PRDM10 (PR/SET domain 10)

Gene

• Entrez ID: 56980
• Gene name: PR/SET domain 10
• Gene symbol: PRDM10
• Synonyms: BHD2, PFM7, TRIS
• Chromosome: 11
• Chromosome location: 11q24.3
• Summary: The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell diff

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT619472	hsa-miR-6826-5p	HITS-CLIP	19536157
MIRT619471	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT619470	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT619469	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT713839	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT713838	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT638410	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT700631	hsa-miR-1178-5p	HITS-CLIP	23313552
MIRT700630	hsa-miR-1182	HITS-CLIP	23313552
MIRT700629	hsa-miR-194-3p	HITS-CLIP	23313552
MIRT700628	hsa-miR-1250-3p	HITS-CLIP	23313552
MIRT700627	hsa-miR-5191	HITS-CLIP	23313552
MIRT700626	hsa-miR-505-3p	HITS-CLIP	23313552
MIRT700625	hsa-miR-374b-3p	HITS-CLIP	23313552
MIRT700624	hsa-miR-1305	HITS-CLIP	23313552
MIRT619476	hsa-miR-4282	HITS-CLIP	23824327
MIRT619475	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT619474	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT619473	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT619472	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT619471	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT619470	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT638410	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT666816	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT619476	hsa-miR-4282	HITS-CLIP	23824327
MIRT619475	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT619474	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT619473	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT619472	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT619471	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT619470	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT638410	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT058532	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT646468	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT646467	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT646466	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT646465	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT646464	hsa-miR-3671	HITS-CLIP	23824327
MIRT646463	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT646462	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT646461	hsa-miR-5590-5p	HITS-CLIP	23824327
MIRT646460	hsa-miR-4659a-5p	HITS-CLIP	23824327
MIRT646459	hsa-miR-4659b-5p	HITS-CLIP	23824327
MIRT646458	hsa-miR-607	HITS-CLIP	23824327
MIRT646457	hsa-miR-4776-3p	HITS-CLIP	23824327
MIRT619472	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT619471	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT619470	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT619469	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT638410	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT619476	hsa-miR-4282	HITS-CLIP	23824327
MIRT619475	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT619474	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT619473	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT619472	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT619471	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT619470	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT619469	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT544464	hsa-miR-3185	PAR-CLIP	21572407
MIRT619472	hsa-miR-6826-5p	HITS-CLIP	19536157
MIRT619471	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT619470	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT619469	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT713839	hsa-miR-4768-5p	HITS-CLIP	19536157
MIRT713838	hsa-miR-6833-3p	HITS-CLIP	19536157
MIRT638410	hsa-miR-6809-3p	HITS-CLIP	19536157
MIRT700631	hsa-miR-1178-5p	HITS-CLIP	23313552
MIRT700630	hsa-miR-1182	HITS-CLIP	23313552
MIRT700629	hsa-miR-194-3p	HITS-CLIP	23313552
MIRT700628	hsa-miR-1250-3p	HITS-CLIP	23313552
MIRT700627	hsa-miR-5191	HITS-CLIP	23313552
MIRT700626	hsa-miR-505-3p	HITS-CLIP	23313552
MIRT700625	hsa-miR-374b-3p	HITS-CLIP	23313552
MIRT700624	hsa-miR-1305	HITS-CLIP	23313552
MIRT619476	hsa-miR-4282	HITS-CLIP	23824327
MIRT619475	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT619474	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT619473	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT619472	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT619471	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT619470	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT638410	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT666816	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT619476	hsa-miR-4282	HITS-CLIP	23824327
