SCAF1 (SR-related CTD associated factor 1)

Gene

• Entrez ID: 58506
• Gene name: SR-related CTD associated factor 1
• Gene symbol: SCAF1
• Synonyms: SRA1
• Chromosome: 19
• Chromosome location: 19q13.33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT026982	hsa-miR-103a-3p	Sequencing	20371350
MIRT028412	hsa-miR-30a-5p	Proteomics	18668040
MIRT044596	hsa-miR-320a	CLASH	23622248
MIRT040703	hsa-miR-92b-3p	CLASH	23622248
MIRT1327708	hsa-miR-1321	CLIP-seq
MIRT1327709	hsa-miR-2110	CLIP-seq
MIRT1327710	hsa-miR-3144-5p	CLIP-seq
MIRT1327711	hsa-miR-3150a-3p	CLIP-seq
MIRT1327712	hsa-miR-3175	CLIP-seq
MIRT1327713	hsa-miR-3184	CLIP-seq
MIRT1327714	hsa-miR-3191	CLIP-seq
MIRT1327715	hsa-miR-423-5p	CLIP-seq
MIRT1327716	hsa-miR-4438	CLIP-seq
MIRT1327717	hsa-miR-4652-5p	CLIP-seq
MIRT1327718	hsa-miR-4667-5p	CLIP-seq
MIRT1327719	hsa-miR-4688	CLIP-seq
MIRT1327720	hsa-miR-4700-5p	CLIP-seq
MIRT1327721	hsa-miR-4728-5p	CLIP-seq
MIRT1327722	hsa-miR-4739	CLIP-seq
MIRT1327723	hsa-miR-4756-5p	CLIP-seq
MIRT1327724	hsa-miR-939	CLIP-seq
MIRT2097289	hsa-miR-3156-3p	CLIP-seq
MIRT2097290	hsa-miR-4301	CLIP-seq
MIRT1327708	hsa-miR-1321	CLIP-seq
MIRT2321618	hsa-miR-198	CLIP-seq
MIRT1327709	hsa-miR-2110	CLIP-seq
MIRT1327711	hsa-miR-3150a-3p	CLIP-seq
MIRT2321619	hsa-miR-3154	CLIP-seq
MIRT1327712	hsa-miR-3175	CLIP-seq
MIRT1327713	hsa-miR-3184	CLIP-seq
MIRT1327715	hsa-miR-423-5p	CLIP-seq
MIRT1327719	hsa-miR-4688	CLIP-seq
MIRT2321620	hsa-miR-4710	CLIP-seq
MIRT1327721	hsa-miR-4728-5p	CLIP-seq
MIRT1327722	hsa-miR-4739	CLIP-seq
MIRT1327723	hsa-miR-4756-5p	CLIP-seq
MIRT2321621	hsa-miR-520a-5p	CLIP-seq
MIRT2321622	hsa-miR-525-5p	CLIP-seq
MIRT2321623	hsa-miR-583	CLIP-seq
MIRT2321624	hsa-miR-607	CLIP-seq
MIRT1327724	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0006366	Process	Transcription by RNA polymerase II	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0019904	Function	Protein domain specific binding	IEA
GO:0099122	Function	RNA polymerase II C-terminal domain binding	IBA	21873635
GO:0099122	Function	RNA polymerase II C-terminal domain binding	IPI	15992770

Other IDs

• MIM: 617264
• HGNC: 30403
• e!Ensembl: ENSG00000126461

Protein

• UniProt ID: Q9H7N4
• Protein name: Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1)
• Protein function: May function in pre-mRNA splicing.
• Sequence:

  MEEEDESRGKTEESGEDRGDGPPDRDPTLSPSAFILRAIQQAVGSSLQGDLPNDKDGSRC
  HGLRWRRCRSPRSEPRSQESGGTDTATVLDMATDSFLAGLVSVLDPPDTWVPSRLDLRPG
  ESEDMLELVAEVRIGDRDPIPLPVPSLLPRLRAWRTGKTVSPQSNSSRPTCARHLTLGTG
  DGGPAPPPAPSSASSSPSPSPSSSSPSPPPPPPPPAPPAPPAPRFDIYDPFHPTDEAYSP
  PPAPEQKYDPFEPTGSNPSSSAGTPSPEEEEEEEEEEEEEEEDEEEEEGLSQSISRISET
  LAGIYDDNSLSQDFPGDESPRPDAQPTQPTPAPGTPPQVDSTRADGAMRRRVFVVGTEAE
  ACREGKVSVEVVTAGGAALPPPLLPPGDSEIEEGEIVQPEEEPRLALSLFRPGGRAARPT
  PAASATPTAQPLPQPPAPRAPEGDDFLSLHAESDGEGALQVDLGEPAPAPPAADSRWGGL
  DLRRKILTQRRERYRQRSPSPAPAPAPAAAAGPPTRKKSRRERKRSGEAKEAASSSSGTQ
  PAPPAPASPWDSKKHRSRDRKPGSHASSSARRRSRSRSRSRSTRRRSRSTDRRRGGSRRS
  RSREKRRRRRRSASPPPATSSSSSSRRERHRGKHRDGGGSKKKKKRSRSRGEKRSGDGSE
  KAPAPAPPPSGSTSCGDRDSRRRGAVPPSIQDLTDHDLFAIKRTITVGRLDKSDPRGPSP
  APASSPKREVLYDSEGLSGEERGGKSSQKDRRRSGAASSSSSSREKGSRRKALDGGDRDR
  DRDRDRDRDRSSKKARPPKESAPSSGPPPKPPVSSGSGSSSSSSSCSSRKVKLQSKVAVL
  IREGVSSTTPAKDAASAGLGSIGVKFSRDRESRSPFLKPDERAPTEMAKAAPGSTKPKKT
  KVKAKAGAKKTKGTKGKTKPSKTRKKVRSGGGSGGSGGQVSLKKSKADSCSQAAGTKGAE
  ETSWSGEERAAKVPSTPPPKAAPPPPALTPDSQTVDSSCKTPEVSFLPEEATEEAGVRGG
  AEEEEEEEEEEEEEEEEEEQQPATTTATSTAAAAPSTAPSAGSTAGDSGAEDGPASRVSQ
  LPTLPPPMPWNLPAGVDCTTSGVLALTALLFKMEEANLASRAKAQELIQATNQILSHRKP
  PSSLGMTPAPVPTSLGLPPGPSSYLLPGSLPLGGCGSTPPTPTGLAATSDKREGSSSSEG
  RGDTDKYLKKLHTQERAVEEVKLAIKPYYQKKDITKEEYKDILRKAVHKICHSKSGEINP
  VKVSNLVRAYVQRYRYFRKHGRKPGDPPGPPRPPKEPGPPDKGGPGLPLPPL

• Sequence length: 1312

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Basal cell neoplasm	Basal Cell Neoplasm, Basal Cell Cancer	rs587776578, rs587776579, rs2117956624, rs2118419579, rs2118365442, rs2118041703, rs2136689212, rs2118336503, rs1587692888, rs267606984, rs878853849, rs1554695110, rs1064793921, rs1588605348, rs1588568813	31174203
Carcinoma	Basal cell carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	31174203
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	29483656

Unknown
Disease name	Disease term	dbSNP ID	References
Cardiovascular diseases	Cardiovascular Diseases		30595370