PTPRO (protein tyrosine phosphatase receptor type O)

Gene

• Entrez ID: 5800
• Gene name: Protein tyrosine phosphatase receptor type O
• Gene symbol: PTPRO
• Synonyms: GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPROT, PTPU2, R-PTP-O
• Chromosome: 12
• Chromosome location: 12p12.3|12p13-p12
• Summary: This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1591750243	G>A	Pathogenic	Splice donor variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT000977	hsa-miR-17-5p	Luciferase reporter assay, Western blot	18644370
MIRT000977	hsa-miR-17-5p	Luciferase reporter assay	18644370
MIRT029550	hsa-miR-26b-5p	Microarray	19088304
MIRT000977	hsa-miR-17-5p	Luciferase reporter assay	27720936
MIRT732856	hsa-miR-6869-5p	Luciferase reporter assay, qRT-PCR, Flow cytometry, ELISA	34007244
MIRT1276365	hsa-miR-1343	CLIP-seq
MIRT1276366	hsa-miR-194	CLIP-seq
MIRT1276367	hsa-miR-2467-5p	CLIP-seq
MIRT1276368	hsa-miR-3115	CLIP-seq
MIRT1276369	hsa-miR-3159	CLIP-seq
MIRT1276370	hsa-miR-361-5p	CLIP-seq
MIRT1276371	hsa-miR-3667-3p	CLIP-seq
MIRT1276372	hsa-miR-3675-5p	CLIP-seq
MIRT1276373	hsa-miR-3690	CLIP-seq
MIRT1276374	hsa-miR-3908	CLIP-seq
MIRT1276375	hsa-miR-3919	CLIP-seq
MIRT1276376	hsa-miR-3925-5p	CLIP-seq
MIRT1276377	hsa-miR-3973	CLIP-seq
MIRT1276378	hsa-miR-4254	CLIP-seq
MIRT1276379	hsa-miR-4283	CLIP-seq
MIRT1276380	hsa-miR-4302	CLIP-seq
MIRT1276381	hsa-miR-4489	CLIP-seq
MIRT1276382	hsa-miR-4502	CLIP-seq
MIRT1276383	hsa-miR-4528	CLIP-seq
MIRT1276384	hsa-miR-4656	CLIP-seq
MIRT1276385	hsa-miR-4747-5p	CLIP-seq
MIRT1276386	hsa-miR-4773	CLIP-seq
MIRT1276387	hsa-miR-486-5p	CLIP-seq
MIRT1276388	hsa-miR-548a-5p	CLIP-seq
MIRT1276389	hsa-miR-548ab	CLIP-seq
MIRT1276390	hsa-miR-548ak	CLIP-seq
MIRT1276391	hsa-miR-548b-5p	CLIP-seq
MIRT1276392	hsa-miR-548c-5p	CLIP-seq
MIRT1276393	hsa-miR-548d-5p	CLIP-seq
MIRT1276394	hsa-miR-548h	CLIP-seq
MIRT1276395	hsa-miR-548i	CLIP-seq
MIRT1276396	hsa-miR-548j	CLIP-seq
MIRT1276397	hsa-miR-548w	CLIP-seq
MIRT1276398	hsa-miR-548y	CLIP-seq
MIRT1276399	hsa-miR-559	CLIP-seq
MIRT1276400	hsa-miR-642b	CLIP-seq
MIRT1276401	hsa-miR-665	CLIP-seq
MIRT1276402	hsa-miR-671-5p	CLIP-seq
MIRT1276403	hsa-miR-802	CLIP-seq
MIRT1276404	hsa-miR-873	CLIP-seq
MIRT1276405	hsa-miR-1323	CLIP-seq
MIRT1276406	hsa-miR-137	CLIP-seq
MIRT1276407	hsa-miR-15a	CLIP-seq
MIRT1276408	hsa-miR-15b	CLIP-seq
MIRT1276409	hsa-miR-16	CLIP-seq
MIRT1276410	hsa-miR-195	CLIP-seq
MIRT1276411	hsa-miR-25	CLIP-seq
MIRT1276412	hsa-miR-3122	CLIP-seq
MIRT1276413	hsa-miR-3124-3p	CLIP-seq
MIRT1276414	hsa-miR-3182	CLIP-seq
MIRT1276415	hsa-miR-3194-3p	CLIP-seq
MIRT1276416	hsa-miR-32	CLIP-seq
MIRT1276370	hsa-miR-361-5p	CLIP-seq
MIRT1276417	hsa-miR-363	CLIP-seq
MIRT1276418	hsa-miR-367	CLIP-seq
MIRT1276419	hsa-miR-3686	CLIP-seq
MIRT1276420	hsa-miR-3913-5p	CLIP-seq
MIRT1276421	hsa-miR-3921	CLIP-seq
MIRT1276377	hsa-miR-3973	CLIP-seq
MIRT1276422	hsa-miR-424	CLIP-seq
MIRT1276423	hsa-miR-4303	CLIP-seq
MIRT1276424	hsa-miR-4325	CLIP-seq
MIRT1276425	hsa-miR-4468	CLIP-seq
MIRT1276426	hsa-miR-4653-5p	CLIP-seq
MIRT1276427	hsa-miR-4742-3p	CLIP-seq
MIRT1276428	hsa-miR-4782-5p	CLIP-seq
MIRT1276429	hsa-miR-497	CLIP-seq
MIRT1276388	hsa-miR-548a-5p	CLIP-seq
MIRT1276389	hsa-miR-548ab	CLIP-seq
MIRT1276390	hsa-miR-548ak	CLIP-seq
MIRT1276391	hsa-miR-548b-5p	CLIP-seq
MIRT1276392	hsa-miR-548c-5p	CLIP-seq
MIRT1276393	hsa-miR-548d-5p	CLIP-seq
MIRT1276394	hsa-miR-548h	CLIP-seq
MIRT1276395	hsa-miR-548i	CLIP-seq
MIRT1276396	hsa-miR-548j	CLIP-seq
MIRT1276430	hsa-miR-548o	CLIP-seq
MIRT1276397	hsa-miR-548w	CLIP-seq
MIRT1276398	hsa-miR-548y	CLIP-seq
MIRT1276399	hsa-miR-559	CLIP-seq
MIRT1276400	hsa-miR-642b	CLIP-seq
MIRT1276404	hsa-miR-873	CLIP-seq
MIRT1276431	hsa-miR-92a	CLIP-seq
MIRT1276432	hsa-miR-92b	CLIP-seq
MIRT1276433	hsa-miR-944	CLIP-seq
MIRT2081303	hsa-miR-3117-5p	CLIP-seq
MIRT2081304	hsa-miR-514	CLIP-seq
MIRT2081305	hsa-miR-514b-3p	CLIP-seq
MIRT2439712	hsa-miR-208a	CLIP-seq
MIRT2439713	hsa-miR-208b	CLIP-seq
MIRT2439714	hsa-miR-3617	CLIP-seq
MIRT2439715	hsa-miR-499-5p	CLIP-seq
MIRT2439716	hsa-miR-641	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
E2F1	Unknown	18644370

