TSHZ3 (teashirt zinc finger homeobox 3)

Gene

• Entrez ID: 57616
• Gene name: Teashirt zinc finger homeobox 3
• Gene symbol: TSHZ3
• Synonyms: TSH3, ZNF537
• Chromosome: 19
• Chromosome location: 19q12
• Summary: This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gene expression in urinary tra

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004604	hsa-miR-155-5p	Luciferase reporter assay	19177201
MIRT004604	hsa-miR-155-5p	Review	20026422
MIRT030966	hsa-miR-21-5p	Microarray	18591254
MIRT050311	hsa-miR-25-3p	CLASH	23622248
MIRT046112	hsa-miR-30b-5p	CLASH	23622248
MIRT1458846	hsa-miR-1183	CLIP-seq
MIRT1458847	hsa-miR-1305	CLIP-seq
MIRT1458848	hsa-miR-1910	CLIP-seq
MIRT1458849	hsa-miR-3121-3p	CLIP-seq
MIRT1458850	hsa-miR-340	CLIP-seq
MIRT1458851	hsa-miR-3671	CLIP-seq
MIRT1458852	hsa-miR-3686	CLIP-seq
MIRT1458853	hsa-miR-3924	CLIP-seq
MIRT1458854	hsa-miR-3973	CLIP-seq
MIRT1458855	hsa-miR-409-3p	CLIP-seq
MIRT1458856	hsa-miR-4257	CLIP-seq
MIRT1458857	hsa-miR-4418	CLIP-seq
MIRT1458858	hsa-miR-4652-3p	CLIP-seq
MIRT1458859	hsa-miR-4721	CLIP-seq
MIRT1458860	hsa-miR-4742-3p	CLIP-seq
MIRT1458861	hsa-miR-4744	CLIP-seq
MIRT1458862	hsa-miR-487a	CLIP-seq
MIRT1458863	hsa-miR-488	CLIP-seq
MIRT1458864	hsa-miR-495	CLIP-seq
MIRT1458865	hsa-miR-509-3-5p	CLIP-seq
MIRT1458866	hsa-miR-509-5p	CLIP-seq
MIRT1458867	hsa-miR-510	CLIP-seq
MIRT1458868	hsa-miR-512-5p	CLIP-seq
MIRT1458869	hsa-miR-548k	CLIP-seq
MIRT1458870	hsa-miR-548p	CLIP-seq
MIRT1458871	hsa-miR-568	CLIP-seq
MIRT1458872	hsa-miR-607	CLIP-seq
MIRT2137707	hsa-miR-330-3p	CLIP-seq
MIRT2137708	hsa-miR-4446-5p	CLIP-seq
MIRT2137709	hsa-miR-4755-5p	CLIP-seq
MIRT2137710	hsa-miR-642a	CLIP-seq
MIRT2358543	hsa-miR-1279	CLIP-seq
MIRT2358544	hsa-miR-3065-5p	CLIP-seq
MIRT2358545	hsa-miR-338-5p	CLIP-seq
MIRT2358546	hsa-miR-3688-3p	CLIP-seq
MIRT2358547	hsa-miR-3907	CLIP-seq
MIRT2358548	hsa-miR-3910	CLIP-seq
MIRT2358549	hsa-miR-3977	CLIP-seq
MIRT2358550	hsa-miR-4289	CLIP-seq
MIRT2358551	hsa-miR-505	CLIP-seq
MIRT2358552	hsa-miR-548an	CLIP-seq
MIRT2358553	hsa-miR-802	CLIP-seq
MIRT2396416	hsa-miR-2116	CLIP-seq
MIRT2396417	hsa-miR-4677-5p	CLIP-seq
MIRT2358545	hsa-miR-338-5p	CLIP-seq
MIRT2434369	hsa-miR-4307	CLIP-seq
MIRT2651835	hsa-miR-1272	CLIP-seq
MIRT2651836	hsa-miR-1322	CLIP-seq
MIRT2358545	hsa-miR-338-5p	CLIP-seq
MIRT1458853	hsa-miR-3924	CLIP-seq
MIRT2651837	hsa-miR-4263	CLIP-seq
MIRT2651838	hsa-miR-4517	CLIP-seq
MIRT1458871	hsa-miR-568	CLIP-seq
MIRT2651839	hsa-miR-576-5p	CLIP-seq
MIRT2651835	hsa-miR-1272	CLIP-seq
MIRT2651836	hsa-miR-1322	CLIP-seq
MIRT2358545	hsa-miR-338-5p	CLIP-seq
MIRT1458853	hsa-miR-3924	CLIP-seq
MIRT2651837	hsa-miR-4263	CLIP-seq
MIRT2651838	hsa-miR-4517	CLIP-seq
MIRT2694308	hsa-miR-548c-3p	CLIP-seq
MIRT1458871	hsa-miR-568	CLIP-seq
MIRT2651839	hsa-miR-576-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0002087	Process	Regulation of respiratory gaseous exchange by nervous system process	ISS
GO:0003677	Function	DNA binding	IBA	21873635
GO:0003682	Function	Chromatin binding	IDA	19343227
GO:0005515	Function	Protein binding	IPI	19343227, 25416956, 31515488, 32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	19343227
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0007275	Process	Multicellular organism development	IEA
GO:0030426	Component	Growth cone	IEA
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IDA	19343227
GO:0046872	Function	Metal ion binding	IEA
GO:0051968	Process	Positive regulation of synaptic transmission, glutamatergic	ISS
GO:0060291	Process	Long-term synaptic potentiation	ISS

