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RAP1A (RAP1A, member of RAS oncogene family)

Gene

5906

RAP1A, member of RAS oncogene family

RAP1A

C21KG, G-22K, KREV-1, KREV1, RAP1, SMGP21

1p13.2

This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide ex

Show/Hide all(318)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006958	hsa-miR-337-3p	Luciferase reporter assay, qRT-PCR, Western blot	22723956
MIRT051421	hsa-let-7e-5p	CLASH	23622248
MIRT554948	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT554947	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT554946	hsa-miR-10a-3p	PAR-CLIP	21572407
MIRT554945	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT554944	hsa-miR-6750-5p	PAR-CLIP	21572407
MIRT554943	hsa-miR-6822-5p	PAR-CLIP	21572407
MIRT554942	hsa-miR-5692b	PAR-CLIP	21572407
MIRT554941	hsa-miR-5692c	PAR-CLIP	21572407
MIRT554940	hsa-miR-6715a-3p	PAR-CLIP	21572407
MIRT554939	hsa-miR-412-3p	PAR-CLIP	21572407
MIRT554938	hsa-miR-6754-3p	PAR-CLIP	21572407
MIRT554937	hsa-miR-6837-3p	PAR-CLIP	21572407
MIRT554936	hsa-miR-4471	PAR-CLIP	21572407
MIRT554935	hsa-miR-8059	PAR-CLIP	21572407
MIRT554934	hsa-miR-4799-5p	PAR-CLIP	21572407
MIRT512898	hsa-miR-551b-5p	PAR-CLIP	23446348
MIRT512897	hsa-miR-18a-5p	PAR-CLIP	23446348
MIRT512896	hsa-miR-18b-5p	PAR-CLIP	23446348
MIRT512895	hsa-miR-4735-3p	PAR-CLIP	23446348
MIRT512894	hsa-miR-5000-5p	PAR-CLIP	23446348
MIRT512893	hsa-miR-4761-5p	PAR-CLIP	23446348
MIRT512892	hsa-miR-759	PAR-CLIP	23446348
MIRT512891	hsa-miR-4470	PAR-CLIP	23446348
MIRT448559	hsa-miR-520f-3p	PAR-CLIP	22100165
MIRT448557	hsa-miR-302c-3p	PAR-CLIP	22100165
MIRT448558	hsa-miR-512-3p	PAR-CLIP	22100165
MIRT448556	hsa-miR-135a-3p	PAR-CLIP	22100165
MIRT448555	hsa-miR-636	PAR-CLIP	22100165
MIRT448554	hsa-miR-4671-3p	PAR-CLIP	22100165
MIRT448553	hsa-miR-4473	PAR-CLIP	22100165
MIRT448552	hsa-miR-1273e	PAR-CLIP	22100165
MIRT448551	hsa-miR-3591-5p	PAR-CLIP	22100165
MIRT554947	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT554948	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT735569	hsa-miR-590-3p	ELISA, Immunohistochemistry (IHC), Luciferase reporter assay, qRT-PCR, Western blotting	33332780
MIRT006958	hsa-miR-337-3p	Luciferase reporter assay, Western blotting, qRT-PCR	33748908
MIRT554948	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT554947	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT554946	hsa-miR-10a-3p	PAR-CLIP	21572407
MIRT554945	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT554944	hsa-miR-6750-5p	PAR-CLIP	21572407
MIRT554943	hsa-miR-6822-5p	PAR-CLIP	21572407
MIRT554942	hsa-miR-5692b	PAR-CLIP	21572407
MIRT554941	hsa-miR-5692c	PAR-CLIP	21572407
MIRT554940	hsa-miR-6715a-3p	PAR-CLIP	21572407
MIRT554939	hsa-miR-412-3p	PAR-CLIP	21572407
MIRT554938	hsa-miR-6754-3p	PAR-CLIP	21572407
MIRT554937	hsa-miR-6837-3p	PAR-CLIP	21572407
MIRT554936	hsa-miR-4471	PAR-CLIP	21572407
MIRT554935	hsa-miR-8059	PAR-CLIP	21572407
MIRT554934	hsa-miR-4799-5p	PAR-CLIP	21572407
MIRT512898	hsa-miR-551b-5p	PAR-CLIP	23446348
MIRT512897	hsa-miR-18a-5p	PAR-CLIP	23446348
