GOPC (golgi associated PDZ and coiled-coil motif containing)

Gene

• Entrez ID: 57120
• Gene name: Golgi associated PDZ and coiled-coil motif containing
• Gene symbol: GOPC
• Synonyms: CAL, FIG, GOPC1, PIST, dJ94G16.2
• Chromosome: 6
• Chromosome location: 6q22.1
• Summary: This gene encodes a Golgi protein with a PDZ domain. The PDZ domain is globular and proteins which contain them bind other proteins through short motifs near the C-termini. Mice which are deficient in the orthologous protein have globozoospermia and are i

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020115	hsa-miR-130b-3p	Sequencing	20371350
MIRT027025	hsa-miR-103a-3p	Sequencing	20371350
MIRT1027357	hsa-miR-140-3p	CLIP-seq
MIRT1027358	hsa-miR-219-2-3p	CLIP-seq
MIRT1027359	hsa-miR-23a	CLIP-seq
MIRT1027360	hsa-miR-23b	CLIP-seq
MIRT1027361	hsa-miR-23c	CLIP-seq
MIRT1027362	hsa-miR-3143	CLIP-seq
MIRT1027363	hsa-miR-33a	CLIP-seq
MIRT1027364	hsa-miR-33b	CLIP-seq
MIRT1027365	hsa-miR-3689a-5p	CLIP-seq
MIRT1027366	hsa-miR-3689b	CLIP-seq
MIRT1027367	hsa-miR-3689e	CLIP-seq
MIRT1027368	hsa-miR-3689f	CLIP-seq
MIRT1027369	hsa-miR-4461	CLIP-seq
MIRT1027370	hsa-miR-4717-3p	CLIP-seq
MIRT1027371	hsa-miR-4789-3p	CLIP-seq
MIRT1027372	hsa-miR-4789-5p	CLIP-seq
MIRT1027373	hsa-miR-491-3p	CLIP-seq
MIRT1027374	hsa-miR-520d-5p	CLIP-seq
MIRT1027375	hsa-miR-524-5p	CLIP-seq
MIRT1027376	hsa-miR-570	CLIP-seq
MIRT1027377	hsa-miR-580	CLIP-seq
MIRT1027378	hsa-miR-584	CLIP-seq
MIRT1027379	hsa-miR-586	CLIP-seq
MIRT1027380	hsa-miR-595	CLIP-seq
MIRT1027381	hsa-miR-601	CLIP-seq
MIRT1027382	hsa-miR-609	CLIP-seq
MIRT1027383	hsa-miR-877	CLIP-seq
MIRT1027384	hsa-miR-142-5p	CLIP-seq
MIRT1027385	hsa-miR-3121-3p	CLIP-seq
MIRT1027386	hsa-miR-548a-5p	CLIP-seq
MIRT1027387	hsa-miR-548aa	CLIP-seq
MIRT1027388	hsa-miR-548ab	CLIP-seq
MIRT1027389	hsa-miR-548ak	CLIP-seq
MIRT1027390	hsa-miR-548b-5p	CLIP-seq
MIRT1027391	hsa-miR-548c-5p	CLIP-seq
MIRT1027392	hsa-miR-548d-5p	CLIP-seq
MIRT1027393	hsa-miR-548h	CLIP-seq
MIRT1027394	hsa-miR-548i	CLIP-seq
MIRT1027395	hsa-miR-548j	CLIP-seq
MIRT1027396	hsa-miR-548k	CLIP-seq
MIRT1027397	hsa-miR-548l	CLIP-seq
MIRT1027398	hsa-miR-548p	CLIP-seq
MIRT1027399	hsa-miR-548w	CLIP-seq
MIRT1027400	hsa-miR-548y	CLIP-seq
MIRT1027401	hsa-miR-559	CLIP-seq
MIRT1920461	hsa-miR-1279	CLIP-seq
MIRT1920462	hsa-miR-3140-3p	CLIP-seq
MIRT1920463	hsa-miR-587	CLIP-seq
MIRT1920464	hsa-miR-664	CLIP-seq
MIRT1920461	hsa-miR-1279	CLIP-seq
MIRT1920462	hsa-miR-3140-3p	CLIP-seq
MIRT1920463	hsa-miR-587	CLIP-seq
MIRT1920464	hsa-miR-664	CLIP-seq
MIRT2004743	hsa-miR-1231	CLIP-seq
MIRT1027357	hsa-miR-140-3p	CLIP-seq
MIRT2004744	hsa-miR-3655	CLIP-seq
MIRT2004745	hsa-miR-409-3p	CLIP-seq
MIRT2004746	hsa-miR-4288	CLIP-seq
MIRT2004747	hsa-miR-495	CLIP-seq
