NCOA5 (nuclear receptor coactivator 5)

Gene

• Entrez ID: 57727
• Gene name: Nuclear receptor coactivator 5
• Gene symbol: NCOA5
• Synonyms: CIA, bA465L10.6
• Chromosome: 20
• Chromosome location: 20q13.12
• Summary: This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptor

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051979	hsa-let-7b-5p	CLASH	23622248
MIRT499974	hsa-miR-6813-3p	PAR-CLIP	24398324
MIRT499973	hsa-miR-3919	PAR-CLIP	24398324
MIRT499972	hsa-miR-4756-3p	PAR-CLIP	24398324
MIRT499971	hsa-miR-212-5p	PAR-CLIP	24398324
MIRT499969	hsa-miR-4284	PAR-CLIP	24398324
MIRT499970	hsa-miR-24-3p	PAR-CLIP	24398324
MIRT499968	hsa-miR-8057	PAR-CLIP	24398324
MIRT499974	hsa-miR-6813-3p	PAR-CLIP	24398324
MIRT499973	hsa-miR-3919	PAR-CLIP	24398324
MIRT499972	hsa-miR-4756-3p	PAR-CLIP	24398324
MIRT499971	hsa-miR-212-5p	PAR-CLIP	24398324
MIRT499969	hsa-miR-4284	PAR-CLIP	24398324
MIRT499970	hsa-miR-24-3p	PAR-CLIP	24398324
MIRT499968	hsa-miR-8057	PAR-CLIP	24398324
MIRT1177312	hsa-miR-1272	CLIP-seq
MIRT1177313	hsa-miR-1322	CLIP-seq
MIRT1177314	hsa-miR-140-3p	CLIP-seq
MIRT1177315	hsa-miR-335	CLIP-seq
MIRT1177316	hsa-miR-342-5p	CLIP-seq
MIRT1177317	hsa-miR-3663-3p	CLIP-seq
MIRT1177318	hsa-miR-3675-5p	CLIP-seq
MIRT1177319	hsa-miR-3689a-3p	CLIP-seq
MIRT1177320	hsa-miR-3689c	CLIP-seq
MIRT1177321	hsa-miR-4305	CLIP-seq
MIRT1177322	hsa-miR-4651	CLIP-seq
MIRT1177323	hsa-miR-4664-5p	CLIP-seq
MIRT1177324	hsa-miR-4695-5p	CLIP-seq
MIRT1177325	hsa-miR-4710	CLIP-seq
MIRT1177326	hsa-miR-4728-5p	CLIP-seq
MIRT1177327	hsa-miR-4773	CLIP-seq
MIRT1177328	hsa-miR-608	CLIP-seq
MIRT1177329	hsa-miR-640	CLIP-seq
MIRT1177330	hsa-miR-759	CLIP-seq
MIRT1177331	hsa-miR-765	CLIP-seq
MIRT2051303	hsa-miR-1234	CLIP-seq
MIRT2051304	hsa-miR-1255a	CLIP-seq
MIRT2051305	hsa-miR-1255b	CLIP-seq
MIRT2051306	hsa-miR-3117-5p	CLIP-seq
MIRT2051307	hsa-miR-3150a-3p	CLIP-seq
MIRT2051308	hsa-miR-3184	CLIP-seq
MIRT2051309	hsa-miR-3192	CLIP-seq
MIRT2051310	hsa-miR-3199	CLIP-seq
MIRT1177319	hsa-miR-3689a-3p	CLIP-seq
MIRT1177320	hsa-miR-3689c	CLIP-seq
MIRT2051311	hsa-miR-3925-5p	CLIP-seq
MIRT2051312	hsa-miR-3973	CLIP-seq
MIRT2051313	hsa-miR-423-5p	CLIP-seq
MIRT2051314	hsa-miR-425	CLIP-seq
MIRT2051315	hsa-miR-4300	CLIP-seq
MIRT2051316	hsa-miR-4515	CLIP-seq
MIRT2051317	hsa-miR-4652-5p	CLIP-seq
MIRT2051318	hsa-miR-4691-5p	CLIP-seq
MIRT1177324	hsa-miR-4695-5p	CLIP-seq
MIRT1177326	hsa-miR-4728-5p	CLIP-seq
MIRT1177327	hsa-miR-4773	CLIP-seq
MIRT2051319	hsa-miR-4796-3p	CLIP-seq
MIRT2051320	hsa-miR-520g	CLIP-seq
MIRT2051321	hsa-miR-520h	CLIP-seq
MIRT2051322	hsa-miR-628-5p	CLIP-seq
