PRSS8 (serine protease 8)

Gene

• Entrez ID: 5652
• Gene name: Serine protease 8
• Gene symbol: PRSS8
• Synonyms: CAP1, PROSTASIN
• Chromosome: 16
• Chromosome location: 16p11.2
• Summary: This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018875	hsa-miR-335-5p	Microarray	18185580
MIRT1268620	hsa-miR-1224-3p	CLIP-seq
MIRT1268621	hsa-miR-1252	CLIP-seq
MIRT1268622	hsa-miR-1260	CLIP-seq
MIRT1268623	hsa-miR-1260b	CLIP-seq
MIRT1268624	hsa-miR-1280	CLIP-seq
MIRT1268625	hsa-miR-24	CLIP-seq
MIRT1268626	hsa-miR-3074-5p	CLIP-seq
MIRT1268627	hsa-miR-31	CLIP-seq
MIRT1268628	hsa-miR-3124-3p	CLIP-seq
MIRT1268629	hsa-miR-3909	CLIP-seq
MIRT1268630	hsa-miR-4260	CLIP-seq
MIRT1268631	hsa-miR-4284	CLIP-seq
MIRT1268632	hsa-miR-4421	CLIP-seq
MIRT1268633	hsa-miR-4476	CLIP-seq
MIRT1268634	hsa-miR-4533	CLIP-seq
MIRT1268635	hsa-miR-532-3p	CLIP-seq
MIRT2078912	hsa-miR-103b	CLIP-seq
MIRT1268625	hsa-miR-24	CLIP-seq
MIRT2078913	hsa-miR-345	CLIP-seq
MIRT2078914	hsa-miR-376a	CLIP-seq
MIRT2078915	hsa-miR-376b	CLIP-seq
MIRT2078916	hsa-miR-4276	CLIP-seq
MIRT2078917	hsa-miR-4522	CLIP-seq
MIRT2078918	hsa-miR-4797-3p	CLIP-seq
MIRT2078919	hsa-miR-663b	CLIP-seq
MIRT2078912	hsa-miR-103b	CLIP-seq
MIRT1268620	hsa-miR-1224-3p	CLIP-seq
MIRT1268622	hsa-miR-1260	CLIP-seq
MIRT1268623	hsa-miR-1260b	CLIP-seq
MIRT1268624	hsa-miR-1280	CLIP-seq
MIRT2305151	hsa-miR-1285	CLIP-seq
MIRT2305152	hsa-miR-146b-3p	CLIP-seq
MIRT2305153	hsa-miR-1587	CLIP-seq
MIRT2305154	hsa-miR-1912	CLIP-seq
MIRT2305155	hsa-miR-1913	CLIP-seq
MIRT2305156	hsa-miR-1915	CLIP-seq
MIRT2305157	hsa-miR-2355-5p	CLIP-seq
MIRT1268625	hsa-miR-24	CLIP-seq
MIRT2305158	hsa-miR-28-5p	CLIP-seq
MIRT1268626	hsa-miR-3074-5p	CLIP-seq
MIRT1268627	hsa-miR-31	CLIP-seq
MIRT1268628	hsa-miR-3124-3p	CLIP-seq
MIRT2305159	hsa-miR-3127-5p	CLIP-seq
MIRT2305160	hsa-miR-3139	CLIP-seq
MIRT2305161	hsa-miR-3155	CLIP-seq
MIRT2305162	hsa-miR-3155b	CLIP-seq
MIRT2305163	hsa-miR-3173-5p	CLIP-seq
MIRT2305164	hsa-miR-3180-5p	CLIP-seq
MIRT2305165	hsa-miR-3187-5p	CLIP-seq
MIRT2305166	hsa-miR-3194-5p	CLIP-seq
MIRT2305167	hsa-miR-324-3p	CLIP-seq
MIRT2305168	hsa-miR-324-5p	CLIP-seq
MIRT2078913	hsa-miR-345	CLIP-seq
MIRT2305169	hsa-miR-3659	CLIP-seq
MIRT2078914	hsa-miR-376a	CLIP-seq
MIRT2078915	hsa-miR-376b	CLIP-seq
MIRT2305170	hsa-miR-378g	CLIP-seq
MIRT1268629	hsa-miR-3909	CLIP-seq
MIRT2305171	hsa-miR-3918	CLIP-seq
MIRT2305172	hsa-miR-3937	CLIP-seq
MIRT1268630	hsa-miR-4260	CLIP-seq
MIRT2305173	hsa-miR-4274	CLIP-seq
MIRT2078916	hsa-miR-4276	CLIP-seq
MIRT2305174	hsa-miR-4281	CLIP-seq
MIRT2305175	hsa-miR-4300	CLIP-seq
MIRT1268632	hsa-miR-4421	CLIP-seq
MIRT2305176	hsa-miR-4433	CLIP-seq
MIRT2305177	hsa-miR-4486	CLIP-seq
MIRT2305178	hsa-miR-4492	CLIP-seq
MIRT2305179	hsa-miR-4498	CLIP-seq
MIRT2078917	hsa-miR-4522	CLIP-seq
MIRT2305180	hsa-miR-4529-5p	CLIP-seq
MIRT1268634	hsa-miR-4533	CLIP-seq
MIRT2305181	hsa-miR-4656	CLIP-seq
MIRT2305182	hsa-miR-4658	CLIP-seq
MIRT2305183	hsa-miR-4662a-5p	CLIP-seq
MIRT2305184	hsa-miR-4674	CLIP-seq
MIRT2305185	hsa-miR-4675	CLIP-seq
MIRT2305186	hsa-miR-4685-5p	CLIP-seq
MIRT2305187	hsa-miR-4726-3p	CLIP-seq
MIRT2305188	hsa-miR-4727-5p	CLIP-seq
MIRT2305189	hsa-miR-4741	CLIP-seq
MIRT2305190	hsa-miR-4747-5p	CLIP-seq
MIRT2305191	hsa-miR-4753-5p	CLIP-seq
MIRT2305192	hsa-miR-4758-5p	CLIP-seq
MIRT2305193	hsa-miR-4787-5p	CLIP-seq
MIRT2078918	hsa-miR-4797-3p	CLIP-seq
MIRT2305194	hsa-miR-484	CLIP-seq
MIRT2305195	hsa-miR-520a-5p	CLIP-seq
MIRT2305196	hsa-miR-525-5p	CLIP-seq
MIRT1268635	hsa-miR-532-3p	CLIP-seq
MIRT2305197	hsa-miR-544	CLIP-seq
MIRT2305198	hsa-miR-552	CLIP-seq
MIRT2305199	hsa-miR-574-5p	CLIP-seq
MIRT2305200	hsa-miR-612	CLIP-seq
MIRT2305201	hsa-miR-622	CLIP-seq
MIRT2078919	hsa-miR-663b	CLIP-seq
MIRT2305202	hsa-miR-708	CLIP-seq
MIRT2305203	hsa-miR-762	CLIP-seq
MIRT2305204	hsa-miR-874	CLIP-seq
MIRT2305205	hsa-miR-920	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SREBF2	Unknown	16806080