Other IDs

• MIM: 614119
• HGNC: 30700
• e!Ensembl: ENSG00000121297

Protein

• UniProt ID: Q63HK5
• Protein name: Teashirt homolog 3 (Zinc finger protein 537)
• Protein function: Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the
• PDB: 2DMI
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13912	zf-C2H2_6	276 → 302		Domain

• Sequence:

  MPRRKQQAPRRAAAYVSEELKAAALVDEGLDPEEHTADGEPSAKYMCPEKELARACPSYQ
  NSPAAEFSCHEMDSESHISETSDRMADFESGSIKNEEETKEVTVPLEDTTVSDSLEQMKA
  VYNNFLSNSYWSNLNLNLHQPSSEKNNGSSSSSSSSSSSCGSGSFDWHQSAMAKTLQQVS
  QSRMLPEPSLFSTVQLYRQSSKLYGSIFTGASKFRCKDCSAAYDTLVELTVHMNETGHYR
  DDNHETDNNNPKRWSKPRKRSLLEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHY
  QKVPLKEPVTPVAAKIIPATRKKASLELELPSSPDSTGGTPKATISDTNDALQKNSNPYI
  TPNNRYGHQNGASYAWHFEARKSQILKCMECGSSHDTLQELTAHMMVTGHFIKVTNSAMK
  KGKPIVETPVTPTITTLLDEKVQSVPLAATTFTSPSNTPASISPKLNVEVKKEVDKEKAV
  TDEKPKQKDKPGEEEEKCDISSKYHYLTENDLEESPKGGLDILKSLENTVTSAINKAQNG
  TPSWGGYPSIHAAYQLPNMMKLSLGSSGKSTPLKPMFGNSEIVSPTKNQTLVSPPSSQTS
  PMPKTNFHAMEELVKKVTEKVAKVEEKMKEPDGKLSPPKRATPSPCSSEVGEPIKMEASS
  DGGFRSQENSPSPPRDGCKDGSPLAEPVENGKELVKPLASSLSGSTAIITDHPPEQPFVN
  PLSALQSVMNIHLGKAAKPSLPALDPMSMLFKMSNSLAEKAAVATPPPLQSKKADHLDRY
  FYHVNNDQPIDLTKGKSDKGCSLGSVLLSPTSTAPATSSSTVTTAKTSAVVSFMSNSPLR
  ENALSDISDMLKNLTESHTSKSSTPSSISEKSDIDGATLEEAEESTPAQKRKGRQSNWNP
  QHLLILQAQFAASLRQTSEGKYIMSDLSPQERMHISRFTGLSMTTISHWLANVKYQLRRT
  GGTKFLKNLDTGHPVFFCNDCASQIRTPSTYISHLESHLGFRLRDLSKLSTEQINSQIAQ
  TKSPSEKMVTSSPEEDLGTSYQCKLCNRTFASKHAVKLHLSKTHGKSPEDHLLYVSELEK
  Q

• Sequence length: 1081

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Autism spectrum disorder	Autism Spectrum Disorders	rs724159978, rs75184679, rs119103221, rs9332964, rs121912562, rs1594344233, rs727504317, rs111033204, rs1801086, rs587784464, rs724159948, rs764659822, rs794727977, rs796052733, rs796052728, rs762292772, rs864321694, rs869312878, rs758432471, rs750896617, rs886039692, rs886039770, rs201037487, rs200483989, rs1057518198, rs1057517708, rs780267761, rs1555910143, rs1057519632, rs775225727, rs751037529, rs1064794848, rs1064795655, rs1131691548, rs1135401811, rs1553248081, rs1454466097, rs1554480537, rs1553578503, rs1553518509, rs774152851, rs1554481395, rs1554464807, rs1554401434, rs1452048149, rs370498156, rs756691187, rs1557863430, rs1557863440, rs1557863546, rs769581210, rs202098093, rs1276388879, rs778792467, rs760059077, rs373783340, rs1557867853, rs772572695, rs753214391, rs749270162, rs548226228, rs1557870645, rs1557874046, rs749548928, rs754532606, rs1557901347, rs1557902023, rs1557909572, rs574335012, rs1557909821, rs1372713010, rs561369202, rs1476293577, rs1557910728, rs1557911386, rs375045125, rs998675361, rs1557916296, rs1557935477, rs866632178, rs1561824498, rs1396313317, rs1564801388, rs1564801473, rs1564950387, rs1565527302, rs1569513495, rs1569305431, rs143944436, rs1563183492, rs1561846159, rs1565819425, rs1562957809, rs1585645641, rs1585016242, rs1595127294, rs1585667374, rs1585653028, rs1585653240, rs1592919048, rs1585645384, rs1789927813	27668656
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928	26634245