ZFAT (zinc finger and AT-hook domain containing)

Gene

• Entrez ID: 57623
• Gene name: Zinc finger and AT-hook domain containing
• Gene symbol: ZFAT
• Synonyms: AITD3, ZFAT1, ZNF406
• Chromosome: 8
• Chromosome location: 8q24.22
• Summary: This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splic

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT047133	hsa-miR-183-5p	CLASH	23622248
MIRT439238	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439238	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1509757	hsa-miR-1324	CLIP-seq
MIRT1509758	hsa-miR-452	CLIP-seq
MIRT1509759	hsa-miR-4676-3p	CLIP-seq
MIRT1509760	hsa-miR-873	CLIP-seq
MIRT1509761	hsa-miR-1207-5p	CLIP-seq
MIRT1509762	hsa-miR-1226	CLIP-seq
MIRT1509763	hsa-miR-1229	CLIP-seq
MIRT1509764	hsa-miR-1245b-3p	CLIP-seq
MIRT1509765	hsa-miR-1321	CLIP-seq
MIRT1509757	hsa-miR-1324	CLIP-seq
MIRT1509766	hsa-miR-153	CLIP-seq
MIRT1509767	hsa-miR-217	CLIP-seq
MIRT1509768	hsa-miR-29a	CLIP-seq
MIRT1509769	hsa-miR-29b	CLIP-seq
MIRT1509770	hsa-miR-29c	CLIP-seq
MIRT1509771	hsa-miR-3616-3p	CLIP-seq
MIRT1509772	hsa-miR-3663-3p	CLIP-seq
MIRT1509773	hsa-miR-3678-3p	CLIP-seq
MIRT1509774	hsa-miR-4270	CLIP-seq
MIRT1509775	hsa-miR-4287	CLIP-seq
MIRT1509776	hsa-miR-4321	CLIP-seq
MIRT1509777	hsa-miR-4428	CLIP-seq
MIRT1509778	hsa-miR-4441	CLIP-seq
MIRT1509779	hsa-miR-4469	CLIP-seq
MIRT1509780	hsa-miR-4494	CLIP-seq
MIRT1509758	hsa-miR-452	CLIP-seq
MIRT1509759	hsa-miR-4676-3p	CLIP-seq
MIRT1509781	hsa-miR-4685-3p	CLIP-seq
MIRT1509782	hsa-miR-4728-5p	CLIP-seq
MIRT1509783	hsa-miR-4733-3p	CLIP-seq
MIRT1509784	hsa-miR-4739	CLIP-seq
MIRT1509785	hsa-miR-4756-5p	CLIP-seq
MIRT1509786	hsa-miR-4763-3p	CLIP-seq
MIRT1509787	hsa-miR-642a	CLIP-seq
MIRT1509788	hsa-miR-767-5p	CLIP-seq
MIRT1509760	hsa-miR-873	CLIP-seq
MIRT1509789	hsa-miR-137	CLIP-seq
MIRT1509790	hsa-miR-138	CLIP-seq
MIRT1509791	hsa-miR-4299	CLIP-seq
MIRT1509792	hsa-miR-4728-3p	CLIP-seq
MIRT1509793	hsa-miR-628-5p	CLIP-seq
MIRT1509761	hsa-miR-1207-5p	CLIP-seq
MIRT2153544	hsa-miR-1264	CLIP-seq
MIRT1509765	hsa-miR-1321	CLIP-seq
MIRT1509768	hsa-miR-29a	CLIP-seq
MIRT1509769	hsa-miR-29b	CLIP-seq
MIRT1509770	hsa-miR-29c	CLIP-seq
MIRT2153545	hsa-miR-3117-5p	CLIP-seq
MIRT1509771	hsa-miR-3616-3p	CLIP-seq
MIRT1509772	hsa-miR-3663-3p	CLIP-seq
MIRT1509774	hsa-miR-4270	CLIP-seq
MIRT1509777	hsa-miR-4428	CLIP-seq
MIRT1509778	hsa-miR-4441	CLIP-seq
MIRT1509792	hsa-miR-4728-3p	CLIP-seq
MIRT1509782	hsa-miR-4728-5p	CLIP-seq
MIRT1509784	hsa-miR-4739	CLIP-seq
MIRT1509785	hsa-miR-4756-5p	CLIP-seq
MIRT1509786	hsa-miR-4763-3p	CLIP-seq
MIRT1509788	hsa-miR-767-5p	CLIP-seq
MIRT1509760	hsa-miR-873	CLIP-seq
MIRT1509762	hsa-miR-1226	CLIP-seq
MIRT1509763	hsa-miR-1229	CLIP-seq
MIRT2153544	hsa-miR-1264	CLIP-seq
MIRT1509766	hsa-miR-153	CLIP-seq
MIRT1509767	hsa-miR-217	CLIP-seq
MIRT2153545	hsa-miR-3117-5p	CLIP-seq
MIRT1509771	hsa-miR-3616-3p	CLIP-seq
MIRT1509775	hsa-miR-4287	CLIP-seq
MIRT1509779	hsa-miR-4469	CLIP-seq
MIRT1509780	hsa-miR-4494	CLIP-seq
MIRT2373850	hsa-miR-4501	CLIP-seq
MIRT1509781	hsa-miR-4685-3p	CLIP-seq
MIRT1509783	hsa-miR-4733-3p	CLIP-seq
MIRT1509787	hsa-miR-642a	CLIP-seq
MIRT2695667	hsa-miR-127-5p	CLIP-seq
MIRT2695668	hsa-miR-3936	CLIP-seq
MIRT2695669	hsa-miR-4635	CLIP-seq
MIRT2695670	hsa-miR-493	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0001228	Function	DNA-binding transcription activator activity, RNA polymerase II-specific	IEA
GO:0002244	Process	Hematopoietic progenitor cell differentiation	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005829	Component	Cytosol	IEA
GO:0006355	Process	Regulation of transcription, DNA-templated	IBA	21873635
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 610931
• HGNC: 19899
• e!Ensembl: ENSG00000066827

