CWC22 (CWC22 spliceosome associated protein)

Gene

• Entrez ID: 57703
• Gene name: CWC22 spliceosome associated protein
• Gene symbol: CWC22
• Synonyms: EIF4GL, NCM, fSAPb
• Chromosome: 2
• Chromosome location: 2q31.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT041798	hsa-miR-484	CLASH	23622248
MIRT039856	hsa-miR-615-3p	CLASH	23622248
MIRT037138	hsa-miR-877-3p	CLASH	23622248
MIRT917383	hsa-miR-1296	CLIP-seq
MIRT917384	hsa-miR-1305	CLIP-seq
MIRT917385	hsa-miR-188-5p	CLIP-seq
MIRT917386	hsa-miR-204	CLIP-seq
MIRT917387	hsa-miR-211	CLIP-seq
MIRT917388	hsa-miR-3115	CLIP-seq
MIRT917389	hsa-miR-3132	CLIP-seq
MIRT917390	hsa-miR-3671	CLIP-seq
MIRT917391	hsa-miR-4299	CLIP-seq
MIRT917392	hsa-miR-4456	CLIP-seq
MIRT917393	hsa-miR-4512	CLIP-seq
MIRT917394	hsa-miR-4775	CLIP-seq
MIRT917395	hsa-miR-548q	CLIP-seq
MIRT917396	hsa-miR-561	CLIP-seq
MIRT917397	hsa-miR-590-3p	CLIP-seq
MIRT917398	hsa-miR-607	CLIP-seq
MIRT2386595	hsa-miR-145	CLIP-seq
MIRT2386596	hsa-miR-198	CLIP-seq
MIRT917384	hsa-miR-1305	CLIP-seq
MIRT917386	hsa-miR-204	CLIP-seq
MIRT917387	hsa-miR-211	CLIP-seq
MIRT917390	hsa-miR-3671	CLIP-seq
MIRT917391	hsa-miR-4299	CLIP-seq
MIRT917392	hsa-miR-4456	CLIP-seq
MIRT917395	hsa-miR-548q	CLIP-seq
MIRT917396	hsa-miR-561	CLIP-seq
MIRT917398	hsa-miR-607	CLIP-seq
MIRT2510969	hsa-miR-1273f	CLIP-seq
MIRT917383	hsa-miR-1296	CLIP-seq
MIRT917384	hsa-miR-1305	CLIP-seq
MIRT2510970	hsa-miR-143	CLIP-seq
MIRT917385	hsa-miR-188-5p	CLIP-seq
MIRT917386	hsa-miR-204	CLIP-seq
MIRT917387	hsa-miR-211	CLIP-seq
MIRT917388	hsa-miR-3115	CLIP-seq
MIRT917389	hsa-miR-3132	CLIP-seq
MIRT2510971	hsa-miR-3163	CLIP-seq
MIRT2510972	hsa-miR-3171	CLIP-seq
MIRT2510973	hsa-miR-340	CLIP-seq
MIRT2510974	hsa-miR-3646	CLIP-seq
MIRT2510975	hsa-miR-3662	CLIP-seq
MIRT917390	hsa-miR-3671	CLIP-seq
MIRT2510976	hsa-miR-3973	CLIP-seq
MIRT2510977	hsa-miR-4275	CLIP-seq
MIRT917391	hsa-miR-4299	CLIP-seq
MIRT917392	hsa-miR-4456	CLIP-seq
MIRT917393	hsa-miR-4512	CLIP-seq
MIRT2510978	hsa-miR-4708-5p	CLIP-seq
MIRT2510979	hsa-miR-4770	CLIP-seq
MIRT917394	hsa-miR-4775	CLIP-seq
MIRT2510980	hsa-miR-513a-3p	CLIP-seq
MIRT2510981	hsa-miR-520g	CLIP-seq
MIRT2510982	hsa-miR-520h	CLIP-seq
MIRT2510983	hsa-miR-548a-5p	CLIP-seq
MIRT2510984	hsa-miR-548ab	CLIP-seq
MIRT2510985	hsa-miR-548ak	CLIP-seq
MIRT2510986	hsa-miR-548b-5p	CLIP-seq
MIRT2510987	hsa-miR-548c-5p	CLIP-seq
MIRT2510988	hsa-miR-548d-5p	CLIP-seq
MIRT2510989	hsa-miR-548h	CLIP-seq
MIRT2510990	hsa-miR-548i	CLIP-seq
MIRT2510991	hsa-miR-548j	CLIP-seq
MIRT917395	hsa-miR-548q	CLIP-seq
MIRT2510992	hsa-miR-548w	CLIP-seq
MIRT2510993	hsa-miR-548y	CLIP-seq
MIRT2510994	hsa-miR-559	CLIP-seq
MIRT917396	hsa-miR-561	CLIP-seq
MIRT2510995	hsa-miR-570	CLIP-seq
MIRT917397	hsa-miR-590-3p	CLIP-seq
MIRT917398	hsa-miR-607	CLIP-seq
MIRT2510969	hsa-miR-1273f	CLIP-seq
MIRT917383	hsa-miR-1296	CLIP-seq
MIRT917384	hsa-miR-1305	CLIP-seq
MIRT2510970	hsa-miR-143	CLIP-seq
MIRT917385	hsa-miR-188-5p	CLIP-seq
MIRT917386	hsa-miR-204	CLIP-seq
MIRT917387	hsa-miR-211	CLIP-seq
MIRT917388	hsa-miR-3115	CLIP-seq
MIRT917389	hsa-miR-3132	CLIP-seq
MIRT2510971	hsa-miR-3163	CLIP-seq
MIRT2510972	hsa-miR-3171	CLIP-seq
MIRT2510973	hsa-miR-340	CLIP-seq
MIRT2510974	hsa-miR-3646	CLIP-seq
MIRT2510975	hsa-miR-3662	CLIP-seq
MIRT917390	hsa-miR-3671	CLIP-seq
MIRT2510977	hsa-miR-4275	CLIP-seq
MIRT917391	hsa-miR-4299	CLIP-seq
MIRT917392	hsa-miR-4456	CLIP-seq
MIRT917393	hsa-miR-4512	CLIP-seq
MIRT2510978	hsa-miR-4708-5p	CLIP-seq
MIRT2510979	hsa-miR-4770	CLIP-seq
MIRT917394	hsa-miR-4775	CLIP-seq
MIRT2510980	hsa-miR-513a-3p	CLIP-seq
MIRT2678826	hsa-miR-520d-5p	CLIP-seq
MIRT2678827	hsa-miR-524-5p	CLIP-seq
MIRT917395	hsa-miR-548q	CLIP-seq
MIRT917396	hsa-miR-561	CLIP-seq
MIRT2510995	hsa-miR-570	CLIP-seq
MIRT917397	hsa-miR-590-3p	CLIP-seq
MIRT917398	hsa-miR-607	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	IBA	21873635
GO:0000398	Process	MRNA splicing, via spliceosome	IC	11991638
GO:0000398	Process	MRNA splicing, via spliceosome	IDA	29360106
GO:0000398	Process	MRNA splicing, via spliceosome	TAS
GO:0003723	Function	RNA binding	IBA	21873635
GO:0003723	Function	RNA binding	IDA	11991638
GO:0005515	Function	Protein binding	IPI	22365833, 22961380, 23084401, 23236153, 29997244, 32296183
GO:0005634	Component	Nucleus	IDA	29360106
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IDA	11991638
GO:0005829	Component	Cytosol	IDA
GO:0016607	Component	Nuclear speck	IDA	22961380
GO:0048024	Process	Regulation of mRNA splicing, via spliceosome	IC	11991638
GO:0071005	Component	U2-type precatalytic spliceosome	IDA	29360106
GO:0071006	Component	U2-type catalytic step 1 spliceosome	IDA	29301961
GO:0071007	Component	U2-type catalytic step 2 spliceosome	IDA	28076346
GO:0071013	Component	Catalytic step 2 spliceosome	IBA	21873635
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638, 22961380