MIRT2004748	hsa-miR-519a	CLIP-seq
MIRT2004749	hsa-miR-519b-3p	CLIP-seq
MIRT2004750	hsa-miR-519c-3p	CLIP-seq
MIRT1027398	hsa-miR-548p	CLIP-seq
MIRT2004751	hsa-miR-632	CLIP-seq
MIRT1027362	hsa-miR-3143	CLIP-seq
MIRT1027365	hsa-miR-3689a-5p	CLIP-seq
MIRT1027366	hsa-miR-3689b	CLIP-seq
MIRT1027367	hsa-miR-3689e	CLIP-seq
MIRT1027368	hsa-miR-3689f	CLIP-seq
MIRT1027374	hsa-miR-520d-5p	CLIP-seq
MIRT1027375	hsa-miR-524-5p	CLIP-seq
MIRT2237505	hsa-miR-128	CLIP-seq
MIRT1027357	hsa-miR-140-3p	CLIP-seq
MIRT2237506	hsa-miR-1910	CLIP-seq
MIRT1027362	hsa-miR-3143	CLIP-seq
MIRT2237507	hsa-miR-3591-3p	CLIP-seq
MIRT2237508	hsa-miR-361-5p	CLIP-seq
MIRT1027365	hsa-miR-3689a-5p	CLIP-seq
MIRT1027366	hsa-miR-3689b	CLIP-seq
MIRT1027367	hsa-miR-3689e	CLIP-seq
MIRT1027368	hsa-miR-3689f	CLIP-seq
MIRT2237509	hsa-miR-377	CLIP-seq
MIRT2237510	hsa-miR-4325	CLIP-seq
MIRT2237511	hsa-miR-455-3p	CLIP-seq
MIRT1027374	hsa-miR-520d-5p	CLIP-seq
MIRT1027375	hsa-miR-524-5p	CLIP-seq
MIRT1027376	hsa-miR-570	CLIP-seq
MIRT2237512	hsa-miR-885-5p	CLIP-seq
MIRT2237505	hsa-miR-128	CLIP-seq
MIRT1027357	hsa-miR-140-3p	CLIP-seq
MIRT1027362	hsa-miR-3143	CLIP-seq
MIRT2388574	hsa-miR-3182	CLIP-seq
MIRT2388575	hsa-miR-4766-5p	CLIP-seq
MIRT2388576	hsa-miR-543	CLIP-seq
MIRT2541246	hsa-miR-1183	CLIP-seq
MIRT2541247	hsa-miR-1224-3p	CLIP-seq
MIRT2541248	hsa-miR-1229	CLIP-seq
MIRT2541249	hsa-miR-1250	CLIP-seq
MIRT1920461	hsa-miR-1279	CLIP-seq
MIRT2237505	hsa-miR-128	CLIP-seq
MIRT2541250	hsa-miR-129-5p	CLIP-seq
MIRT2541251	hsa-miR-1302	CLIP-seq
MIRT2541252	hsa-miR-1303	CLIP-seq
MIRT1027357	hsa-miR-140-3p	CLIP-seq
MIRT2541253	hsa-miR-145	CLIP-seq
MIRT2541254	hsa-miR-197	CLIP-seq
MIRT2541255	hsa-miR-2110	CLIP-seq
MIRT2541256	hsa-miR-2113	CLIP-seq
MIRT2541257	hsa-miR-221	CLIP-seq
MIRT2541258	hsa-miR-222	CLIP-seq
MIRT2541259	hsa-miR-2681	CLIP-seq
MIRT2541260	hsa-miR-27a	CLIP-seq
MIRT2541261	hsa-miR-27b	CLIP-seq
MIRT2541262	hsa-miR-29a	CLIP-seq
MIRT2541263	hsa-miR-29b	CLIP-seq
MIRT2541264	hsa-miR-29c	CLIP-seq
MIRT2541265	hsa-miR-3065-3p	CLIP-seq
MIRT2541266	hsa-miR-3120-3p	CLIP-seq
MIRT2541267	hsa-miR-3123	CLIP-seq
MIRT2541268	hsa-miR-3138	CLIP-seq
MIRT1920462	hsa-miR-3140-3p	CLIP-seq
MIRT2541269	hsa-miR-3148	CLIP-seq
MIRT2541270	hsa-miR-3163	CLIP-seq
MIRT2541271	hsa-miR-3200-5p	CLIP-seq
MIRT2541272	hsa-miR-340	CLIP-seq
MIRT2237507	hsa-miR-3591-3p	CLIP-seq
MIRT2541273	hsa-miR-3616-5p	CLIP-seq
MIRT2541274	hsa-miR-3647-5p	CLIP-seq
MIRT2541275	hsa-miR-3661	CLIP-seq
MIRT2541276	hsa-miR-3668	CLIP-seq
MIRT2541277	hsa-miR-3671	CLIP-seq
MIRT2541278	hsa-miR-3678-3p	CLIP-seq
MIRT2541279	hsa-miR-3687	CLIP-seq
MIRT2541280	hsa-miR-371-5p	CLIP-seq
MIRT2541281	hsa-miR-371b-5p	CLIP-seq
MIRT2237509	hsa-miR-377	CLIP-seq
MIRT2541282	hsa-miR-3907	CLIP-seq
