REXO4 (REX4 homolog, 3'-5' exonuclease)

Gene

• Entrez ID: 57109
• Gene name: REX4 homolog, 3'-5' exonuclease
• Gene symbol: REXO4
• Synonyms: REX4, XPMC2, XPMC2H
• Chromosome: 9
• Chromosome location: 9q34.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028599	hsa-miR-30a-5p	Proteomics	18668040
MIRT041926	hsa-miR-484	CLASH	23622248
MIRT040143	hsa-miR-615-3p	CLASH	23622248
MIRT1301451	hsa-miR-1286	CLIP-seq
MIRT1301452	hsa-miR-1343	CLIP-seq
MIRT1301453	hsa-miR-149	CLIP-seq
MIRT1301454	hsa-miR-15a	CLIP-seq
MIRT1301455	hsa-miR-15b	CLIP-seq
MIRT1301456	hsa-miR-16	CLIP-seq
MIRT1301457	hsa-miR-194	CLIP-seq
MIRT1301458	hsa-miR-195	CLIP-seq
MIRT1301459	hsa-miR-214	CLIP-seq
MIRT1301460	hsa-miR-3064-5p	CLIP-seq
MIRT1301461	hsa-miR-30a	CLIP-seq
MIRT1301462	hsa-miR-30b	CLIP-seq
MIRT1301463	hsa-miR-30c	CLIP-seq
MIRT1301464	hsa-miR-30d	CLIP-seq
MIRT1301465	hsa-miR-30e	CLIP-seq
MIRT1301466	hsa-miR-3169	CLIP-seq
MIRT1301467	hsa-miR-3171	CLIP-seq
MIRT1301468	hsa-miR-3180	CLIP-seq
MIRT1301469	hsa-miR-3180-3p	CLIP-seq
MIRT1301470	hsa-miR-3196	CLIP-seq
MIRT1301471	hsa-miR-3591-3p	CLIP-seq
MIRT1301472	hsa-miR-3619-5p	CLIP-seq
MIRT1301473	hsa-miR-3691-3p	CLIP-seq
MIRT1301474	hsa-miR-424	CLIP-seq
MIRT1301475	hsa-miR-4326	CLIP-seq
MIRT1301476	hsa-miR-4436b-3p	CLIP-seq
MIRT1301477	hsa-miR-4687-3p	CLIP-seq
MIRT1301478	hsa-miR-4729	CLIP-seq
MIRT1301479	hsa-miR-4781-5p	CLIP-seq
MIRT1301480	hsa-miR-497	CLIP-seq
MIRT1301481	hsa-miR-621	CLIP-seq
MIRT1301482	hsa-miR-744	CLIP-seq
MIRT1301483	hsa-miR-760	CLIP-seq
MIRT1301484	hsa-miR-761	CLIP-seq
MIRT1301485	hsa-miR-892b	CLIP-seq
MIRT2089479	hsa-miR-1269	CLIP-seq
MIRT2089480	hsa-miR-1269b	CLIP-seq
MIRT2089481	hsa-miR-1288	CLIP-seq
MIRT2089482	hsa-miR-1915	CLIP-seq
MIRT2089483	hsa-miR-2277-3p	CLIP-seq
MIRT2089484	hsa-miR-3065-3p	CLIP-seq
MIRT2089485	hsa-miR-34a	CLIP-seq
MIRT2089486	hsa-miR-34c-5p	CLIP-seq
MIRT2089487	hsa-miR-4267	CLIP-seq
MIRT2089488	hsa-miR-4426	CLIP-seq
MIRT2089489	hsa-miR-4467	CLIP-seq
MIRT2089490	hsa-miR-449a	CLIP-seq
MIRT2089491	hsa-miR-449b	CLIP-seq
MIRT2089492	hsa-miR-4515	CLIP-seq
MIRT2089493	hsa-miR-4647	CLIP-seq
MIRT2089494	hsa-miR-4662b	CLIP-seq
MIRT2089495	hsa-miR-4671-5p	CLIP-seq
MIRT2089496	hsa-miR-4740-5p	CLIP-seq
MIRT2089497	hsa-miR-4749-3p	CLIP-seq
MIRT2089498	hsa-miR-542-3p	CLIP-seq
MIRT2089499	hsa-miR-597	CLIP-seq
MIRT2314412	hsa-miR-125a-3p	CLIP-seq
MIRT2314413	hsa-miR-1266	CLIP-seq
MIRT1301451	hsa-miR-1286	CLIP-seq
MIRT1301454	hsa-miR-15a	CLIP-seq
MIRT1301455	hsa-miR-15b	CLIP-seq
MIRT1301456	hsa-miR-16	CLIP-seq
MIRT2314414	hsa-miR-1913	CLIP-seq
MIRT2089482	hsa-miR-1915	CLIP-seq
MIRT1301458	hsa-miR-195	CLIP-seq
MIRT2314415	hsa-miR-198	CLIP-seq
MIRT1301459	hsa-miR-214	CLIP-seq
MIRT2314416	hsa-miR-28-5p	CLIP-seq
MIRT2314417	hsa-miR-3125	CLIP-seq
MIRT2314418	hsa-miR-3136-3p	CLIP-seq
MIRT2314419	hsa-miR-3139	CLIP-seq
MIRT1301466	hsa-miR-3169	CLIP-seq
MIRT1301468	hsa-miR-3180	CLIP-seq
MIRT1301469	hsa-miR-3180-3p	CLIP-seq
MIRT1301470	hsa-miR-3196	CLIP-seq
MIRT2314420	hsa-miR-324-3p	CLIP-seq
MIRT2314421	hsa-miR-346	CLIP-seq
MIRT1301472	hsa-miR-3619-5p	CLIP-seq
MIRT2314422	hsa-miR-3622a-3p	CLIP-seq
MIRT2314423	hsa-miR-3622b-3p	CLIP-seq
MIRT2314424	hsa-miR-3650	CLIP-seq
MIRT2314425	hsa-miR-3664-3p	CLIP-seq
MIRT2314426	hsa-miR-3916	CLIP-seq
MIRT2314427	hsa-miR-3934	CLIP-seq
MIRT1301474	hsa-miR-424	CLIP-seq
MIRT2089487	hsa-miR-4267	CLIP-seq
MIRT2314428	hsa-miR-4274	CLIP-seq
MIRT2314429	hsa-miR-4288	CLIP-seq
MIRT2314430	hsa-miR-4291	CLIP-seq
MIRT2314431	hsa-miR-4433	CLIP-seq
MIRT1301476	hsa-miR-4436b-3p	CLIP-seq
MIRT2314432	hsa-miR-4459	CLIP-seq
MIRT2314433	hsa-miR-4518	CLIP-seq
MIRT2314434	hsa-miR-4652-3p	CLIP-seq
MIRT2314435	hsa-miR-4711-3p	CLIP-seq
MIRT2089497	hsa-miR-4749-3p	CLIP-seq
MIRT2314436	hsa-miR-4768-3p	CLIP-seq
MIRT1301479	hsa-miR-4781-5p	CLIP-seq
MIRT1301480	hsa-miR-497	CLIP-seq
MIRT2314437	hsa-miR-614	CLIP-seq
MIRT2314438	hsa-miR-632	CLIP-seq
MIRT2314439	hsa-miR-663b	CLIP-seq
MIRT2314440	hsa-miR-708	CLIP-seq
MIRT1301482	hsa-miR-744	CLIP-seq
MIRT1301484	hsa-miR-761	CLIP-seq
MIRT2314441	hsa-miR-764	CLIP-seq
MIRT2314442	hsa-miR-922	CLIP-seq
MIRT2393632	hsa-miR-4641	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000726	Process	Non-recombinational repair	IBA	21873635
GO:0000726	Process	Non-recombinational repair	IDA	21602889
GO:0000737	Process	DNA catabolic process, endonucleolytic	IBA	21873635
GO:0000737	Process	DNA catabolic process, endonucleolytic	IDA	21602889
GO:0000738	Process	DNA catabolic process, exonucleolytic	IBA	21873635
GO:0000738	Process	DNA catabolic process, exonucleolytic	IDA	21602889
GO:0003690	Function	Double-stranded DNA binding	IDA	21602889
GO:0003697	Function	Single-stranded DNA binding	IDA	21602889
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0004519	Function	Endonuclease activity	IDA	21602889
GO:0004527	Function	Exonuclease activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	NAS	10908561
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0006355	Process	Regulation of transcription, DNA-templated	NAS	10908561
GO:0006364	Process	RRNA processing	IEA
GO:0008408	Function	3'-5' exonuclease activity	IDA	21602889
GO:0016607	Component	Nuclear speck	IDA