MIRT512896	hsa-miR-18b-5p	PAR-CLIP	23446348
MIRT512895	hsa-miR-4735-3p	PAR-CLIP	23446348
MIRT512894	hsa-miR-5000-5p	PAR-CLIP	23446348
MIRT512893	hsa-miR-4761-5p	PAR-CLIP	23446348
MIRT512892	hsa-miR-759	PAR-CLIP	23446348
MIRT512891	hsa-miR-4470	PAR-CLIP	23446348
MIRT448559	hsa-miR-520f-3p	PAR-CLIP	22100165
MIRT448557	hsa-miR-302c-3p	PAR-CLIP	22100165
MIRT448558	hsa-miR-512-3p	PAR-CLIP	22100165
MIRT448556	hsa-miR-135a-3p	PAR-CLIP	22100165
MIRT448555	hsa-miR-636	PAR-CLIP	22100165
MIRT448554	hsa-miR-4671-3p	PAR-CLIP	22100165
MIRT448553	hsa-miR-4473	PAR-CLIP	22100165
MIRT448552	hsa-miR-1273e	PAR-CLIP	22100165
MIRT448551	hsa-miR-3591-5p	PAR-CLIP	22100165
MIRT1289834	hsa-miR-1279	CLIP-seq
MIRT1289835	hsa-miR-1297	CLIP-seq
MIRT1289836	hsa-miR-19a	CLIP-seq
MIRT1289837	hsa-miR-19b	CLIP-seq
MIRT1289838	hsa-miR-23a	CLIP-seq
MIRT1289839	hsa-miR-23b	CLIP-seq
MIRT1289840	hsa-miR-23c	CLIP-seq
MIRT1289841	hsa-miR-25	CLIP-seq
MIRT1289842	hsa-miR-26a	CLIP-seq
MIRT1289843	hsa-miR-26b	CLIP-seq
MIRT1289844	hsa-miR-3156-5p	CLIP-seq
MIRT1289845	hsa-miR-32	CLIP-seq
MIRT1289846	hsa-miR-320a	CLIP-seq
MIRT1289847	hsa-miR-320b	CLIP-seq
MIRT1289848	hsa-miR-320c	CLIP-seq
MIRT1289849	hsa-miR-320d	CLIP-seq
MIRT1289850	hsa-miR-363	CLIP-seq
MIRT1289851	hsa-miR-3660	CLIP-seq
MIRT1289852	hsa-miR-367	CLIP-seq
MIRT1289853	hsa-miR-3925-3p	CLIP-seq
MIRT1289854	hsa-miR-4428	CLIP-seq
MIRT1289855	hsa-miR-4429	CLIP-seq
MIRT1289856	hsa-miR-4465	CLIP-seq
MIRT1289857	hsa-miR-4526	CLIP-seq
MIRT1289858	hsa-miR-4645-3p	CLIP-seq
MIRT1289859	hsa-miR-4672	CLIP-seq
MIRT1289860	hsa-miR-4685-5p	CLIP-seq
MIRT1289861	hsa-miR-4789-5p	CLIP-seq
MIRT1289862	hsa-miR-5096	CLIP-seq
MIRT1289863	hsa-miR-515-5p	CLIP-seq
MIRT1289864	hsa-miR-518a-5p	CLIP-seq
MIRT1289865	hsa-miR-527	CLIP-seq
MIRT1289866	hsa-miR-539	CLIP-seq
MIRT1289867	hsa-miR-766	CLIP-seq
MIRT1289868	hsa-miR-92a	CLIP-seq
MIRT1289869	hsa-miR-92b	CLIP-seq
MIRT1289870	hsa-miR-1245b-3p	CLIP-seq
MIRT1289834	hsa-miR-1279	CLIP-seq
MIRT1289835	hsa-miR-1297	CLIP-seq
MIRT1289871	hsa-miR-1298	CLIP-seq
MIRT1289872	hsa-miR-1299	CLIP-seq
MIRT1289873	hsa-miR-149	CLIP-seq
MIRT1289836	hsa-miR-19a	CLIP-seq
MIRT1289837	hsa-miR-19b	CLIP-seq
MIRT1289838	hsa-miR-23a	CLIP-seq
MIRT1289839	hsa-miR-23b	CLIP-seq
MIRT1289840	hsa-miR-23c	CLIP-seq
MIRT1289874	hsa-miR-24	CLIP-seq
MIRT1289841	hsa-miR-25	CLIP-seq
MIRT1289842	hsa-miR-26a	CLIP-seq
MIRT1289843	hsa-miR-26b	CLIP-seq
MIRT1289875	hsa-miR-3064-5p	CLIP-seq
MIRT1289876	hsa-miR-3126-3p	CLIP-seq
MIRT1289877	hsa-miR-3145-3p	CLIP-seq
MIRT1289878	hsa-miR-3163	CLIP-seq
MIRT1289845	hsa-miR-32	CLIP-seq
MIRT1289879	hsa-miR-3613-3p	CLIP-seq
MIRT1289880	hsa-miR-3616-5p	CLIP-seq
MIRT1289850	hsa-miR-363	CLIP-seq
MIRT1289881	hsa-miR-3646	CLIP-seq
MIRT1289882	hsa-miR-3647-5p	CLIP-seq
MIRT1289883	hsa-miR-3662	CLIP-seq
MIRT1289852	hsa-miR-367	CLIP-seq
MIRT1289884	hsa-miR-3682-3p	CLIP-seq
MIRT1289885	hsa-miR-3685	CLIP-seq
MIRT1289886	hsa-miR-371b-5p	CLIP-seq
MIRT1289887	hsa-miR-384	CLIP-seq
MIRT1289853	hsa-miR-3925-3p	CLIP-seq
MIRT1289888	hsa-miR-3942-3p	CLIP-seq
MIRT1289889	hsa-miR-4277	CLIP-seq
MIRT1289890	hsa-miR-4284	CLIP-seq
