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ENPP5 (ectonucleotide pyrophosphatase/phosphodiesterase family member 5)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
59084
Gene nameGene Name - the full gene name approved by the HGNC.
Ectonucleotide pyrophosphatase/phosphodiesterase family member 5
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
ENPP5
SynonymsGene synonyms aliases
NPP-5, NPP5
ChromosomeChromosome number
6
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p21.1
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a type-I transmembrane glycoprotein. Studies in rat suggest the encoded protein may play a role in neuronal cell communications. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2014]
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020237 hsa-miR-130b-3p Sequencing 20371350
MIRT031180 hsa-miR-19b-3p Sequencing 20371350
MIRT050870 hsa-miR-17-5p CLASH 23622248
MIRT712521 hsa-miR-3158-3p HITS-CLIP 19536157
MIRT712520 hsa-miR-3918 HITS-CLIP 19536157
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000210 Function NAD+ diphosphatase activity IDA 28898552
GO:0005576 Component Extracellular region IEA
GO:0005886 Component Plasma membrane ISS
GO:0007154 Process Cell communication ISS
GO:0008270 Function Zinc ion binding IDA 28898552
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9UJA9
Protein name Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 (E-NPP 5) (NPP-5) (EC 3.1.-.-)
Protein function Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates. Lacks lysopholipase D activity. May play a role in neuronal cell communication.
PDB 5VEM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01663 Phosphodiest
30 342
Type I phosphodiesterase / nucleotide pyrophosphatase
Family
Sequence
Sequence length 477
Interactions View interactions
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17013881
Unknown
Disease name Disease term dbSNP ID References
Prostatic neoplasms Prostatic Neoplasms 17013881

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