MIRT2051323	hsa-miR-661	CLIP-seq
MIRT1177330	hsa-miR-759	CLIP-seq
MIRT1177331	hsa-miR-765	CLIP-seq
MIRT2051324	hsa-miR-920	CLIP-seq
MIRT2280381	hsa-miR-1207-3p	CLIP-seq
MIRT2280382	hsa-miR-1207-5p	CLIP-seq
MIRT2051303	hsa-miR-1234	CLIP-seq
MIRT2051304	hsa-miR-1255a	CLIP-seq
MIRT2051305	hsa-miR-1255b	CLIP-seq
MIRT2280383	hsa-miR-149	CLIP-seq
MIRT2280384	hsa-miR-2278	CLIP-seq
MIRT2280385	hsa-miR-2861	CLIP-seq
MIRT2280386	hsa-miR-298	CLIP-seq
MIRT2280387	hsa-miR-3065-5p	CLIP-seq
MIRT2051306	hsa-miR-3117-5p	CLIP-seq
MIRT2280388	hsa-miR-3125	CLIP-seq
MIRT2051307	hsa-miR-3150a-3p	CLIP-seq
MIRT2280389	hsa-miR-3175	CLIP-seq
MIRT2051308	hsa-miR-3184	CLIP-seq
MIRT2280390	hsa-miR-3187-3p	CLIP-seq
MIRT2280391	hsa-miR-3189-3p	CLIP-seq
MIRT2051309	hsa-miR-3192	CLIP-seq
MIRT2051310	hsa-miR-3199	CLIP-seq
MIRT2280392	hsa-miR-3529	CLIP-seq
MIRT2280393	hsa-miR-3665	CLIP-seq
MIRT1177319	hsa-miR-3689a-3p	CLIP-seq
MIRT1177320	hsa-miR-3689c	CLIP-seq
MIRT2280394	hsa-miR-379	CLIP-seq
MIRT2280395	hsa-miR-3916	CLIP-seq
MIRT2051311	hsa-miR-3925-5p	CLIP-seq
MIRT2280396	hsa-miR-410	CLIP-seq
MIRT2051313	hsa-miR-423-5p	CLIP-seq
MIRT2051315	hsa-miR-4300	CLIP-seq
MIRT2280397	hsa-miR-4451	CLIP-seq
MIRT2051316	hsa-miR-4515	CLIP-seq
MIRT2280398	hsa-miR-4529-5p	CLIP-seq
MIRT2280399	hsa-miR-4536	CLIP-seq
MIRT2280400	hsa-miR-4650-3p	CLIP-seq
MIRT2051317	hsa-miR-4652-5p	CLIP-seq
MIRT2280401	hsa-miR-4667-5p	CLIP-seq
MIRT2280402	hsa-miR-4691-3p	CLIP-seq
MIRT2051318	hsa-miR-4691-5p	CLIP-seq
MIRT1177324	hsa-miR-4695-5p	CLIP-seq
MIRT2280403	hsa-miR-4700-5p	CLIP-seq
MIRT1177326	hsa-miR-4728-5p	CLIP-seq
MIRT2280404	hsa-miR-4731-3p	CLIP-seq
MIRT2280405	hsa-miR-4736	CLIP-seq
MIRT2280406	hsa-miR-4763-3p	CLIP-seq
MIRT2280407	hsa-miR-4769-3p	CLIP-seq
MIRT2280408	hsa-miR-4801	CLIP-seq
MIRT2280409	hsa-miR-4803	CLIP-seq
MIRT2280410	hsa-miR-4804-3p	CLIP-seq
MIRT2280411	hsa-miR-512-5p	CLIP-seq
MIRT2280412	hsa-miR-548aa	CLIP-seq
MIRT2280413	hsa-miR-583	CLIP-seq
MIRT2280414	hsa-miR-635	CLIP-seq
MIRT2280415	hsa-miR-639	CLIP-seq
MIRT2051323	hsa-miR-661	CLIP-seq
MIRT1177331	hsa-miR-765	CLIP-seq
MIRT2051324	hsa-miR-920	CLIP-seq
MIRT2280416	hsa-miR-939	CLIP-seq
MIRT2578827	hsa-miR-105	CLIP-seq
MIRT2051303	hsa-miR-1234	CLIP-seq
MIRT2578828	hsa-miR-1270	CLIP-seq
MIRT2578829	hsa-miR-128	CLIP-seq
MIRT2280383	hsa-miR-149	CLIP-seq
MIRT2578830	hsa-miR-1910	CLIP-seq
MIRT2578831	hsa-miR-1976	CLIP-seq
MIRT2578832	hsa-miR-2052	CLIP-seq
MIRT2578833	hsa-miR-2682	CLIP-seq
MIRT2578834	hsa-miR-27a	CLIP-seq
MIRT2578835	hsa-miR-27b	CLIP-seq
MIRT2578836	hsa-miR-28-5p	CLIP-seq
