PTPRA (protein tyrosine phosphatase receptor type A)

Gene

• Entrez ID: 5786
• Gene name: Protein tyrosine phosphatase receptor type A
• Gene symbol: PTPRA
• Synonyms: HEPTP, HLPR, HPTPA, HPTPalpha, LRP, PTPA, PTPRL2, R-PTP-alpha, RPTPA
• Chromosome: 20
• Chromosome location: 20p13
• Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017376	hsa-miR-335-5p	Microarray	18185580
MIRT735767	hsa-miR-636	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC), qRT-PCR, In situ hybridization	31821171
MIRT1275840	hsa-miR-1185	CLIP-seq
MIRT1275841	hsa-miR-1238	CLIP-seq
MIRT1275842	hsa-miR-1275	CLIP-seq
MIRT1275843	hsa-miR-146a	CLIP-seq
MIRT1275844	hsa-miR-146b-5p	CLIP-seq
MIRT1275845	hsa-miR-185	CLIP-seq
MIRT1275846	hsa-miR-2113	CLIP-seq
MIRT1275847	hsa-miR-218	CLIP-seq
MIRT1275848	hsa-miR-3124-3p	CLIP-seq
MIRT1275849	hsa-miR-3140-3p	CLIP-seq
MIRT1275850	hsa-miR-3144-5p	CLIP-seq
MIRT1275851	hsa-miR-3145-3p	CLIP-seq
MIRT1275852	hsa-miR-3167	CLIP-seq
MIRT1275853	hsa-miR-3605-5p	CLIP-seq
MIRT1275854	hsa-miR-3679-5p	CLIP-seq
MIRT1275855	hsa-miR-3921	CLIP-seq
MIRT1275856	hsa-miR-4251	CLIP-seq
MIRT1275857	hsa-miR-4259	CLIP-seq
MIRT1275858	hsa-miR-4270	CLIP-seq
MIRT1275859	hsa-miR-4306	CLIP-seq
MIRT1275860	hsa-miR-4329	CLIP-seq
MIRT1275861	hsa-miR-4441	CLIP-seq
MIRT1275862	hsa-miR-4450	CLIP-seq
MIRT1275863	hsa-miR-4525	CLIP-seq
MIRT1275864	hsa-miR-4644	CLIP-seq
MIRT1275865	hsa-miR-4653-5p	CLIP-seq
MIRT1275866	hsa-miR-4665-5p	CLIP-seq
MIRT1275867	hsa-miR-4699-3p	CLIP-seq
MIRT1275868	hsa-miR-4715-5p	CLIP-seq
MIRT1275869	hsa-miR-4723-5p	CLIP-seq
MIRT1275870	hsa-miR-4728-5p	CLIP-seq
MIRT1275871	hsa-miR-491-5p	CLIP-seq
MIRT1275872	hsa-miR-499-3p	CLIP-seq
MIRT1275873	hsa-miR-499a-3p	CLIP-seq
MIRT1275874	hsa-miR-589	CLIP-seq
MIRT1275875	hsa-miR-625	CLIP-seq
MIRT1275876	hsa-miR-876-5p	CLIP-seq
MIRT1275877	hsa-miR-3148	CLIP-seq
MIRT1275878	hsa-miR-3978	CLIP-seq
MIRT1275879	hsa-miR-4759	CLIP-seq
MIRT1275867	hsa-miR-4699-3p	CLIP-seq
MIRT2604601	hsa-miR-3163	CLIP-seq
MIRT2604602	hsa-miR-3170	CLIP-seq
MIRT2604603	hsa-miR-3692	CLIP-seq
MIRT2604604	hsa-miR-4260	CLIP-seq
MIRT2604605	hsa-miR-4263	CLIP-seq
MIRT2604606	hsa-miR-4282	CLIP-seq
MIRT2604607	hsa-miR-4662a-3p	CLIP-seq
MIRT2604608	hsa-miR-4731-3p	CLIP-seq
MIRT2604609	hsa-miR-4789-5p	CLIP-seq
MIRT2604610	hsa-miR-4799-5p	CLIP-seq
MIRT2604611	hsa-miR-4801	CLIP-seq
MIRT2604612	hsa-miR-495	CLIP-seq
MIRT2604613	hsa-miR-513a-3p	CLIP-seq
MIRT2604614	hsa-miR-576-5p	CLIP-seq
MIRT2604615	hsa-miR-656	CLIP-seq
MIRT2604601	hsa-miR-3163	CLIP-seq
MIRT2604603	hsa-miR-3692	CLIP-seq
MIRT2604605	hsa-miR-4263	CLIP-seq
MIRT2604606	hsa-miR-4282	CLIP-seq
MIRT2604610	hsa-miR-4799-5p	CLIP-seq
MIRT2604613	hsa-miR-513a-3p	CLIP-seq
MIRT2604614	hsa-miR-576-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	TAS
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA	21873635
GO:0004725	Function	Protein tyrosine phosphatase activity	ISS
GO:0005001	Function	Transmembrane receptor protein tyrosine phosphatase activity	TAS	2169617
GO:0005515	Function	Protein binding	IPI	7518772, 9535845, 10698938, 11923305, 19380743, 22801373, 24189400, 28065597, 28330616, 28514442, 31980649
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	2169617
GO:0005925	Component	Focal adhesion	ISS
GO:0006468	Process	Protein phosphorylation	IEA
GO:0006470	Process	Protein dephosphorylation	IBA	21873635
GO:0007229	Process	Integrin-mediated signaling pathway	ISS
GO:0007411	Process	Axon guidance	TAS
GO:0008286	Process	Insulin receptor signaling pathway	IEA
GO:0016020	Component	Membrane	ISS
GO:0035335	Process	Peptidyl-tyrosine dephosphorylation	IEA
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0050804	Process	Modulation of chemical synaptic transmission	IEA
GO:0051893	Process	Regulation of focal adhesion assembly	ISS
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0098685	Component	Schaffer collateral - CA1 synapse	IEA
GO:0099699	Component	Integral component of synaptic membrane	IEA

Other IDs

• MIM: 176884
• HGNC: 9664
• e!Ensembl: ENSG00000132670

Protein

• UniProt ID: P18433
• Protein name: Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)
• Protein function: Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphoryla
• PDB: 6UZT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00102	Y_phosphatase	265 → 500	Protein-tyrosine phosphatase	Domain
  PF00102	Y_phosphatase	558 → 790	Protein-tyrosine phosphatase	Domain

• Sequence:

  MDSWFILVLLGSGLICVSANNATTVAPSVGITRLINSSTAEPVKEEAKTSNPTSSLTSLS
  VAPTFSPNITLGPTYLTTVNSSDSDNGTTRTASTNSIGITISPNGTWLPDNQFTDARTEP
  WEGNSSTAATTPETFPPSGNSDSKDRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKY
  KQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKL
  FREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASF
  INGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCW
  TYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGM
  LKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQ
  RCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKL
  TSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQK
  DSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITV
  ELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQ
  QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQ
  YEFCYKVVQEYIDAFSDYANFK

• Sequence length: 802

Pathways

Reactome:

NCAM signaling for neurite out-growth
RAF/MAP kinase cascade

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	21831360, 25393624

Unknown
Disease name	Disease term	dbSNP ID	References
Myocardial ischemia	Myocardial Ischemia		16214533