MIRT619475	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT619474	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT619473	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT619472	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT619471	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT619470	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT638410	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT058532	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT646468	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT646467	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT646466	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT646465	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT646464	hsa-miR-3671	HITS-CLIP	23824327
MIRT646463	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT646462	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT646461	hsa-miR-5590-5p	HITS-CLIP	23824327
MIRT646460	hsa-miR-4659a-5p	HITS-CLIP	23824327
MIRT646459	hsa-miR-4659b-5p	HITS-CLIP	23824327
MIRT646458	hsa-miR-607	HITS-CLIP	23824327
MIRT646457	hsa-miR-4776-3p	HITS-CLIP	23824327
MIRT619472	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT619471	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT619470	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT619469	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT638410	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT619476	hsa-miR-4282	HITS-CLIP	23824327
MIRT619475	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT619474	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT619473	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT619472	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT619471	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT619470	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT619469	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT544464	hsa-miR-3185	PAR-CLIP	21572407
MIRT1259863	hsa-miR-1237	CLIP-seq
MIRT1259864	hsa-miR-1248	CLIP-seq
MIRT1259865	hsa-miR-140-3p	CLIP-seq
MIRT1259866	hsa-miR-3156-5p	CLIP-seq
MIRT1259867	hsa-miR-331-3p	CLIP-seq
MIRT1259868	hsa-miR-3612	CLIP-seq
MIRT1259869	hsa-miR-3679-3p	CLIP-seq
MIRT1259870	hsa-miR-3689a-3p	CLIP-seq
MIRT1259871	hsa-miR-3689c	CLIP-seq
MIRT1259872	hsa-miR-4728-5p	CLIP-seq
MIRT1259873	hsa-miR-4766-5p	CLIP-seq
MIRT1259874	hsa-miR-650	CLIP-seq
MIRT1259875	hsa-miR-1236	CLIP-seq
MIRT1259876	hsa-miR-1243	CLIP-seq
MIRT1259877	hsa-miR-1276	CLIP-seq
MIRT1259878	hsa-miR-1290	CLIP-seq
MIRT1259879	hsa-miR-3167	CLIP-seq
MIRT1259880	hsa-miR-4463	CLIP-seq
MIRT1259881	hsa-miR-4659a-3p	CLIP-seq
MIRT1259882	hsa-miR-4659b-3p	CLIP-seq
MIRT1259883	hsa-miR-520d-5p	CLIP-seq
MIRT1259884	hsa-miR-524-5p	CLIP-seq
MIRT1259885	hsa-miR-548u	CLIP-seq
MIRT1259886	hsa-miR-579	CLIP-seq
MIRT1259887	hsa-miR-600	CLIP-seq
MIRT1259888	hsa-miR-664	CLIP-seq
MIRT1259889	hsa-miR-876-5p	CLIP-seq
MIRT1259890	hsa-miR-106a	CLIP-seq
MIRT1259891	hsa-miR-106b	CLIP-seq
MIRT1259892	hsa-miR-142-5p	CLIP-seq
MIRT1259893	hsa-miR-155	CLIP-seq
MIRT1259894	hsa-miR-17	CLIP-seq
MIRT1259895	hsa-miR-20a	CLIP-seq
MIRT1259896	hsa-miR-20b	CLIP-seq
MIRT1259897	hsa-miR-221	CLIP-seq
MIRT1259898	hsa-miR-222	CLIP-seq
MIRT1259899	hsa-miR-3129-3p	CLIP-seq
MIRT1259900	hsa-miR-338-5p	CLIP-seq
MIRT1259901	hsa-miR-3609	CLIP-seq
MIRT1259902	hsa-miR-365	CLIP-seq
MIRT1259903	hsa-miR-4330	CLIP-seq
MIRT1259904	hsa-miR-4643	CLIP-seq
MIRT1259905	hsa-miR-466	CLIP-seq
MIRT1259906	hsa-miR-4666-5p	CLIP-seq
MIRT1259907	hsa-miR-4717-5p	CLIP-seq
MIRT1259908	hsa-miR-4789-3p	CLIP-seq
MIRT1259909	hsa-miR-4794	CLIP-seq
MIRT1259910	hsa-miR-4796-3p	CLIP-seq
MIRT1259911	hsa-miR-519d	CLIP-seq
MIRT1259912	hsa-miR-548ah	CLIP-seq
MIRT1259913	hsa-miR-892b	CLIP-seq
MIRT1259914	hsa-miR-93	CLIP-seq
MIRT1259900	hsa-miR-338-5p	CLIP-seq
MIRT2076570	hsa-miR-4711-3p	CLIP-seq
MIRT1259886	hsa-miR-579	CLIP-seq
MIRT1259892	hsa-miR-142-5p	CLIP-seq
MIRT1259897	hsa-miR-221	CLIP-seq
MIRT1259898	hsa-miR-222	CLIP-seq
MIRT1259900	hsa-miR-338-5p	CLIP-seq
MIRT2303178	hsa-miR-4267	CLIP-seq
MIRT2303179	hsa-miR-4318	CLIP-seq
MIRT1259907	hsa-miR-4717-5p	CLIP-seq
MIRT1259909	hsa-miR-4794	CLIP-seq
MIRT1259913	hsa-miR-892b	CLIP-seq
MIRT2303180	hsa-miR-9	CLIP-seq
MIRT2599859	hsa-miR-1269	CLIP-seq
MIRT2599860	hsa-miR-1269b	CLIP-seq
MIRT2599861	hsa-miR-1288	CLIP-seq
MIRT2599862	hsa-miR-139-5p	CLIP-seq
MIRT2599863	hsa-miR-3618	CLIP-seq
MIRT2599864	hsa-miR-3654	CLIP-seq
MIRT2599865	hsa-miR-378	CLIP-seq
MIRT2599866	hsa-miR-378b	CLIP-seq
MIRT2599867	hsa-miR-378c	CLIP-seq
MIRT2599868	hsa-miR-378d	CLIP-seq
MIRT2599869	hsa-miR-378e	CLIP-seq
MIRT2599870	hsa-miR-378f	CLIP-seq
MIRT2599871	hsa-miR-378h	CLIP-seq
MIRT2599872	hsa-miR-378i	CLIP-seq
MIRT2599873	hsa-miR-422a	CLIP-seq
MIRT2599874	hsa-miR-4515	CLIP-seq
MIRT2599875	hsa-miR-4740-5p	CLIP-seq
MIRT1259909	hsa-miR-4794	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IDA	31143550
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005634	Component	Nucleus	IBA	21873635
GO:0008168	Function	Methyltransferase activity	IEA
GO:0010468	Process	Regulation of gene expression	IBA	21873635
GO:0017053	Component	Transcription repressor complex	IDA	31143550
GO:0032259	Process	Methylation	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA	21873635
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	31143550
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 618319
• HGNC: 13995
• e!Ensembl: ENSG00000170325