MIRT1289891	hsa-miR-4328	CLIP-seq
MIRT1289892	hsa-miR-4423-3p	CLIP-seq
MIRT1289893	hsa-miR-4434	CLIP-seq
MIRT1289856	hsa-miR-4465	CLIP-seq
MIRT1289894	hsa-miR-4516	CLIP-seq
MIRT1289859	hsa-miR-4672	CLIP-seq
MIRT1289860	hsa-miR-4685-5p	CLIP-seq
MIRT1289895	hsa-miR-4709-5p	CLIP-seq
MIRT1289896	hsa-miR-4733-5p	CLIP-seq
MIRT1289897	hsa-miR-4768-3p	CLIP-seq
MIRT1289898	hsa-miR-4775	CLIP-seq
MIRT1289861	hsa-miR-4789-5p	CLIP-seq
MIRT1289899	hsa-miR-4794	CLIP-seq
MIRT1289900	hsa-miR-486-5p	CLIP-seq
MIRT1289862	hsa-miR-5096	CLIP-seq
MIRT1289901	hsa-miR-511	CLIP-seq
MIRT1289863	hsa-miR-515-5p	CLIP-seq
MIRT1289864	hsa-miR-518a-5p	CLIP-seq
MIRT1289865	hsa-miR-527	CLIP-seq
MIRT1289902	hsa-miR-558	CLIP-seq
MIRT1289903	hsa-miR-573	CLIP-seq
MIRT1289904	hsa-miR-587	CLIP-seq
MIRT1289867	hsa-miR-766	CLIP-seq
MIRT1289905	hsa-miR-875-3p	CLIP-seq
MIRT1289906	hsa-miR-888	CLIP-seq
MIRT1289868	hsa-miR-92a	CLIP-seq
MIRT1289869	hsa-miR-92b	CLIP-seq
MIRT1289907	hsa-miR-935	CLIP-seq
MIRT2086103	hsa-miR-1	CLIP-seq
MIRT1289871	hsa-miR-1298	CLIP-seq
MIRT1289872	hsa-miR-1299	CLIP-seq
MIRT1289873	hsa-miR-149	CLIP-seq
MIRT2086104	hsa-miR-206	CLIP-seq
MIRT1289838	hsa-miR-23a	CLIP-seq
MIRT1289839	hsa-miR-23b	CLIP-seq
MIRT1289840	hsa-miR-23c	CLIP-seq
MIRT1289874	hsa-miR-24	CLIP-seq
MIRT1289841	hsa-miR-25	CLIP-seq
MIRT2086105	hsa-miR-299-5p	CLIP-seq
MIRT1289875	hsa-miR-3064-5p	CLIP-seq
MIRT1289876	hsa-miR-3126-3p	CLIP-seq
MIRT1289844	hsa-miR-3156-5p	CLIP-seq
MIRT1289845	hsa-miR-32	CLIP-seq
MIRT1289850	hsa-miR-363	CLIP-seq
MIRT1289851	hsa-miR-3660	CLIP-seq
MIRT1289852	hsa-miR-367	CLIP-seq
MIRT2086106	hsa-miR-3673	CLIP-seq
MIRT2086107	hsa-miR-3942-5p	CLIP-seq
MIRT1289889	hsa-miR-4277	CLIP-seq
MIRT1289890	hsa-miR-4284	CLIP-seq
MIRT1289891	hsa-miR-4328	CLIP-seq
MIRT1289892	hsa-miR-4423-3p	CLIP-seq
MIRT1289854	hsa-miR-4428	CLIP-seq
MIRT1289857	hsa-miR-4526	CLIP-seq
MIRT1289858	hsa-miR-4645-3p	CLIP-seq
MIRT2086108	hsa-miR-4703-5p	CLIP-seq
MIRT1289895	hsa-miR-4709-5p	CLIP-seq
MIRT2086109	hsa-miR-4731-3p	CLIP-seq
MIRT1289896	hsa-miR-4733-5p	CLIP-seq
MIRT1289899	hsa-miR-4794	CLIP-seq
MIRT2086110	hsa-miR-4801	CLIP-seq
MIRT1289900	hsa-miR-486-5p	CLIP-seq
MIRT1289862	hsa-miR-5096	CLIP-seq
MIRT1289901	hsa-miR-511	CLIP-seq
MIRT1289864	hsa-miR-518a-5p	CLIP-seq
MIRT1289865	hsa-miR-527	CLIP-seq
MIRT1289866	hsa-miR-539	CLIP-seq
MIRT1289902	hsa-miR-558	CLIP-seq
MIRT2086111	hsa-miR-571	CLIP-seq
MIRT2086112	hsa-miR-613	CLIP-seq
MIRT2086113	hsa-miR-628-5p	CLIP-seq
MIRT2086114	hsa-miR-656	CLIP-seq
MIRT1289905	hsa-miR-875-3p	CLIP-seq
MIRT1289868	hsa-miR-92a	CLIP-seq
MIRT1289869	hsa-miR-92b	CLIP-seq
MIRT1289907	hsa-miR-935	CLIP-seq
MIRT2086103	hsa-miR-1	CLIP-seq
MIRT1289871	hsa-miR-1298	CLIP-seq
MIRT1289872	hsa-miR-1299	CLIP-seq
MIRT2086104	hsa-miR-206	CLIP-seq
MIRT1289838	hsa-miR-23a	CLIP-seq
MIRT1289839	hsa-miR-23b	CLIP-seq
MIRT1289840	hsa-miR-23c	CLIP-seq
MIRT2311356	hsa-miR-300	CLIP-seq
MIRT2311357	hsa-miR-3123	CLIP-seq
MIRT1289844	hsa-miR-3156-5p	CLIP-seq
MIRT1289878	hsa-miR-3163	CLIP-seq
MIRT2311358	hsa-miR-335	CLIP-seq
MIRT1289880	hsa-miR-3616-5p	CLIP-seq
