Function	Small GTPase binding	IPI	18309292
GO:0042803	Function	Protein homodimerization activity	IPI	18309292
GO:0043087	Process	Regulation of GTPase activity	IDA	18309292
GO:0043547	Process	Positive regulation of GTPase activity	IDA	15141215
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IEA
GO:0090630	Process	Activation of GTPase activity	IBA	21873635
GO:1903697	Process	Negative regulation of microvillus assembly	IMP	22797597

Other IDs

• MIM: 600278
• HGNC: 9858
• e!Ensembl: ENSG00000076864

Protein

• UniProt ID: P47736
• Protein name: Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1)
• Protein function: GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.
• PDB: 1SRQ, 3BRW
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02188	GoLoco	1 → 17	GoLoco motif	Motif
  PF02145	Rap_GAP	210 → 391	Rap/ran-GAP	Family

• Sequence:

  MIEKMQGSRMDEQRCSFPPPLKTEEDYIPYPSVHEVLGREGPFPLILLPQFGGYWIEGTN
  HEITSIPETEPLQSPTTKVKLECNPTARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDV
  IGDQEHLRLLLRTKCRTYHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLYPKASRL
  IVTFDEHVISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFR
  GGLDVTHGQTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDE
  NTPFVPDMIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPE
  FQEFLLTKLINAEYACYKAEKFAKLEERTRAALLETLYEELHIHSQSMMGLGGDEDKMEN
  GSGGGGFFESFKRVIRSRSQSMDAMGLSNKKPNTVSTSHSGSFAPNNPDLAKAAGISLIV
  PGKSPTRKKSGPFGSRRSSAIGIENIQEVQEKRESPPAGQKTPDSGHVSQEPKSENSSTQ
  SSPEMPTTKNRAETAAQRAEALKDFSRSSSSASSFASVVEETEGVDGEDTGLESVSSSGT
  PHKRDSFIYSTWLEDSVSTTSGGSSPGPSRSPHPDAGKLGDPACPEIKIQLEASEQHMPQ
  LGC

• Sequence length: 663

Pathways

KEGG:

Rap1 signaling pathway

Reactome:

Rap1 signalling
RET signaling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	22614916, 19147557
Pancreatic cancer	Malignant neoplasm of pancreas	rs118203998, rs180177143, rs587776417, rs587776527, rs864622498, rs876659571, rs587778587, rs886039619, rs745533713, rs1555460431, rs200612497	22614916

Unknown
Disease name	Disease term	dbSNP ID	References
Pancreatic neoplasm	Pancreatic Neoplasm		22614916
Promyelocytic leukemia	Acute Promyelocytic Leukemia		22614916
Thyroid neoplasm	Thyroid Neoplasm		22614916
Thyroid carcinoma	Thyroid carcinoma		22614916
Thyroid gland follicular adenoma	Thyroid Gland Follicular Adenoma		22614916