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PTPN9 (protein tyrosine phosphatase non-receptor type 9)

Gene

5780

Protein tyrosine phosphatase non-receptor type 9

PTPN9

MEG2, PTPMEG2

15q24.2

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tran

Show/Hide all(243)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016099	hsa-miR-769-5p	Sequencing	20371350
MIRT021174	hsa-miR-186-5p	Sequencing	20371350
MIRT023053	hsa-miR-124-3p	Microarray	18668037
MIRT035526	hsa-miR-24-3p	Luciferase reporter assay	23418360
MIRT035526	hsa-miR-24-3p	Luciferase reporter assay	23418360
MIRT048461	hsa-miR-100-5p	CLASH	23622248
MIRT047068	hsa-miR-183-5p	CLASH	23622248
MIRT044505	hsa-miR-320a	CLASH	23622248
MIRT038760	hsa-miR-93-3p	CLASH	23622248
MIRT038760	hsa-miR-93-3p	CLASH	23622248
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT632516	hsa-miR-519a-3p	HITS-CLIP	23824327
MIRT632515	hsa-miR-519b-3p	HITS-CLIP	23824327
MIRT632514	hsa-miR-519c-3p	HITS-CLIP	23824327
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT614408	hsa-miR-8064	HITS-CLIP	23824327
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT632516	hsa-miR-519a-3p	HITS-CLIP	23824327
MIRT632515	hsa-miR-519b-3p	HITS-CLIP	23824327
MIRT632514	hsa-miR-519c-3p	HITS-CLIP	23824327
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT614408	hsa-miR-8064	HITS-CLIP	23824327
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT614408	hsa-miR-8064	HITS-CLIP	23824327
MIRT726832	hsa-miR-193a-3p	HITS-CLIP	22473208
MIRT726831	hsa-miR-193b-3p	HITS-CLIP	22473208
MIRT731565	hsa-miR-96-5p	Luciferase reporter assay, qRT-PCR, Western blot	27857177
MIRT731565	hsa-miR-96-5p	Luciferase reporter assay, qRT-PCR, Western blot	27857177
MIRT731565	hsa-miR-96-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	27857177
MIRT731565	hsa-miR-96-5p	Immunohistochemistry, Luciferase reporter assay, qRT-PCR, Western blot	27857177
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT632516	hsa-miR-519a-3p	HITS-CLIP	23824327
MIRT632515	hsa-miR-519b-3p	HITS-CLIP	23824327
MIRT632514	hsa-miR-519c-3p	HITS-CLIP	23824327
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT614408	hsa-miR-8064	HITS-CLIP	23824327
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT632516	hsa-miR-519a-3p	HITS-CLIP	23824327
MIRT632515	hsa-miR-519b-3p	HITS-CLIP	23824327
MIRT632514	hsa-miR-519c-3p	HITS-CLIP	23824327
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT614408	hsa-miR-8064	HITS-CLIP	23824327
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT614409	hsa-miR-8485	HITS-CLIP	23824327
MIRT614408	hsa-miR-8064	HITS-CLIP	23824327
MIRT756015	hsa-miR-197-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunoprecipitaion (IP)	35156900
MIRT756015	hsa-miR-197-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunoprecipitaion (IP)	35156900
MIRT1275770	hsa-miR-1207-3p	CLIP-seq
MIRT1275771	hsa-miR-124	CLIP-seq
MIRT1275772	hsa-miR-1299	CLIP-seq
MIRT1275773	hsa-miR-1321	CLIP-seq
MIRT1275774	hsa-miR-135a	CLIP-seq
MIRT1275775	hsa-miR-135b	CLIP-seq
MIRT1275776	hsa-miR-140-5p	CLIP-seq
MIRT1275777	hsa-miR-1910	CLIP-seq
MIRT1275778	hsa-miR-198	CLIP-seq
MIRT1275779	hsa-miR-22	CLIP-seq
MIRT1275780	hsa-miR-2355-5p	CLIP-seq