MIRT1289882	hsa-miR-3647-5p	CLIP-seq
MIRT1289851	hsa-miR-3660	CLIP-seq
MIRT2086106	hsa-miR-3673	CLIP-seq
MIRT2311359	hsa-miR-381	CLIP-seq
MIRT1289888	hsa-miR-3942-3p	CLIP-seq
MIRT2086107	hsa-miR-3942-5p	CLIP-seq
MIRT1289889	hsa-miR-4277	CLIP-seq
MIRT1289892	hsa-miR-4423-3p	CLIP-seq
MIRT1289893	hsa-miR-4434	CLIP-seq
MIRT1289894	hsa-miR-4516	CLIP-seq
MIRT1289857	hsa-miR-4526	CLIP-seq
MIRT1289858	hsa-miR-4645-3p	CLIP-seq
MIRT2311360	hsa-miR-4666-3p	CLIP-seq
MIRT2086108	hsa-miR-4703-5p	CLIP-seq
MIRT1289895	hsa-miR-4709-5p	CLIP-seq
MIRT2086109	hsa-miR-4731-3p	CLIP-seq
MIRT1289897	hsa-miR-4768-3p	CLIP-seq
MIRT2086110	hsa-miR-4801	CLIP-seq
MIRT1289866	hsa-miR-539	CLIP-seq
MIRT2086111	hsa-miR-571	CLIP-seq
MIRT1289903	hsa-miR-573	CLIP-seq
MIRT2086112	hsa-miR-613	CLIP-seq
MIRT1289905	hsa-miR-875-3p	CLIP-seq
MIRT1289907	hsa-miR-935	CLIP-seq
MIRT1289878	hsa-miR-3163	CLIP-seq
MIRT2607680	hsa-miR-1304	CLIP-seq
MIRT2607681	hsa-miR-142-5p	CLIP-seq
MIRT2086105	hsa-miR-299-5p	CLIP-seq
MIRT2607682	hsa-miR-3184	CLIP-seq
MIRT2607683	hsa-miR-340	CLIP-seq
MIRT1289879	hsa-miR-3613-3p	CLIP-seq
MIRT1289886	hsa-miR-371b-5p	CLIP-seq
MIRT2086107	hsa-miR-3942-5p	CLIP-seq
MIRT2607684	hsa-miR-423-5p	CLIP-seq
MIRT1289858	hsa-miR-4645-3p	CLIP-seq
MIRT2607685	hsa-miR-4686	CLIP-seq
MIRT2086108	hsa-miR-4703-5p	CLIP-seq
MIRT2086109	hsa-miR-4731-3p	CLIP-seq
MIRT2086110	hsa-miR-4801	CLIP-seq
MIRT2607686	hsa-miR-520f	CLIP-seq
MIRT2607687	hsa-miR-548a-5p	CLIP-seq
MIRT2607688	hsa-miR-548ab	CLIP-seq
MIRT2607689	hsa-miR-548ak	CLIP-seq
MIRT2607690	hsa-miR-548b-5p	CLIP-seq
MIRT2607691	hsa-miR-548c-5p	CLIP-seq
MIRT2607692	hsa-miR-548d-5p	CLIP-seq
MIRT2607693	hsa-miR-548h	CLIP-seq
MIRT2607694	hsa-miR-548i	CLIP-seq
MIRT2607695	hsa-miR-548j	CLIP-seq
MIRT2607696	hsa-miR-548k	CLIP-seq
MIRT2607697	hsa-miR-548l	CLIP-seq
MIRT2607698	hsa-miR-548w	CLIP-seq
MIRT2607699	hsa-miR-548y	CLIP-seq
MIRT2607700	hsa-miR-559	CLIP-seq
MIRT2086111	hsa-miR-571	CLIP-seq
MIRT2086114	hsa-miR-656	CLIP-seq
MIRT1289906	hsa-miR-888	CLIP-seq
MIRT2607680	hsa-miR-1304	CLIP-seq
MIRT2607681	hsa-miR-142-5p	CLIP-seq
MIRT2086105	hsa-miR-299-5p	CLIP-seq
MIRT2607682	hsa-miR-3184	CLIP-seq
MIRT2607683	hsa-miR-340	CLIP-seq
MIRT1289879	hsa-miR-3613-3p	CLIP-seq
MIRT1289886	hsa-miR-371b-5p	CLIP-seq
MIRT2086107	hsa-miR-3942-5p	CLIP-seq
MIRT2607684	hsa-miR-423-5p	CLIP-seq
MIRT1289858	hsa-miR-4645-3p	CLIP-seq
MIRT2607685	hsa-miR-4686	CLIP-seq
MIRT2086108	hsa-miR-4703-5p	CLIP-seq
MIRT2086109	hsa-miR-4731-3p	CLIP-seq
MIRT2086110	hsa-miR-4801	CLIP-seq
MIRT2607687	hsa-miR-548a-5p	CLIP-seq
MIRT2607688	hsa-miR-548ab	CLIP-seq
MIRT2607689	hsa-miR-548ak	CLIP-seq
MIRT2607690	hsa-miR-548b-5p	CLIP-seq
MIRT2607691	hsa-miR-548c-5p	CLIP-seq
MIRT2607692	hsa-miR-548d-5p	CLIP-seq
MIRT2607693	hsa-miR-548h	CLIP-seq
MIRT2607694	hsa-miR-548i	CLIP-seq
MIRT2607695	hsa-miR-548j	CLIP-seq
MIRT2607696	hsa-miR-548k	CLIP-seq
MIRT2607697	hsa-miR-548l	CLIP-seq
MIRT2607698	hsa-miR-548w	CLIP-seq
MIRT2607699	hsa-miR-548y	CLIP-seq
MIRT2607700	hsa-miR-559	CLIP-seq
MIRT2086111	hsa-miR-571	CLIP-seq
MIRT2086114	hsa-miR-656	CLIP-seq
MIRT1289906	hsa-miR-888	CLIP-seq