MIRT2541283	hsa-miR-3941	CLIP-seq
MIRT2004745	hsa-miR-409-3p	CLIP-seq
MIRT2541284	hsa-miR-4261	CLIP-seq
MIRT2541285	hsa-miR-4263	CLIP-seq
MIRT2541286	hsa-miR-4271	CLIP-seq
MIRT2541287	hsa-miR-4275	CLIP-seq
MIRT2541288	hsa-miR-4282	CLIP-seq
MIRT2541289	hsa-miR-4298	CLIP-seq
MIRT2541290	hsa-miR-4303	CLIP-seq
MIRT2541291	hsa-miR-4418	CLIP-seq
MIRT2541292	hsa-miR-4442	CLIP-seq
MIRT2541293	hsa-miR-4457	CLIP-seq
MIRT2541294	hsa-miR-4474-5p	CLIP-seq
MIRT2541295	hsa-miR-4496	CLIP-seq
MIRT2541296	hsa-miR-4527	CLIP-seq
MIRT2541297	hsa-miR-4635	CLIP-seq
MIRT2541298	hsa-miR-4643	CLIP-seq
MIRT2541299	hsa-miR-4653-3p	CLIP-seq
MIRT2541300	hsa-miR-466	CLIP-seq
MIRT2541301	hsa-miR-4668-3p	CLIP-seq
MIRT2541302	hsa-miR-4668-5p	CLIP-seq
MIRT2541303	hsa-miR-4670-3p	CLIP-seq
MIRT2541304	hsa-miR-4672	CLIP-seq
MIRT2541305	hsa-miR-4693-5p	CLIP-seq
MIRT2541306	hsa-miR-4695-3p	CLIP-seq
MIRT2541307	hsa-miR-4698	CLIP-seq
MIRT2541308	hsa-miR-4699-3p	CLIP-seq
MIRT1027370	hsa-miR-4717-3p	CLIP-seq
MIRT2541309	hsa-miR-4719	CLIP-seq
MIRT2541310	hsa-miR-4725-3p	CLIP-seq
MIRT2541311	hsa-miR-4729	CLIP-seq
MIRT2541312	hsa-miR-4738-3p	CLIP-seq
MIRT2541313	hsa-miR-4752	CLIP-seq
MIRT2541314	hsa-miR-4756-3p	CLIP-seq
MIRT2541315	hsa-miR-4760-5p	CLIP-seq
MIRT1027371	hsa-miR-4789-3p	CLIP-seq
MIRT2541316	hsa-miR-4799-5p	CLIP-seq
MIRT2541317	hsa-miR-4800-5p	CLIP-seq
MIRT2541318	hsa-miR-491-5p	CLIP-seq
MIRT2004747	hsa-miR-495	CLIP-seq
MIRT2541319	hsa-miR-509-3-5p	CLIP-seq
MIRT2541320	hsa-miR-509-5p	CLIP-seq
MIRT2541321	hsa-miR-511	CLIP-seq
MIRT2541322	hsa-miR-513b	CLIP-seq
MIRT2541323	hsa-miR-513c	CLIP-seq
MIRT2541324	hsa-miR-514b-5p	CLIP-seq
MIRT2541325	hsa-miR-545	CLIP-seq
MIRT2541326	hsa-miR-548a-3p	CLIP-seq
MIRT1027387	hsa-miR-548aa	CLIP-seq
MIRT2541327	hsa-miR-548ac	CLIP-seq
MIRT2541328	hsa-miR-548c-3p	CLIP-seq
MIRT2541329	hsa-miR-548d-3p	CLIP-seq
MIRT2541330	hsa-miR-548e	CLIP-seq
MIRT2541331	hsa-miR-548f	CLIP-seq
MIRT2541332	hsa-miR-548g	CLIP-seq
MIRT1027398	hsa-miR-548p	CLIP-seq
MIRT2541333	hsa-miR-548v	CLIP-seq
MIRT2541334	hsa-miR-548z	CLIP-seq
MIRT2541335	hsa-miR-568	CLIP-seq
MIRT1027376	hsa-miR-570	CLIP-seq
MIRT2541336	hsa-miR-573	CLIP-seq
MIRT2541337	hsa-miR-576-5p	CLIP-seq
MIRT1920463	hsa-miR-587	CLIP-seq
MIRT2541338	hsa-miR-590-3p	CLIP-seq
MIRT2541339	hsa-miR-607	CLIP-seq
MIRT2541340	hsa-miR-619	CLIP-seq
MIRT2541341	hsa-miR-631	CLIP-seq
MIRT1920464	hsa-miR-664	CLIP-seq
MIRT2541342	hsa-miR-711	CLIP-seq
MIRT2541343	hsa-miR-875-3p	CLIP-seq
MIRT1027383	hsa-miR-877	CLIP-seq
MIRT2541344	hsa-miR-888	CLIP-seq
MIRT2541246	hsa-miR-1183	CLIP-seq
MIRT2541247	hsa-miR-1224-3p	CLIP-seq
MIRT2541248	hsa-miR-1229	CLIP-seq
MIRT2541249	hsa-miR-1250	CLIP-seq
MIRT2681775	hsa-miR-1267	CLIP-seq
MIRT1920461	hsa-miR-1279	CLIP-seq
