RARS2 (arginyl-tRNA synthetase 2, mitochondrial)

Gene

• Entrez ID: 57038
• Gene name: Arginyl-tRNA synthetase 2, mitochondrial
• Gene symbol: RARS2
• Synonyms: ArgRS, DALRD2, PCH6, PRO1992, RARSL
• Chromosome: 6
• Chromosome location: 6q15
• Summary: This nuclear gene encodes a protein that localizes to the mitochondria, where it catalyzes the transfer of L-arginine to its cognate tRNA, an important step in translation of mitochondrially-encoded proteins. Defects in this gene are a cause of pontocereb

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs34647222	C>T	Likely-pathogenic, uncertain-significance	Non coding transcript variant, coding sequence variant, missense variant
rs63749985	T>C,G	Pathogenic	Intron variant
rs138360045	T>C,G	Conflicting-interpretations-of-pathogenicity	Non coding transcript variant, intron variant, synonymous variant, 5 prime UTR variant, coding sequence variant
rs143389605	T>C,G	Uncertain-significance, likely-pathogenic	Coding sequence variant, 5 prime UTR variant, intron variant, missense variant, non coding transcript variant
rs144896612	T>C	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, non coding transcript variant, missense variant
rs145189950	C>G,T	Uncertain-significance, likely-benign, benign, conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant, non coding transcript variant
rs145499324	T>C,G	Benign, conflicting-interpretations-of-pathogenicity	Coding sequence variant, synonymous variant, non coding transcript variant, missense variant
rs147844153	G>A	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Genic downstream transcript variant, coding sequence variant, non coding transcript variant, missense variant
rs199728745	G>A	Pathogenic	Coding sequence variant, stop gained, non coding transcript variant
rs199835443	G>A,C	Likely-pathogenic, pathogenic	Coding sequence variant, stop gained, non coding transcript variant, missense variant
rs387907048	T>C	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs750433723	C>T	Likely-pathogenic	Intron variant, genic downstream transcript variant
rs756502974	C>T	Likely-pathogenic, uncertain-significance	Missense variant, coding sequence variant, non coding transcript variant, genic downstream transcript variant
rs756696262	TT>-,TTT	Likely-pathogenic	Coding sequence variant, non coding transcript variant, frameshift variant
rs757743894	TTT>-	Pathogenic, conflicting-interpretations-of-pathogenicity	5 prime UTR variant, inframe deletion, coding sequence variant, non coding transcript variant, intron variant
rs759331139	C>G,T	Likely-pathogenic	Missense variant, coding sequence variant, non coding transcript variant, genic downstream transcript variant
rs759420180	AA>-,AAA	Pathogenic	Coding sequence variant, genic downstream transcript variant, frameshift variant, non coding transcript variant, intron variant
rs759922477	C>G,T	Pathogenic	Splice donor variant, downstream transcript variant, genic downstream transcript variant
rs764875815	C>T	Likely-pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant, non coding transcript variant
rs765044856	C>T	Likely-pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs765088174	T>C	Likely-pathogenic	Coding sequence variant, downstream transcript variant, missense variant, genic downstream transcript variant, non coding transcript variant
rs769473411	G>A	Pathogenic	Coding sequence variant, stop gained, non coding transcript variant
rs772887102	A>C	Pathogenic, likely-pathogenic	Intron variant, coding sequence variant, 5 prime UTR variant, missense variant, non coding transcript variant
rs773838753	GA>-	Pathogenic	Non coding transcript variant, frameshift variant, coding sequence variant
rs775295739	A>C,G	Likely-pathogenic	Non coding transcript variant, genic downstream transcript variant, missense variant, coding sequence variant
rs777942571	G>-	Likely-pathogenic	Non coding transcript variant, 5 prime UTR variant, frameshift variant, intron variant, coding sequence variant
rs781417096	T>-	Pathogenic	Non coding transcript variant, genic downstream transcript variant, frameshift variant, coding sequence variant
rs863224180	A>T	Likely-pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs863224182	->C	Pathogenic	Frameshift variant, coding sequence variant, non coding transcript variant
rs863224183	->A,AA	Pathogenic	Genic downstream transcript variant, coding sequence variant, frameshift variant, downstream transcript variant, non coding transcript variant
rs863224186	G>A	Likely-pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs886041639	C>A	Pathogenic	Genic downstream transcript variant, stop gained, coding sequence variant, intron variant, non coding transcript variant