MIRT1275781	hsa-miR-24	CLIP-seq
MIRT1275782	hsa-miR-3146	CLIP-seq
MIRT1275783	hsa-miR-3150b-3p	CLIP-seq
MIRT1275784	hsa-miR-3169	CLIP-seq
MIRT1275785	hsa-miR-3173-3p	CLIP-seq
MIRT1275786	hsa-miR-3182	CLIP-seq
MIRT1275787	hsa-miR-3545-5p	CLIP-seq
MIRT1275788	hsa-miR-3653	CLIP-seq
MIRT1275789	hsa-miR-3657	CLIP-seq
MIRT1275790	hsa-miR-3658	CLIP-seq
MIRT1275791	hsa-miR-3667-3p	CLIP-seq
MIRT1275792	hsa-miR-3688-3p	CLIP-seq
MIRT1275793	hsa-miR-3714	CLIP-seq
MIRT1275794	hsa-miR-383	CLIP-seq
MIRT1275795	hsa-miR-3909	CLIP-seq
MIRT1275796	hsa-miR-3910	CLIP-seq
MIRT1275797	hsa-miR-3978	CLIP-seq
MIRT1275798	hsa-miR-4264	CLIP-seq
MIRT1275799	hsa-miR-4311	CLIP-seq
MIRT1275800	hsa-miR-4419a	CLIP-seq
MIRT1275801	hsa-miR-4427	CLIP-seq
MIRT1275802	hsa-miR-4460	CLIP-seq
MIRT1275803	hsa-miR-4461	CLIP-seq
MIRT1275804	hsa-miR-4476	CLIP-seq
MIRT1275805	hsa-miR-4477b	CLIP-seq
MIRT1275806	hsa-miR-4481	CLIP-seq
MIRT1275807	hsa-miR-4494	CLIP-seq
MIRT1275808	hsa-miR-4496	CLIP-seq
MIRT1275809	hsa-miR-4510	CLIP-seq
MIRT1275810	hsa-miR-4511	CLIP-seq
MIRT1275811	hsa-miR-4515	CLIP-seq
MIRT1275812	hsa-miR-4533	CLIP-seq
MIRT1275813	hsa-miR-455-3p	CLIP-seq
MIRT1275814	hsa-miR-4669	CLIP-seq
MIRT1275815	hsa-miR-4680-3p	CLIP-seq
MIRT1275816	hsa-miR-4685-5p	CLIP-seq
MIRT1275817	hsa-miR-4714-3p	CLIP-seq
MIRT1275818	hsa-miR-4727-3p	CLIP-seq
MIRT1275819	hsa-miR-4739	CLIP-seq
MIRT1275820	hsa-miR-4745-5p	CLIP-seq
MIRT1275821	hsa-miR-4747-5p	CLIP-seq
MIRT1275822	hsa-miR-4756-5p	CLIP-seq
MIRT1275823	hsa-miR-4762-3p	CLIP-seq
MIRT1275824	hsa-miR-4772-5p	CLIP-seq
MIRT1275825	hsa-miR-4779	CLIP-seq
MIRT1275826	hsa-miR-4782-5p	CLIP-seq
MIRT1275827	hsa-miR-4784	CLIP-seq
MIRT1275828	hsa-miR-4802-5p	CLIP-seq
MIRT1275829	hsa-miR-499a-5p	CLIP-seq
MIRT1275830	hsa-miR-506	CLIP-seq
MIRT1275831	hsa-miR-516b	CLIP-seq
MIRT1275832	hsa-miR-548b-3p	CLIP-seq
MIRT1275833	hsa-miR-576-3p	CLIP-seq
MIRT1275834	hsa-miR-640	CLIP-seq
MIRT1275835	hsa-miR-659	CLIP-seq
MIRT1275836	hsa-miR-765	CLIP-seq
MIRT1275837	hsa-miR-873	CLIP-seq
MIRT1275838	hsa-miR-875-3p	CLIP-seq
MIRT1275839	hsa-miR-944	CLIP-seq
MIRT1556873	hsa-miR-1236	CLIP-seq
MIRT1275783	hsa-miR-3150b-3p	CLIP-seq
MIRT1275789	hsa-miR-3657	CLIP-seq
MIRT1275795	hsa-miR-3909	CLIP-seq
MIRT1275814	hsa-miR-4669	CLIP-seq
MIRT1275827	hsa-miR-4784	CLIP-seq
MIRT1275833	hsa-miR-576-3p	CLIP-seq
MIRT2081140	hsa-miR-1	CLIP-seq
MIRT2081141	hsa-miR-105	CLIP-seq
MIRT2081142	hsa-miR-1182	CLIP-seq
MIRT2081143	hsa-miR-1225-3p	CLIP-seq
MIRT2081144	hsa-miR-1273f	CLIP-seq
MIRT2081145	hsa-miR-1290	CLIP-seq
MIRT2081146	hsa-miR-1291	CLIP-seq
MIRT2081147	hsa-miR-129-5p	CLIP-seq
MIRT1275772	hsa-miR-1299	CLIP-seq
MIRT2081148	hsa-miR-1304	CLIP-seq
MIRT2081149	hsa-miR-1343	CLIP-seq
MIRT2081150	hsa-miR-197	CLIP-seq
MIRT2081151	hsa-miR-206	CLIP-seq
MIRT2081152	hsa-miR-3122	CLIP-seq
MIRT2081153	hsa-miR-3130-5p	CLIP-seq
MIRT2081154	hsa-miR-3150a-3p	CLIP-seq
MIRT2081155	hsa-miR-3175	CLIP-seq
MIRT2081156	hsa-miR-326	CLIP-seq
MIRT2081157	hsa-miR-328	CLIP-seq
MIRT2081158	hsa-miR-330-5p	CLIP-seq
MIRT2081159	hsa-miR-3677-5p	CLIP-seq
MIRT2081160	hsa-miR-3688-5p	CLIP-seq
MIRT2081161	hsa-miR-3913-5p	CLIP-seq
MIRT2081162	hsa-miR-3945	CLIP-seq
MIRT1275797	hsa-miR-3978	CLIP-seq
MIRT2081163	hsa-miR-4253	CLIP-seq
