DUSP22 (dual specificity phosphatase 22)

Gene

• Entrez ID: 56940
• Gene name: Dual specificity phosphatase 22
• Gene symbol: DUSP22
• Synonyms: JKAP, JSP-1, JSP1, LMW-DSP2, LMWDSP2, MKP-x, MKPX, VHX
• Chromosome: 6
• Chromosome location: 6p25.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019217	hsa-miR-335-5p	Microarray	18185580
MIRT030306	hsa-miR-26b-5p	Microarray	19088304
MIRT658847	hsa-miR-6856-3p	HITS-CLIP	23824327
MIRT658846	hsa-miR-449b-3p	HITS-CLIP	23824327
MIRT658845	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT658844	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT658843	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT658842	hsa-miR-139-5p	HITS-CLIP	23824327
MIRT658841	hsa-miR-4497	HITS-CLIP	23824327
MIRT658840	hsa-miR-1180-3p	HITS-CLIP	23824327
MIRT658839	hsa-miR-4664-3p	HITS-CLIP	23824327
MIRT658847	hsa-miR-6856-3p	HITS-CLIP	23824327
MIRT658846	hsa-miR-449b-3p	HITS-CLIP	23824327
MIRT658845	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT658844	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT658843	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT658842	hsa-miR-139-5p	HITS-CLIP	23824327
MIRT658841	hsa-miR-4497	HITS-CLIP	23824327
MIRT658840	hsa-miR-1180-3p	HITS-CLIP	23824327
MIRT658839	hsa-miR-4664-3p	HITS-CLIP	23824327
MIRT2215813	hsa-miR-4756-3p	CLIP-seq
MIRT2387154	hsa-miR-548aa	CLIP-seq
MIRT2520030	hsa-miR-1226	CLIP-seq
MIRT2520031	hsa-miR-1271	CLIP-seq
MIRT2520032	hsa-miR-182	CLIP-seq
MIRT2520033	hsa-miR-186	CLIP-seq
MIRT2520034	hsa-miR-29a	CLIP-seq
MIRT2520035	hsa-miR-29b	CLIP-seq
MIRT2520036	hsa-miR-29c	CLIP-seq
MIRT2520037	hsa-miR-3065-3p	CLIP-seq
MIRT2520038	hsa-miR-3133	CLIP-seq
MIRT2520039	hsa-miR-3140-3p	CLIP-seq
MIRT2520040	hsa-miR-3168	CLIP-seq
MIRT2520041	hsa-miR-362-5p	CLIP-seq
MIRT2520042	hsa-miR-3664-5p	CLIP-seq
MIRT2520043	hsa-miR-3936	CLIP-seq
MIRT2520044	hsa-miR-4450	CLIP-seq
MIRT2520045	hsa-miR-450b-5p	CLIP-seq
MIRT2520046	hsa-miR-4519	CLIP-seq
MIRT2520047	hsa-miR-4639-5p	CLIP-seq
MIRT2520048	hsa-miR-4668-5p	CLIP-seq
MIRT2520049	hsa-miR-4744	CLIP-seq
MIRT2520050	hsa-miR-4753-3p	CLIP-seq
MIRT2520051	hsa-miR-4768-5p	CLIP-seq
MIRT2520052	hsa-miR-4781-3p	CLIP-seq
MIRT2520053	hsa-miR-491-5p	CLIP-seq
MIRT2520054	hsa-miR-500b	CLIP-seq
MIRT2520055	hsa-miR-501-5p	CLIP-seq
MIRT2520056	hsa-miR-513c	CLIP-seq
MIRT2520057	hsa-miR-514b-5p	CLIP-seq
MIRT2520058	hsa-miR-618	CLIP-seq
MIRT2520059	hsa-miR-629	CLIP-seq
MIRT2520060	hsa-miR-885-3p	CLIP-seq
MIRT2520061	hsa-miR-96	CLIP-seq
MIRT2520043	hsa-miR-3936	CLIP-seq
MIRT2520044	hsa-miR-4450	CLIP-seq
MIRT2520046	hsa-miR-4519	CLIP-seq
MIRT2520048	hsa-miR-4668-5p	CLIP-seq
MIRT2520053	hsa-miR-491-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	16636663
GO:0004725	Function	Protein tyrosine phosphatase activity	IDA	24714587
GO:0004726	Function	Non-membrane spanning protein tyrosine phosphatase activity	IDA	20018849
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	20018849
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	24714587
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IBA	21873635
GO:0008138	Function	Protein tyrosine/serine/threonine phosphatase activity	IEA
GO:0030336	Process	Negative regulation of cell migration	IMP	20018849
GO:0031941	Component	Filamentous actin	IDA	20018849
GO:0035335	Process	Peptidyl-tyrosine dephosphorylation	IDA	20018849
GO:0042127	Process	Regulation of cell population proliferation	IBA	21873635
GO:0046330	Process	Positive regulation of JNK cascade	IBA	21873635
GO:0051895	Process	Negative regulation of focal adhesion assembly	IDA	20018849
GO:0061851	Component	Leading edge of lamellipodium	IDA	20018849
GO:0071364	Process	Cellular response to epidermal growth factor stimulus	IDA	20018849
GO:0106306	Function	Protein serine phosphatase activity	IEA
GO:0106307	Function	Protein threonine phosphatase activity	IEA
GO:1903996	Process	Negative regulation of non-membrane spanning protein tyrosine kinase activity	IMP	20018849
GO:1990782	Function	Protein tyrosine kinase binding	IPI	24714587

Other IDs

• MIM: 616778
• HGNC: 16077
• e!Ensembl: ENSG00000112679

Protein

• UniProt ID: Q9NRW4
• Protein name: Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) (JNK pathway associated phosphatase) (JKAP) (JNK-stimulatory phosphatase-1) (JSP-1) (Low molecular weight dual specificity phosphatase 2) (LMW-DSP2) (Mitogen-activated protein kinase phos
• Protein function: Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues (PubMed:24714587, PubMed:38225265). Activates the JNK signaling pathway (PubMed:11717427). Inhibits T-cell receptor signaling a
• PDB: 1WRM, 4WOH, 6L1S, 6LMY, 6LOT, 6LOU, 6LVQ, 7C8S
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00782	DSPc	12 → 141	Dual specificity phosphatase, catalytic domain	Domain

• Sequence:

  MGNGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKYLCIPAADSPS
  QNLTRHFKESIKFIHECRLRGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRA
  GRSCANPNVGFQRQLQEFEKHEVHQYRQWLKEEYGESPLQDAEEAKNILAAPGILKFWAF
  LRRL

• Sequence length: 184

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Alopecia	Alopecia		28196072