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000902	Process	Cell morphogenesis	ISS
GO:0002548	Process	Monocyte chemotaxis	IMP	19233845
GO:0003093	Process	Regulation of glomerular filtration	IBA	21873635
GO:0003093	Process	Regulation of glomerular filtration	ISS
GO:0003105	Process	Negative regulation of glomerular filtration	ISS
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA	21873635
GO:0004725	Function	Protein tyrosine phosphatase activity	IDA	19167335
GO:0004725	Function	Protein tyrosine phosphatase activity	IMP	19233845
GO:0004725	Function	Protein tyrosine phosphatase activity	TAS	10498613
GO:0005001	Function	Transmembrane receptor protein tyrosine phosphatase activity	NAS	7665166
GO:0005515	Function	Protein binding	IPI	19167335, 28330616
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	ISS
GO:0005887	Component	Integral component of plasma membrane	NAS	7665166
GO:0006470	Process	Protein dephosphorylation	ISS
GO:0006470	Process	Protein dephosphorylation	TAS	10498613
GO:0007411	Process	Axon guidance	IBA	21873635
GO:0007411	Process	Axon guidance	ISS
GO:0010812	Process	Negative regulation of cell-substrate adhesion	ISS
GO:0010977	Process	Negative regulation of neuron projection development	ISS
GO:0016021	Component	Integral component of membrane	TAS	10498613
GO:0016324	Component	Apical plasma membrane	ISS
GO:0016328	Component	Lateral plasma membrane	ISS
GO:0016791	Function	Phosphatase activity	ISS
GO:0017147	Function	Wnt-protein binding	IBA	21873635
GO:0017147	Function	Wnt-protein binding	ISS
GO:0030027	Component	Lamellipodium	ISS
GO:0030032	Process	Lamellipodium assembly	ISS
GO:0030424	Component	Axon	ISS
GO:0030426	Component	Growth cone	ISS
GO:0032835	Process	Glomerulus development	IMP	21722858
GO:0035335	Process	Peptidyl-tyrosine dephosphorylation	IMP	19233845
GO:0036060	Process	Slit diaphragm assembly	ISS
GO:0036060	Process	Slit diaphragm assembly	NAS	20633639
GO:0042803	Function	Protein homodimerization activity	ISS
GO:0043005	Component	Neuron projection	ISS
GO:0043197	Component	Dendritic spine	ISS
GO:0045296	Function	Cadherin binding	IBA	21873635
GO:0045296	Function	Cadherin binding	IPI	28926625
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0072112	Process	Glomerular visceral epithelial cell differentiation	IBA	21873635
GO:0072112	Process	Glomerular visceral epithelial cell differentiation	ISS
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IBA	21873635
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	ISS
GO:0090260	Process	Negative regulation of retinal ganglion cell axon guidance	ISS
GO:0098978	Component	Glutamatergic synapse	IBA	21873635
GO:0098982	Component	GABA-ergic synapse	IBA	21873635
GO:1990264	Process	Peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	IBA	21873635