rs1057522050	A>G,T	Likely-pathogenic	Genic downstream transcript variant, non coding transcript variant, coding sequence variant, missense variant
rs1064795060	CTGGAAAACACGATCCCAGCTGAACT>-	Likely-pathogenic	Genic downstream transcript variant, non coding transcript variant, coding sequence variant, frameshift variant
rs1258569046	A>T	Likely-pathogenic	Coding sequence variant, missense variant, non coding transcript variant
rs1554203400	G>-	Likely-pathogenic	5 prime UTR variant, coding sequence variant, non coding transcript variant, frameshift variant
rs1582264160	G>-	Pathogenic	Genic downstream transcript variant, coding sequence variant, frameshift variant, non coding transcript variant
rs1582576986	A>G	Likely-pathogenic	Missense variant, 5 prime UTR variant, non coding transcript variant, coding sequence variant, intron variant
rs1582712331	AC>-	Pathogenic	Coding sequence variant, 5 prime UTR variant, frameshift variant, non coding transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT027320	hsa-miR-101-3p	Sequencing	20371350
MIRT028668	hsa-miR-30a-5p	Proteomics	18668040
MIRT030355	hsa-miR-26b-5p	Sequencing	20371350
MIRT722414	hsa-miR-499a-3p	HITS-CLIP	19536157
MIRT722413	hsa-miR-499b-3p	HITS-CLIP	19536157
MIRT722412	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT722411	hsa-miR-6086	HITS-CLIP	19536157
MIRT722410	hsa-miR-6499-3p	HITS-CLIP	19536157
MIRT722409	hsa-miR-3689d	HITS-CLIP	19536157
MIRT722407	hsa-miR-6851-5p	HITS-CLIP	19536157
MIRT722408	hsa-miR-7847-3p	HITS-CLIP	19536157
MIRT710075	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT722406	hsa-miR-455-3p	HITS-CLIP	19536157
MIRT722405	hsa-miR-6516-5p	HITS-CLIP	19536157
MIRT710077	hsa-miR-6779-3p	HITS-CLIP	19536157
MIRT516294	hsa-miR-5011-5p	HITS-CLIP	19536157
MIRT710076	hsa-miR-146b-3p	HITS-CLIP	19536157
MIRT516293	hsa-miR-190a-3p	HITS-CLIP	19536157
MIRT710075	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT516294	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707279	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT707278	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT516293	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT516292	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT707277	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT516294	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT516293	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT516292	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT516294	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT516293	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT516292	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT439816	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439816	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT722414	hsa-miR-499a-3p	HITS-CLIP	19536157
MIRT722413	hsa-miR-499b-3p	HITS-CLIP	19536157
MIRT722412	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT722411	hsa-miR-6086	HITS-CLIP	19536157
MIRT722410	hsa-miR-6499-3p	HITS-CLIP	19536157
MIRT722409	hsa-miR-3689d	HITS-CLIP	19536157
MIRT722407	hsa-miR-6851-5p	HITS-CLIP	19536157
MIRT722408	hsa-miR-7847-3p	HITS-CLIP	19536157
MIRT710075	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT722406	hsa-miR-455-3p	HITS-CLIP	19536157
MIRT722405	hsa-miR-6516-5p	HITS-CLIP	19536157
MIRT710077	hsa-miR-6779-3p	HITS-CLIP	19536157
MIRT516294	hsa-miR-5011-5p	HITS-CLIP	19536157
MIRT710076	hsa-miR-146b-3p	HITS-CLIP	19536157
MIRT516293	hsa-miR-190a-3p	HITS-CLIP	19536157
MIRT710075	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT516294	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707279	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT707278	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT516293	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT516292	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT707277	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT516294	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT516293	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT516292	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT516294	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT516293	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT516292	hsa-miR-1277-5p	PAR-CLIP	23446348

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22681889
GO:0004814	Function	Arginine-tRNA ligase activity	IBA	21873635
GO:0004814	Function	Arginine-tRNA ligase activity	TAS
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005524	Function	ATP binding	IEA
GO:0005739	Component	Mitochondrion	IBA	21873635
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006418	Process	TRNA aminoacylation for protein translation	TAS
GO:0006420	Process	Arginyl-tRNA aminoacylation	IBA	21873635
GO:0032543	Process	Mitochondrial translation	IBA	21873635

