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ADCK1 (aarF domain containing kinase 1)

Gene

57143

AarF domain containing kinase 1

ADCK1

MCP2

14q24.3

Show/Hide all(183)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017275	hsa-miR-335-5p	Microarray	18185580
MIRT767672	hsa-miR-1207-3p	CLIP-seq
MIRT767673	hsa-miR-1293	CLIP-seq
MIRT767674	hsa-miR-31	CLIP-seq
MIRT767675	hsa-miR-3612	CLIP-seq
MIRT767676	hsa-miR-3919	CLIP-seq
MIRT767677	hsa-miR-4443	CLIP-seq
MIRT767678	hsa-miR-4483	CLIP-seq
MIRT767679	hsa-miR-4756-3p	CLIP-seq
MIRT767680	hsa-miR-4786-5p	CLIP-seq
MIRT767681	hsa-miR-591	CLIP-seq
MIRT767682	hsa-miR-646	CLIP-seq
MIRT767683	hsa-miR-650	CLIP-seq
MIRT1926209	hsa-miR-191	CLIP-seq
MIRT1926210	hsa-miR-3144-5p	CLIP-seq
MIRT1926211	hsa-miR-3191	CLIP-seq
MIRT1926212	hsa-miR-3202	CLIP-seq
MIRT1926213	hsa-miR-4434	CLIP-seq
MIRT1926214	hsa-miR-4516	CLIP-seq
MIRT1926215	hsa-miR-4652-5p	CLIP-seq
MIRT1926216	hsa-miR-4727-3p	CLIP-seq
MIRT1926217	hsa-miR-4747-5p	CLIP-seq
MIRT1926218	hsa-miR-491-5p	CLIP-seq
MIRT767672	hsa-miR-1207-3p	CLIP-seq
MIRT767673	hsa-miR-1293	CLIP-seq
MIRT1926209	hsa-miR-191	CLIP-seq
MIRT2167439	hsa-miR-3065-5p	CLIP-seq
MIRT1926210	hsa-miR-3144-5p	CLIP-seq
MIRT1926211	hsa-miR-3191	CLIP-seq
MIRT1926212	hsa-miR-3202	CLIP-seq
MIRT2167440	hsa-miR-326	CLIP-seq
MIRT2167441	hsa-miR-330-5p	CLIP-seq
MIRT767675	hsa-miR-3612	CLIP-seq
MIRT2167442	hsa-miR-4283	CLIP-seq
MIRT767677	hsa-miR-4443	CLIP-seq
MIRT767678	hsa-miR-4483	CLIP-seq
MIRT2167443	hsa-miR-4489	CLIP-seq
MIRT2167444	hsa-miR-4522	CLIP-seq
MIRT1926215	hsa-miR-4652-5p	CLIP-seq
MIRT2167445	hsa-miR-4667-5p	CLIP-seq
MIRT2167446	hsa-miR-4694-3p	CLIP-seq
MIRT2167447	hsa-miR-4700-5p	CLIP-seq
MIRT1926216	hsa-miR-4727-3p	CLIP-seq
MIRT2167448	hsa-miR-4734	CLIP-seq
MIRT1926217	hsa-miR-4747-5p	CLIP-seq
MIRT2167449	hsa-miR-4767	CLIP-seq
MIRT1926218	hsa-miR-491-5p	CLIP-seq
MIRT2167450	hsa-miR-604	CLIP-seq
MIRT2167451	hsa-miR-637	CLIP-seq
MIRT767682	hsa-miR-646	CLIP-seq
MIRT767683	hsa-miR-650	CLIP-seq
MIRT2443178	hsa-miR-125a-5p	CLIP-seq
MIRT2443179	hsa-miR-125b	CLIP-seq
MIRT2443180	hsa-miR-1291	CLIP-seq
MIRT2443181	hsa-miR-296-5p	CLIP-seq
MIRT2443182	hsa-miR-4265	CLIP-seq
MIRT2443183	hsa-miR-4296	CLIP-seq
MIRT2443184	hsa-miR-4319	CLIP-seq
MIRT2443185	hsa-miR-4322	CLIP-seq
MIRT2443186	hsa-miR-4324	CLIP-seq
MIRT2443187	hsa-miR-4329	CLIP-seq
MIRT2443188	hsa-miR-4417	CLIP-seq
MIRT2470035	hsa-miR-1	CLIP-seq
MIRT2470036	hsa-miR-103b	CLIP-seq
MIRT2470037	hsa-miR-1193	CLIP-seq
MIRT767672	hsa-miR-1207-3p	CLIP-seq
MIRT2470038	hsa-miR-1253	CLIP-seq
MIRT2470039	hsa-miR-1270	CLIP-seq
MIRT2470040	hsa-miR-128	CLIP-seq
MIRT767673	hsa-miR-1293	CLIP-seq
MIRT2470041	hsa-miR-134	CLIP-seq
MIRT2470042	hsa-miR-147b	CLIP-seq
MIRT2470043	hsa-miR-206	CLIP-seq
MIRT2470044	hsa-miR-2277-3p	CLIP-seq
