STAMBPL1 (STAM binding protein like 1)

Gene

• Entrez ID: 57559
• Gene name: STAM binding protein like 1
• Gene symbol: STAMBPL1
• Synonyms: ALMalpha, AMSH-FP, AMSH-LP, bA399O19.2
• Chromosome: 10
• Chromosome location: 10q23.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024279	hsa-miR-215-5p	Microarray	19074876
MIRT026552	hsa-miR-192-5p	Microarray	19074876
MIRT027048	hsa-miR-103a-3p	Sequencing	20371350
MIRT036575	hsa-miR-941	CLASH	23622248
MIRT528487	hsa-miR-5197-5p	PAR-CLIP	22012620
MIRT528485	hsa-miR-548p	PAR-CLIP	22012620
MIRT528484	hsa-miR-1237-3p	PAR-CLIP	22012620
MIRT528483	hsa-miR-1248	PAR-CLIP	22012620
MIRT528482	hsa-miR-412-3p	PAR-CLIP	22012620
MIRT528481	hsa-miR-6754-3p	PAR-CLIP	22012620
MIRT528479	hsa-miR-6837-3p	PAR-CLIP	22012620
MIRT528480	hsa-miR-4778-3p	PAR-CLIP	22012620
MIRT528478	hsa-miR-130a-5p	PAR-CLIP	22012620
MIRT528477	hsa-miR-23a-3p	PAR-CLIP	22012620
MIRT528476	hsa-miR-23b-3p	PAR-CLIP	22012620
MIRT528475	hsa-miR-23c	PAR-CLIP	22012620
MIRT528474	hsa-miR-6868-3p	PAR-CLIP	22012620
MIRT512872	hsa-miR-508-5p	PAR-CLIP	23446348
MIRT512871	hsa-miR-6849-3p	PAR-CLIP	23446348
MIRT512870	hsa-miR-885-5p	PAR-CLIP	23446348
MIRT512869	hsa-miR-766-3p	PAR-CLIP	23446348
MIRT512868	hsa-miR-4633-5p	PAR-CLIP	23446348
MIRT512867	hsa-miR-6512-3p	PAR-CLIP	23446348
MIRT512866	hsa-miR-6720-5p	PAR-CLIP	23446348
MIRT528487	hsa-miR-5197-5p	PAR-CLIP	22012620
MIRT528485	hsa-miR-548p	PAR-CLIP	22012620
MIRT528484	hsa-miR-1237-3p	PAR-CLIP	22012620
MIRT528483	hsa-miR-1248	PAR-CLIP	22012620
MIRT528482	hsa-miR-412-3p	PAR-CLIP	22012620
MIRT528481	hsa-miR-6754-3p	PAR-CLIP	22012620
MIRT528479	hsa-miR-6837-3p	PAR-CLIP	22012620
MIRT528480	hsa-miR-4778-3p	PAR-CLIP	22012620
MIRT528478	hsa-miR-130a-5p	PAR-CLIP	22012620
MIRT528477	hsa-miR-23a-3p	PAR-CLIP	22012620
MIRT528476	hsa-miR-23b-3p	PAR-CLIP	22012620
MIRT528475	hsa-miR-23c	PAR-CLIP	22012620
MIRT528474	hsa-miR-6868-3p	PAR-CLIP	22012620
MIRT512872	hsa-miR-508-5p	PAR-CLIP	23446348
MIRT512871	hsa-miR-6849-3p	PAR-CLIP	23446348
MIRT512870	hsa-miR-885-5p	PAR-CLIP	23446348
MIRT512869	hsa-miR-766-3p	PAR-CLIP	23446348
MIRT512868	hsa-miR-4633-5p	PAR-CLIP	23446348
MIRT512867	hsa-miR-6512-3p	PAR-CLIP	23446348
MIRT512866	hsa-miR-6720-5p	PAR-CLIP	23446348
MIRT1395006	hsa-miR-103a	CLIP-seq
MIRT1395007	hsa-miR-107	CLIP-seq
MIRT1395008	hsa-miR-1225-5p	CLIP-seq
MIRT1395009	hsa-miR-1301	CLIP-seq
MIRT1395010	hsa-miR-3126-3p	CLIP-seq
MIRT1395011	hsa-miR-3176	CLIP-seq
MIRT1395012	hsa-miR-3187-3p	CLIP-seq
MIRT1395013	hsa-miR-323-3p	CLIP-seq
MIRT1395014	hsa-miR-3591-3p	CLIP-seq
MIRT1395015	hsa-miR-361-5p	CLIP-seq
MIRT1395016	hsa-miR-3922-3p	CLIP-seq
MIRT1395017	hsa-miR-4529-5p	CLIP-seq
MIRT1395018	hsa-miR-4795-3p	CLIP-seq
MIRT1395019	hsa-miR-5047	CLIP-seq
MIRT2634484	hsa-miR-19a	CLIP-seq
MIRT2634485	hsa-miR-19b	CLIP-seq
MIRT2634486	hsa-miR-3120-3p	CLIP-seq
MIRT2634487	hsa-miR-3662	CLIP-seq
MIRT2634488	hsa-miR-3942-5p	CLIP-seq
MIRT2634489	hsa-miR-4703-5p	CLIP-seq
MIRT2634490	hsa-miR-568	CLIP-seq
MIRT2634491	hsa-miR-642b	CLIP-seq
MIRT2634484	hsa-miR-19a	CLIP-seq
MIRT2634485	hsa-miR-19b	CLIP-seq
MIRT2634486	hsa-miR-3120-3p	CLIP-seq
MIRT2634487	hsa-miR-3662	CLIP-seq
MIRT2634488	hsa-miR-3942-5p	CLIP-seq
MIRT2634489	hsa-miR-4703-5p	CLIP-seq
MIRT2634490	hsa-miR-568	CLIP-seq
MIRT2634491	hsa-miR-642b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004843	Function	Thiol-dependent ubiquitin-specific protease activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	21163940, 21516116, 25416956, 32296183
GO:0005768	Component	Endosome	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IBA	21873635
GO:0016579	Process	Protein deubiquitination	TAS
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0061578	Function	Lys63-specific deubiquitinase activity	IBA	21873635
GO:0061578	Function	Lys63-specific deubiquitinase activity	TAS
GO:0070122	Function	Isopeptidase activity	IEA
GO:0070536	Process	Protein K63-linked deubiquitination	IBA	21873635