MIRT2237505	hsa-miR-128	CLIP-seq
MIRT2541250	hsa-miR-129-5p	CLIP-seq
MIRT2541251	hsa-miR-1302	CLIP-seq
MIRT2681776	hsa-miR-1304	CLIP-seq
MIRT1027357	hsa-miR-140-3p	CLIP-seq
MIRT2541254	hsa-miR-197	CLIP-seq
MIRT2681777	hsa-miR-2054	CLIP-seq
MIRT2541255	hsa-miR-2110	CLIP-seq
MIRT2541256	hsa-miR-2113	CLIP-seq
MIRT2541257	hsa-miR-221	CLIP-seq
MIRT2541258	hsa-miR-222	CLIP-seq
MIRT2681778	hsa-miR-2467-5p	CLIP-seq
MIRT2541259	hsa-miR-2681	CLIP-seq
MIRT2541260	hsa-miR-27a	CLIP-seq
MIRT2541261	hsa-miR-27b	CLIP-seq
MIRT2541262	hsa-miR-29a	CLIP-seq
MIRT2541263	hsa-miR-29b	CLIP-seq
MIRT2541264	hsa-miR-29c	CLIP-seq
MIRT2541265	hsa-miR-3065-3p	CLIP-seq
MIRT2541266	hsa-miR-3120-3p	CLIP-seq
MIRT2541267	hsa-miR-3123	CLIP-seq
MIRT2541268	hsa-miR-3138	CLIP-seq
MIRT1920462	hsa-miR-3140-3p	CLIP-seq
MIRT2541269	hsa-miR-3148	CLIP-seq
MIRT2541270	hsa-miR-3163	CLIP-seq
MIRT2681779	hsa-miR-3188	CLIP-seq
MIRT2541271	hsa-miR-3200-5p	CLIP-seq
MIRT2541272	hsa-miR-340	CLIP-seq
MIRT2237507	hsa-miR-3591-3p	CLIP-seq
MIRT2541273	hsa-miR-3616-5p	CLIP-seq
MIRT2541274	hsa-miR-3647-5p	CLIP-seq
MIRT2541275	hsa-miR-3661	CLIP-seq
MIRT2541277	hsa-miR-3671	CLIP-seq
MIRT2541279	hsa-miR-3687	CLIP-seq
MIRT2541280	hsa-miR-371-5p	CLIP-seq
MIRT2541281	hsa-miR-371b-5p	CLIP-seq
MIRT2237509	hsa-miR-377	CLIP-seq
MIRT2541282	hsa-miR-3907	CLIP-seq
MIRT2541283	hsa-miR-3941	CLIP-seq
MIRT2681780	hsa-miR-3975	CLIP-seq
MIRT2004745	hsa-miR-409-3p	CLIP-seq
MIRT2541285	hsa-miR-4263	CLIP-seq
MIRT2541286	hsa-miR-4271	CLIP-seq
MIRT2541287	hsa-miR-4275	CLIP-seq
MIRT2541288	hsa-miR-4282	CLIP-seq
MIRT2541289	hsa-miR-4298	CLIP-seq
MIRT2541290	hsa-miR-4303	CLIP-seq
MIRT2541291	hsa-miR-4418	CLIP-seq
MIRT2541292	hsa-miR-4442	CLIP-seq
MIRT2541293	hsa-miR-4457	CLIP-seq
MIRT2541294	hsa-miR-4474-5p	CLIP-seq
MIRT2541295	hsa-miR-4496	CLIP-seq
MIRT2541296	hsa-miR-4527	CLIP-seq
MIRT2541297	hsa-miR-4635	CLIP-seq
MIRT2541298	hsa-miR-4643	CLIP-seq
MIRT2541299	hsa-miR-4653-3p	CLIP-seq
MIRT2541300	hsa-miR-466	CLIP-seq
MIRT2541302	hsa-miR-4668-5p	CLIP-seq
MIRT2541303	hsa-miR-4670-3p	CLIP-seq
MIRT2541304	hsa-miR-4672	CLIP-seq
MIRT2541305	hsa-miR-4693-5p	CLIP-seq
MIRT2541307	hsa-miR-4698	CLIP-seq
MIRT1027370	hsa-miR-4717-3p	CLIP-seq
MIRT2541309	hsa-miR-4719	CLIP-seq
MIRT2541310	hsa-miR-4725-3p	CLIP-seq
MIRT2541312	hsa-miR-4738-3p	CLIP-seq
MIRT2541313	hsa-miR-4752	CLIP-seq
MIRT2541314	hsa-miR-4756-3p	CLIP-seq
MIRT2541315	hsa-miR-4760-5p	CLIP-seq
MIRT1027371	hsa-miR-4789-3p	CLIP-seq
MIRT2541316	hsa-miR-4799-5p	CLIP-seq
MIRT2541317	hsa-miR-4800-5p	CLIP-seq
MIRT2681781	hsa-miR-485-3p	CLIP-seq
MIRT2681782	hsa-miR-485-5p	CLIP-seq
MIRT2541318	hsa-miR-491-5p	CLIP-seq
MIRT2004747	hsa-miR-495	CLIP-seq
MIRT2541319	hsa-miR-509-3-5p	CLIP-seq
MIRT2541320	hsa-miR-509-5p	CLIP-seq
