JCAD (junctional cadherin 5 associated)

Gene

• Entrez ID: 57608
• Gene name: Junctional cadherin 5 associated
• Gene symbol: JCAD
• Synonyms: KIAA1462
• Chromosome: 10
• Chromosome location: 10p11.23
• Summary: This gene encodes an endothelial cell-to-cell junction protein. Naturally occurring mutations in this gene are associated with coronary artery disease, late onset alzheimer disease, and emphysema distribution. [provided by RefSeq, Mar 2017]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024230	hsa-miR-218-5p	Sequencing	20371350
MIRT025102	hsa-miR-181a-5p	Sequencing	20371350
MIRT027286	hsa-miR-101-3p	Sequencing	20371350
MIRT027286	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT029461	hsa-miR-26b-5p	Microarray	19088304
MIRT037521	hsa-miR-744-5p	CLASH	23622248
MIRT043021	hsa-miR-324-5p	CLASH	23622248
MIRT045014	hsa-miR-186-5p	CLASH	23622248
MIRT045594	hsa-miR-149-5p	CLASH	23622248
MIRT230396	hsa-miR-590-3p	PAR-CLIP	23446348
MIRT230396	hsa-miR-590-3p	PAR-CLIP	21572407
MIRT511330	hsa-miR-4740-3p	PAR-CLIP	23446348
MIRT511330	hsa-miR-4740-3p	PAR-CLIP	26701625
MIRT544055	hsa-miR-335-3p	PAR-CLIP	21572407
MIRT544056	hsa-miR-30e-3p	PAR-CLIP	21572407
MIRT544057	hsa-miR-30d-3p	PAR-CLIP	21572407
MIRT544058	hsa-miR-30a-3p	PAR-CLIP	21572407
MIRT544059	hsa-miR-582-5p	PAR-CLIP	21572407
MIRT544060	hsa-miR-4775	PAR-CLIP	21572407
MIRT544061	hsa-miR-873-5p	PAR-CLIP	21572407
MIRT544062	hsa-miR-6504-3p	PAR-CLIP	21572407
MIRT544063	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT544064	hsa-miR-144-3p	PAR-CLIP	21572407
MIRT544065	hsa-miR-6882-5p	PAR-CLIP	21572407
MIRT656918	hsa-miR-3680-3p	HITS-CLIP	23824327
MIRT656919	hsa-miR-557	HITS-CLIP	23824327
MIRT656920	hsa-miR-507	HITS-CLIP	23824327
MIRT656921	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT656922	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT656923	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT656924	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT656925	hsa-miR-527	HITS-CLIP	23824327
MIRT656926	hsa-miR-518a-5p	HITS-CLIP	23824327
MIRT656927	hsa-miR-548aw	HITS-CLIP	23824327
MIRT656928	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT656929	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT656930	hsa-miR-623	HITS-CLIP	23824327
MIRT656931	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT656932	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT656933	hsa-miR-181c-3p	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005912	Component	Adherens junction	IBA	21873635
GO:0005912	Component	Adherens junction	IDA	28705794
GO:0007155	Process	Cell adhesion	IEA
GO:0032587	Component	Ruffle membrane	IBA	21873635
GO:0032587	Component	Ruffle membrane	IDA	28705794
GO:0043410	Process	Positive regulation of MAPK cascade	IMP	28705794
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	28705794
GO:0090050	Process	Positive regulation of cell migration involved in sprouting angiogenesis	IMP	28705794
GO:1900748	Process	Positive regulation of vascular endothelial growth factor signaling pathway	IMP	28705794
GO:1903589	Process	Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IBA	21873635
GO:1903589	Process	Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IMP	28705794
GO:1903672	Process	Positive regulation of sprouting angiogenesis	IEA

Other IDs

• MIM: 614398
• HGNC: 29283
• e!Ensembl: ENSG00000165757

Protein

• UniProt ID: Q9P266
• Protein name: Junctional protein associated with coronary artery disease (JCAD)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15351	JCAD	1 → 1348	Junctional protein associated with coronary artery disease	Family

