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DMRT3 (doublesex and mab-3 related transcription factor 3)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
58524
Gene nameGene Name - the full gene name approved by the HGNC.
Doublesex and mab-3 related transcription factor 3
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
DMRT3
SynonymsGene synonyms aliases
DMRTA3
ChromosomeChromosome number
9
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9p24.3
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018492 hsa-miR-335-5p Microarray 18185580
MIRT939224 hsa-miR-3622a-3p CLIP-seq
MIRT939225 hsa-miR-3622b-3p CLIP-seq
MIRT939226 hsa-miR-4701-5p CLIP-seq
MIRT939227 hsa-miR-588 CLIP-seq
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
GO:0005515 Function Protein binding IPI 25416956, 32296183
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9NQL9
Protein name Doublesex- and mab-3-related transcription factor 3
Protein function Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated l
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00751 DM
25 71
DM DNA binding domain
Family
PF03474 DMA
249 285
DMRTA motif
Domain
Sequence
MNGYGSPYLYMGGPVSQPPRAPLQRTPKCARCRNHGVLSWLKGHKRYCRFKDCTCEKCIL
IIERQRVMAAQ
VALRRQQANESLESLIPDSLRALPGPPPPGDAVAAPQPPPASQPSQPQP
PRPAAELAAAAALRWTAEPQPGALQAQLAKPDLTEERLGDGKSADNTEVFSDKDTDQRSS
PDVAKSKGCFTPESPEIVSVEEGGYAVQKNGGNPESRPDSPKCHAEQNHLLIEGPSGTVS
LPFSLKANRPPLEVLKKIFPNQKPTVLELILKGCGGDLVSAVEVLLSSRSSVTGAERTSA
EPESLALPSNGHIFEHTLSSYPISSSKWSVGSAFRVPDTLRFSADSSNVVPSPLAGPLQP
PFPQPPRYPLMLRNTLARSQSSPFLPNDVTLWNTMTLQQQYQLRSQYVSPFPSNSTSVFR
SSPVLPARATEDPRISIPDDGCPFVSKQSIYTEDDYDERSDSSDSRTLNTSS
Sequence length 472
Interactions View interactions
Associated diseases
Causal
Disease name Disease term dbSNP ID References
46, xy partial gonadal dysgenesis 46,XY partial gonadal dysgenesis rs193922688 17644778
Azoospermia Azoospermia rs200969445, rs144567652, rs765353898
Cryptorchidism Cryptorchidism rs121912555, rs104894697, rs104894698, rs398122886
Nephroblastoma Nephroblastoma rs1553551874, rs1555913934, rs769116796
Unknown
Disease name Disease term dbSNP ID References
Ambiguous genitalia Ambiguous Genitalia rs782562963
Gonadal dysgenesis Gonadal Dysgenesis
Gynecomastia Gynecomastia
Hypertrophy of clitoris Hypertrophy of clitoris

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