PTPRZ1 (protein tyrosine phosphatase receptor type Z1)

Gene

• Entrez ID: 5803
• Gene name: Protein tyrosine phosphatase receptor type Z1
• Gene symbol: PTPRZ1
• Synonyms: HPTPZ, HPTPzeta, PTP-ZETA, PTP18, PTPRZ, PTPZ, R-PTP-zeta-2, RPTPB, RPTPbeta, phosphacan
• Chromosome: 7
• Chromosome location: 7q31.32
• Summary: This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternative

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022444	hsa-miR-124-3p	Microarray	18668037
MIRT025060	hsa-miR-181a-5p	Microarray	17612493
MIRT053463	hsa-miR-200c-3p	Microarray	23807165
MIRT1276598	hsa-miR-3529	CLIP-seq
MIRT1276599	hsa-miR-3667-5p	CLIP-seq
MIRT1276600	hsa-miR-379	CLIP-seq
MIRT1276601	hsa-miR-4451	CLIP-seq
MIRT1276602	hsa-miR-4650-3p	CLIP-seq
MIRT1276603	hsa-miR-548a-3p	CLIP-seq
MIRT1276604	hsa-miR-548e	CLIP-seq
MIRT1276605	hsa-miR-548f	CLIP-seq
MIRT1276606	hsa-miR-582-3p	CLIP-seq
MIRT1276607	hsa-miR-125a-3p	CLIP-seq
MIRT1276608	hsa-miR-3150a-5p	CLIP-seq
MIRT1276609	hsa-miR-3150b-5p	CLIP-seq
MIRT1276610	hsa-miR-3673	CLIP-seq
MIRT1276611	hsa-miR-3692	CLIP-seq
MIRT1276612	hsa-miR-3934	CLIP-seq
MIRT1276613	hsa-miR-4678	CLIP-seq
MIRT1276614	hsa-miR-4693-5p	CLIP-seq
MIRT1276615	hsa-miR-4703-3p	CLIP-seq
MIRT1276616	hsa-miR-493	CLIP-seq
MIRT1276617	hsa-miR-764	CLIP-seq
MIRT2081329	hsa-miR-133a	CLIP-seq
MIRT2081330	hsa-miR-133b	CLIP-seq
MIRT2081331	hsa-miR-3117-5p	CLIP-seq
MIRT2081332	hsa-miR-4704-5p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ELK1	Unknown	20224786
EPAS1	Unknown	20224786

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA	21873635
GO:0004725	Function	Protein tyrosine phosphatase activity	IDA	10706604
GO:0004725	Function	Protein tyrosine phosphatase activity	ISS
GO:0005001	Function	Transmembrane receptor protein tyrosine phosphatase activity	TAS	1323835
GO:0005178	Function	Integrin binding	IDA	19141530
GO:0005515	Function	Protein binding	IPI	10706604, 17681947, 19141530, 21969550
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IDA	19141530
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	8387522
GO:0006470	Process	Protein dephosphorylation	IBA	21873635
GO:0007417	Process	Central nervous system development	TAS	8387522
GO:0007611	Process	Learning or memory	ISS
GO:0019221	Process	Cytokine-mediated signaling pathway	TAS
GO:0031226	Component	Intrinsic component of plasma membrane	ISS
GO:0031641	Process	Regulation of myelination	ISS
GO:0035335	Process	Peptidyl-tyrosine dephosphorylation	IBA	21873635
GO:0035335	Process	Peptidyl-tyrosine dephosphorylation	ISS
GO:0043524	Process	Negative regulation of neuron apoptotic process	ISS
GO:0048709	Process	Oligodendrocyte differentiation	ISS
GO:0048714	Process	Positive regulation of oligodendrocyte differentiation	ISS
GO:0070445	Process	Regulation of oligodendrocyte progenitor proliferation	ISS

Other IDs

• MIM: 176891
• HGNC: 9685
• e!Ensembl: ENSG00000106278

Protein

• UniProt ID: P23471
• Protein name: Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2)
• Protein function: Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a r
• PDB: 3JXF, 3S97, 5AWX, 5H08, 8FN8, 8FN9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00194	Carb_anhydrase	37 → 299	Eukaryotic-type carbonic anhydrase	Domain
  PF00041	fn3	313 → 401	Fibronectin type III domain	Domain
  PF00102	Y_phosphatase	1750 → 1991	Protein-tyrosine phosphatase	Domain
  PF00102	Y_phosphatase	2048 → 2281	Protein-tyrosine phosphatase	Domain