Other IDs

• MIM: 612352
• HGNC: 24105
• e!Ensembl: ENSG00000138134

Protein

• UniProt ID: Q96FJ0
• Protein name: AMSH-like protease (AMSH-LP) (EC 3.4.19.-) (STAM-binding protein-like 1)
• Protein function: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:18758443, PubMed:35114100). Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby i
• PDB: 2ZNR, 2ZNV, 7L97
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08969	USP8_dimer	22 → 132	USP8 dimerisation domain	Domain
  PF01398	JAB	264 → 373	JAB1/Mov34/MPN/PAD-1 ubiquitin protease	Family

• Sequence:

  MDQPFTVNSLKKLAAMPDHTDVSLSPEERVRALSKLGCNITISEDITPRRYFRSGVEMER
  MASVYLEEGNLENAFVLYNKFITLFVEKLPNHRDYQQCAVPEKQDIMKKLKEIAFPRTDE
  LKNDLLKKYNVEYQEYLQSKNKYKAEILKKLEHQRLIEAERKRIAQMRQQQLESEQFLFF
  EDQLKKQELARGQMRSQQTSGLSEQIDGSALSCFSTHQNNSLLNVFADQPNKSDATNYAS
  HSPPVNRALTPAATLSAVQNLVVEGLRCVVLPEDLCHKFLQLAESNTVRGIETCGILCGK
  LTHNEFTITHVIVPKQSAGPDYCDMENVEELFNVQDQHDLLTLGWIHTHPTQTAFLSSVD
  LHTHCSYQLMLPEAIAIVCSPKHKDTGIFRLTNAGMLEVSACKKKGFHPHTKEPRLFSIC
  KHVLVKDIKIIVLDLR

• Sequence length: 436

Pathways

Reactome:

Metalloprotease DUBs

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Aortic aneurysm	Aortic Aneurysm, Familial Thoracic 6	rs1555554098, rs267606902, rs121434526, rs121434527, rs121434528, rs387906592, rs387906781, rs387906782, rs397516685, rs397514037, rs112901682, rs397515325, rs397515330, rs794728025, rs112602953, rs794728021, rs8046180, rs797045725, rs876657852, rs878854466, rs886038978, rs746972765, rs886039303, rs886040965, rs886040966, rs886040967, rs886229659, rs1553781304, rs1060502531, rs1553795301, rs1553803235, rs1213452826, rs869025352, rs1553780501, rs1553785222, rs1382893400, rs1554841990, rs1430822242, rs1567692384, rs1576422965, rs1596712899, rs2059732940, rs2041090817, rs1439991530	21733706, 17994018, 21248741, 25759435, 26153420, 24020716, 27567161, 19409525, 19639654, 24621862, 21937134, 25644172, 24243736, 22831780, 26034244, 27611364, 20734336, 22946110, 22752479, 21212136, 24998021, 21288906, 24293535, 27481187, 25944730
Connective tissue disease	Connective Tissue Diseases	rs5742905, rs80338688, rs80356506, rs104894800, rs104894948, rs28931614, rs121913482, rs28933068, rs121913483, rs137854464, rs121912870, rs387906980, rs587777352, rs527236145, rs189754995, rs730880214, rs794728188, rs863223852, rs745672741, rs763514968, rs1064793914, rs1085307608, rs1131691804, rs1555399144, rs1554787779, rs1555167139, rs1939205327
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	19654303
Lung carcinoma	Carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	19654303
Moyamoya disease	MOYAMOYA DISEASE 5	rs121434527, rs121434528, rs387906592, rs397514563, rs797045187, rs1555675538, rs1568149971, rs1599150380, rs2079443410
Multisystemic smooth muscle dysfunction syndrome	MULTISYSTEMIC SMOOTH MUSCLE DYSFUNCTION SYNDROME	rs387906592, rs886039303	22752479, 22946110, 22831780, 20734336, 20970362, 22302747
Nasopharyngeal carcinoma	Nasopharyngeal carcinoma	rs200046052	20512145
Thoracic aortic aneurysm	Aortic Aneurysm, Familial Thoracic 2	rs137854466, rs121434526, rs147195031, rs397515812, rs113905529, rs113001196, rs397516685, rs363811, rs140630, rs794728199, rs794728165, rs886038940, rs1555395191, rs1555399368, rs1057523406, rs1555394581, rs1555395670, rs363815, rs794728205, rs1060501017, rs1060501036, rs113695103, rs1555397421, rs112836174, rs61730051
Thoracic aortic aneurysm and aortic dissection	Familial thoracic aortic aneurysm and aortic dissection	rs121964962, rs121964964, rs5742905, rs121964969, rs28934891, rs375846341, rs121964972, rs121964973, rs587776600, rs121908172, rs121908173, rs121918714, rs104893809, rs104893815, rs104893810, rs104893811, rs104893816, rs104893817, rs104893819, rs111854391, rs113605875, rs111426349, rs267606902, rs121913552, rs267606796, rs137854458, rs137854461, rs137854463, rs137854464, rs137854466, rs112989722, rs137854476, rs137854477, rs137854478, rs137854479, rs137854480, rs137854485, rs786200923, rs113485686, rs397509370, rs121912927, rs121912923, rs121912926, rs121434526, rs121434527, rs121434528, rs387906592, rs387906606, rs387906623, rs387906697, rs387906781, rs387906782, rs387906850, rs587776881, rs387906853, rs193922183, rs193922185, rs193921256, rs112202622, rs193922198, rs193922204, rs113871094, rs147195031, rs193922236, rs397514558, rs397514590, rs397515757, rs113812345, rs25403, rs397515766, rs397515767, rs25404, rs397515774, rs397515784, rs397515788, rs397515793, rs397515805, rs397515808, rs397515811, rs397515812, rs111231312, rs113905529, rs113249837, rs397515821, rs397515823, rs397515829, rs111687884, rs113080385, rs397515848, rs397515854, rs397515867, rs397516685, rs112901682, rs397515330, rs587779450, rs587779