Transcription factors

Show/Hide all(2)

Transcription factor	Regulation	Reference
TWIST1	Repression	19051271
TWIST2	Repression	19051271

Show/Hide all(50)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003924	Function	GTPase activity	IBA	21873635
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	ISS
GO:0005515	Function	Protein binding	IPI	7791872, 8756332, 10608844, 11022048, 11359771, 12845325, 15569673, 16698549, 17916086
GO:0005525	Function	GTP binding	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	11359771, 23209302
GO:0005769	Component	Early endosome	ISS
GO:0005770	Component	Late endosome	ISS
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0007399	Process	Nervous system development	IEA
GO:0009743	Process	Response to carbohydrate	IEA
GO:0010976	Process	Positive regulation of neuron projection development	ISS
GO:0019003	Function	GDP binding	IBA	21873635
GO:0030033	Process	Microvillus assembly	IMP	22797597
GO:0030054	Component	Cell junction	ISS
GO:0031267	Function	Small GTPase binding	IEA
GO:0032045	Component	Guanyl-nucleotide exchange factor complex	IEA
GO:0032486	Process	Rap protein signal transduction	IBA	21873635
GO:0032486	Process	Rap protein signal transduction	IMP	21840392
GO:0032966	Process	Negative regulation of collagen biosynthetic process	IEA
GO:0035579	Component	Specific granule membrane	TAS
GO:0035690	Process	Cellular response to drug	IEA
GO:0038180	Process	Nerve growth factor signaling pathway	ISS
GO:0043005	Component	Neuron projection	IEA
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0043547	Process	Positive regulation of GTPase activity	ISS
GO:0044877	Function	Protein-containing complex binding	IDA	23209302
GO:0045335	Component	Phagocytic vesicle	IEA
GO:0045860	Process	Positive regulation of protein kinase activity	ISS
GO:0046326	Process	Positive regulation of glucose import	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	11359771
GO:0050796	Process	Regulation of insulin secretion	TAS
GO:0061028	Process	Establishment of endothelial barrier	IMP	21840392
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	ISS
GO:0071320	Process	Cellular response to cAMP	IBA	21873635
GO:0071320	Process	Cellular response to cAMP	IDA	21840392
GO:0072659	Process	Protein localization to plasma membrane	IDA	17916086
GO:0097327	Process	Response to antineoplastic agent	IEA
GO:0097421	Process	Liver regeneration	IEA
GO:0098696	Process	Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	12202034
GO:0098696	Process	Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP	12202034
GO:0098978	Component	Glutamatergic synapse	IDA	12202034
GO:0098978	Component	Glutamatergic synapse	IMP	12202034
GO:1901888	Process	Regulation of cell junction assembly	IMP	21840392
GO:1905451	Process	Positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	IEA
GO:1990090	Process	Cellular response to nerve growth factor stimulus	ISS
GO:2000301	Process	Negative regulation of synaptic vesicle exocytosis	IBA	21873635
GO:2001214	Process	Positive regulation of vasculogenesis	ISS

MIM	HGNC	e!Ensembl
179520	9855	ENSG00000116473

Protein

UniProt ID

P62834

Protein name

Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)

Protein function

Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (PubMed:17916086). Plays a role

PDB

1C1Y , 1GUA , 3KUC , 4KVG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00071	Ras	5 → 167	Ras family	Domain

Sequence

MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG
TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL
EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS
CLLL

Sequence length

184

Interactions

View interactions

	KEGG		Reactome
	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway Focal adhesion Adherens junction Tight junction Platelet activation Leukocyte transendothelial migration Long-term potentiation Neurotrophin signaling pathway Cushing syndrome Pancreatic secretion Renal cell carcinoma Lipid and atherosclerosis		Frs2-mediated activation ARMS-mediated activation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Signaling downstream of RAS mutants

Associated diseases

Show/Hide Causal Diseases (13)