• Sequence:

  MYSVEDLLISHGYKLSRDPPASREDNPKGRQAARTGTRAGQGLQNGHEDGPAALAHRKTS
  AGKGHVSDSESRRSTPRGHGEPQSTSASRTSEAGFCNQPPSAWSSHPPTGNDQAYRRRGR
  QEARSQKPREHENLEARGMAQAHSLPVHVREGPWEVGGRSEHVMKKPVWEEELRMSGPAK
  WQNVSLESWNQPRKLGRQMSDGDGERLFQDLYPFIQGEHVLNSQNKGKSRSLPRVLSPES
  LSCTEIPIPLNERHSPKMPPYPPTCAPNLDSTRNSEKSGCSAPFPRPKFGRPLKPPSYSS
  HQQSRGGADSSDSQDSQQMDAYVPRHELCLSDPGLEPPVYVPPPSYRSPPQNIPNPYLED
  TVPINVCGGHSQQQSPTEKAGASGQPPSGPPGTGNEYGVSPRLPQGLPAHPRPVTAYDGF
  VQYIPFDDPRLRHFKLAQPQGFCEDIKLDDKSYNSSPVTAQEPAHGGMQPDGAIWNPQSL
  IPPSGDERGLVLADSSPRWLWGQPPGDGENSGLPNQRDRCVARGQWPDVRGSQHGHTGRQ
  VSSPYSQGESTCETQTKLKKFQTGTRTKKSSKKKMNETIFCLVSIPVKSESHLPDRDMDN
  NDLKPSADQKNGSDKSPALQEQSLLSMSSTDLELQALTGSMGGRTEFQKQDLGEPEEDRQ
  TNDLSFIHLTKHRELKHSGSWPGHRYRDQQTQTSFSEEPQSSQLLPGAKLGGPSRAALSP
  KCSDPAASEAQTHTAFPTGDHKQRPSARNLKGHRSLSPSSNSAFSRTSLSVDQAPTPKAG
  RSQPCVDVHGLGAHPGPKREVVKGEPTGPCNSKQLFGQFLLKPVSRRPWDLISQLESFNK
  ELQEEEESSSSSSSSSSSSEESEAEPQQENRAHCRQEDVGFRGNSPEMRVEPQPRMWVPE
  SPVCRSGRGESKSESWSEELQPGHPRAWPPSPGRFRVEEGGGAPFCSADGSTSAEKRHLE
  VSNGMDELAGSPFPVTRMSSRSSDAKPLPASYPAEPREPQESPKITSAFSSVKPSEAVPR
  KFDSGGERGAGLPLSLSNKNRGLSAPDLRSVGLTPGQEQGASELEGSLGEASTIEIPPGE
  SLQARAARILGIEVAVESLLPGIRRAGQNQPAEPDASACTPESPQEELLSRPAPADVPRV
  STDAFYGRRKCGWTKSPLFVGDRDSARRAPQAFEHSDVDGVVTSTDPVPEPEPSPLESKF
  FEQKDVETKPPFRSTLFHFVERTPSVAGSEKRLRSPSKVIESLQEKLASPPRRADPDRLM
  RMKEVSSVSRMRVLSFRNADSQEDAEELKATTRGQAGLPGGLVSPGSGDRAQRLGHSLSV
  SKDSISREEKEHPAAQKEKSMDQDFWCPDSYDPSRVERV

• Sequence length: 1359

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs-1, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	26343387, 23202125, 21378988, 28714975, 29212778, 30104761
Coronary heart disease	Coronary heart disease	rs-1	21088011, 21378988
Myocardial infarction	Myocardial Infarction	rs12316150, rs41303970, rs909253, rs7291467, rs2234693	26343387

Unknown
Disease name	Disease term	dbSNP ID	References
Coronary arteriosclerosis	Coronary Arteriosclerosis		21378988