461, rs587779471, rs587779476, rs587779478, rs587779479, rs587779482, rs587779490, rs587779504, rs397509372, rs587779518, rs587779534, rs587779536, rs587779540, rs587779550, rs587779535, rs587779563, rs587779583, rs587779584, rs587779596, rs587779604, rs587779609, rs587779500, rs587779620, rs587779625, rs587779626, rs587779541, rs587779650, rs587779671, rs112371422, rs587779685, rs587779687, rs587779691, rs587779692, rs587779695, rs587779533, rs587779706, rs587779712, rs587782948, rs587782977, rs587782979, rs587781259, rs767864243, rs146579504, rs864309481, rs370547023, rs727503476, rs727503472, rs727504292, rs727503054, rs140593, rs727503057, rs727505006, rs727504421, rs730880223, rs730880102, rs112645512, rs730880097, rs730880214, rs771298943, rs764160782, rs770095972, rs781444670, rs794727798, rs149119723, rs794728040, rs794728054, rs794728057, rs794728060, rs112602953, rs794728021, rs794728288, rs794728283, rs794728281, rs794728280, rs794728337, rs112118237, rs794728336, rs794728270, rs794728319, rs794728262, rs794728253, rs76702162, rs794728335, rs794728334, rs763091520, rs761857514, rs794728234, rs140627, rs140630, rs794728228, rs794728216, rs763449629, rs794728208, rs794728204, rs794728306, rs794728203, rs794728305, rs794728322, rs794728195, rs794728194, rs794728190, rs794728188, rs113422242, rs794728166, rs794728325, rs794728165, rs794728162, rs112660651, rs796051885, rs863223796, rs863223792, rs863223847, rs863223852, rs863223854, rs863223444, rs863223478, rs863223473, rs863223829, rs760079636, rs863223818, rs863223750, rs863223762, rs863223756, rs768713596, rs745672741, rs863223759, rs863223760, rs863223737, rs863223738, rs863223739, rs863223740, rs863223768, rs863223754, rs372010465, rs148865119, rs863224935, rs864622754, rs869025531, rs869025537, rs869025494, rs112642323, rs869025414, rs869025411, rs869025418, rs869312903, rs876657852, rs878854610, rs878854611, rs878853686, rs878853689, rs878853682, rs745409628, rs794728044, rs886038853, rs886038952, rs863223845, rs886039106, rs886038783, rs886038919, rs886038954, rs886038978, rs746972765, rs886038870, rs886038869, rs886038975, rs886038786, rs886038955, rs886038930, rs886039092, rs886039158, rs886038894, rs886038949, rs886038967, rs886038976, rs886039047, rs886038957, rs794728241, rs886038959, rs886038790, rs886039167, rs886038838, rs886038979, rs886039120, rs886038970, rs886038940, rs886039035, rs886039196, rs886038802, rs886038956, rs886038996, rs886038877, rs886039054, rs886039038, rs886038984, rs886038972, rs886039034, rs886039036, rs886039072, rs886039066, rs886038987, rs565513365, rs886039551, rs886039492, rs140583, rs886039550, rs886037823, rs886039820, rs886040966, rs886041046, rs886044547, rs755952006, rs1057518075, rs397514037, rs1057518653, rs1057521150, rs1057521106, rs1057524810, rs1057523796, rs1057523647, rs1057521101, rs1060501984, rs104893807, rs1060502045, rs1060502046, rs1060502827, rs1555399379, rs1060501035, rs1555412070, rs1555394151, rs1060501051, rs753486471, rs1060500770, rs1060500766, rs1060501092, rs1060501055, rs1060501021, rs1060501038, rs1060500773, rs1064796256, rs1064797017, rs1064794130, rs1064796636, rs1064794789, rs1555414236, rs757106110, rs1085307921, rs1085308004, rs1131691996, rs1131691766, rs363804, rs397515764, rs1555394195, rs113603747, rs528689432, rs587782947, rs1553303213, rs1553630171, rs1555360368, rs1555393875, rs1555395256, rs1555396427, rs1555397548, rs1006530719, rs587779704, rs587779578, rs104893812, rs1553630235, rs1553630289, rs1553630426, rs1553631693, rs1554122857, rs1057524497, rs1554700672, rs1555395486, rs1555396998, rs1555360229, rs1555412069, rs1555413