MIRT2081164	hsa-miR-4266	CLIP-seq
MIRT2081165	hsa-miR-4271	CLIP-seq
MIRT2081166	hsa-miR-4323	CLIP-seq
MIRT2081167	hsa-miR-4482	CLIP-seq
MIRT2081168	hsa-miR-4667-5p	CLIP-seq
MIRT2081169	hsa-miR-4700-5p	CLIP-seq
MIRT2081170	hsa-miR-4725-3p	CLIP-seq
MIRT2081171	hsa-miR-4729	CLIP-seq
MIRT1275821	hsa-miR-4747-5p	CLIP-seq
MIRT1275826	hsa-miR-4782-5p	CLIP-seq
MIRT2081172	hsa-miR-5096	CLIP-seq
MIRT2081173	hsa-miR-513a-5p	CLIP-seq
MIRT1275831	hsa-miR-516b	CLIP-seq
MIRT2081174	hsa-miR-548an	CLIP-seq
MIRT2081175	hsa-miR-601	CLIP-seq
MIRT2081176	hsa-miR-613	CLIP-seq
MIRT2081177	hsa-miR-621	CLIP-seq
MIRT2081178	hsa-miR-637	CLIP-seq
MIRT2081179	hsa-miR-651	CLIP-seq
MIRT1275837	hsa-miR-873	CLIP-seq
MIRT1275838	hsa-miR-875-3p	CLIP-seq
MIRT2081180	hsa-miR-939	CLIP-seq
MIRT2081141	hsa-miR-105	CLIP-seq
MIRT2081142	hsa-miR-1182	CLIP-seq
MIRT1275771	hsa-miR-124	CLIP-seq
MIRT2307073	hsa-miR-1289	CLIP-seq
MIRT2081146	hsa-miR-1291	CLIP-seq
MIRT1275777	hsa-miR-1910	CLIP-seq
MIRT2307074	hsa-miR-193b	CLIP-seq
MIRT2081153	hsa-miR-3130-5p	CLIP-seq
MIRT2307075	hsa-miR-3140-5p	CLIP-seq
MIRT2081154	hsa-miR-3150a-3p	CLIP-seq
MIRT2081155	hsa-miR-3175	CLIP-seq
MIRT2081156	hsa-miR-326	CLIP-seq
MIRT2081158	hsa-miR-330-5p	CLIP-seq
MIRT2307076	hsa-miR-3545-3p	CLIP-seq
MIRT1275793	hsa-miR-3714	CLIP-seq
MIRT1275796	hsa-miR-3910	CLIP-seq
MIRT1275798	hsa-miR-4264	CLIP-seq
MIRT1275801	hsa-miR-4427	CLIP-seq
MIRT1275804	hsa-miR-4476	CLIP-seq
MIRT1275805	hsa-miR-4477b	CLIP-seq
MIRT2081167	hsa-miR-4482	CLIP-seq
MIRT1275807	hsa-miR-4494	CLIP-seq
MIRT2307077	hsa-miR-4539	CLIP-seq
MIRT1275813	hsa-miR-455-3p	CLIP-seq
MIRT2081168	hsa-miR-4667-5p	CLIP-seq
MIRT1275815	hsa-miR-4680-3p	CLIP-seq
MIRT2081169	hsa-miR-4700-5p	CLIP-seq
MIRT1275823	hsa-miR-4762-3p	CLIP-seq
MIRT2307078	hsa-miR-4772-3p	CLIP-seq
MIRT1275829	hsa-miR-499a-5p	CLIP-seq
MIRT1275830	hsa-miR-506	CLIP-seq
MIRT2081174	hsa-miR-548an	CLIP-seq
MIRT2081178	hsa-miR-637	CLIP-seq
MIRT1275837	hsa-miR-873	CLIP-seq
MIRT2307079	hsa-miR-892b	CLIP-seq
MIRT2081180	hsa-miR-939	CLIP-seq
MIRT1275806	hsa-miR-4481	CLIP-seq
MIRT1275808	hsa-miR-4496	CLIP-seq
MIRT1275812	hsa-miR-4533	CLIP-seq
MIRT1275820	hsa-miR-4745-5p	CLIP-seq
MIRT1275821	hsa-miR-4747-5p	CLIP-seq
MIRT2081142	hsa-miR-1182	CLIP-seq
MIRT1275783	hsa-miR-3150b-3p	CLIP-seq
MIRT1275827	hsa-miR-4784	CLIP-seq
MIRT2081140	hsa-miR-1	CLIP-seq
MIRT2081142	hsa-miR-1182	CLIP-seq
MIRT2689087	hsa-miR-122	CLIP-seq
MIRT2307073	hsa-miR-1289	CLIP-seq
MIRT2081145	hsa-miR-1290	CLIP-seq
MIRT2081147	hsa-miR-129-5p	CLIP-seq
MIRT2081149	hsa-miR-1343	CLIP-seq
MIRT2081151	hsa-miR-206	CLIP-seq
MIRT2689088	hsa-miR-3121-3p	CLIP-seq
MIRT2081152	hsa-miR-3122	CLIP-seq
MIRT1275783	hsa-miR-3150b-3p	CLIP-seq
MIRT2081161	hsa-miR-3913-5p	CLIP-seq
MIRT2081164	hsa-miR-4266	CLIP-seq
MIRT2081165	hsa-miR-4271	CLIP-seq
MIRT2689089	hsa-miR-4491	CLIP-seq
MIRT2689090	hsa-miR-4657	CLIP-seq
MIRT2689091	hsa-miR-4663	CLIP-seq
MIRT2081170	hsa-miR-4725-3p	CLIP-seq
MIRT1275821	hsa-miR-4747-5p	CLIP-seq
MIRT1275827	hsa-miR-4784	CLIP-seq
MIRT2689092	hsa-miR-512-3p	CLIP-seq
MIRT2081173	hsa-miR-513a-5p	CLIP-seq
MIRT2689093	hsa-miR-554	CLIP-seq
MIRT2081176	hsa-miR-613	CLIP-seq
MIRT2081179	hsa-miR-651	CLIP-seq
MIRT2689094	hsa-miR-665	CLIP-seq

