RAD52 (RAD52 DNA repair protein)

Gene

• Entrez ID: 5893
• Gene name: RAD52 DNA repair protein
• Gene symbol: RAD52
• Synonyms: -
• Chromosome: 12
• Chromosome location: 12p13.33
• Summary: The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT000156	hsa-miR-210-3p	immunoprecipitaion, qRT-PCR	19826008
MIRT000156	hsa-miR-210-3p	Luciferase reporter assay, qRT-PCR, Western blot	19141645
MIRT000156	hsa-miR-210-3p	Luciferase reporter assay, qRT-PCR, Western blot	19141645
MIRT003914	hsa-miR-373-3p	Luciferase reporter assay, qRT-PCR, Western blot	19141645
MIRT717823	hsa-miR-3671	HITS-CLIP	19536157
MIRT717822	hsa-miR-607	HITS-CLIP	19536157
MIRT000156	hsa-miR-210-3p	Western blotting, Microarray, Immunoprecipitaion (IP), qRT-PCR, Immunocytochemistry (ICC)	31468617
MIRT717823	hsa-miR-3671	HITS-CLIP	19536157
MIRT717822	hsa-miR-607	HITS-CLIP	19536157
MIRT1288218	hsa-miR-1228	CLIP-seq
MIRT1288219	hsa-miR-124	CLIP-seq
MIRT1288220	hsa-miR-2467-3p	CLIP-seq
MIRT1288221	hsa-miR-29a	CLIP-seq
MIRT1288222	hsa-miR-29b	CLIP-seq
MIRT1288223	hsa-miR-29c	CLIP-seq
MIRT1288224	hsa-miR-330-3p	CLIP-seq
MIRT1288225	hsa-miR-339-5p	CLIP-seq
MIRT1288226	hsa-miR-3714	CLIP-seq
MIRT1288227	hsa-miR-3910	CLIP-seq
MIRT1288228	hsa-miR-4257	CLIP-seq
MIRT1288229	hsa-miR-4645-5p	CLIP-seq
MIRT1288230	hsa-miR-4673	CLIP-seq
MIRT1288231	hsa-miR-4709-5p	CLIP-seq
MIRT1288232	hsa-miR-4733-3p	CLIP-seq
MIRT1288233	hsa-miR-4742-3p	CLIP-seq
MIRT1288234	hsa-miR-506	CLIP-seq
MIRT2085319	hsa-miR-296-5p	CLIP-seq
MIRT2085320	hsa-miR-3136-3p	CLIP-seq
MIRT2085321	hsa-miR-34c-3p	CLIP-seq
MIRT2085322	hsa-miR-3614-5p	CLIP-seq
MIRT2085323	hsa-miR-635	CLIP-seq
MIRT2310760	hsa-miR-1244	CLIP-seq
MIRT2310761	hsa-miR-1298	CLIP-seq
MIRT2310762	hsa-miR-2114	CLIP-seq
MIRT2310763	hsa-miR-338-3p	CLIP-seq
MIRT2310764	hsa-miR-3925-3p	CLIP-seq
MIRT2310765	hsa-miR-433	CLIP-seq
MIRT2310766	hsa-miR-4530	CLIP-seq
MIRT2310767	hsa-miR-4789-5p	CLIP-seq
MIRT2310768	hsa-miR-503	CLIP-seq
MIRT2310769	hsa-miR-515-5p	CLIP-seq
MIRT2310770	hsa-miR-766	CLIP-seq
MIRT1288218	hsa-miR-1228	CLIP-seq
MIRT2393419	hsa-miR-128	CLIP-seq
MIRT2393420	hsa-miR-24	CLIP-seq
MIRT1288225	hsa-miR-339-5p	CLIP-seq
MIRT2393421	hsa-miR-342-3p	CLIP-seq
MIRT2393422	hsa-miR-4284	CLIP-seq
MIRT1288233	hsa-miR-4742-3p	CLIP-seq
MIRT2457698	hsa-miR-3148	CLIP-seq
MIRT2457699	hsa-miR-3647-3p	CLIP-seq
MIRT2457700	hsa-miR-3692	CLIP-seq
MIRT2457701	hsa-miR-4795-5p	CLIP-seq
MIRT2607140	hsa-miR-1207-3p	CLIP-seq
MIRT1288218	hsa-miR-1228	CLIP-seq
MIRT1288219	hsa-miR-124	CLIP-seq
MIRT2607141	hsa-miR-185	CLIP-seq
MIRT2607142	hsa-miR-203	CLIP-seq
MIRT2607143	hsa-miR-2110	CLIP-seq
MIRT1288220	hsa-miR-2467-3p	CLIP-seq
MIRT2085319	hsa-miR-296-5p	CLIP-seq
MIRT1288221	hsa-miR-29a	CLIP-seq
MIRT1288222	hsa-miR-29b	CLIP-seq
MIRT1288223	hsa-miR-29c	CLIP-seq
MIRT2607144	hsa-miR-300	CLIP-seq
MIRT2607145	hsa-miR-3127-5p	CLIP-seq
MIRT2085320	hsa-miR-3136-3p	CLIP-seq
MIRT2457698	hsa-miR-3148	CLIP-seq
MIRT2607146	hsa-miR-3194-3p	CLIP-seq
