KIF17 (kinesin family member 17)

Gene

• Entrez ID: 57576
• Gene name: Kinesin family member 17
• Gene symbol: KIF17
• Synonyms: KIF17B, KIF3X, KLP-2, OSM-3
• Chromosome: 1
• Chromosome location: 1p36.12

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016958	hsa-miR-335-5p	Microarray	18185580
MIRT1093454	hsa-miR-148a	CLIP-seq
MIRT1093455	hsa-miR-148b	CLIP-seq
MIRT1093456	hsa-miR-152	CLIP-seq
MIRT1093457	hsa-miR-34a	CLIP-seq
MIRT1093458	hsa-miR-34c-5p	CLIP-seq
MIRT1093459	hsa-miR-449a	CLIP-seq
MIRT1093460	hsa-miR-449b	CLIP-seq
MIRT1093461	hsa-miR-4651	CLIP-seq
MIRT1093462	hsa-miR-541	CLIP-seq
MIRT1093463	hsa-miR-608	CLIP-seq
MIRT1093464	hsa-miR-654-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003777	Function	Microtubule motor activity	IBA	21873635
GO:0005524	Function	ATP binding	IEA
GO:0005815	Component	Microtubule organizing center	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0005871	Component	Kinesin complex	IBA	21873635
GO:0005874	Component	Microtubule	IBA	21873635
GO:0005929	Component	Cilium	IBA	21873635
GO:0005929	Component	Cilium	ISS
GO:0005929	Component	Cilium	TAS
GO:0005930	Component	Axoneme	IEA
GO:0007018	Process	Microtubule-based movement	IBA	21873635
GO:0008017	Function	Microtubule binding	IBA	21873635
GO:0008574	Function	ATP-dependent microtubule motor activity, plus-end-directed	IBA	21873635
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0016887	Function	ATPase activity	IBA	21873635
GO:0030030	Process	Cell projection organization	IBA	21873635
GO:0032391	Component	Photoreceptor connecting cilium	IEA
GO:0032839	Component	Dendrite cytoplasm	IEA
GO:0035735	Process	Intraciliary transport involved in cilium assembly	TAS
GO:0036064	Component	Ciliary basal body	IEA
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0098971	Process	Anterograde dendritic transport of neurotransmitter receptor complex	IBA	21873635
GO:1990075	Component	Periciliary membrane compartment	IEA

Other IDs

• MIM: 605037
• HGNC: 19167
• e!Ensembl: ENSG00000117245

Protein

• UniProt ID: Q9P2E2
• Protein name: Kinesin-like protein KIF17 (KIF3-related motor protein)
• Protein function: Dendrite-specific motor protein which, in association with the Apba1-containing complex (LIN-10-LIN-2-LIN-7 complex), transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. {ECO:0000250|UniProtKB:Q99
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00225	Kinesin	11 → 335	Kinesin motor domain	Domain

• Sequence:

  MASEAVKVVVRCRPMNQRERELRCQPVVTVDCARAQCCIQNPGAADEPPKQFTFDGAYHV
  DHVTEQIYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDPPSQRGIIPRAFEH
  VFESVQCAENTKFLVRASYLEIYNEDVRDLLGADTKQKLELKEHPEKGVYVKGLSMHTVH
  SVAQCEHIMETGWKNRSVGYTLMNKDSSRSHSIFTISIEMSAVDERGKDHLRAGKLNLVD
  LAGSERQSKTGATGERLKEATKINLSLSALGNVISALVDGRCKHVPYRDSKLTRLLQDSL
  GGNTKTLMVACLSPADNNYDETLSTLRYANRAKNIRNKPRINEDPKDALLREYQEEIKKL
  KAILTQQMSPSSLSALLSRQVPPDPVQVEEKLLPQPVIQHDVEAEKQLIREEYEERLARL
  KADYKAEQESRARLEEDITAMRNSYDVRLSTLEENLRKETEAVLQVGVLYKAEVMSRAEF
  ASSAEYPPAFQYETVVKPKVFSTTDTLPSDDVSKTQVSSRFAELPKVEPSKSEISLGSSE
  SSSLEETSVSEAFPGPEEPSNVEVSMPTEESRSRYFLDECLGQEAAGHLLGEQNYLPQEE
  PQEVPLQGLLGLQDPFAEVEAKLARLSSTVARTDAPQADVPKVPVQVPAPTDLLEPSDAR
  PEAEAADDFPPRPEVDLASEVALEVVRTAEPGVWLEAQAPVALVAQPEPLPATAGVKRES
  VGMEVAVLTDDPLPVVDQQQVLARLQLLEQQVVGGEQAKNKDLKEKHKRRKRYADERRKQ
  LVAALQNSDEDSGDWVLLNVYDSIQEEVRAKSKLLEKMQRKLRAAEVEIKDLQSEFQLEK
  IDYLATIRRQERDSMLLQQLLEQVQPLIRRDCNYSNLEKILRESCWDEDNGFWKIPHPVI
  TKTSLPVAVSTGPQNKPARKTSAADNGEPNMEDDRYRLMLSRSNSENIASNYFRSKRASQ
  ILSTDARKSLTHHNSPPGLSCPLSNNSAIPPTQAPEMPQPRPFRLESLDIPFTKAKRKKS
  KSNFGSEPL

• Sequence length: 1029

Pathways

KEGG:

Motor proteins

Reactome:

Intraflagellar transport

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	20646681, 25354644

Unknown
Disease name	Disease term	dbSNP ID	References
Eosinophilia	Eosinophilic esophagitis		25017104