DAZ3 (deleted in azoospermia 3)

Gene

• Entrez ID: 57054
• Gene name: Deleted in azoospermia 3
• Gene symbol: DAZ3
• Synonyms: pDP1679
• Chromosome: Y
• Chromosome location: Yq11.23
• Summary: This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT923387	hsa-let-7a	CLIP-seq
MIRT923388	hsa-let-7b	CLIP-seq
MIRT923389	hsa-let-7c	CLIP-seq
MIRT923390	hsa-let-7d	CLIP-seq
MIRT923391	hsa-let-7e	CLIP-seq
MIRT923392	hsa-let-7f	CLIP-seq
MIRT923393	hsa-let-7g	CLIP-seq
MIRT923394	hsa-let-7i	CLIP-seq
MIRT923395	hsa-miR-1270	CLIP-seq
MIRT923396	hsa-miR-1304	CLIP-seq
MIRT923397	hsa-miR-202	CLIP-seq
MIRT923398	hsa-miR-203	CLIP-seq
MIRT923399	hsa-miR-3140-3p	CLIP-seq
MIRT923400	hsa-miR-3140-5p	CLIP-seq
MIRT923401	hsa-miR-3682-5p	CLIP-seq
MIRT923402	hsa-miR-3923	CLIP-seq
MIRT923403	hsa-miR-4276	CLIP-seq
MIRT923404	hsa-miR-4302	CLIP-seq
MIRT923405	hsa-miR-432	CLIP-seq
MIRT923406	hsa-miR-4434	CLIP-seq
MIRT923407	hsa-miR-4458	CLIP-seq
MIRT923408	hsa-miR-4500	CLIP-seq
MIRT923409	hsa-miR-4516	CLIP-seq
MIRT923410	hsa-miR-4531	CLIP-seq
MIRT923411	hsa-miR-4733-5p	CLIP-seq
MIRT923412	hsa-miR-4766-5p	CLIP-seq
MIRT923413	hsa-miR-4777-5p	CLIP-seq
MIRT923414	hsa-miR-513a-3p	CLIP-seq
MIRT923415	hsa-miR-518d-5p	CLIP-seq
MIRT923416	hsa-miR-519b-5p	CLIP-seq
MIRT923417	hsa-miR-519c-5p	CLIP-seq
MIRT923418	hsa-miR-520c-5p	CLIP-seq
MIRT923419	hsa-miR-526a	CLIP-seq
MIRT923420	hsa-miR-548u	CLIP-seq
MIRT923421	hsa-miR-561	CLIP-seq
MIRT923422	hsa-miR-606	CLIP-seq
MIRT923423	hsa-miR-620	CLIP-seq
MIRT923424	hsa-miR-628-3p	CLIP-seq
MIRT923425	hsa-miR-98	CLIP-seq
MIRT923403	hsa-miR-4276	CLIP-seq
MIRT923404	hsa-miR-4302	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003730	Function	MRNA 3'-UTR binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	10857750
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0007275	Process	Multicellular organism development	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0008494	Function	Translation activator activity	IBA	21873635
GO:0030154	Process	Cell differentiation	IEA
GO:0032991	Component	Protein-containing complex	IDA	10857750
GO:0045948	Process	Positive regulation of translational initiation	IBA	21873635
GO:0070935	Process	3'-UTR-mediated mRNA stabilization	IBA	21873635

Other IDs

• MIM: 400027
• HGNC: 15965
• e!Ensembl: ENSG00000187191

Protein

• UniProt ID: Q9NR90
• Protein name: Deleted in azoospermia protein 3
• Protein function: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00076	RRM_1	42 → 109	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
  PF18872	Daz	170 → 190	Daz repeat	Repeat
  PF18872	Daz	194 → 214	Daz repeat	Repeat
  PF18872	Daz	218 → 238	Daz repeat	Repeat
  PF18872	Daz	242 → 262	Daz repeat	Repeat
  PF18872	Daz	266 → 286	Daz repeat	Repeat
  PF18872	Daz	290 → 310	Daz repeat	Repeat
  PF18872	Daz	314 → 334	Daz repeat	Repeat
  PF18872	Daz	338 → 358	Daz repeat	Repeat
  PF18872	Daz	362 → 382	Daz repeat	Repeat
  PF18872	Daz	386 → 406	Daz repeat	Repeat
  PF18872	Daz	410 → 430	Daz repeat	Repeat
  PF18872	Daz	434 → 454	Daz repeat	Repeat

• Sequence:

  MSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCF
  GRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLC
  ARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQAYSAYPHSPGQVIT
  GCQLLVYNYQEYPTYPDSAFQVTTGYQLPVYNYQPFPAYPRSPFQVTAGYQLPVYNYQAF
  PAYPNSPFQVATGYQFPVYNYQPFPAYPSSPFQVTAGYQLPVYNYQAFPAYPNSPFQVAT
  GYQFPVYNYQAFPAYPNSPVQVTTGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQAF
  PAYPNSPVQVTTGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQAFPAYPNSPVQVTT
  GYQLPVYNYQAFPAYPNSAVQVTTGYQFHVYNYQMPPQCPVGEQRRNLWTEAYKWWYLVC
  LIQRRD

• Sequence length: 486

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Azoospermia	Azoospermia	rs200969445, rs144567652, rs765353898
Cryptorchidism	Cryptorchidism	rs121912555, rs104894697, rs104894698, rs398122886
Non-obstructive azoospermia	Non-obstructive azoospermia	rs587777872, rs879253743, rs1600840291, rs1600877766, rs753462162, rs1588618614, rs1602684496, rs377712900
Oligospermia	Oligospermia	rs1602125411, rs2047796277, rs377712900

Unknown
Disease name	Disease term	dbSNP ID	References
Nonobstructive spermatogenic failure, y-linked	Spermatogenic Failure, Nonobstructive, Y-Linked
Partial chromosome y deletion	Partial chromosome Y deletion