MIRT2541321	hsa-miR-511	CLIP-seq
MIRT2541322	hsa-miR-513b	CLIP-seq
MIRT2541323	hsa-miR-513c	CLIP-seq
MIRT2541324	hsa-miR-514b-5p	CLIP-seq
MIRT2541325	hsa-miR-545	CLIP-seq
MIRT2541326	hsa-miR-548a-3p	CLIP-seq
MIRT1027387	hsa-miR-548aa	CLIP-seq
MIRT2541327	hsa-miR-548ac	CLIP-seq
MIRT2541328	hsa-miR-548c-3p	CLIP-seq
MIRT2541329	hsa-miR-548d-3p	CLIP-seq
MIRT2541330	hsa-miR-548e	CLIP-seq
MIRT2541331	hsa-miR-548f	CLIP-seq
MIRT2541332	hsa-miR-548g	CLIP-seq
MIRT1027398	hsa-miR-548p	CLIP-seq
MIRT2541333	hsa-miR-548v	CLIP-seq
MIRT2541334	hsa-miR-548z	CLIP-seq
MIRT2541335	hsa-miR-568	CLIP-seq
MIRT1027376	hsa-miR-570	CLIP-seq
MIRT2541336	hsa-miR-573	CLIP-seq
MIRT2541337	hsa-miR-576-5p	CLIP-seq
MIRT1920463	hsa-miR-587	CLIP-seq
MIRT2541339	hsa-miR-607	CLIP-seq
MIRT2541341	hsa-miR-631	CLIP-seq
MIRT1920464	hsa-miR-664	CLIP-seq
MIRT2541342	hsa-miR-711	CLIP-seq
MIRT2541343	hsa-miR-875-3p	CLIP-seq
MIRT2541344	hsa-miR-888	CLIP-seq
MIRT2681783	hsa-miR-944	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005515	Function	Protein binding	IPI	11384996, 11707463, 12471024, 19027007, 20195357, 25416956, 25609649, 26179146, 29892012, 31515488
GO:0005737	Component	Cytoplasm	IDA	11707463
GO:0005765	Component	Lysosomal membrane	TAS
GO:0005794	Component	Golgi apparatus	IBA	21873635
GO:0005794	Component	Golgi apparatus	IDA	11384996
GO:0005886	Component	Plasma membrane	NAS	11707463
GO:0005886	Component	Plasma membrane	TAS
GO:0006888	Process	Endoplasmic reticulum to Golgi vesicle-mediated transport	NAS	11707463
GO:0006893	Process	Golgi to plasma membrane transport	NAS	11707463
GO:0010360	Process	Negative regulation of anion channel activity	IMP	11707463
GO:0014069	Component	Postsynaptic density	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IBA	21873635
GO:0016020	Component	Membrane	IDA	11707463
GO:0030140	Component	Trans-Golgi network transport vesicle	IBA	21873635
GO:0030140	Component	Trans-Golgi network transport vesicle	IDA	11707463
GO:0030140	Component	Trans-Golgi network transport vesicle	NAS	11384996
GO:0030425	Component	Dendrite	IEA
GO:0030660	Component	Golgi-associated vesicle membrane	TAS
GO:0032991	Component	Protein-containing complex	IDA	18468998
GO:0042802	Function	Identical protein binding	IPI	11707463
GO:0043004	Process	Cytoplasmic sequestering of CFTR protein	IBA	21873635
GO:0043004	Process	Cytoplasmic sequestering of CFTR protein	IMP	11707463
GO:0044325	Function	Ion channel binding	IBA	21873635
GO:0044325	Function	Ion channel binding	IPI	11707463
GO:0045176	Process	Apical protein localization	NAS	11707463
GO:2000009	Process	Negative regulation of protein localization to cell surface	IBA	21873635
GO:2000009	Process	Negative regulation of protein localization to cell surface	IMP	11707463