Other IDs

• MIM: 602930
• HGNC: 12820
• e!Ensembl: ENSG00000148300

Protein

• UniProt ID: Q9GZR2
• Protein name: RNA exonuclease 4 (EC 3.1.-.-) (Exonuclease XPMC2) (Prevents mitotic catastrophe 2 protein homolog) (hPMC2)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00929	RNase_T	244 → 394	Exonuclease	Family

• Sequence:

  MGKAKVPASKRAPSSPVAKPGPVKTLTRKKNKKKKRFWKSKAREVSKKPASGPGAVVRPP
  KAPEDFSQNWKALQEWLLKQKSQAPEKPLVISQMGSKKKPKIIQQNKKETSPQVKGEEMP
  AGKDQEASRGSVPSGSKMDRRAPVPRTKASGTEHNKKGTKERTNGDIVPERGDIEHKKRK
  AKEAAPAPPTEEDIWFDDVDPADIEAAIGPEAAKIARKQLGQSEGSVSLSLVKEQAFGGL
  TRALALDCEMVGVGPKGEESMAARVSIVNQYGKCVYDKYVKPTEPVTDYRTAVSGIRPEN
  LKQGEELEVVQKEVAEMLKGRILVGHALHNDLKVLFLDHPKKKIRDTQKYKPFKSQVKSG
  RPSLRLLSEKILGLQVQQAEHCSIQDAQAAMRLYVMVKKEWESMARDRRPLLTAPDHCSD
  DA

• Sequence length: 422

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Lung carcinoma	Squamous cell carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	28604730