Causal
Disease name	Disease term	dbSNP ID	References
Congenital diaphragmatic hernia	Congenital diaphragmatic hernia	rs121908602, rs121908604, rs864309713, rs780263938, rs756636036, rs775394591
Congenital ocular coloboma	Congenital ocular coloboma (disorder)	rs587778875, rs587777249, rs767611891, rs2091986259, rs2091987023, rs2091988799
Cryptorchidism	Cryptorchidism	rs121912555, rs104894697, rs104894698, rs398122886
Hearing loss	Conductive hearing loss, Sensorineural Hearing Loss (disorder)	rs267607135, rs267606855, rs779841884, rs267606854, rs28942097, rs121908073, rs121908076, rs74315289, rs121908144, rs111033313, rs74315437, rs121908348, rs121908349, rs121908350, rs397515359, rs180177151, rs180177154, rs180177153, rs35689081, rs35887622, rs80338944, rs104894396, rs104894398, rs80338947, rs80338948, rs80338942, rs104894402, rs104894403, rs80338945, rs28931594, rs80338940, rs80338941, rs80356590, rs80338950, rs387906706, rs387906707, rs387906708, rs398122848, rs387907016, rs587776894, rs387907088, rs397515411, rs370965183, rs398122930, rs199897298, rs111033187, rs111033448, rs199606180, rs111033284, rs397516413, rs111033305, rs111033220, rs111033256, rs111033297, rs111033253, rs104894408, rs111033295, rs397516874, rs76434661, rs111033335, rs397517323, rs111033247, rs367928692, rs374793617, rs143939430, rs397515605, rs80338939, rs200656442, rs779748859, rs587781261, rs587781262, rs143343083, rs200147906, rs730880338, rs797044491, rs146281367, rs756484720, rs869025593, rs201306709, rs540895576, rs777777359, rs879255246, rs1554358720, rs142498437, rs377145777, rs1057517519, rs779077039, rs952741388, rs1060499797, rs764139009, rs1060499590, rs1064794012, rs1064797115, rs756790858, rs775633137, rs1554952443, rs1554952193, rs782063761, rs1199012623, rs756147087, rs1555648043, rs1555661490, rs1553196233, rs781546107, rs111033190, rs775428246, rs782539587, rs537227442, rs148695069, rs1554835827, rs953422571, rs1554834186, rs1554834161, rs1554835103, rs1554577339, rs1554577402, rs768471577, rs782279338, rs781951909, rs998045226, rs375759781, rs755804651, rs1557458426, rs767797828, rs538027448, rs1559366084, rs367688416, rs1558480402, rs1558490542, rs1559870857, rs1560690591, rs1561299289, rs1562817224, rs1562817529, rs1562822565, rs1562835391, rs1564113368, rs1564554255, rs773851192, rs1564555240, rs761261855, rs1564805114, rs1565522273, rs1565127413, rs781790246, rs1565430886, rs1565469959, rs746667217, rs1565819402, rs1565855932, rs150529554, rs1567939793, rs201866631, rs754472294, rs1559372512, rs1558464965, rs1558488902, rs775062249, rs1226171550, rs1561590396, rs765574676, rs762876554, rs757327146, rs1564949059, rs1565519673, rs368050948, rs1565541888, rs781989117, rs1565402473, rs750358148, rs1386887007, rs1209665716, rs1567641234, rs1237955948, rs1569042782, rs752672077, rs146689036, rs1560070780, rs149712664, rs1564556995, rs762226905, rs773573968, rs1568528171, rs1198256157, rs377267777, rs370564476, rs1577876794, rs747787770, rs759432278, rs1043716893, rs1581138934, rs2033773650, rs1421964916, rs771766431, rs780917129, rs1895773215, rs1895769400, rs761543680, rs1565920060
Hydrocephalus	Hydrocephalus	rs387907320, rs369384363, rs387907321, rs372127610, rs770273135, rs797045095, rs797045707, rs769795916, rs781251438, rs922703465, rs376078512, rs1567043467, rs1587149916, rs1586841546
Kabuki syndrome	Kabuki make-up syndrome	rs267607237, rs267607240, rs267607239, rs398122929, rs397514628, rs398122829, rs398122969, rs398123704, rs398123708, rs398123715, rs398123721, rs398123729, rs398123744, rs398123751, rs398123753, rs367537992, rs587783703, rs587783702, rs587783700, rs587783699, rs587783698, rs587783697, rs587783696, rs587783695, rs587783693, rs587783692, rs587783691, rs587783690, rs587783688, rs587783687, rs587783686, rs587783685, rs587783683, rs587783682, rs587783681, rs587783729, rs587783728, rs587783727, rs587783725, rs556669370, rs587783723, rs587783719, rs587783715, rs587783713, rs587783712, rs587783711, rs587783705, rs587783689, rs587783714, rs587783708, rs727503979, rs727503987, rs727503983, rs793888515, rs793888514, rs793888513, rs793888511, rs793888512, rs35584294, rs793888509, rs793888510, rs786205676, rs786205478, rs756471180, rs794727420, rs794727549, rs794727688, rs797045001, rs797045659, rs797045658, rs797045672, rs797045671, rs797045669, rs797045668, rs797045667, rs797045663, rs797045662, rs797045660, rs797045670, rs797045661, rs797045642, rs797045643, rs797045644, rs863224890, rs863224886, rs886