579, rs1555397203, rs112375043, rs1555397720, rs140599, rs1555400373, rs1555405031, rs1555397008, rs1555405108, rs1015798796, rs1553631968, rs1555394904, rs1553303352, rs1553508338, rs1555398835, rs1555401011, rs1555395826, rs1555399481, rs1347651454, rs1553508039, rs1553507180, rs1553507867, rs1553808296, rs727503475, rs1554799402, rs1554701881, rs1554702262, rs1555393516, rs1555393856, rs1555394142, rs1555395209, rs1555395742, rs1555396638, rs1555398830, rs1555399166, rs1555399387, rs1555400378, rs1555401687, rs1555459260, rs1433428588, rs1401035675, rs1553292123, rs1553303357, rs1553303745, rs1393544920, rs1553507574, rs1553507991, rs587779433, rs587779458, rs1553508957, rs1553509869, rs1554122896, rs1554123064, rs1554787526, rs1554792869, rs1554805638, rs1554726251, rs1554698926, rs1554700603, rs869025352, rs1555360047, rs1555393539, rs1555393823, rs1555393837, rs1555393844, rs1555393871, rs1555393880, rs1555394146, rs1555394149, rs1555394196, rs1555394396, rs1555394400, rs1555394433, rs112550005, rs1555394566, rs112836174, rs1555394781, rs1555394927, rs1555395002, rs1555395206, rs794728247, rs1304643689, rs1555395461, rs1555395652, rs1555395658, rs1555395840, rs765387131, rs1555396429, rs1555396760, rs1555396835, rs1555397000, rs1555397014, rs1555397016, rs1555397148, rs1555397154, rs778710767, rs1555397557, rs1555397646, rs1555397704, rs1555398143, rs1555398272, rs1555398406, rs372404949, rs1555398680, rs1555398681, rs1555398828, rs1057523406, rs1555399143, rs1555399147, rs1555399205, rs1555399257, rs1555399361, rs1555399388, rs1555399764, rs1555399835, rs1555399839, rs1555400285, rs1555401686, rs1555401699, rs363852, rs1555404819, rs1555405039, rs1555405056, rs1555405534, rs1555407416, rs1555405092, rs730880215, rs1557179684, rs1555395980, rs1555396789, rs1555399816, rs1555393647, rs1555395645, rs1556337063, rs1553507614, rs1553509391, rs1553630438, rs1553630274, rs1555394238, rs1555396418, rs1206813753, rs1555399271, rs1555395663, rs1555397652, rs1555398283, rs1445085747, rs1554702463, rs363810, rs363806, rs1555395820, rs1555394189, rs1555394397, rs1555394399, rs1555394783, rs363815, rs1555395267, rs111239111, rs1555396993, rs1060501076, rs113693945, rs1555398404, rs1555398625, rs1555399162, rs1555399210, rs193922188, rs1060501017, rs1060501041, rs1555400049, rs1555400278, rs1555400279, rs1156747241, rs1555400372, rs1555400387, rs752010116, rs1555401679, rs1555404810, rs141502207, rs1553292145, rs375737772, rs1566891654, rs1566897374, rs1566905976, rs1566891655, rs1346043320, rs1566999621, rs1567002059, rs1567002115, rs1567003613, rs863223832, rs1566891808, rs1245476075, rs1566890005, rs1352478541, rs1566913670, rs1566894230, rs765692335, rs1566914030, rs1566999458, rs1569482431, rs886039176, rs1566891701, rs1566999423, rs1566999601, rs1566999610, rs1559472349, rs1566891668, rs1566891675, rs1566892872, rs1566898120, rs1566900492, rs1566903914, rs1566904526, rs1555397419, rs1566906506, rs1555398627, rs1566919637, rs869312034, rs1566900540, rs794728192, rs1566938153, rs1566892735, rs1603360542, rs1597516325, rs1597531796, rs755528878, rs1575165264, rs1597512600, rs1597516347, rs1555398144, rs1595942351, rs1595960447, rs1595965925, rs1595965945, rs1576468385, rs1595956832, rs1320208623, rs1575165272, rs1597562812, rs1575166666, rs1588477255, rs794728193, rs1688258933, rs1699392675, rs760797386, rs1699709401, rs1827902114, rs2035418540, rs2043116624, rs1555395745, rs2043594915, rs2043746138, rs2043846274, rs2044515247, rs1291288543, rs373782713, rs2042873946, rs1688274077	19409525, 21248741, 19639654, 20734336, 23099432, 22302747, 17994018, 22752479, 21733706, 20970362