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CYSLTR2 (cysteinyl leukotriene receptor 2)

Gene

57105

Cysteinyl leukotriene receptor 2

CYSLTR2

CYSLT2, CYSLT2R, GPCR21, HG57, HPN321, KPG_011, PSEC0146, hGPCR21

13q14.2

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded

Show/Hide all(122)

miRTarBase ID	miRNA	Experiments	Reference
MIRT719246	hsa-miR-3714	HITS-CLIP	19536157
MIRT719245	hsa-miR-9500	HITS-CLIP	19536157
MIRT719244	hsa-miR-3162-3p	HITS-CLIP	19536157
MIRT719243	hsa-miR-4469	HITS-CLIP	19536157
MIRT719242	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT719241	hsa-miR-4287	HITS-CLIP	19536157
MIRT719240	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT719239	hsa-miR-605-3p	HITS-CLIP	19536157
MIRT719238	hsa-miR-103a-3p	HITS-CLIP	19536157
MIRT719237	hsa-miR-107	HITS-CLIP	19536157
MIRT719236	hsa-miR-4747-5p	HITS-CLIP	19536157
MIRT719235	hsa-miR-5196-5p	HITS-CLIP	19536157
MIRT719234	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT659192	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT659191	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT659190	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT668798	hsa-miR-1248	HITS-CLIP	23824327
MIRT659189	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT659188	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT659187	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT668797	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT668796	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT659192	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT659191	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT659190	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT659189	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT659188	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT659187	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT719246	hsa-miR-3714	HITS-CLIP	19536157
MIRT719245	hsa-miR-9500	HITS-CLIP	19536157
MIRT719244	hsa-miR-3162-3p	HITS-CLIP	19536157
MIRT719243	hsa-miR-4469	HITS-CLIP	19536157
MIRT719242	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT719241	hsa-miR-4287	HITS-CLIP	19536157
MIRT719240	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT719239	hsa-miR-605-3p	HITS-CLIP	19536157
MIRT719238	hsa-miR-103a-3p	HITS-CLIP	19536157
MIRT719237	hsa-miR-107	HITS-CLIP	19536157
MIRT719236	hsa-miR-4747-5p	HITS-CLIP	19536157
MIRT719235	hsa-miR-5196-5p	HITS-CLIP	19536157
MIRT719234	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT659192	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT659191	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT659190	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT668798	hsa-miR-1248	HITS-CLIP	23824327
MIRT659189	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT659188	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT659187	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT668797	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT668796	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT659192	hsa-miR-500a-5p	HITS-CLIP	23824327
