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TMEM181 (transmembrane protein 181)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
57583
Gene nameGene Name - the full gene name approved by the HGNC.
Transmembrane protein 181
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
TMEM181
SynonymsGene synonyms aliases
GPR178, KIAA1423
ChromosomeChromosome number
6
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q25.3
SummarySummary of gene provided in NCBI Entrez Gene.
The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010]
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018233 hsa-miR-335-5p Microarray 18185580
MIRT036698 hsa-miR-935 CLASH 23622248
MIRT665787 hsa-miR-124-3p HITS-CLIP 23824327
MIRT665788 hsa-miR-506-3p HITS-CLIP 23824327
MIRT665787 hsa-miR-124-3p HITS-CLIP 23824327
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0009405 Process Pathogenesis IMP 19965467
GO:0015643 Function Toxic substance binding IBA 21873635
GO:0015643 Function Toxic substance binding IDA 19965467
GO:0016021 Component Integral component of membrane IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9P2C4
Protein name Transmembrane protein 181
Protein function Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06664 MIG-14_Wnt-bd
265 560
Family
Sequence
MGAAPSPTQASSRGGGPGPPAPTRAVSSSSRARGGALSALGPSPARPLTTSPAPAPPPRS
RPARQQPDPQCWEKRGGAGGDTKGGAAGPGPGRLRGMDAEYPAFEPPLCSELKHLCRRLR
EAYRELKEDLTPFKDDRYYRLAPMRLYTLSKRHFVLVFVVFFICFGLTIFVGIRGPKVIQ
TSAANFSLNNSKKLKPIQILSNPLSTYNQQLWLTCVVELDQSKETSIKTSFPMTVKVDGV
AQDGTTMYIHNKVHNRTRTLTCAGKCAEIIVAHLGYLNYTQYTVIVGFEHLKLPIKGMNF
TWKTYNPAFSRLEIWFRFFFVVLTFIVTCLFAHSLRKFSMRDWGIEQKWMSVLLPLLLLY
NDPFFPLSFLVNSWLPGMLDDLFQSMFLCALLLFWLCVYHGIRVQGERKCLTFYLPKFFI
VGLLWLASVTLGIWQTVNELHDPMYQYRVDTGNFQGMKVFFMVVAAVYILYLLFLIVRAC
SELRHMPYVDLRLKFLTALTFVVLVISIAILYLRFGAQVLQDNFVAELSTHYQNSAEFLS
FYGLLNFYLYTLAFVYSPSK
NALYESQLKDNPAFSMLNDSDDDVIYGSDYEEMPLQNGQA
IRAKYKEESDSD
Sequence length 612
Interactions View interactions
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Glaucoma Glaucoma, Open-Angle rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328, rs121909193, rs74315330, rs74315329, rs74315332, rs74315334, rs74315336, rs74315338, rs74315341, rs121909194, rs74315331, rs1558603396, rs387907175, rs587778873, rs587778875, rs104894979, rs137854895, rs766425037, rs72549380, rs148542782, rs541217363, rs753021890, rs771076928, rs56010818, rs777678299, rs1446110883, rs1573274915, rs1587545234, rs751768343, rs944452644 29891935

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