MIRT2607147	hsa-miR-324-5p	CLIP-seq
MIRT1288224	hsa-miR-330-3p	CLIP-seq
MIRT1288225	hsa-miR-339-5p	CLIP-seq
MIRT2085321	hsa-miR-34c-3p	CLIP-seq
MIRT2085322	hsa-miR-3614-5p	CLIP-seq
MIRT2607148	hsa-miR-3622a-3p	CLIP-seq
MIRT2607149	hsa-miR-3622b-3p	CLIP-seq
MIRT2457699	hsa-miR-3647-3p	CLIP-seq
MIRT2607150	hsa-miR-3663-3p	CLIP-seq
MIRT2607151	hsa-miR-3664-5p	CLIP-seq
MIRT2457700	hsa-miR-3692	CLIP-seq
MIRT1288226	hsa-miR-3714	CLIP-seq
MIRT2607152	hsa-miR-381	CLIP-seq
MIRT2607153	hsa-miR-383	CLIP-seq
MIRT1288227	hsa-miR-3910	CLIP-seq
MIRT2607154	hsa-miR-3918	CLIP-seq
MIRT2607155	hsa-miR-3921	CLIP-seq
MIRT2310764	hsa-miR-3925-3p	CLIP-seq
MIRT2607156	hsa-miR-4251	CLIP-seq
MIRT1288228	hsa-miR-4257	CLIP-seq
MIRT2607157	hsa-miR-4271	CLIP-seq
MIRT2607158	hsa-miR-4282	CLIP-seq
MIRT2607159	hsa-miR-4303	CLIP-seq
MIRT2607160	hsa-miR-4306	CLIP-seq
MIRT2607161	hsa-miR-4329	CLIP-seq
MIRT2607162	hsa-miR-4504	CLIP-seq
MIRT2607163	hsa-miR-4539	CLIP-seq
MIRT2607164	hsa-miR-4644	CLIP-seq
MIRT1288229	hsa-miR-4645-5p	CLIP-seq
MIRT2607165	hsa-miR-4653-5p	CLIP-seq
MIRT2607166	hsa-miR-4666-3p	CLIP-seq
MIRT2607167	hsa-miR-4670-5p	CLIP-seq
MIRT1288230	hsa-miR-4673	CLIP-seq
MIRT2607168	hsa-miR-4680-5p	CLIP-seq
MIRT2607169	hsa-miR-4687-5p	CLIP-seq
MIRT1288231	hsa-miR-4709-5p	CLIP-seq
MIRT2607170	hsa-miR-4724-5p	CLIP-seq
MIRT2607171	hsa-miR-4725-3p	CLIP-seq
MIRT1288232	hsa-miR-4733-3p	CLIP-seq
MIRT1288233	hsa-miR-4742-3p	CLIP-seq
MIRT2607172	hsa-miR-4752	CLIP-seq
MIRT2607173	hsa-miR-4762-3p	CLIP-seq
MIRT2607174	hsa-miR-4778-3p	CLIP-seq
MIRT2310767	hsa-miR-4789-5p	CLIP-seq
MIRT2457701	hsa-miR-4795-5p	CLIP-seq
MIRT2607175	hsa-miR-491-3p	CLIP-seq
MIRT1288234	hsa-miR-506	CLIP-seq
MIRT2607176	hsa-miR-507	CLIP-seq
MIRT2607177	hsa-miR-508-5p	CLIP-seq
MIRT2607178	hsa-miR-513a-3p	CLIP-seq
MIRT2607179	hsa-miR-542-3p	CLIP-seq
MIRT2607180	hsa-miR-548ac	CLIP-seq
MIRT2607181	hsa-miR-548ae	CLIP-seq
MIRT2607182	hsa-miR-548aj	CLIP-seq
MIRT2607183	hsa-miR-548am	CLIP-seq
MIRT2607184	hsa-miR-548d-3p	CLIP-seq
MIRT2607185	hsa-miR-548x	CLIP-seq
MIRT2607186	hsa-miR-548z	CLIP-seq
MIRT2607187	hsa-miR-557	CLIP-seq
MIRT2085323	hsa-miR-635	CLIP-seq
MIRT2607188	hsa-miR-767-5p	CLIP-seq
MIRT2607140	hsa-miR-1207-3p	CLIP-seq
MIRT1288218	hsa-miR-1228	CLIP-seq
MIRT1288219	hsa-miR-124	CLIP-seq
MIRT2607141	hsa-miR-185	CLIP-seq
MIRT2607142	hsa-miR-203	CLIP-seq
MIRT2607143	hsa-miR-2110	CLIP-seq
MIRT1288220	hsa-miR-2467-3p	CLIP-seq
MIRT2085319	hsa-miR-296-5p	CLIP-seq
MIRT1288221	hsa-miR-29a	CLIP-seq
MIRT1288222	hsa-miR-29b	CLIP-seq
MIRT1288223	hsa-miR-29c	CLIP-seq
MIRT2607144	hsa-miR-300	CLIP-seq
MIRT2085320	hsa-miR-3136-3p	CLIP-seq
MIRT2457698	hsa-miR-3148	CLIP-seq
MIRT2607146	hsa-miR-3194-3p	CLIP-seq
MIRT2607147	hsa-miR-324-5p	CLIP-seq
MIRT1288224	hsa-miR-330-3p	CLIP-seq
MIRT1288225	hsa-miR-339-5p	CLIP-seq
MIRT2085321	hsa-miR-34c-3p	CLIP-seq
MIRT2085322	hsa-miR-3614-5p	CLIP-seq
MIRT2607148	hsa-miR-3622a-3p	CLIP-seq
MIRT2607149	hsa-miR-3622b-3p	CLIP-seq
MIRT2457699	hsa-miR-3647-3p	CLIP-seq