Other IDs

• MIM: 606845
• HGNC: 17643
• e!Ensembl: ENSG00000047932

Protein

• UniProt ID: Q9HD26
• Protein name: Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST)
• Protein function: Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By
• PDB: 2DC2, 2LOB, 4E34, 4E35, 4JOE, 4JOF, 4JOG, 4JOH, 4JOJ, 4JOK, 4JOP, 4JOR, 4K6Y, 4K72, 4K75, 4K76, 4K78, 4NMO, 4NMP, 4NMQ, 4NMR, 4NMS, 4NMT, 4NMV, 4Q6H, 4Q6S, 5IC3, 5K4F, 6OV7, 6V84, 6XNJ, 7JZO, 7JZP, 7JZQ, 7JZR
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00595	PDZ	288 → 368	PDZ domain	Domain

• Sequence:

  MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQA
  DITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVH
  DQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVK
  LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQL
  EAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLG
  ISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR
  GEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQG
  FNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY

• Sequence length: 462

Pathways

Reactome:

RHO GTPases regulate CFTR trafficking

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Atrial fibrillation	Atrial Fibrillation	rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557, rs587777558, rs587777559, rs587777560, rs886037778, rs769405762, rs770372675	29892015
Male infertility	Male infertility due to globozoospermia	rs554675432, rs9332971, rs397507505, rs797045116, rs748618094, rs781431741, rs1555979575, rs377581367
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	22535842

Unknown
Disease name	Disease term	dbSNP ID	References
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation	rs199865688, rs397515994, rs757096307	29892015