MIRT2470045	hsa-miR-2392	CLIP-seq
MIRT767674	hsa-miR-31	CLIP-seq
MIRT2470046	hsa-miR-3118	CLIP-seq
MIRT2470047	hsa-miR-3150b-3p	CLIP-seq
MIRT2470048	hsa-miR-3164	CLIP-seq
MIRT2470049	hsa-miR-3173-3p	CLIP-seq
MIRT2470050	hsa-miR-3185	CLIP-seq
MIRT2167440	hsa-miR-326	CLIP-seq
MIRT2470051	hsa-miR-328	CLIP-seq
MIRT2167441	hsa-miR-330-5p	CLIP-seq
MIRT767675	hsa-miR-3612	CLIP-seq
MIRT2470052	hsa-miR-3670	CLIP-seq
MIRT2470053	hsa-miR-3688-5p	CLIP-seq
MIRT2470054	hsa-miR-3929	CLIP-seq
MIRT2167442	hsa-miR-4283	CLIP-seq
MIRT2470055	hsa-miR-4302	CLIP-seq
MIRT2470056	hsa-miR-432	CLIP-seq
MIRT2470057	hsa-miR-4419b	CLIP-seq
MIRT1926213	hsa-miR-4434	CLIP-seq
MIRT767677	hsa-miR-4443	CLIP-seq
MIRT2470058	hsa-miR-4470	CLIP-seq
MIRT2470059	hsa-miR-4478	CLIP-seq
MIRT767678	hsa-miR-4483	CLIP-seq
MIRT2167443	hsa-miR-4489	CLIP-seq
MIRT1926214	hsa-miR-4516	CLIP-seq
MIRT2470060	hsa-miR-4519	CLIP-seq
MIRT2470061	hsa-miR-4520a-3p	CLIP-seq
MIRT2167444	hsa-miR-4522	CLIP-seq
MIRT2470062	hsa-miR-4531	CLIP-seq
MIRT2470063	hsa-miR-4653-3p	CLIP-seq
MIRT2470064	hsa-miR-4663	CLIP-seq
MIRT2167445	hsa-miR-4667-5p	CLIP-seq
MIRT2167446	hsa-miR-4694-3p	CLIP-seq
MIRT2167447	hsa-miR-4700-5p	CLIP-seq
MIRT2470065	hsa-miR-4715-5p	CLIP-seq
MIRT2167448	hsa-miR-4734	CLIP-seq
MIRT2167449	hsa-miR-4767	CLIP-seq
MIRT2470066	hsa-miR-4778-3p	CLIP-seq
MIRT2470067	hsa-miR-4784	CLIP-seq
MIRT2470068	hsa-miR-4802-3p	CLIP-seq
MIRT2470069	hsa-miR-516b	CLIP-seq
MIRT2470070	hsa-miR-571	CLIP-seq
MIRT2167450	hsa-miR-604	CLIP-seq
MIRT2470071	hsa-miR-613	CLIP-seq
MIRT2470072	hsa-miR-617	CLIP-seq
MIRT2470073	hsa-miR-620	CLIP-seq
MIRT2470074	hsa-miR-627	CLIP-seq
MIRT2167451	hsa-miR-637	CLIP-seq
MIRT767682	hsa-miR-646	CLIP-seq
MIRT2470075	hsa-miR-648	CLIP-seq
MIRT767683	hsa-miR-650	CLIP-seq
MIRT2470076	hsa-miR-658	CLIP-seq
MIRT2470077	hsa-miR-720	CLIP-seq
MIRT2470078	hsa-miR-765	CLIP-seq
MIRT2470079	hsa-miR-924	CLIP-seq
MIRT2470035	hsa-miR-1	CLIP-seq
MIRT2470036	hsa-miR-103b	CLIP-seq
MIRT2470037	hsa-miR-1193	CLIP-seq
MIRT767672	hsa-miR-1207-3p	CLIP-seq
MIRT2470040	hsa-miR-128	CLIP-seq
MIRT767673	hsa-miR-1293	CLIP-seq
MIRT2470042	hsa-miR-147b	CLIP-seq
MIRT1926209	hsa-miR-191	CLIP-seq
MIRT2470043	hsa-miR-206	CLIP-seq
MIRT2470044	hsa-miR-2277-3p	CLIP-seq
MIRT2470045	hsa-miR-2392	CLIP-seq
MIRT767674	hsa-miR-31	CLIP-seq
MIRT2470047	hsa-miR-3150b-3p	CLIP-seq
MIRT2470049	hsa-miR-3173-3p	CLIP-seq
MIRT1926212	hsa-miR-3202	CLIP-seq
MIRT2167440	hsa-miR-326	CLIP-seq
MIRT2470051	hsa-miR-328	CLIP-seq
MIRT2167441	hsa-miR-330-5p	CLIP-seq
MIRT767675	hsa-miR-3612	CLIP-seq
MIRT2470052	hsa-miR-3670	CLIP-seq
MIRT2470053	hsa-miR-3688-5p	CLIP-seq
MIRT2470054	hsa-miR-3929	CLIP-seq
MIRT2167442	hsa-miR-4283	CLIP-seq
MIRT2470055	hsa-miR-4302	CLIP-seq
MIRT2470057	hsa-miR-4419b	CLIP-seq
MIRT1926213	hsa-miR-4434	CLIP-seq
