LXN (latexin)

Gene

• Entrez ID: 56925
• Gene name: Latexin
• Gene symbol: LXN
• Synonyms: ECI, TCI
• Chromosome: 3
• Chromosome location: 3q25.32
• Summary: This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. The encoded protein, latexin, downregulates the population size of hematopoietic stem cells. This protein is found to be downregulated in cancer cells because o

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049272	hsa-miR-92a-3p	CLASH	23622248
MIRT1122687	hsa-miR-106a	CLIP-seq
MIRT1122688	hsa-miR-106b	CLIP-seq
MIRT1122689	hsa-miR-142-5p	CLIP-seq
MIRT1122690	hsa-miR-145	CLIP-seq
MIRT1122691	hsa-miR-17	CLIP-seq
MIRT1122692	hsa-miR-1825	CLIP-seq
MIRT1122693	hsa-miR-199a-5p	CLIP-seq
MIRT1122694	hsa-miR-199b-5p	CLIP-seq
MIRT1122695	hsa-miR-20a	CLIP-seq
MIRT1122696	hsa-miR-20b	CLIP-seq
MIRT1122697	hsa-miR-3117-5p	CLIP-seq
MIRT1122698	hsa-miR-3122	CLIP-seq
MIRT1122699	hsa-miR-3149	CLIP-seq
MIRT1122700	hsa-miR-340	CLIP-seq
MIRT1122701	hsa-miR-3609	CLIP-seq
MIRT1122702	hsa-miR-3913-5p	CLIP-seq
MIRT1122703	hsa-miR-410	CLIP-seq
MIRT1122704	hsa-miR-450b-3p	CLIP-seq
MIRT1122705	hsa-miR-4729	CLIP-seq
MIRT1122706	hsa-miR-4796-3p	CLIP-seq
MIRT1122707	hsa-miR-519d	CLIP-seq
MIRT1122708	hsa-miR-548ah	CLIP-seq
MIRT1122709	hsa-miR-769-3p	CLIP-seq
MIRT1122710	hsa-miR-93	CLIP-seq
MIRT1122689	hsa-miR-142-5p	CLIP-seq
MIRT1122697	hsa-miR-3117-5p	CLIP-seq
MIRT1122698	hsa-miR-3122	CLIP-seq
MIRT1122700	hsa-miR-340	CLIP-seq
MIRT2034678	hsa-miR-3617	CLIP-seq
MIRT1122702	hsa-miR-3913-5p	CLIP-seq
MIRT1122704	hsa-miR-450b-3p	CLIP-seq
MIRT2034679	hsa-miR-4757-5p	CLIP-seq
MIRT2034680	hsa-miR-641	CLIP-seq
MIRT1122709	hsa-miR-769-3p	CLIP-seq
MIRT1122697	hsa-miR-3117-5p	CLIP-seq
MIRT1122698	hsa-miR-3122	CLIP-seq
MIRT1122702	hsa-miR-3913-5p	CLIP-seq
MIRT1122704	hsa-miR-450b-3p	CLIP-seq
MIRT1122709	hsa-miR-769-3p	CLIP-seq
MIRT2564194	hsa-miR-1183	CLIP-seq
MIRT2564195	hsa-miR-1284	CLIP-seq
MIRT1122689	hsa-miR-142-5p	CLIP-seq
MIRT1122697	hsa-miR-3117-5p	CLIP-seq
MIRT1122698	hsa-miR-3122	CLIP-seq
MIRT1122699	hsa-miR-3149	CLIP-seq
MIRT2564196	hsa-miR-3168	CLIP-seq
MIRT1122700	hsa-miR-340	CLIP-seq
MIRT1122702	hsa-miR-3913-5p	CLIP-seq
MIRT1122704	hsa-miR-450b-3p	CLIP-seq
MIRT2564197	hsa-miR-4642	CLIP-seq
MIRT2034679	hsa-miR-4757-5p	CLIP-seq
MIRT2564198	hsa-miR-561	CLIP-seq
MIRT1122709	hsa-miR-769-3p	CLIP-seq
MIRT2564194	hsa-miR-1183	CLIP-seq
MIRT2564195	hsa-miR-1284	CLIP-seq
MIRT1122689	hsa-miR-142-5p	CLIP-seq
MIRT1122697	hsa-miR-3117-5p	CLIP-seq
MIRT1122698	hsa-miR-3122	CLIP-seq
MIRT1122699	hsa-miR-3149	CLIP-seq
MIRT2564196	hsa-miR-3168	CLIP-seq
MIRT1122700	hsa-miR-340	CLIP-seq
MIRT1122702	hsa-miR-3913-5p	CLIP-seq
MIRT1122704	hsa-miR-450b-3p	CLIP-seq
MIRT2564197	hsa-miR-4642	CLIP-seq
MIRT2034679	hsa-miR-4757-5p	CLIP-seq
MIRT2564198	hsa-miR-561	CLIP-seq
MIRT1122709	hsa-miR-769-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
KLF4	Repression	23364479
NANOG	Repression	23364479