MIRT2280385	hsa-miR-2861	CLIP-seq
MIRT2051306	hsa-miR-3117-5p	CLIP-seq
MIRT2578837	hsa-miR-3139	CLIP-seq
MIRT2578838	hsa-miR-3140-3p	CLIP-seq
MIRT2578839	hsa-miR-3151	CLIP-seq
MIRT2578840	hsa-miR-3162-3p	CLIP-seq
MIRT2578841	hsa-miR-3170	CLIP-seq
MIRT2051309	hsa-miR-3192	CLIP-seq
MIRT1177315	hsa-miR-335	CLIP-seq
MIRT2578842	hsa-miR-34b	CLIP-seq
MIRT2578843	hsa-miR-3545-5p	CLIP-seq
MIRT2578844	hsa-miR-3663-5p	CLIP-seq
MIRT2578845	hsa-miR-3664-3p	CLIP-seq
MIRT2578846	hsa-miR-3670	CLIP-seq
MIRT1177319	hsa-miR-3689a-3p	CLIP-seq
MIRT1177320	hsa-miR-3689c	CLIP-seq
MIRT2578847	hsa-miR-370	CLIP-seq
MIRT2578848	hsa-miR-3913-3p	CLIP-seq
MIRT2578849	hsa-miR-3922-5p	CLIP-seq
MIRT2051311	hsa-miR-3925-5p	CLIP-seq
MIRT2051312	hsa-miR-3973	CLIP-seq
MIRT2578850	hsa-miR-4261	CLIP-seq
MIRT2578851	hsa-miR-4281	CLIP-seq
MIRT2051315	hsa-miR-4300	CLIP-seq
MIRT1177321	hsa-miR-4305	CLIP-seq
MIRT2578852	hsa-miR-4420	CLIP-seq
MIRT2578853	hsa-miR-4433	CLIP-seq
MIRT2578854	hsa-miR-4480	CLIP-seq
MIRT2578855	hsa-miR-4496	CLIP-seq
MIRT2578856	hsa-miR-449c	CLIP-seq
MIRT2578857	hsa-miR-4514	CLIP-seq
MIRT2578858	hsa-miR-4531	CLIP-seq
MIRT2280399	hsa-miR-4536	CLIP-seq
MIRT2578859	hsa-miR-455-3p	CLIP-seq
MIRT2578860	hsa-miR-4633-3p	CLIP-seq
MIRT2578861	hsa-miR-4659a-3p	CLIP-seq
MIRT2578862	hsa-miR-4659b-3p	CLIP-seq
MIRT2578863	hsa-miR-4683	CLIP-seq
MIRT2051318	hsa-miR-4691-5p	CLIP-seq
MIRT2578864	hsa-miR-4692	CLIP-seq
MIRT1177324	hsa-miR-4695-5p	CLIP-seq
MIRT2578865	hsa-miR-4712-5p	CLIP-seq
MIRT2578866	hsa-miR-4722-3p	CLIP-seq
MIRT2578867	hsa-miR-4722-5p	CLIP-seq
MIRT1177326	hsa-miR-4728-5p	CLIP-seq
MIRT2578868	hsa-miR-4753-5p	CLIP-seq
MIRT2578869	hsa-miR-4763-5p	CLIP-seq
MIRT1177327	hsa-miR-4773	CLIP-seq
MIRT2051319	hsa-miR-4796-3p	CLIP-seq
MIRT2578870	hsa-miR-489	CLIP-seq
MIRT2578871	hsa-miR-513a-5p	CLIP-seq
MIRT2051320	hsa-miR-520g	CLIP-seq
MIRT2051321	hsa-miR-520h	CLIP-seq
MIRT2578872	hsa-miR-541	CLIP-seq
MIRT2578873	hsa-miR-550a	CLIP-seq
MIRT2578874	hsa-miR-582-3p	CLIP-seq
MIRT2578875	hsa-miR-618	CLIP-seq
MIRT2578876	hsa-miR-620	CLIP-seq
MIRT2051322	hsa-miR-628-5p	CLIP-seq
MIRT2578877	hsa-miR-645	CLIP-seq
MIRT2578878	hsa-miR-654-5p	CLIP-seq
MIRT2051323	hsa-miR-661	CLIP-seq
MIRT2578879	hsa-miR-708	CLIP-seq
MIRT1177331	hsa-miR-765	CLIP-seq
MIRT2578880	hsa-miR-767-3p	CLIP-seq
MIRT2578881	hsa-miR-770-5p	CLIP-seq
MIRT2578882	hsa-miR-873	CLIP-seq
MIRT2051324	hsa-miR-920	CLIP-seq
MIRT2578883	hsa-miR-936	CLIP-seq
MIRT2578884	hsa-miR-940	CLIP-seq
MIRT2578827	hsa-miR-105	CLIP-seq
MIRT2578829	hsa-miR-128	CLIP-seq
MIRT2280383	hsa-miR-149	CLIP-seq
