PTGIR (prostaglandin I2 receptor)

Gene

• Entrez ID: 5739
• Gene name: Prostaglandin I2 receptor
• Gene symbol: PTGIR
• Synonyms: IP, PRIPR
• Chromosome: 19
• Chromosome location: 19q13.32
• Summary: The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1273090	hsa-miR-1	CLIP-seq
MIRT1273091	hsa-miR-1207-5p	CLIP-seq
MIRT1273092	hsa-miR-122	CLIP-seq
MIRT1273093	hsa-miR-1266	CLIP-seq
MIRT1273094	hsa-miR-1273g	CLIP-seq
MIRT1273095	hsa-miR-149	CLIP-seq
MIRT1273096	hsa-miR-1972	CLIP-seq
MIRT1273097	hsa-miR-206	CLIP-seq
MIRT1273098	hsa-miR-2113	CLIP-seq
MIRT1273099	hsa-miR-3198	CLIP-seq
MIRT1273100	hsa-miR-323b-3p	CLIP-seq
MIRT1273101	hsa-miR-3664-3p	CLIP-seq
MIRT1273102	hsa-miR-3673	CLIP-seq
MIRT1273103	hsa-miR-4270	CLIP-seq
MIRT1273104	hsa-miR-4300	CLIP-seq
MIRT1273105	hsa-miR-4309	CLIP-seq
MIRT1273106	hsa-miR-4318	CLIP-seq
MIRT1273107	hsa-miR-432	CLIP-seq
MIRT1273108	hsa-miR-4436b-3p	CLIP-seq
MIRT1273109	hsa-miR-4441	CLIP-seq
MIRT1273110	hsa-miR-4468	CLIP-seq
MIRT1273111	hsa-miR-4492	CLIP-seq
MIRT1273112	hsa-miR-4498	CLIP-seq
MIRT1273113	hsa-miR-4518	CLIP-seq
MIRT1273114	hsa-miR-4650-5p	CLIP-seq
MIRT1273115	hsa-miR-4671-5p	CLIP-seq
MIRT1273116	hsa-miR-4752	CLIP-seq
MIRT1273117	hsa-miR-4756-3p	CLIP-seq
MIRT1273118	hsa-miR-4763-3p	CLIP-seq
MIRT1273119	hsa-miR-613	CLIP-seq
MIRT1273120	hsa-miR-760	CLIP-seq
MIRT1273121	hsa-miR-762	CLIP-seq
MIRT1273122	hsa-miR-920	CLIP-seq
MIRT1273123	hsa-miR-940	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
POU2F1	Activation	19118563
SP1	Activation	19118563
SPI1	Activation	19118563

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005829	Component	Cytosol	IDA	20622039
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	20622039
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	7512962
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	7512962
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	20622039
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA	21873635
GO:0007267	Process	Cell-cell signaling	TAS	7512962
GO:0010642	Process	Negative regulation of platelet-derived growth factor receptor signaling pathway	ISS	20622039
GO:0016501	Function	Prostacyclin receptor activity	IBA	21873635
GO:0032496	Process	Response to lipopolysaccharide	IEA
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	IBA	21873635
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	IDA	20622039
GO:0050790	Process	Regulation of catalytic activity	IEA

Other IDs

• MIM: 600022
• HGNC: 9602
• e!Ensembl: ENSG00000160013

Protein

• UniProt ID: P43119
• Protein name: Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor)
• Protein function: Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
• PDB: 8X79, 8X7A
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	30 → 292	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
  LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
  LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
  GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
  LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
  QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
  PPTQQSSGSAVGTSSKAEASVACSLC

• Sequence length: 386

Pathways

KEGG:

Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activation

Reactome:

Prostanoid ligand receptors
Prostacyclin signalling through prostacyclin receptor
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma, Aspirin-Induced	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	20485159

Unknown
Disease name	Disease term	dbSNP ID	References
Heart diseases	Heart Diseases		16154102
Ulcerative colitis	Ulcerative Colitis		23128233