Other IDs

• MIM: 615186
• HGNC: 29322
• e!Ensembl: ENSG00000163510

Protein

• UniProt ID: Q9HCG8
• Protein name: Pre-mRNA-splicing factor CWC22 homolog (Nucampholin homolog) (fSAPb)
• Protein function: Required for pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:12226669, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106). As a component of the minor spliceosome, involved in the spli
• PDB: 4C9B, 5MQF, 5XJC, 5YZG, 5Z56, 5Z57, 5Z58, 6FF7, 6ICZ, 6QDV, 6YVH, 6ZYM, 7A5P, 7DVQ, 7QTT, 7W59, 7W5A, 7W5B, 8C6J, 8CH6, 8I0R, 8I0S, 8I0T, 8I0U, 8I0V, 8I0W, 9FMD
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02847	MA3	455 → 561	MA3 domain	Family

• Sequence:

  MKSSVAQIKPSSGHDRRENLNSYQRNSSPEDRYEEQERSPRDRDYFDYSRSDYEHSRRGR
  SYDSSMESRNRDREKRRERERDTDRKRSRKSPSPGRRNPETSVTQSSSAQDEPATKKKKD
  ELDPLLTRTGGAYIPPAKLRMMQEQITDKNSLAYQRMSWEALKKSINGLINKVNISNISI
  IIQELLQENIVRGRGLLSRSVLQAQSASPIFTHVYAALVAIINSKFPQIGELILKRLILN
  FRKGYRRNDKQLCLTASKFVAHLINQNVAHEVLCLEMLTLLLERPTDDSVEVAIGFLKEC
  GLKLTQVSPRGINAIFERLRNILHESEIDKRVQYMIEVMFAVRKDGFKDHPIILEGLDLV
  EEDDQFTHMLPLEDDYNPEDVLNVFKMDPNFMENEEKYKAIKKEILDEGDTDSNTDQDAG
  SSEEDEEEEEEEGEEDEEGQKVTIHDKTEINLVSFRRTIYLAIQSSLDFEECAHKLLKME
  FPESQTKELCNMILDCCAQQRTYEKFFGLLAGRFCMLKKEYMESFEGIFKEQYDTIHRLE
  TNKLRNVAKMFAHLLYTDSLPWSVLECIKLSEETTTSSSRIFVKIFFQELCEYMGLPKLN
  ARLKDETLQPFFEGLLPRDNPRNTRFAINFFTSIGLGGLTDELREHLKNTPKVIVAQKPD
  VEQNKSSPSSSSSASSSSESDSSDSDSDSSDSSSESSSEESDSSSISSHSSASANDVRKK
  GHGKTRSKEVDKLIRNQQTNDRKQKERRQEHGHQETRTERERRSEKHRDQNSSGSNWRDP
  ITKYTSDKDVPSERNNYSRVANDRDQEMHIDLENKHGDPKKKRGERRNSFSENEKHTHRI
  KDSENFRRKDRSKSKEMNRKHSGSRSDEDRYQNGAERRWEKSSRYSEQSRESKKNQDRRR
  EKSPAKQK

• Sequence length: 908

Pathways

Reactome:

mRNA Splicing - Major Pathway

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	30285260, 28991256