Protein

• UniProt ID: Q9P243
• Protein name: Zinc finger protein ZFAT (Zinc finger gene in AITD susceptibility region) (Zinc finger protein 406)
• Protein function: May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity).
• PDB: 2ELM, 2ELN, 2ELO, 2ELP, 2ELQ, 2ELR, 2ELS, 2ELT, 2ELU, 2ELV, 2RSH, 2RSI, 2RSJ, 2RUT, 2RUU, 2RUV, 2RUW, 2RUX, 2RUY, 2RUZ, 2RV0, 2RV1, 2RV2, 2RV3, 2RV6, 2RV7
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00096	zf-C2H2	271 → 293	Zinc finger, C2H2 type	Domain
  PF13909	zf-H2C2_5	299 → 323		Domain
  PF00096	zf-C2H2	909 → 931	Zinc finger, C2H2 type	Domain
  PF13909	zf-H2C2_5	966 → 989		Domain

• Sequence:

  METRAAENTAIFMCKCCNLFSPNQSELLSHVSEKHMEEGVNVDEIIIPLRPLSTPEPPNS
  SKTGDEFLVMKRKRGRPKGSTKKSSTEEELAENIVSPTEDSPLAPEEGNSLPPSSLECSK
  CCRKFSNTRQLRKHICIIVLNLGEEEGEAGNESDLELEKKCKEDDREKASKRPRSQKTEK
  VQKISGKEARQLSGAKKPIISVVLTAHEAIPGATKIVPVEAGPPETGATNSETTSADLVP
  RRGYQEYAIQQTPYEQPMKSSRLGPTQLKIFTCEYCNKVFKFKHSLQAHLRIHTNEKPYK
  CPQCSYASAIKANLNVHLRKHTGEKFACDYCSFTCLSKGHLKVHIERVHKKIKQHCRFCK
  KKYSDVKNLIKHIRDAHDPQDKKVKEALDELCLMTREGKRQLLYDCHICERKFKNELDRD
  RHMLVHGDKWPFACELCGHGATKYQALELHVRKHPFVYVCAVCRKKFVSSIRLRTHIKEV
  HGAAQEALVFTSSINQSFCLLEPGGDIQQEALGDQLQLVEEEFALQGVNALKEEACPGDT
  QLEEGRKEPEAPGEMPAPAVHLASPQAESTALPPCELETTVVSSSDLHSQEVVSDDFLLK
  NDTSSAEAHAAPEKPPDMQHRSSVQTQGEVITLLLSKAQSAGSDQESHGAQSPLGEGQNM
  AVLSAGDPDPSRCLRSNPAEASDLLPPVAGGGDTITHQPDSCKAAPEHRSGITAFMKVLN
  SLQKKQMNTSLCERIRKVYGDLECEYCGKLFWYQVHFDMHVRTHTREHLYYCSQCHYSSI
  TKNCLKRHVIQKHSNILLKCPTDGCDYSTPDKYKLQAHLKVHTALDKRSYSCPVCEKSFS
  EDRLIKSHIKTNHPEVSMSTISEVLGRRVQLKGLIGKRAMKCPYCDFYFMKNGSDLQRHI
  WAHEGVKPFKCSLCEYATRSKSNLKAHMNRHSTEKTHLCDMCGKKFKSKGTLKSHKLLHT
  ADGKQFKCTVCDYTAAQKPQLLRHMEQHVSFKPFRCAHCHYSCNISGSLKRHYNRKHPNE
  EYANVGTGELAAEVLIQQGGLKCPVCSFVYGTKWEFNRHLKNKHGLKVVEIDGDPKWETA
  TEAPEEPSTQYLHITEAEEDVQGTQAAVAALQDLRYTSESGDRLDPTAVNILQQIIELGA
  ETHDATALASVVAMAPGTVTVVKQVTEEEPSSNHTVMIQETVQQASVELAEQHHLVVSSD
  DVEGIETVTVYTQGGEASEFIVYVQEAMQPVEEQAVEQPAQEL

• Sequence length: 1243

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Hypertension	Hypertensive disease	rs13306026, rs13333226	21626137

Unknown
Disease name	Disease term	dbSNP ID	References
Autoimmune thyroiditis	Autoimmune thyroiditis
Pelvic organ prolapse	Pelvic Organ Prolapse		22105264
Thyroiditis	Thyroiditis