MIRT2578830	hsa-miR-1910	CLIP-seq
MIRT2578831	hsa-miR-1976	CLIP-seq
MIRT2578833	hsa-miR-2682	CLIP-seq
MIRT2578834	hsa-miR-27a	CLIP-seq
MIRT2578835	hsa-miR-27b	CLIP-seq
MIRT2578836	hsa-miR-28-5p	CLIP-seq
MIRT2280385	hsa-miR-2861	CLIP-seq
MIRT2051306	hsa-miR-3117-5p	CLIP-seq
MIRT2578837	hsa-miR-3139	CLIP-seq
MIRT2578838	hsa-miR-3140-3p	CLIP-seq
MIRT2578839	hsa-miR-3151	CLIP-seq
MIRT2578840	hsa-miR-3162-3p	CLIP-seq
MIRT2578841	hsa-miR-3170	CLIP-seq
MIRT1177315	hsa-miR-335	CLIP-seq
MIRT2578843	hsa-miR-3545-5p	CLIP-seq
MIRT2578844	hsa-miR-3663-5p	CLIP-seq
MIRT2578845	hsa-miR-3664-3p	CLIP-seq
MIRT2578846	hsa-miR-3670	CLIP-seq
MIRT2578847	hsa-miR-370	CLIP-seq
MIRT2578848	hsa-miR-3913-3p	CLIP-seq
MIRT2578849	hsa-miR-3922-5p	CLIP-seq
MIRT2051312	hsa-miR-3973	CLIP-seq
MIRT2578850	hsa-miR-4261	CLIP-seq
MIRT2578851	hsa-miR-4281	CLIP-seq
MIRT1177321	hsa-miR-4305	CLIP-seq
MIRT2578853	hsa-miR-4433	CLIP-seq
MIRT2578854	hsa-miR-4480	CLIP-seq
MIRT2578855	hsa-miR-4496	CLIP-seq
MIRT2578856	hsa-miR-449c	CLIP-seq
MIRT2578857	hsa-miR-4514	CLIP-seq
MIRT2280399	hsa-miR-4536	CLIP-seq
MIRT2578859	hsa-miR-455-3p	CLIP-seq
MIRT2578860	hsa-miR-4633-3p	CLIP-seq
MIRT2578861	hsa-miR-4659a-3p	CLIP-seq
MIRT2578862	hsa-miR-4659b-3p	CLIP-seq
MIRT2578864	hsa-miR-4692	CLIP-seq
MIRT2578865	hsa-miR-4712-5p	CLIP-seq
MIRT2578866	hsa-miR-4722-3p	CLIP-seq
MIRT2578867	hsa-miR-4722-5p	CLIP-seq
MIRT2578868	hsa-miR-4753-5p	CLIP-seq
MIRT2578869	hsa-miR-4763-5p	CLIP-seq
MIRT2051319	hsa-miR-4796-3p	CLIP-seq
MIRT2578870	hsa-miR-489	CLIP-seq
MIRT2578871	hsa-miR-513a-5p	CLIP-seq
MIRT2051320	hsa-miR-520g	CLIP-seq
MIRT2051321	hsa-miR-520h	CLIP-seq
MIRT2578872	hsa-miR-541	CLIP-seq
MIRT2578873	hsa-miR-550a	CLIP-seq
MIRT2578874	hsa-miR-582-3p	CLIP-seq
MIRT2578875	hsa-miR-618	CLIP-seq
MIRT2051322	hsa-miR-628-5p	CLIP-seq
MIRT2578877	hsa-miR-645	CLIP-seq
MIRT2578878	hsa-miR-654-5p	CLIP-seq
MIRT2051323	hsa-miR-661	CLIP-seq
MIRT2578879	hsa-miR-708	CLIP-seq
MIRT2578880	hsa-miR-767-3p	CLIP-seq
MIRT2578881	hsa-miR-770-5p	CLIP-seq
MIRT2578882	hsa-miR-873	CLIP-seq
MIRT2578883	hsa-miR-936	CLIP-seq
MIRT2578884	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	NAS	25755249
GO:0003682	Function	Chromatin binding	IEA
GO:0003714	Function	Transcription corepressor activity	NAS	25755249
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	11113208
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005654	Component	Nucleoplasm	IDA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0042593	Process	Glucose homeostasis	IEA
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	IEA