MIRT767677	hsa-miR-4443	CLIP-seq
MIRT2470058	hsa-miR-4470	CLIP-seq
MIRT2470059	hsa-miR-4478	CLIP-seq
MIRT767678	hsa-miR-4483	CLIP-seq
MIRT2167443	hsa-miR-4489	CLIP-seq
MIRT1926214	hsa-miR-4516	CLIP-seq
MIRT2470060	hsa-miR-4519	CLIP-seq
MIRT2470061	hsa-miR-4520a-3p	CLIP-seq
MIRT2167444	hsa-miR-4522	CLIP-seq
MIRT2470063	hsa-miR-4653-3p	CLIP-seq
MIRT2167445	hsa-miR-4667-5p	CLIP-seq
MIRT2167447	hsa-miR-4700-5p	CLIP-seq
MIRT2470065	hsa-miR-4715-5p	CLIP-seq
MIRT1926216	hsa-miR-4727-3p	CLIP-seq
MIRT2167448	hsa-miR-4734	CLIP-seq
MIRT1926217	hsa-miR-4747-5p	CLIP-seq
MIRT2167449	hsa-miR-4767	CLIP-seq
MIRT2470067	hsa-miR-4784	CLIP-seq
MIRT2470068	hsa-miR-4802-3p	CLIP-seq
MIRT2470070	hsa-miR-571	CLIP-seq
MIRT2167450	hsa-miR-604	CLIP-seq
MIRT2470071	hsa-miR-613	CLIP-seq
MIRT2167451	hsa-miR-637	CLIP-seq
MIRT767682	hsa-miR-646	CLIP-seq
MIRT2470075	hsa-miR-648	CLIP-seq
MIRT767683	hsa-miR-650	CLIP-seq
MIRT2470076	hsa-miR-658	CLIP-seq
MIRT2470078	hsa-miR-765	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005743	Component	Mitochondrial inner membrane	IBA	21873635
GO:0006468	Process	Protein phosphorylation	IEA
GO:0007005	Process	Mitochondrion organization	IBA	21873635
GO:0010637	Process	Negative regulation of mitochondrial fusion	IMP	31125351
GO:0032592	Component	Integral component of mitochondrial membrane	IBA	21873635
GO:0055088	Process	Lipid homeostasis	IBA	21873635
GO:1903852	Process	Positive regulation of cristae formation	IMP	31125351

MIM	HGNC	e!Ensembl
620399	19038	ENSG00000063761

Protein

UniProt ID

Q86TW2

Protein name

AarF domain-containing protein kinase 1 (EC 2.7.-.-)

Protein function

Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase-independent manner to regulate essential mitochondrial structural proteins OPA1 and IMMT (PubMed:31125351). The a

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03109	ABC1	143 → 259	ABC1 family	Family

Sequence

MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSV
PYGSEEYLQLRSKSWPVFLQVHLRSARRLCELCCANRGTFIKVGQHLGALDYLLPEEYTS
TLKVLHSQAPQSSMQEIRQVIREDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTV
AVKVQHPKVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNA
EKVSQMLRHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGK
MYSEMIFVNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSL
IWTDMKRVKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANY
LPQISHLLNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNT
CSFFRRTQISFSEAFNLWQINLHELILRVKGLKLADRVLALICWLFPAPL

Sequence length

530

Interactions

View interactions

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	27846195

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Obsessive-compulsive disorder	Obsessive-Compulsive Disorder		30456828

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