MIRT659191	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT659190	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT659189	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT659188	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT659187	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT922064	hsa-miR-1284	CLIP-seq
MIRT922065	hsa-miR-145	CLIP-seq
MIRT922066	hsa-miR-204	CLIP-seq
MIRT922067	hsa-miR-211	CLIP-seq
MIRT922068	hsa-miR-2115	CLIP-seq
MIRT922069	hsa-miR-3124-3p	CLIP-seq
MIRT922070	hsa-miR-3145-5p	CLIP-seq
MIRT922071	hsa-miR-3194-3p	CLIP-seq
MIRT922072	hsa-miR-326	CLIP-seq
MIRT922073	hsa-miR-330-5p	CLIP-seq
MIRT922074	hsa-miR-3685	CLIP-seq
MIRT922075	hsa-miR-384	CLIP-seq
MIRT922076	hsa-miR-4283	CLIP-seq
MIRT922077	hsa-miR-4436b-3p	CLIP-seq
MIRT922078	hsa-miR-4446-5p	CLIP-seq
MIRT922079	hsa-miR-4489	CLIP-seq
MIRT922080	hsa-miR-4658	CLIP-seq
MIRT922081	hsa-miR-4667-5p	CLIP-seq
MIRT922082	hsa-miR-4700-5p	CLIP-seq
MIRT922083	hsa-miR-4712-5p	CLIP-seq
MIRT922084	hsa-miR-4731-3p	CLIP-seq
MIRT922085	hsa-miR-4755-5p	CLIP-seq
MIRT922086	hsa-miR-4758-5p	CLIP-seq
MIRT922087	hsa-miR-4761-3p	CLIP-seq
MIRT922088	hsa-miR-4780	CLIP-seq
MIRT922089	hsa-miR-4789-5p	CLIP-seq
MIRT922090	hsa-miR-4801	CLIP-seq
MIRT922091	hsa-miR-508-5p	CLIP-seq
MIRT922092	hsa-miR-544	CLIP-seq
MIRT922093	hsa-miR-579	CLIP-seq
MIRT922094	hsa-miR-623	CLIP-seq
MIRT922095	hsa-miR-637	CLIP-seq
MIRT922096	hsa-miR-767-3p	CLIP-seq
MIRT922097	hsa-miR-770-5p	CLIP-seq
MIRT1973120	hsa-miR-1237	CLIP-seq
MIRT1973121	hsa-miR-4713-5p	CLIP-seq
MIRT1973122	hsa-miR-874	CLIP-seq
MIRT2208779	hsa-miR-128	CLIP-seq
MIRT2208780	hsa-miR-27a	CLIP-seq
MIRT2208781	hsa-miR-27b	CLIP-seq
MIRT2208782	hsa-miR-3145-3p	CLIP-seq
MIRT2208783	hsa-miR-3157-5p	CLIP-seq
MIRT2208784	hsa-miR-3614-3p	CLIP-seq
MIRT2208785	hsa-miR-3667-3p	CLIP-seq
MIRT2208786	hsa-miR-4297	CLIP-seq
MIRT2208787	hsa-miR-4474-5p	CLIP-seq
MIRT2208788	hsa-miR-4690-3p	CLIP-seq
MIRT2208789	hsa-miR-5096	CLIP-seq
MIRT2208790	hsa-miR-513a-5p	CLIP-seq
MIRT2447951	hsa-miR-2110	CLIP-seq
MIRT2447952	hsa-miR-3135b	CLIP-seq
MIRT2447953	hsa-miR-320e	CLIP-seq
MIRT2447954	hsa-miR-4271	CLIP-seq
MIRT2447955	hsa-miR-4300	CLIP-seq
MIRT2447956	hsa-miR-4434	CLIP-seq
MIRT2447957	hsa-miR-4487	CLIP-seq
MIRT2447958	hsa-miR-4516	CLIP-seq
MIRT2447959	hsa-miR-4531	CLIP-seq
MIRT922081	hsa-miR-4667-5p	CLIP-seq
MIRT922082	hsa-miR-4700-5p	CLIP-seq
MIRT2447960	hsa-miR-4725-3p	CLIP-seq
MIRT2447961	hsa-miR-4731-5p	CLIP-seq
MIRT2447962	hsa-miR-920	CLIP-seq
MIRT2447963	hsa-miR-939	CLIP-seq
MIRT2679008	hsa-miR-3065-5p	CLIP-seq
MIRT2679009	hsa-miR-3647-3p	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001631	Function	Cysteinyl leukotriene receptor activity	IBA	21873635
GO:0004974	Function	Leukotriene receptor activity	NAS	10913337
GO:0005515	Function	Protein binding	IPI	21203429, 21525870, 24550280, 26617989, 30126976, 32296183
GO:0005575	Component	Cellular_component	ND
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0006955	Process	Immune response	NAS	10913337
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007218	Process	Neuropeptide signaling pathway	IBA	21873635
GO:0008528	Function	G protein-coupled peptide receptor activity	IBA	21873635
GO:0061737	Process	Leukotriene signaling pathway	IEA

