PTGER3 (prostaglandin E receptor 3)

Gene

• Entrez ID: 5733
• Gene name: Prostaglandin E receptor 3
• Gene symbol: PTGER3
• Synonyms: EP3, EP3-I, EP3-II, EP3-III, EP3-IV, EP3-VI, EP3e, PGE2-R, lnc003875
• Chromosome: 1
• Chromosome location: 1p31.1
• Summary: The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system,

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT528588	hsa-miR-519d-5p	PAR-CLIP	22012620
MIRT528587	hsa-miR-5695	PAR-CLIP	22012620
MIRT528586	hsa-miR-515-5p	PAR-CLIP	22012620
MIRT528585	hsa-miR-519e-5p	PAR-CLIP	22012620
MIRT528584	hsa-miR-489-3p	PAR-CLIP	22012620
MIRT528583	hsa-miR-6818-3p	PAR-CLIP	22012620
MIRT528582	hsa-miR-514a-3p	PAR-CLIP	22012620
MIRT528581	hsa-miR-514b-3p	PAR-CLIP	22012620
MIRT445841	hsa-miR-5003-3p	PAR-CLIP	22100165
MIRT445840	hsa-miR-556-5p	PAR-CLIP	22100165
MIRT445839	hsa-miR-27b-5p	PAR-CLIP	22100165
MIRT732988	hsa-miR-106b-5p	Microarray	33435900
MIRT528588	hsa-miR-519d-5p	PAR-CLIP	22012620
MIRT528587	hsa-miR-5695	PAR-CLIP	22012620
MIRT528586	hsa-miR-515-5p	PAR-CLIP	22012620
MIRT528585	hsa-miR-519e-5p	PAR-CLIP	22012620
MIRT528584	hsa-miR-489-3p	PAR-CLIP	22012620
MIRT528583	hsa-miR-6818-3p	PAR-CLIP	22012620
MIRT528582	hsa-miR-514a-3p	PAR-CLIP	22012620
MIRT528581	hsa-miR-514b-3p	PAR-CLIP	22012620
MIRT445841	hsa-miR-5003-3p	PAR-CLIP	22100165
MIRT445840	hsa-miR-556-5p	PAR-CLIP	22100165
MIRT445839	hsa-miR-27b-5p	PAR-CLIP	22100165
MIRT1272629	hsa-miR-1200	CLIP-seq
MIRT1272630	hsa-miR-181a	CLIP-seq
MIRT1272631	hsa-miR-181b	CLIP-seq
MIRT1272632	hsa-miR-181c	CLIP-seq
MIRT1272633	hsa-miR-181d	CLIP-seq
MIRT1272634	hsa-miR-186	CLIP-seq
MIRT1272635	hsa-miR-208a	CLIP-seq
MIRT1272636	hsa-miR-208b	CLIP-seq
MIRT1272637	hsa-miR-3074-5p	CLIP-seq
MIRT737845	hsa-miR-3120-3p	CLIP-seq
MIRT1272638	hsa-miR-3129-3p	CLIP-seq
MIRT1272639	hsa-miR-3133	CLIP-seq
MIRT1272640	hsa-miR-3140-5p	CLIP-seq
MIRT1272641	hsa-miR-3145-3p	CLIP-seq
MIRT1272642	hsa-miR-3177-5p	CLIP-seq
MIRT1272643	hsa-miR-320a	CLIP-seq
MIRT1272644	hsa-miR-320b	CLIP-seq
MIRT1272645	hsa-miR-320c	CLIP-seq
MIRT1272646	hsa-miR-320d	CLIP-seq
MIRT1272647	hsa-miR-3617	CLIP-seq
MIRT1272648	hsa-miR-3658	CLIP-seq
MIRT737844	hsa-miR-3908	CLIP-seq
MIRT1272649	hsa-miR-3920	CLIP-seq
MIRT737842	hsa-miR-3925-5p	CLIP-seq
MIRT1272650	hsa-miR-4262	CLIP-seq
MIRT737843	hsa-miR-4311	CLIP-seq
MIRT1272651	hsa-miR-4312	CLIP-seq
MIRT1272652	hsa-miR-4429	CLIP-seq
MIRT1272653	hsa-miR-4668-3p	CLIP-seq
MIRT1272654	hsa-miR-4719	CLIP-seq
MIRT1272655	hsa-miR-4744	CLIP-seq
MIRT1272656	hsa-miR-487a	CLIP-seq
MIRT1272657	hsa-miR-488	CLIP-seq
MIRT1272658	hsa-miR-499-5p	CLIP-seq
MIRT1272659	hsa-miR-561	CLIP-seq
MIRT1272660	hsa-miR-579	CLIP-seq
MIRT1272661	hsa-miR-598	CLIP-seq
MIRT1272662	hsa-miR-641	CLIP-seq
MIRT1272663	hsa-miR-1238	CLIP-seq
MIRT1272664	hsa-miR-4272	CLIP-seq
MIRT1272653	hsa-miR-4668-3p	CLIP-seq
MIRT1272665	hsa-miR-4691-5p	CLIP-seq