Protein

• UniProt ID: Q9NQV6
• Protein name: PR domain zinc finger protein 10 (PR domain-containing protein 10) (Tristanin)
• Protein function: Transcriptional activator, essential for early embryonic development and survival of embryonic stem cells (ESCs) (By similarity). Supports cell growth and survival during early development by transcriptionally activating the expression of the tr
• PDB: 3IHX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12171	zf-C2H2_jaz	354 → 378	Zinc-finger double-stranded RNA-binding	Family
  PF16638	Tristanin_u2	380 → 510		Disordered
  PF12874	zf-met	560 → 580		Domain
  PF00096	zf-C2H2	644 → 666	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	672 → 695	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	772 → 795	Zinc finger, C2H2 type	Domain

• Sequence:

  MDSKDESSHVWPTSAEHEQNAAQVHFVPDTGTVAQIVYTDDQVRPPQQVVYTADGASYTS
  VDGPEHTLVYIHPVEAAQTLFTDPGQVAYVQQDATAQQASLPVHNQVLPSIESVDGSDPL
  ATLQTPLGRLEAKEEEDEDEDEDTEEDEEEDGEDTDLDDWEPDPPRPFDPHDLWCEECNN
  AHASVCPKHGPLHPIPNRPVLTRARASLPLVLYIDRFLGGVFSKRRIPKRTQFGPVEGPL
  VRGSELKDCYIHLKVSLDKGDRKERDLHEDLWFELSDETLCNWMMFVRPAQNHLEQNLVA
  YQYGHHVYYTTIKNVEPKQELKVWYAASYAEFVNQKIHDISEEERKVLREQEKNWPCYEC
  NRRFISSEQLQQHLNSHDEKLDVFSRTRGRGRGRGKRRFGPGRRPGRPPKFIRLEITSEN
  GEKSDDGTQDLLHFPTKEQFDEAEPATLNGLDQPEQTTIPIPQLPQETQSSLEHEPETHT
  LHLQPQHEESVVPTQSTLTADDMRRAKRIRLELQNAALQHLFIRKSFRPFKCLQCGKAFR
  EKDKLDQHLRFHGREGNCPLTCDLCNKGFISSTSLESHMKLHSDQKTYSCIFCPESFDRL
  DLLKDHVAIHINDGYFTCPTCKKRFPDFIQVKKHVRSFHSEKIYQCTECDKAFCRPDKLR
  LHMLRHSDRKDFLCSTCGKQFKRKDKLREHMQRMHNPEREAKKADRISRSKTFKPRITST
  DYDSFTFKCRLCMMGFRRRGMLVNHLSKRHPDMKIEEVPELTLPIIKPNRDYFCQYCDKV
  YKSASKRKAHILKNHPGAELPPSIRKLRPAGPGEPDPMLSTHTQLTGTIATPPVCCPHCS
  KQYSSKTKMVQHIRKKHPEFAQLSNTIHTPLTTAVISATPAVLTTDSATGETVVTTDLLT
  QAMTELSQTLTTDYRTPQGDYQRIQYIPVSQSASGLQQPQHIQLQVVQVASATSPHQSQQ
  STVDVGQLHDPQPYPQHAIQVQHIQVSGQPLSPSAQQAQQGLSPSHIQGSSSTQGQALQQ
  QQQQQQNSSVQHTYLPSAWNSFRGYSSEIQMMTLPPGQFVITDSGVATPVTTGQVKAVTS
  GHYVLSESQSELEEKQTSALSGGVQVEPPAHSDSLDPQTNSQQQTTQYIITTTTNGNGSS
  EVHITKP

• Sequence length: 1147

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	30251476