Show/Hide all(12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004725	Function	Protein tyrosine phosphatase activity	IBA	21873635
GO:0004725	Function	Protein tyrosine phosphatase activity	IDA	19167335, 27655914
GO:0004726	Function	Non-membrane spanning protein tyrosine phosphatase activity	TAS	1557404
GO:0005515	Function	Protein binding	IPI	12907755, 15322554, 16189514, 21516116, 25416956, 31515488, 32296183
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	10940933
GO:0006470	Process	Protein dephosphorylation	IBA	21873635
GO:0010977	Process	Negative regulation of neuron projection development	IDA	27655914
GO:0035335	Process	Peptidyl-tyrosine dephosphorylation	IDA	27655914
GO:0044306	Component	Neuron projection terminus	IDA	27655914
GO:0071345	Process	Cellular response to cytokine stimulus	TAS
GO:1903078	Process	Positive regulation of protein localization to plasma membrane	IDA	27655914

MIM	HGNC	e!Ensembl
600768	9661	ENSG00000169410

Protein

UniProt ID

P43378

Protein name

Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase MEG2)

Protein function

Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus.

PDB

2PA5 , 4GE2 , 4GE5 , 4GE6 , 4ICZ , 6KZQ , 6L03

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00650	CRAL_TRIO	89 → 238	CRAL/TRIO domain	Domain
PF00102	Y_phosphatase	327 → 573	Protein-tyrosine phosphatase	Domain

Sequence

MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLR
AIELFHSYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDPTGASIALFTARLHHPH
KSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFP
ARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTSEVTQHLPRECLPENLGGYVK
IDLATWNFQFLPQVNGHPDPFDEIILFSLPPALDWDSVHVPGPHAMTIQELVDYVNARQK
QGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINA
SFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEK
DSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASL
IDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT
LNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSSGQNLLAVESQ

Sequence length

593

Interactions

View interactions

	Reactome
			Interleukin-37 signaling

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs10520699, rs11852999, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	29059683

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