• Sequence:

  MRILKRFLACIQLLCVCRLDWANGYYRQQRKLVEEIGWSYTGALNQKNWGKKYPTCNSPK
  QSPINIDEDLTQVNVNLKKLKFQGWDKTSLENTFIHNTGKTVEINLTNDYRVSGGVSEMV
  FKASKITFHWGKCNMSSDGSEHSLEGQKFPLEMQIYCFDADRFSSFEEAVKGKGKLRALS
  ILFEVGTEENLDFKAIIDGVESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPC
  TDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVMLMDYLQNNFREQQYKFSRQVFSSY
  TGKEEIHEAVCSSEPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTK
  HEFLTDGYQDLGAILNNLLPNMSYVLQIVAICTNGLYGKYSDQLIVDMPTDNPELDLFPE
  LIGTEEIIKEEEEGKDIEEGAIVNPGRDSATNQIRKKEPQISTTTHYNRIGTKYNEAKTN
  RSPTRGSEFSGKGDVPNTSLNSTSQPVTKLATEKDISLTSQTVTELPPHTVEGTSASLND
  GSKTVLRSPHMNLSGTAESLNTVSITEYEEESLLTSFKLDTGAEDSSGSSPATSAIPFIS
  ENISQGYIFSSENPETITYDVLIPESARNASEDSTSSGSEESLKDPSMEGNVWFPSSTDI
  TAQPDVGSGRESFLQTNYTEIRVDESEKTTKSFSAGPVMSQGPSVTDLEMPHYSTFAYFP
  TEVTPHAFTPSSRQQDLVSTVNVVYSQTTQPVYNGETPLQPSYSSEVFPLVTPLLLDNQI
  LNTTPAASSSDSALHATPVFPSVDVSFESILSSYDGAPLLPFSSASFSSELFRHLHTVSQ
  ILPQVTSATESDKVPLHASLPVAGGDLLLEPSLAQYSDVLSTTHAASETLEFGSESGVLY
  KTLMFSQVEPPSSDAMMHARSSGPEPSYALSDNEGSQHIFTVSYSSAIPVHDSVGVTYQG
  SLFSGPSHIPIPKSSLITPTASLLQPTHALSGDGEWSGASSDSEFLLPDTDGLTALNISS
  PVSVAEFTYTTSVFGDDNKALSKSEIIYGNETELQIPSFNEMVYPSESTVMPNMYDNVNK
  LNASLQETSVSISSTKGMFPGSLAHTTTKVFDHEISQVPENNFSVQPTHTVSQASGDTSL
  KPVLSANSEPASSDPASSEMLSPSTQLLFYETSASFSTEVLLQPSFQASDVDTLLKTVLP
  AVPSDPILVETPKVDKISSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGL
  TISYASEKYEPVLLKSESSHQVVPSLYSNDELFQTANLEINQAHPPKGRHVFATPVLSID
  EPLNTLINKLIHSDEILTSTKSSVTGKVFAGIPTVASDTFVSTDHSVPIGNGHVAITAVS
  PHRDGSVTSTKLLFPSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSIH
  KCMSCSSYRESQEKVMNDSDTHENSLMDQNNPISYSLSENSEEDNRVTSVSSDSQTGMDR
  SPGKSPSANGLSQKHNDGKEENDIQTGSALLPLSPESKAWAVLTSDEESGSGQGTSDSLN
  ENETSTDFSFADTNEKDADGILAAGDSEITPGFPQSPTSSVTSENSEVFHVSEAEASNSS
  HESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLEDSTSPR
  VISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGI
  TADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAA
  QGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQ
  VLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAY
  AKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEE
  QYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPAGKTKLEKQFQLLSQSNIQQSDY
  SAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLL
  HTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLS
  NEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAANRDGPMI
  VHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
  SLVSTRQEENPSTSLDSNGAALPDGNIAESLESLV

• Sequence length: 2315

Pathways

KEGG:

Epithelial cell signaling in Helicobacter pylori infection

Reactome:

Other interleukin signaling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	18186075, 22832403, 17579610