EXOSC5 (exosome component 5)

Gene

• Entrez ID: 56915
• Gene name: Exosome component 5
• Gene symbol: EXOSC5
• Synonyms: CABAC, RRP41B, RRP46, Rrp46p, hRrp46p, p12B
• Chromosome: 19
• Chromosome location: 19q13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049878	hsa-miR-31-5p	CLASH	23622248
MIRT973220	hsa-miR-1233	CLIP-seq
MIRT973221	hsa-miR-1273g	CLIP-seq
MIRT973222	hsa-miR-146b-3p	CLIP-seq
MIRT973223	hsa-miR-1972	CLIP-seq
MIRT973224	hsa-miR-3922-5p	CLIP-seq
MIRT973225	hsa-miR-409-5p	CLIP-seq
MIRT973226	hsa-miR-4286	CLIP-seq
MIRT973227	hsa-miR-4488	CLIP-seq
MIRT973228	hsa-miR-4675	CLIP-seq
MIRT973229	hsa-miR-4697-5p	CLIP-seq
MIRT973230	hsa-miR-4741	CLIP-seq
MIRT973231	hsa-miR-513a-5p	CLIP-seq
MIRT1988364	hsa-miR-3121-5p	CLIP-seq
MIRT1988365	hsa-miR-3670	CLIP-seq
MIRT1988366	hsa-miR-4448	CLIP-seq
MIRT1988367	hsa-miR-587	CLIP-seq
MIRT2222824	hsa-miR-4775	CLIP-seq
MIRT2526529	hsa-miR-1205	CLIP-seq
MIRT973220	hsa-miR-1233	CLIP-seq
MIRT973221	hsa-miR-1273g	CLIP-seq
MIRT2526530	hsa-miR-1293	CLIP-seq
MIRT2526531	hsa-miR-138	CLIP-seq
MIRT973222	hsa-miR-146b-3p	CLIP-seq
MIRT2526532	hsa-miR-1587	CLIP-seq
MIRT973223	hsa-miR-1972	CLIP-seq
MIRT2526533	hsa-miR-3155	CLIP-seq
MIRT2526534	hsa-miR-3155b	CLIP-seq
MIRT2526535	hsa-miR-3612	CLIP-seq
MIRT2526536	hsa-miR-378g	CLIP-seq
MIRT2526537	hsa-miR-3919	CLIP-seq
MIRT973224	hsa-miR-3922-5p	CLIP-seq
MIRT2526538	hsa-miR-3977	CLIP-seq
MIRT973225	hsa-miR-409-5p	CLIP-seq
MIRT2526539	hsa-miR-4278	CLIP-seq
MIRT973226	hsa-miR-4286	CLIP-seq
MIRT2526540	hsa-miR-4443	CLIP-seq
MIRT2526541	hsa-miR-4481	CLIP-seq
MIRT2526542	hsa-miR-4483	CLIP-seq
MIRT2526543	hsa-miR-4492	CLIP-seq
MIRT2526544	hsa-miR-4498	CLIP-seq
MIRT2526545	hsa-miR-4505	CLIP-seq
MIRT2526546	hsa-miR-4641	CLIP-seq
MIRT2526547	hsa-miR-4656	CLIP-seq
MIRT973228	hsa-miR-4675	CLIP-seq
MIRT2526548	hsa-miR-4708-3p	CLIP-seq
MIRT2526549	hsa-miR-4716-3p	CLIP-seq
MIRT973230	hsa-miR-4741	CLIP-seq
MIRT2526550	hsa-miR-4745-5p	CLIP-seq
MIRT2526551	hsa-miR-4756-3p	CLIP-seq
MIRT2526552	hsa-miR-4758-5p	CLIP-seq
MIRT2526553	hsa-miR-4797-5p	CLIP-seq
MIRT2526554	hsa-miR-484	CLIP-seq
MIRT973231	hsa-miR-513a-5p	CLIP-seq
MIRT2526555	hsa-miR-558	CLIP-seq
MIRT2526556	hsa-miR-650	CLIP-seq
MIRT2526557	hsa-miR-762	CLIP-seq
MIRT2526529	hsa-miR-1205	CLIP-seq
MIRT973220	hsa-miR-1233	CLIP-seq
MIRT973221	hsa-miR-1273g	CLIP-seq
MIRT2526531	hsa-miR-138	CLIP-seq
MIRT973222	hsa-miR-146b-3p	CLIP-seq
MIRT2526532	hsa-miR-1587	CLIP-seq
MIRT973223	hsa-miR-1972	CLIP-seq
MIRT2526533	hsa-miR-3155	CLIP-seq
MIRT2526534	hsa-miR-3155b	CLIP-seq
MIRT2526536	hsa-miR-378g	CLIP-seq
MIRT2526537	hsa-miR-3919	CLIP-seq
MIRT973224	hsa-miR-3922-5p	CLIP-seq
MIRT2526538	hsa-miR-3977	CLIP-seq
MIRT973225	hsa-miR-409-5p	CLIP-seq
MIRT973226	hsa-miR-4286	CLIP-seq
MIRT2526543	hsa-miR-4492	CLIP-seq
MIRT2526544	hsa-miR-4498	CLIP-seq
MIRT2526545	hsa-miR-4505	CLIP-seq
MIRT2526546	hsa-miR-4641	CLIP-seq
MIRT2526547	hsa-miR-4656	CLIP-seq
MIRT973228	hsa-miR-4675	CLIP-seq
MIRT2526548	hsa-miR-4708-3p	CLIP-seq
MIRT973230	hsa-miR-4741	CLIP-seq
MIRT2526551	hsa-miR-4756-3p	CLIP-seq
MIRT2526553	hsa-miR-4797-5p	CLIP-seq
MIRT2526554	hsa-miR-484	CLIP-seq
MIRT973231	hsa-miR-513a-5p	CLIP-seq
MIRT2526555	hsa-miR-558	CLIP-seq
MIRT2526557	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000175	Function	3'-5'-exoribonuclease activity	NAS	11110791
GO:0000176	Component	Nuclear exosome (RNase complex)	IBA	21873635
GO:0000177	Component	Cytoplasmic exosome (RNase complex)	IBA	21873635
GO:0000178	Component	Exosome (RNase complex)	IDA	20531389
GO:0003723	Function	RNA binding	IEA
GO:0004532	Function	Exoribonuclease activity	IDA	17174896
GO:0005515	Function	Protein binding	IPI	11812149, 12419256, 15231747, 17185417, 18334637, 19060904, 20531389, 21255825, 21876179, 22407013, 24981860, 25043052, 25416956, 26496610, 27107012, 28514442, 31515488, 32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IBA	21873635
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	NAS	11110791
GO:0005737	Component	Cytoplasm	NAS	11110791
GO:0005829	Component	Cytosol	TAS
GO:0006364	Process	RRNA processing	NAS	11110791
GO:0006364	Process	RRNA processing	TAS
GO:0016075	Process	RRNA catabolic process	IBA	21873635
GO:0034427	Process	Nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'	IBA	21873635
GO:0034475	Process	U4 snRNA 3'-end processing	IBA	21873635
GO:0035327	Component	Transcriptionally active chromatin	IMP	20699273
GO:0043488	Process	Regulation of mRNA stability	TAS
GO:0043928	Process	Exonucleolytic catabolism of deadenylated mRNA	IMP	11782436
GO:0043928	Process	Exonucleolytic catabolism of deadenylated mRNA	TAS
GO:0045006	Process	DNA deamination	IDA	21255825
GO:0051607	Process	Defense response to virus	IMP	21791617
GO:0071028	Process	Nuclear mRNA surveillance	IBA	21873635
GO:0071051	Process	Polyadenylation-dependent snoRNA 3'-end processing	IBA	21873635
GO:0090503	Process	RNA phosphodiester bond hydrolysis, exonucleolytic	IEA