Other IDs

• MIM: 611524
• HGNC: 21406
• e!Ensembl: ENSG00000146282

Protein

• UniProt ID: Q5T160
• Protein name: Probable arginine--tRNA ligase, mitochondrial (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS)
• Protein function: Catalyzes the attachment of arginine to tRNA(Arg) in a two-step reaction: arginine is first activated by ATP to form Arg-AMP and then transferred to the acceptor end of tRNA(Arg).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00750	tRNA-synt_1d	102 → 449	tRNA synthetases class I (R)	Family
  PF05746	DALR_1	463 → 578	DALR anticodon binding domain	Domain

• Sequence:

  MACGFRRAIACQLSRVLNLPPENLITSISAVPISQKEEVADFQLSVDSLLEKDNDHSRPD
  IQVQAKRLAEKLRCDTVVSEISTGQRTVNFKINRELLTKTVLQQVIEDGSKYGLKSELFS
  GLPQKKIVVEFSSPNVAKKFHVGHLRSTIIGNFIANLKEALGHQVIRINYLGDWGMQFGL
  LGTGFQLFGYEEKLQSNPLQHLFEVYVQVNKEAADDKSVAKAAQEFFQRLELGDVQALSL
  WQKFRDLSIEEYIRVYKRLGVYFDEYSGESFYREKSQEVLKLLESKGLLLKTIKGTAVVD
  LSGNGDPSSICTVMRSDGTSLYATRDLAAAIDRMDKYNFDTMIYVTDKGQKKHFQQVFQM
  LKIMGYDWAERCQHVPFGVVQGMKTRRGDVTFLEDVLNEIQLRMLQNMASIKTTKELKNP
  QETAERVGLAALIIQDFKGLLLSDYKFSWDRVFQSRGDTGVFLQYTHARLHSLEETFGCG
  YLNDFNTACLQEPQSVSILQHLLRFDEVLYKSSQDFQPRHIVSYLLTLSHLAAVAHKTLQ
  IKDSPPEVAGARLHLFKAVRSVLANGMKLLGITPVCRM

• Sequence length: 578

Pathways

KEGG:

Aminoacyl-tRNA biosynthesis

Reactome:

Mitochondrial tRNA aminoacylation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Developmental delay	Global developmental delay	rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291, rs886041382, rs1057518991, rs1057518699, rs753254213, rs748294403, rs762552974, rs1135401795, rs1553121073, rs1553122926, rs1364690005, rs1554086554, rs1554210415, rs1554168326, rs1554776342, rs1553873247, rs1567860112, rs779009256, rs1557447255, rs1564568350, rs780011005, rs1597464953, rs1200336864, rs1569513017, rs1587459606, rs1570332505, rs748888652, rs1575155995, rs2087029320, rs1589669105, rs1601769604, rs1184981709, rs749201074
Epilepsy	Epilepsy	rs113994140, rs119454947, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs1805032, rs387906420, rs121917752, rs121918622, rs121434579, rs1581220270, rs281865564, rs387907313, rs397514564, rs397514670, rs768241563, rs587776973, rs587776974, rs587776975, rs879255234, rs587776976, rs587776977, rs121917993, rs398123588, rs13306758, rs587777363, rs587777364, rs587777458, rs587777459, rs541024038, rs797044545, rs730882240, rs786205703, rs794726859, rs796053126, rs796053035, rs796053216, rs796052839, rs869025201, rs797044999, rs797044998, rs797045045, rs794726762, rs869312971, rs869312972, rs879255652, rs886037938, rs886037958, rs886037959, rs886037960, rs886037961, rs886037962, rs886037965, rs886037966, rs886039245, rs886039246, rs886039251, rs886039252, rs772872014, rs886039253, rs886039256, rs757511744, rs886039261, rs886039263, rs578185749, rs886039266, rs886039268, rs886039269, rs886039273, rs368820286, rs1057518801, rs1057518688, rs1057519107, rs1057519273, rs752753379, rs767795673, rs1057519424, rs755946598, rs760609867, rs1057521066, rs1057524233, rs1060501488, rs1060501487, rs755127868, rs751533302, rs771373457, rs1475605360, rs1555401942, rs1553567864, rs200661329, rs766667249, rs1556607762, rs1555882921, rs1555882867, rs1555900914, rs1553546836, rs77216276, rs755595256, rs1554169267, rs747661902, rs2105890565, rs1021001959, rs1555441032, rs1555439541, rs1556526609, rs1315483224, rs759952667, rs1555885023, rs1553456695, rs1555942720, rs1569083500, rs1559127505, rs1206309859, rs1567139896, rs1567134495, rs1431914212, rs1569166925, rs1569255443, rs1568955379, rs1567152003, rs374158137, rs1567129567, rs1569523728, rs1568991466, rs1569186093, rs1569254004, rs1372605067, rs1569067939, rs1568963062, rs1563959514, rs1569012755, rs1559118914, rs1602338615, rs1596522356, rs1364913665, rs1596522300, rs1596526976, rs1229740428, rs1596385588, rs1596500172, rs1596505517, rs1601925213, rs1601970168, rs1602010382, rs1602903591, rs1603014297, rs1603014708, rs1601875057, rs1601970824, rs1601755632, rs1587393982, rs1592977444, rs1575562076, rs1570998206, rs1588057922, rs1596528731, rs1602349641, rs1587401875, rs2065899210, rs1596526915, rs2093486364, rs2056165149, rs2056100951, rs781482552, rs1899868619, rs1900088045, rs1898675878, rs1898686157, rs1898837245, rs1898844513, rs2082841677, rs2085727988, rs2092933941, rs2091657024, rs1899864955, rs1898844907, rs2083056830, rs2084070588, rs1899713412, rs2082695884, rs1977106116, rs1977105425, rs1443687532	20635367
Pontoneocerebellar hypoplasia	Pontocerebellar Hypoplasia Type 1, Pontocerebellar Hypoplasia Type 6, Congenital pontocerebellar hypoplasia	rs63749985, rs113994152, rs113994153, rs113994154, rs113994150, rs137853063, rs267607036, rs267607035, rs886037629, rs147391618, rs141138948, rs672601331, rs387907196, rs672601332, rs397515426, rs398122918, rs587780333, rs374550999, rs587777391, rs587777392, rs587777393, rs587777394, rs587777395, rs587777465, rs587777466, rs587777616, rs606231285, rs587784476, rs886037738, rs886037739, rs730880294, rs886037740, rs730882145, rs746260871, rs796052019, rs371295780, rs772731615, rs797046052, rs797046051, rs756696262, rs797045567, rs797046057, rs797046054, rs797046055, rs863224183, rs199835443, rs863224182, rs863224186, rs757743894, rs772887102, rs774923951, rs875989844, rs879253779, rs879253780, rs776969714, rs886041639, rs886041316, rs1057518749, rs1057518750, rs1057518887, rs1057519294, rs1057519296, rs1553730885, rs1570621473, rs371848318, rs777030573, rs758153898, rs1064795060, rs777942571, rs1554203400, rs779282547, rs1553230375, rs765088174, rs759922477, rs1554093168, rs755246924, rs1477347690, rs774157225, rs1420939606, rs781417096, rs780563835, rs772263867, rs139632595, rs768997239, rs200594402, rs1160669103, rs759331139, rs1566713184, rs753591864, rs769473411, rs1566696845, rs201467485, rs1258569046, rs1598480419, rs1309003036, rs759420180, rs199728745, rs773838753, rs1582712331, rs772146380, rs1223645705, rs774056037, rs1570621555, rs778263701, rs1557531984, rs750266350, rs1570626350, rs1584071201, rs1582576986, rs1246937494, rs1650621772, rs760433806, rs1447478732, rs1472685858, rs1712612585, rs1256144022, rs774755297, rs752086581, rs1887100431, rs762979613, rs774877872, rs201386427, rs199862050	20952379, 27061686, 27604308, 22086604, 26083569, 20635367, 25356970, 24896178, 26795593, 20635367