Other IDs

• MIM: 616825
• HGNC: 15909
• e!Ensembl: ENSG00000124160

Protein

• UniProt ID: Q9HCD5
• Protein name: Nuclear receptor coactivator 5 (NCoA-5) (Coactivator independent of AF-2) (CIA)
• Protein function: Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuc
• PDB: 1V95, 2J7X, 2J7Y, 4ZI1
• Sequence:

  MNTAPSRPSPTRRDPYGFGDSRDSRRDRSPIRGSPRREPRDGRNGRDARDSRDIRDPRDL
  RDHRHSRDLRDHRDSRSVRDVRDVRDLRDFRDLRDSRDFRDQRDPMYDRYRDMRDSRDPM
  YRREGSYDRYLRMDDYCRRKDDSYFDRYRDSFDGRGPPGPESQSRAKERLKREERRREEL
  YRQYFEEIQRRFDAERPVDCSVIVVNKQTKDYAESVGRKVRDLGMVVDLIFLNTEVSLSQ
  ALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQEHRNMPQADAMVLVARNYERYKNE
  CREKEREEIARQAAKMADEAILQERERGGPEEGVRGGHPPAIQSLINLLADNRYLTAEET
  DKIINYLRERKERLMRSSTDSLPGPISRQPLGATSGASLKTQPSSQPLQSGQVLPSATPT
  PSAPPTSQQELQAKILSLFNSGTVTANSSSASPSVAAGNTPNQNFSTAANSQPQQRSQAS
  GNQPPSILGQGGSAQNMGPRPGAPSQGLFGQPSSRLAPASNMTSQRPVSSTGINFDNPSV
  QKALDTLIQSGPALSHLVSQTTAQMGQPQAPMGSYQRHY

• Sequence length: 579

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Diffuse lymphoma	Diffuse Large B-Cell Lymphoma	rs121912651, rs121913289, rs121913293, rs878854402, rs869025340, rs1349928568, rs1569115687, rs121913291	31407831
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544	21833088, 31407831

Unknown
Disease name	Disease term	dbSNP ID	References
B-cell lymphoma	Marginal Zone B-Cell Lymphoma		31407831
Hodgkin disease	Hodgkin Disease		30194254
Mental depression	Major Depressive Disorder	rs587778876, rs587778877	29942085
Mood disorder	Mood Disorders		29942085