MIRT1272666	hsa-miR-4698	CLIP-seq
MIRT1272667	hsa-miR-605	CLIP-seq
MIRT1552675	hsa-miR-3622b-5p	CLIP-seq
MIRT1552676	hsa-miR-4461	CLIP-seq
MIRT1921278	hsa-miR-203	CLIP-seq
MIRT1921279	hsa-miR-2681	CLIP-seq
MIRT2080159	hsa-miR-106a	CLIP-seq
MIRT2080160	hsa-miR-106b	CLIP-seq
MIRT2080161	hsa-miR-17	CLIP-seq
MIRT2080162	hsa-miR-20a	CLIP-seq
MIRT2080163	hsa-miR-20b	CLIP-seq
MIRT2080164	hsa-miR-302a	CLIP-seq
MIRT2080165	hsa-miR-302b	CLIP-seq
MIRT2080166	hsa-miR-302c	CLIP-seq
MIRT2080167	hsa-miR-302d	CLIP-seq
MIRT2080168	hsa-miR-302e	CLIP-seq
MIRT2080169	hsa-miR-3688-3p	CLIP-seq
MIRT2080170	hsa-miR-371b-5p	CLIP-seq
MIRT2080171	hsa-miR-372	CLIP-seq
MIRT2080172	hsa-miR-373	CLIP-seq
MIRT2080173	hsa-miR-3978	CLIP-seq
MIRT2080174	hsa-miR-4643	CLIP-seq
MIRT1272666	hsa-miR-4698	CLIP-seq
MIRT2080175	hsa-miR-4717-3p	CLIP-seq
MIRT2080176	hsa-miR-4802-3p	CLIP-seq
MIRT2080177	hsa-miR-519d	CLIP-seq
MIRT2080178	hsa-miR-520a-3p	CLIP-seq
MIRT2080179	hsa-miR-520b	CLIP-seq
MIRT2080180	hsa-miR-520c-3p	CLIP-seq
MIRT2080181	hsa-miR-520d-3p	CLIP-seq
MIRT2080182	hsa-miR-520e	CLIP-seq
MIRT2080183	hsa-miR-93	CLIP-seq
MIRT2306430	hsa-miR-128	CLIP-seq
MIRT1272630	hsa-miR-181a	CLIP-seq
MIRT1272631	hsa-miR-181b	CLIP-seq
MIRT1272632	hsa-miR-181c	CLIP-seq
MIRT1272633	hsa-miR-181d	CLIP-seq
MIRT1272634	hsa-miR-186	CLIP-seq
MIRT2306431	hsa-miR-27a	CLIP-seq
MIRT2306432	hsa-miR-27b	CLIP-seq
MIRT1272639	hsa-miR-3133	CLIP-seq
MIRT1272641	hsa-miR-3145-3p	CLIP-seq
MIRT2306433	hsa-miR-3149	CLIP-seq
MIRT2306434	hsa-miR-34b	CLIP-seq
MIRT1272650	hsa-miR-4262	CLIP-seq
MIRT2306435	hsa-miR-450b-5p	CLIP-seq
MIRT2306436	hsa-miR-4659a-3p	CLIP-seq
MIRT2306437	hsa-miR-4659b-3p	CLIP-seq
MIRT1272666	hsa-miR-4698	CLIP-seq
MIRT2306438	hsa-miR-4700-3p	CLIP-seq
MIRT2306439	hsa-miR-4708-5p	CLIP-seq
MIRT2306440	hsa-miR-4756-3p	CLIP-seq
MIRT2306441	hsa-miR-4760-3p	CLIP-seq
MIRT2306442	hsa-miR-507	CLIP-seq
MIRT2306443	hsa-miR-513a-5p	CLIP-seq
MIRT2306444	hsa-miR-520d-5p	CLIP-seq
MIRT2306445	hsa-miR-524-5p	CLIP-seq
MIRT2306446	hsa-miR-557	CLIP-seq
MIRT1272660	hsa-miR-579	CLIP-seq
MIRT2306447	hsa-miR-630	CLIP-seq
MIRT2306448	hsa-miR-664	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004957	Function	Prostaglandin E receptor activity	IBA	21873635
GO:0004957	Function	Prostaglandin E receptor activity	NAS	9073510
GO:0005635	Component	Nuclear envelope	TAS	10336471
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	31097585
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	8307176
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IBA	21873635
GO:0008219	Process	Cell death	TAS	10947062
GO:0014827	Process	Intestine smooth muscle contraction	IBA	21873635
GO:0016021	Component	Integral component of membrane	NAS	9073510
GO:0031622	Process	Positive regulation of fever generation	ISS
GO:0060455	Process	Negative regulation of gastric acid secretion	IBA	21873635