039399, rs886039398, rs886040960, rs886041106, rs886041398, rs886041404, rs886041405, rs886043414, rs886043497, rs886043506, rs1057516039, rs1057517992, rs1057518571, rs1057518680, rs1057519067, rs1057519422, rs1057519595, rs1060499665, rs1060499669, rs1060499724, rs1060499552, rs1555190375, rs1064794026, rs1064796275, rs1064796125, rs1064793351, rs1555044700, rs1555185301, rs1555186232, rs1555187577, rs1555188129, rs1555188155, rs1555188469, rs1135401809, rs940178682, rs1555188653, rs1555189207, rs1555194045, rs1555195441, rs1555198491, rs1555198886, rs1555191598, rs1555196415, rs1555186079, rs1555186436, rs1555187105, rs188017299, rs1555191521, rs1555194510, rs1555197682, rs1555198201, rs1555187758, rs1555190324, rs1555192996, rs1555185299, rs1555192667, rs1555195442, rs1555185217, rs1555188501, rs1556328781, rs1556341546, rs886040420, rs1555190635, rs1555187452, rs35493001, rs1555187956, rs1333678798, rs1555186053, rs1251778848, rs1556346208, rs1555188379, rs1452715535, rs1555187117, rs1556357314, rs1555184777, rs1555186066, rs1350605713, rs1555192751, rs1555188518, rs1555195432, rs1422752351, rs1555188704, rs767415197, rs1556330304, rs1556350571, rs1555184624, rs1555184635, rs1555184782, rs1555184893, rs1555185610, rs398123728, rs1555185699, rs1555185817, rs1555185969, rs1555185978, rs1555186044, rs1555186087, rs1555186257, rs1555186527, rs1555186627, rs1355372507, rs1555187461, rs1555187485, rs1555187575, rs1555187741, rs1555187869, rs1555188026, rs1555188080, rs1555188430, rs1555188520, rs1555188537, rs1555188561, rs1555188670, rs1555188687, rs1555189038, rs763440821, rs1555189421, rs1555189450, rs1210590639, rs1555190391, rs1555190550, rs1555190806, rs1555190907, rs1555191147, rs1555191177, rs1555191203, rs1555191324, rs1555191665, rs1555191740, rs1555192051, rs1555192113, rs1555192210, rs1555192218, rs1555192437, rs1555192451, rs1555192457, rs1555192531, rs1555193738, rs1555193755, rs1555193912, rs1555194236, rs1555194303, rs1290729871, rs1555194822, rs1555195118, rs1240601136, rs764942, rs1555195573, rs1555196016, rs1555196084, rs1555196459, rs1555196590, rs1555196742, rs370492566, rs1555196984, rs1555197101, rs770315135, rs1555197738, rs1555198318, rs1555198590, rs1555198640, rs1555198921, rs1555957146, rs1555186619, rs1556311265, rs1556357274, rs1565756561, rs1565756106, rs781145102, rs1565771606, rs1565781216, rs1364500207, rs1565826250, rs1565780936, rs767737749, rs1565776616, rs1565789522, rs1565802369, rs1565812092, rs1565813691, rs1565817210, rs1569537333, rs1450363794, rs1565809463, rs1565773113, rs1565763192, rs1565807707, rs1565822457, rs1569542167, rs1565756115, rs755440519, rs1565820584, rs1565753611, rs1057518149, rs1565779530, rs1592159322, rs1592129081, rs1592161182, rs1592153986, rs1602868720, rs1592133086, rs1592123162, rs1592106062, rs1592106640, rs1592112854, rs1592116886, rs1592117125, rs1592118953, rs1592118976, rs1592123024, rs1592129138, rs1592131106, rs1565790749, rs1592133696, rs1592135715, rs1592136317, rs1592136884, rs1592137369, rs1592137413, rs1592138822, rs1592142239, rs1592145939, rs1592146526, rs1592151169, rs1592156633, rs1592157335, rs1592157505, rs1592160494, rs1602985802, rs1318649487, rs867333942, rs1592110749, rs1057520722, rs1602799769, rs1602928572, rs1603068073, rs1592105909, rs1592106879, rs1592139221, rs1592150075, rs912069418, rs1602928108, rs1592102369, rs1592130816, rs1592139573, rs1592142093, rs1592106220, rs1592122640, rs1592132971, rs1592136242, rs1592162768, rs398123725, rs1592152233, rs1943461045, rs1592159924, rs1592162790, rs1942357670, rs1942587772, rs1942608745, rs1942615152, rs1942616266, rs1943016958, rs1943319609, rs1943527583, rs1157281284, rs1938072820, rs1938074857, rs1938252263, rs2044750709	26280580
Microcephaly	Microcephaly	rs397704721, rs267607176, rs267607177, rs397704725, rs267606717, rs267606718, rs199422202, rs121434311, rs199422203, rs199422126, rs387906274, rs121434305, rs199422125, rs199422135, rs189678019, rs199422184, rs137852994, rs137852995, rs137852996, rs137852997, rs145489194, rs80338860, rs137852494, rs121918609, rs199422207, rs199422206, rs29001566, rs864321658, rs199422138, rs199422139, rs199422141, rs199422144, rs199422147, rs199422151, rs199422152, rs199422153, rs199422157, rs199422159, rs199422160, rs199422161, rs140602858, rs199422164, rs199422165, rs148294838, rs199422134, rs199422168, rs199422172, rs199422173, rs199422131, rs199422177, rs199422180, rs199422185, rs199422186, rs199422187, rs143931757, rs199422189, rs199422192, rs199422194, rs199422195, rs199422196, rs199422197, rs199422199, rs753597039, rs1488084787, rs387906961, rs755862917, rs387907082, rs587776899, rs387907083, rs587776900, rs587776901, rs387907084, rs863223322, rs764201220, rs202247811, rs763915472, rs587776986, rs587777036, rs398122971, rs374351172, rs373278668, rs398122976, rs121909123, rs587783393, rs730882076, rs587783211, rs144716013, rs606231255, rs587783215, rs587783216, rs587783220, rs587783221, rs587783225, rs587783227, rs587783228, rs587783230, rs587783238, rs587783239, rs587783240, rs587783245, rs587783247, rs587783248, rs587783258, rs587783259, rs587783263, rs587783265, rs587783268, rs587783269, rs587783272, rs587783275, rs587783277, rs587783278, rs587783280, rs587783282, rs587783283, rs587783285, rs587783287, rs587783288, rs587783289, rs587783292, rs587783295, rs587784452, rs587783741, rs587783735, rs587783392, rs587783390, rs587783387, rs587783410, rs202058504, rs587783423, rs587783421, rs587783414, rs587784553, rs587784558, rs587784546, rs587784549, rs587784554, rs587784412, rs876661307, rs869025200, rs747831095, rs748529285, rs797045316, rs797045315, rs797045314, rs759632528, rs797045313, rs797045311, rs754282058, rs797045441, rs797045454, rs797045430, rs869312853, rs797046109, rs767399782, rs863225127, rs863225464, rs863225465, rs780270096, rs864321621, rs864321620, rs775277800, rs879253817, rs869312824, rs761447719, rs753406334, rs147622433, rs199422137, rs879255522, rs879255524, rs879255523, rs886037892, rs886037893, rs886037894, rs886037895, rs199422169, rs886041709, rs886041282, rs138228629, rs759188041, rs769688376, rs1057517688, rs1057519087, rs1057518268, rs933106143, rs201362977, rs754909135, rs1057520873, rs1060499758, rs1060499757, rs199422146, rs748016594, rs1085307120, rs763715733, rs1064795945, rs763800571, rs1554728351, rs1553227021, rs555866170, rs1553895368, rs1334947797, rs769818500, rs1321892596, rs1553227645, rs1404276011, rs1553228275, rs1554471681, rs1554496609, rs1555420891, rs1555418825, rs587784548, rs1555723585, rs199736219, rs745997770, rs765275884, rs1553924800, rs1554730137, rs1229568621, rs1482100822, rs979186313, rs758157294, rs1555294652, rs1555299107, rs1553264033, rs1553259539, rs1553254322, rs1553259528, rs981349334, rs1553264036, rs1553253022, rs754267846, rs776034810, rs1342429887, rs752140135, rs1006898944, rs571640983, rs1477524771, rs763909256, rs199910503, rs1553223496, rs759663956, rs1553446603, rs1555139372, rs1555143325, rs1350194762, rs1555141158, rs1553225179, rs769481947, rs769364943, rs748011724, rs1334301723, rs746341112, rs149225624, rs765113367, rs1567024512, rs142865061, rs772050241, rs201721894, rs1557966012, rs1379578836, rs1568334868, rs1185537869, rs1602333390, rs1163303148, rs774338373, rs770540184, rs1571600045, rs1571601267, rs1571602991, rs1588472215, rs1599841026, rs1558328287, rs1571600860, rs1571596976, rs1309880692, rs1435239428, rs1588634016, rs1751797979, rs1810830776, rs1815354949, rs1949984655, rs886039658, rs1943461045, rs777711720, rs2031759596, rs1555710223, rs1221031683, rs774069989, rs2058919680, rs1170413397, rs1213710245, rs1599851667, rs1599760058, rs1971033478, rs746967357
Nystagmus	Nystagmus	rs137852207, rs137852208, rs1928435502, rs137852209, rs137852210, rs1929191668, rs137852211, rs137852212, rs2124209414, rs387906720, rs387906721, rs1602791884, rs786205896
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840
Osteoporosis	Osteoporosis	rs72658152, rs72667023, rs587776916, rs72656370, rs768615287	20548944
Precocious puberty	Precocious Puberty	rs879255238, rs879255239, rs879255240, rs1264639964, rs1566764505
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	31374203
Scoliosis	Scoliosis, unspecified	rs1057518828, rs147296805, rs758163506, rs1555613564, rs1596852902, rs1596853067, rs1596853085

Show/Hide Unknown Diseases (15)

Unknown
Disease name	Disease term	dbSNP ID	References
Abnormal dermatoglyphic pattern	Abnormal dermatoglyphic pattern
Aortic coarctation	Aortic coarctation
Cerebral cortical atrophy	Cerebral cortical atrophy
Congenital hypoplasia of penis	Congenital hypoplasia of penis
Dwarfism	Dwarfism
Heart septal defects	Heart Septal Defects
High palate	Byzanthine arch palate
Hydronephrosis	Hydronephrosis
Hypodontia	Hypodontia
Hypospadias	Hypospadias
Macrotia	Macrotia
Microcornea	Microcornea
Microdontia	Microdontia (disorder)
Ptosis	Blepharoptosis, Ptosis	rs139920573
Strabismus	Strabismus

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