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0005737	Component	Cytoplasm	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0008191	Function	Metalloendopeptidase inhibitor activity	IBA	21873635
GO:0008201	Function	Heparin binding	IEA
GO:0010951	Process	Negative regulation of endopeptidase activity	IEA
GO:0050965	Process	Detection of temperature stimulus involved in sensory perception of pain	IEA

Other IDs

• MIM: 609305
• HGNC: 13347
• e!Ensembl: ENSG00000079257

Protein

• UniProt ID: Q9BS40
• Protein name: Latexin (Endogenous carboxypeptidase inhibitor) (ECI) (Protein MUM) (Tissue carboxypeptidase inhibitor) (TCI)
• Protein function: Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.
• PDB: 2BO9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06907	Latexin	3 → 219	Latexin	Family

• Sequence:

  MEIPPTNYPASRAALVAQNYINYQQGTPHRVFEVQKVKQASMEDIPGRGHKYHLKFAVEE
  IIQKQVKVNCTAEVLYPSTGQETAPEVNFTFEGETGKNPDEEDNTFYQRLKSMKEPLEAQ
  NIPDNFGNVSPEMTLVLHLAWVACGYIIWQNSTEDTWYKMVKIQTVKQVQRNDDFIELDY
  TILLHNIASQEIIPWQMQVLWHPQYGTKVKHNSRLPKEVQLE

• Sequence length: 222

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Combined oxidative phosphorylation deficiency	Combined Oxidative Phosphorylation Deficiency 1	rs587776508, rs576462794, rs118203917, rs387906327, rs139430866, rs387906962, rs138119149, rs387907061, rs1562800908, rs397515421, rs397514598, rs397514610, rs397514611, rs397514612, rs201431517, rs397514613, rs397514614, rs200286768, rs397515463, rs397515464, rs397515465, rs397515466, rs587777218, rs587777244, rs587777417, rs587777418, rs587777419, rs587777583, rs587777584, rs587777585, rs587777589, rs587777591, rs587777593, rs587777594, rs115079861, rs587777788, rs144972972, rs606231472, rs869320746, rs886037734, rs730880255, rs886037735, rs886037736, rs730882154, rs730882155, rs794726869, rs114638163, rs143712760, rs780383722, rs200105202, rs1554169353, rs751459058, rs775690041, rs863224897, rs863225449, rs869025313, rs869025314, rs869025315, rs781798317, rs754022333, rs869320703, rs869320704, rs771894262, rs764427452, rs879255657, rs778100619, rs759477396, rs1057518742, rs1057518743, rs1057517685, rs1057519299, rs1057523346, rs1057524183, rs1060502161, rs184469579, rs1064794140, rs755122704, rs1064797230, rs202183509, rs1131691396, rs1131692037, rs1161932777, rs144042123, rs777725264, rs563189672, rs763672163, rs746538436, rs1554042187, rs767427194, rs1555532483, rs1394499137, rs1555532484, rs763658299, rs763770476, rs199863563, rs148620369, rs1554147776, rs761385155, rs1555575927, rs1555576642, rs1554169280, rs1407198979, rs1274363168, rs1555726849, rs770871640, rs1555404423, rs924099073, rs775439829, rs1554268077, rs1308121771, rs1047420796, rs1322974029, rs751069628, rs368934219, rs761709212, rs1555342802, rs761334309, rs1554116357, rs536000212, rs565910322, rs376766195, rs1562168768, rs763443331, rs1370579526, rs755068980, rs1567773277, rs761097220, rs780533096, rs746356243, rs1559114055, rs752550279, rs1559094461, rs146988468, rs1561990552, rs1298860043, rs746746116, rs1568293849, rs1559359546, rs1561938413, rs565224393, rs1565216037, rs1035101172, rs1565235204, rs763770414, rs764714439, rs777185638, rs1169927428, rs1229314240, rs1429774361, rs374954001, rs1599560256, rs1582724664, rs1574663066, rs778120270, rs1574675683, rs1365308037, rs1582970514, rs777028011, rs1582957532, rs1170907347, rs773688171, rs1777047446, rs947204455, rs1049082567, rs754537066, rs758094541, rs1689552727, rs2077262520, rs748779965, rs1785349774
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	17145863