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004252	Function	Serine-type endopeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	19911255
GO:0005576	Component	Extracellular region	TAS	10077646
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005886	Component	Plasma membrane	IDA	19911255
GO:0005886	Component	Plasma membrane	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0008236	Function	Serine-type peptidase activity	TAS	8034638
GO:0010765	Process	Positive regulation of sodium ion transport	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0017080	Function	Sodium channel regulator activity	IBA	21873635
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 23533145
GO:0070268	Process	Cornification	TAS

Other IDs

• MIM: 600823
• HGNC: 9491
• e!Ensembl: ENSG00000052344

Protein

• UniProt ID: Q16651
• Protein name: Prostasin (EC 3.4.21.-) (Channel-activating protease 1) (CAP1) (Serine protease 8) [Cleaved into: Prostasin light chain; Prostasin heavy chain]
• Protein function: Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G). {ECO:0000269|PubMed:15246975, ECO:0000269
• PDB: 3DFJ, 3DFL, 3E0N, 3E0P, 3E16, 3E1X, 3FVF, 3GYL, 3GYM
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00089	Trypsin	45 → 281	Trypsin	Domain

• Sequence:

  MAQKGVLGPGQLGAVAILLYLGLLRSGTGAEGAEAPCGVAPQARITGGSSAVAGQWPWQV
  SITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAHQLDSYSEDAKVSTLKDI
  IPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNGLHCTVTGWGHVAPSV
  SLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDACQGDSGG
  PLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPRVVPQTQESQ
  PDSNLCGSHLAFSSAPAQGLLRPILFLPLGLALGLLSPWLSEH

• Sequence length: 343

Pathways

Reactome:

Formation of the cornified envelope

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Anencephaly	Iniencephaly, Exencephaly	rs773607884	24722141
Neural tube defect	Neural Tube Defects	rs121918220, rs121434297, rs137853061, rs137853062, rs3127334, rs267607167, rs267607168, rs387907204, rs139365610, rs137955120, rs786201015, rs786201016, rs768434408, rs777661576, rs747846362, rs200137991, rs780014899, rs574132670, rs786204013, rs147257424, rs763539350, rs776483190, rs757259023, rs781461462, rs762921297, rs1114167354, rs557643577, rs147277149, rs765586205, rs377443637, rs1563593163, rs1303000329, rs1565818580, rs986604359, rs1293600145, rs114727354, rs146357218, rs768980918, rs140277700, rs139645527, rs750323424, rs368321176, rs1579619636, rs893229476, rs754990692, rs763079713, rs1593037878, rs747100389, rs372056091, rs1593083585, rs778121031, rs748778907, rs776969786, rs1189298981, rs375908206, rs1734858651, rs778738842	24722141
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	16541421

Unknown
Disease name	Disease term	dbSNP ID	References
Acrania	Acrania		24722141
Craniorachischisis	Craniorachischisis		24722141
Dermatologic disorders	Dermatologic disorders		22705055
Diastematomyelia	Diastematomyelia		24722141
Embryopathy	Embryopathies		22705055
Fetal diseases	Fetal Diseases		22705055
Neurenteric cyst	Neurenteric Cyst		24722141
Primary tethered cord syndrome	Tethered Cord Syndrome		24722141
Prostatic neoplasms	Prostatic Neoplasms		16541421
Spinal cord myelodysplasia	Spinal Cord Myelodysplasia		24722141