Scoliosis	Scoliosis, unspecified	rs1057518828, rs147296805, rs758163506, rs1555613564, rs1596852902, rs1596853067, rs1596853085
Microcephaly	Secondary microcephaly	rs397704721, rs267607176, rs267607177, rs397704725, rs267606717, rs267606718, rs199422202, rs121434311, rs199422203, rs199422126, rs387906274, rs121434305, rs199422125, rs199422135, rs189678019, rs199422184, rs137852994, rs137852995, rs137852996, rs137852997, rs145489194, rs80338860, rs137852494, rs121918609, rs199422207, rs199422206, rs29001566, rs864321658, rs199422138, rs199422139, rs199422141, rs199422144, rs199422147, rs199422151, rs199422152, rs199422153, rs199422157, rs199422159, rs199422160, rs199422161, rs140602858, rs199422164, rs199422165, rs148294838, rs199422134, rs199422168, rs199422172, rs199422173, rs199422131, rs199422177, rs199422180, rs199422185, rs199422186, rs199422187, rs143931757, rs199422189, rs199422192, rs199422194, rs199422195, rs199422196, rs199422197, rs199422199, rs753597039, rs1488084787, rs387906961, rs755862917, rs387907082, rs587776899, rs387907083, rs587776900, rs587776901, rs387907084, rs863223322, rs764201220, rs202247811, rs763915472, rs587776986, rs587777036, rs398122971, rs374351172, rs373278668, rs398122976, rs121909123, rs587783393, rs730882076, rs587783211, rs144716013, rs606231255, rs587783215, rs587783216, rs587783220, rs587783221, rs587783225, rs587783227, rs587783228, rs587783230, rs587783238, rs587783239, rs587783240, rs587783245, rs587783247, rs587783248, rs587783258, rs587783259, rs587783263, rs587783265, rs587783268, rs587783269, rs587783272, rs587783275, rs587783277, rs587783278, rs587783280, rs587783282, rs587783283, rs587783285, rs587783287, rs587783288, rs587783289, rs587783292, rs587783295, rs587784452, rs587783741, rs587783735, rs587783392, rs587783390, rs587783387, rs587783410, rs202058504, rs587783423, rs587783421, rs587783414, rs587784553, rs587784558, rs587784546, rs587784549, rs587784554, rs587784412, rs876661307, rs869025200, rs747831095, rs748529285, rs797045316, rs797045315, rs797045314, rs759632528, rs797045313, rs797045311, rs754282058, rs797045441, rs797045454, rs797045430, rs869312853, rs797046109, rs767399782, rs863225127, rs863225464, rs863225465, rs780270096, rs864321621, rs864321620, rs775277800, rs879253817, rs869312824, rs761447719, rs753406334, rs147622433, rs199422137, rs879255522, rs879255524, rs879255523, rs886037892, rs886037893, rs886037894, rs886037895, rs199422169, rs886041709, rs886041282, rs138228629, rs759188041, rs769688376, rs1057517688, rs1057519087, rs1057518268, rs933106143, rs201362977, rs754909135, rs1057520873, rs1060499758, rs1060499757, rs199422146, rs748016594, rs1085307120, rs763715733, rs1064795945, rs763800571, rs1554728351, rs1553227021, rs555866170, rs1553895368, rs1334947797, rs769818500, rs1321892596, rs1553227645, rs1404276011, rs1553228275, rs1554471681, rs1554496609, rs1555420891, rs1555418825, rs587784548, rs1555723585, rs199736219, rs745997770, rs765275884, rs1553924800, rs1554730137, rs1229568621, rs1482100822, rs979186313, rs758157294, rs1555294652, rs1555299107, rs1553264033, rs1553259539, rs1553254322, rs1553259528, rs981349334, rs1553264036, rs1553253022, rs754267846, rs776034810, rs1342429887, rs752140135, rs1006898944, rs571640983, rs1477524771, rs763909256, rs199910503, rs1553223496, rs759663956, rs1553446603, rs1555139372, rs1555143325, rs1350194762, rs1555141158, rs1553225179, rs769481947, rs769364943, rs748011724, rs1334301723, rs746341112, rs149225624, rs765113367, rs1567024512, rs142865061, rs772050241, rs201721894, rs1557966012, rs1379578836, rs1568334868, rs1185537869, rs1602333390, rs1163303148, rs774338373, rs770540184, rs1571600045, rs1571601267, rs1571602991, rs1588472215, rs1599841026, rs1558328287, rs1571600860, rs1571596976, rs1309880692, rs1435239428, rs1588634016, rs1751797979, rs1810830776, rs1815354949, rs1949984655, rs886039658, rs1943461045, rs777711720, rs2031759596, rs1555710223, rs1221031683, rs774069989, rs2058919680, rs1170413397, rs1213710245, rs1599851667, rs1599760058, rs1971033478, rs746967357

Unknown
Disease name	Disease term	dbSNP ID	References
Brainstem atrophy	Atrophy/Degeneration affecting the brainstem
Cerebellar atrophy	Cerebellar atrophy
Cerebellar hypoplasia	Cerebellar Hypoplasia
Cerebral atrophy	Cerebral atrophy
Meibomian cyst	Meibomian Cyst