Other IDs

• MIM: 600579
• HGNC: 9678
• e!Ensembl: ENSG00000151490

Protein

• UniProt ID: Q16827
• Protein name: Receptor-type tyrosine-protein phosphatase O (R-PTP-O) (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTP-U2) (PTPase U2)
• Protein function: Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity).
• PDB: 2G59, 2GJT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00041	fn3	434 → 521	Fibronectin type III domain	Domain
  PF00041	fn3	724 → 805	Fibronectin type III domain	Domain
  PF00102	Y_phosphatase	962 → 1194	Protein-tyrosine phosphatase	Domain

• Sequence:

  MGHLPTGIHGARRLLPLLWLFVLFKNATAFHVTVQDDNNIVVSLEASDVISPASVYVVKI
  TGESKNYFFEFEEFNSTLPPPVIFKASYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLP
  VTSVSIYDYKPSPETGVLFEIHYPEKYNVFTRVNISYWEGKDFRTMLYKDFFKGKTVFNH
  WLPGMCYSNITFQLVSEATFNKSTLVEYSGVSHEPKQHRTAPYPPQNISVRIVNLNKNNW
  EEQSGNFPEESFMRSQDTIGKEKLFHFTEETPEIPSGNISSGWPDFNSSDYETTSQPYWW
  DSASAAPESEDEFVSVLPMEYENNSTLSETEKSTSGSFSFFPVQMILTWLPPKPPTAFDG
  FHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTFSSSGSCETRKSQSAKSLSF
  YISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQR
  LEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYP
  LGPTAVVLSWTRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLP
  AWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAPEITSVEYFNSLLYISWTYGDDTTDL
  SHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVK
  LEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTI
  SSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLVT
  LIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWRRSIFAFLTLLPSCLWTDYLLAFY
  INPWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLP
  LNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRND
  FWKMVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRH
  FRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGV
  GRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKK
  QQFCISDVIYENVSKS

• Sequence length: 1216

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	21499247
Nephrotic syndrome	Nephrotic Syndrome, NEPHROTIC SYNDROME, TYPE 6	rs876657369, rs121912601, rs121912602, rs876657370, rs121912603, rs121912604, rs121912605, rs121907900, rs121907901, rs28941778, rs587776576, rs28942089, rs587776577, rs28941777, rs121907910, rs1568296260, rs119473033, rs74315342, rs74315343, rs74315345, rs74315346, rs74315347, rs74315348, rs121434394, rs267606919, rs121912488, rs267606953, rs267606954, rs267606955, rs104886210, rs1591732280, rs1591750243, rs140511594, rs140781106, rs147972030, rs587776969, rs386833863, rs386833880, rs386833882, rs386833892, rs386833895, rs386833909, rs386833911, rs386833920, rs386833935, rs386833947, rs1555763603, rs398122978, rs398122979, rs398122980, rs369573693, rs398122981, rs398122982, rs398122983, rs200482683, rs730882194, rs180177201, rs587777552, rs587777553, rs775170915, rs749740335, rs12568913, rs530318579, rs786204583, rs786204708, rs786204632, rs138656762, rs797044992, rs797044994, rs797044995, rs864321632, rs864321687, rs864321688, rs864321633, rs869025495, rs869025541, rs869312747, rs145473779, rs757674160, rs869320695, rs138909849, rs869312984, rs1057516900, rs763818901, rs199506378, rs1057517164, rs1057516523, rs1057516414, rs778055996, rs1057516395, rs1057516747, rs1057516880, rs1057516680, rs778217926, rs1057519347, rs764587648, rs1060499703, rs121907903, rs769259446, rs1131692252, rs1131692253, rs1131692254, rs1131692255, rs1131692256, rs746887949, rs1131692235, rs1135402911, rs1135402912, rs1135402913, rs1554946480, rs1555331969, rs773173317, rs1555816634, rs775006954, rs1320543506, rs534522842, rs1272948499, rs1191455921, rs1291398331, rs1554939785, rs776016942, rs1031744496, rs748812981, rs755972674, rs1553312833, rs967339926, rs1462028977, rs1212702104, rs1167223941, rs762631237, rs1553316575, rs1553315173, rs1553316648, rs1553316611, rs780761368, rs368572297, rs1568070817, rs1321552081, rs1558108130, rs1558091788, rs1565707103, rs1558355124, rs1564622701, rs1351580598, rs1589475328, rs1589413498, rs1572255744, rs1572262824, rs761410195, rs1602413491, rs1590326226, rs375998390, rs570583897, rs369363545, rs201488687, rs1334894971, rs763782471, rs138047529, rs895782232, rs1572255047, rs1589433172, rs1589509476, rs1572277600, rs1572282458, rs1584675898, rs759043857, rs1853443391	30065916

Unknown
Disease name	Disease term	dbSNP ID	References
Antiphospholipid syndrome	Antiphospholipid Syndrome		28424481
Genetic steroid-resistant nephrotic syndrome	Genetic steroid-resistant nephrotic syndrome
Glomerulosclerosis	Focal glomerulosclerosis
Hypoalbuminemia	Hypoalbuminemia
Liver neoplasms	Liver neoplasms		19233941, 20163174
Liver cancer	Malignant neoplasm of liver		19233941, 20163174
Nephritis	NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE		21722858