Other IDs

• MIM: 606492
• HGNC: 24662
• e!Ensembl: ENSG00000077348

Protein

• UniProt ID: Q9NQT4
• Protein name: Exosome complex component RRP46 (Chronic myelogenous leukemia tumor antigen 28) (Exosome component 5) (Ribosomal RNA-processing protein 46) (p12B)
• Protein function: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturat
• PDB: 2NN6, 6D6Q, 6D6R, 6H25, 9G8M, 9G8N, 9G8O, 9G8P
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01138	RNase_PH	27 → 147		Domain
  PF03725	RNase_PH_C	150 → 216		Domain

• Sequence:

  MEEETHTDAKIRAENGTGSSPRGPGCSLRHFACEQNLLSRPDGSASFLQGDTSVLAGVYG
  PAEVKVSKEIFNKATLEVILRPKIGLPGVAEKSRERLIRNTCEAVVLGTLHPRTSITVVL
  QVVSDAGSLLACCLNAACMALVDAGVPMRALFCGVACALDSDGTLVLDPTSKQEKEARAV
  LTFALDSVERKLLMSSTKGLYSDTELQQCLAAAQAASQHVFRFYRESLQRRYSKS

• Sequence length: 235

Pathways

KEGG:

RNA degradation

Reactome:

ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	21364753

Unknown
Disease name	Disease term	dbSNP ID	References
Stomach neoplasms	Malignant neoplasm of stomach, Stomach Neoplasms		21364753