MIRT2607150	hsa-miR-3663-3p	CLIP-seq
MIRT2457700	hsa-miR-3692	CLIP-seq
MIRT1288226	hsa-miR-3714	CLIP-seq
MIRT2607152	hsa-miR-381	CLIP-seq
MIRT2607153	hsa-miR-383	CLIP-seq
MIRT1288227	hsa-miR-3910	CLIP-seq
MIRT2607155	hsa-miR-3921	CLIP-seq
MIRT2607156	hsa-miR-4251	CLIP-seq
MIRT1288228	hsa-miR-4257	CLIP-seq
MIRT2607157	hsa-miR-4271	CLIP-seq
MIRT2607158	hsa-miR-4282	CLIP-seq
MIRT2607159	hsa-miR-4303	CLIP-seq
MIRT2607160	hsa-miR-4306	CLIP-seq
MIRT2607161	hsa-miR-4329	CLIP-seq
MIRT2607163	hsa-miR-4539	CLIP-seq
MIRT2607164	hsa-miR-4644	CLIP-seq
MIRT1288229	hsa-miR-4645-5p	CLIP-seq
MIRT2607165	hsa-miR-4653-5p	CLIP-seq
MIRT2607166	hsa-miR-4666-3p	CLIP-seq
MIRT2607167	hsa-miR-4670-5p	CLIP-seq
MIRT1288230	hsa-miR-4673	CLIP-seq
MIRT2607168	hsa-miR-4680-5p	CLIP-seq
MIRT2607169	hsa-miR-4687-5p	CLIP-seq
MIRT1288231	hsa-miR-4709-5p	CLIP-seq
MIRT2607170	hsa-miR-4724-5p	CLIP-seq
MIRT2607171	hsa-miR-4725-3p	CLIP-seq
MIRT1288232	hsa-miR-4733-3p	CLIP-seq
MIRT1288233	hsa-miR-4742-3p	CLIP-seq
MIRT2607172	hsa-miR-4752	CLIP-seq
MIRT2607173	hsa-miR-4762-3p	CLIP-seq
MIRT2607174	hsa-miR-4778-3p	CLIP-seq
MIRT2310767	hsa-miR-4789-5p	CLIP-seq
MIRT2457701	hsa-miR-4795-5p	CLIP-seq
MIRT2607175	hsa-miR-491-3p	CLIP-seq
MIRT1288234	hsa-miR-506	CLIP-seq
MIRT2607176	hsa-miR-507	CLIP-seq
MIRT2607178	hsa-miR-513a-3p	CLIP-seq
MIRT2607180	hsa-miR-548ac	CLIP-seq
MIRT2607181	hsa-miR-548ae	CLIP-seq
MIRT2607182	hsa-miR-548aj	CLIP-seq
MIRT2607183	hsa-miR-548am	CLIP-seq
MIRT2607184	hsa-miR-548d-3p	CLIP-seq
MIRT2607185	hsa-miR-548x	CLIP-seq
MIRT2607186	hsa-miR-548z	CLIP-seq
MIRT2607187	hsa-miR-557	CLIP-seq
MIRT2085323	hsa-miR-635	CLIP-seq
MIRT2607188	hsa-miR-767-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000724	Process	Double-strand break repair via homologous recombination	IBA	21873635
GO:0000730	Process	DNA recombinase assembly	IEA
GO:0003677	Function	DNA binding	IDA	19506022
GO:0003697	Function	Single-stranded DNA binding	IMP	12370410
GO:0005515	Function	Protein binding	IPI	8702565, 12750383, 14734547, 17765923, 19338310, 24126761, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	19506022
GO:0005654	Component	Nucleoplasm	TAS
GO:0006302	Process	Double-strand break repair	TAS	7774919
GO:0006310	Process	DNA recombination	IMP	8702565, 12370410
GO:0006312	Process	Mitotic recombination	IBA	21873635
GO:0006974	Process	Cellular response to DNA damage stimulus	IGI	19506022
GO:0010792	Process	DNA double-strand break processing involved in repair via single-strand annealing	IDA	19506022
GO:0032991	Component	Protein-containing complex	IDA	19506022
GO:0032993	Component	Protein-DNA complex	IMP	12370410
GO:0034599	Process	Cellular response to oxidative stress	IDA	19506022
GO:0042802	Function	Identical protein binding	IPI	10744977, 12370410, 12750383, 21804533, 32296183
GO:0045002	Process	Double-strand break repair via single-strand annealing	IBA	21873635
GO:2000819	Process	Regulation of nucleotide-excision repair	IDA	19506022