MIM	HGNC	e!Ensembl
605666	18274	ENSG00000152207

Protein

UniProt ID

Q9NS75

Protein name

Cysteinyl leukotriene receptor 2 (CysLTR2) (G-protein coupled receptor GPCR21) (hGPCR21) (G-protein coupled receptor HG57) (HPN321)

Protein function

Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins an

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	55 → 305	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSI
YVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYV
NMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQ
NGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRV
SHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACF
NPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV

Sequence length

346

Interactions

View interactions

	KEGG		Reactome
	Calcium signaling pathway Neuroactive ligand-receptor interaction		Glucagon signaling in metabolic regulation Leukotriene receptors G alpha (q) signalling events G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production LTC4-CYSLTR mediated IL4 production

Associated diseases

Show/Hide Causal Diseases (5)

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma, Aspirin-Induced	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	20485159, 16502481
Cataract	CATARACT, MARNER TYPE	rs118203965, rs118203966, rs104893685, rs121908938, rs104894175, rs121909048, rs28937573, rs121909049, rs121909050, rs74315488, rs80358200, rs80358203, rs121434643, rs56141211, rs132630322, rs121917775, rs121917735, rs121917736, rs137853199, rs137853200, rs121917867, rs121917869, rs121913555, rs104893736, rs121909595, rs121909596, rs121909597, rs28931605, rs121909598, rs104893618, rs1695062782, rs74315486, rs74315487, rs74315490, rs74315489, rs745938679, rs1566402656, rs74315439, rs74315441, rs121912973, rs121917823, rs1593332981, rs121917825, rs121917827, rs113994108, rs387906963, rs387906964, rs1240503246, rs387906965, rs387906966, rs750207077, rs387907336, rs387907337, rs387907342, rs140332366, rs397514703, rs398122937, rs398122378, rs398122392, rs398122944, rs137853924, rs398122947, rs397515623, rs397515624, rs397515625, rs397515626, rs398122948, rs587778872, rs398123066, rs587777601, rs370424081, rs786205221, rs786205222, rs864309684, rs864309688, rs864309701, rs864309689, rs864309690, rs864309681, rs864309686, rs864309696, rs864309693, rs864309687, rs864309691, rs864309692, rs864309695, rs864309678, rs864309685, rs864309700, rs864309698, rs864309683, rs864309682, rs864309679, rs111534978, rs864309680, rs864309702, rs864622780, rs756898971, rs869312732, rs775038545, rs878852983, rs1114167312, rs1114167313, rs1114167314, rs1114167315, rs1114167307, rs886041410, rs886041412, rs1057518738, rs1057517926, rs1057518878, rs1057519616, rs12799308, rs1064793935, rs1064797219, rs1085307126, rs1085307127, rs765628635, rs1114167427, rs1114167433, rs1554744860, rs1554743428, rs747093432, rs1411557416, rs1555179713, rs1481963503, rs1555549755, rs1456161420, rs1555547008, rs1555889308, rs1555888762, rs766522434, rs1264025914, rs1553585262, rs1567671947, rs1337897299, rs764945940, rs1307969607, rs949335475, rs1184095219, rs776129797, rs1569203234, rs1567668570, rs749141857, rs764098604, rs1184398243, rs1578956689, rs1568480054, rs1564745688, rs1564722302, rs1564723150, rs1571175950, rs1569602837, rs1576552712, rs1575369255, rs981126461, rs1570403798, rs200557771, rs1477743112, rs1651879427, rs1651881222, rs1651919374, rs2024441691, rs148284531, rs1246080692
Pulmonary fibrosis	Pulmonary Fibrosis	rs121918666, rs199422300, rs121917737, rs121917834, rs199422294, rs201159197, rs199422297, rs199422305, rs751381953, rs876661305, rs878853260, rs863223336, rs786205702, rs1555811762, rs1060502990, rs1555903332, rs1554038539, rs1554042899, rs938938578	15328359
Retinal detachment	Retinal Detachment	rs1555976049, rs1592230091
Uveal melanoma	Uveal melanoma	rs1559588632	27089179

Show/Hide Unknown Diseases (8)

Unknown
Disease name	Disease term	dbSNP ID	References
Alveolitis	Alveolitis, Fibrosing		15328359
Choroidal melanoma	Malignant melanoma of choroid		27089179
Congenital cataract	Congenital lamellar cataract
Inferior lens subluxation	Inferior lens subluxation
Inflammatory abnormality of the eye	Inflammatory abnormality of the eye
Iris melanoma	Malignant melanoma of iris		27089179
Ciliary body melanoma	Malignant melanoma of ciliary body
Ocular hypertension	Ocular Hypertension

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