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MIR146B (microRNA 146b)
Gene
Gene Gene ontology Other IDs Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
574447
Gene nameGene Name - the full gene name approved by the HGNC.
MicroRNA 146b
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
MIR146B
SynonymsGene synonyms aliases
MIRN146B, miRNA146B, mir-146b
ChromosomeChromosome number
10
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q24.32
SummarySummary of gene provided in NCBI Entrez Gene.
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0032700 Process Negative regulation of interleukin-17 production IDA 30362152
GO:0035195 Process Gene silencing by miRNA IDA 30362152
GO:0035195 Process Gene silencing by miRNA IEA
GO:1903231 Function MRNA binding involved in posttranscriptional gene silencing IDA 30362152
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Associated diseases
MIM
HGNC
e!Ensembl
Interactions View interactions
Associated diseases
Gene Gene ontology Other IDs Associated diseases
Causal
Disease name Disease term dbSNP ID References
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs-1, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537 20524934
Unknown
Disease name Disease term dbSNP ID References
Coronary arteriosclerosis Coronary Arteriosclerosis 20524934
Kidney failure Kidney Failure, Acute 30682439
Acute kidney insufficiency Acute Kidney Insufficiency 30682439

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