Other IDs

• MIM: 600392
• HGNC: 9824
• e!Ensembl: ENSG00000002016

Protein

• UniProt ID: P43351
• Protein name: DNA repair protein RAD52 homolog
• Protein function: Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase. {ECO:0000269|PubMed:12379650, ECO
• PDB: 1H2I, 1KN0, 5JRB, 5XRZ, 5XS0, 8BJM, 8H1P, 8RIL, 8RJ3, 8RJW, 8TKQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04098	Rad52_Rad22	35 → 183	Rad52/22 family double-strand break repair protein	Family

• Sequence:

  MSGTEEAILGGRDSHPAAGGGSVLCFGQCQYTAEEYQAIQKALRQRLGPEYISSRMAGGG
  QKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVRVQLKDGSY
  HEDVGYGVSEGLKSKALSLEKARKEAVTDGLKRALRSFGNALGNCILDKDYLRSLNKLPR
  QLPLEVDLTKAKRQDLEPSVEEARYNSCRPNMALGHPQLQQVTSPSRPSHAVIPADQDCS
  SRSLSSSAVESEATHQRKLRQKQLQQQFRERMEKQQVRVSTPSAEKSEAAPPAPPVTHST
  PVTVSEPLLEKDFLAGVTQELIKTLEDNSEKWAVTPDAGDGVVKPSSRADPAQTSDTLAL
  NNQMVTQNRTPHSVCHQKPQAKSGSWDLQTYSADQRTTGNWESHRKSQDMKKRKYDPS

• Sequence length: 418

Pathways

KEGG:

Homologous recombination

Reactome:

SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Carcinoma	Squamous cell carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	26013599
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	26013599, 22899653
Lung carcinoma	Carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	22899653

Unknown
Disease name	Disease term	dbSNP ID	References
Lung neoplasms	Lung Neoplasms		26013599