Other IDs

• MIM: 176806
• HGNC: 9595
• e!Ensembl: ENSG00000050628

Protein

• UniProt ID: P43115
• Protein name: Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor)
• Protein function: Receptor for prostaglandin E2 (PGE2) (PubMed:7883006, PubMed:7981210, PubMed:8117308, PubMed:8135729, PubMed:8307176). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elev
• PDB: 6AK3, 6M9T, 7WU9, 8GDC
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	65 → 346	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL
  TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW
  EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG
  VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL
  ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI
  MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQI
  RYHTNNYASSSTSLPCQCSSTLMWSDHLER

• Sequence length: 390

Pathways

KEGG:

Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Regulation of lipolysis in adipocytes
Human cytomegalovirus infection
Pathways in cancer

Reactome:

Prostanoid ligand receptors
G alpha (i) signalling events

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Glaucoma	Glaucoma, Open-Angle	rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328, rs121909193, rs74315330, rs74315329, rs74315332, rs74315334, rs74315336, rs74315338, rs74315341, rs121909194, rs74315331, rs1558603396, rs387907175, rs587778873, rs587778875, rs104894979, rs137854895, rs766425037, rs72549380, rs148542782, rs541217363, rs753021890, rs771076928, rs56010818, rs777678299, rs1446110883, rs1573274915, rs1587545234, rs751768343, rs944452644	22419738
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	22397921

Unknown
Disease name	Disease term	dbSNP ID	References
Mucous membrane pemphigoid	Pemphigoid, Benign Mucous Membrane		21966456
Ocular cicatricial pemphigoid	Ocular Cicatricial Pemphigoid		21966456
Sclerocystic ovaries	Sclerocystic Ovaries		21411543
Polycystic ovary syndrome	Polycystic Ovary Syndrome		21411543
Stevens-johnson syndrome	Toxic Epidermal Necrolysis, Stevens-Johnson Syndrome, Drug-Induced Stevens Johnson Syndrome, Mycoplasma-Induced Stevens-Johnson Syndrome, Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum		21966456