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LRRC8A (leucine rich repeat containing 8 VRAC subunit A)

Gene

56262

Leucine rich repeat containing 8 VRAC subunit A

LRRC8A

AGM5, HsLRRC8A, LRRC8, SWELL1

9q34.11

This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative fou

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001358	hsa-miR-1-3p	pSILAC	18668040
MIRT001358	hsa-miR-1-3p	Microarray	15685193
MIRT016581	hsa-miR-193b-3p	Microarray	20304954
MIRT018758	hsa-miR-335-5p	Microarray	18185580
MIRT001358	hsa-miR-1-3p	Microarray	15685193
MIRT001358	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT001358	hsa-miR-1-3p	Proteomics	18668040
MIRT028222	hsa-miR-33a-5p	Sequencing	20371350
MIRT032470	hsa-let-7b-5p	Proteomics	18668040
MIRT051458	hsa-let-7e-5p	CLASH	23622248
MIRT045587	hsa-miR-149-5p	CLASH	23622248
MIRT054164	hsa-miR-191-5p	Immunoprecipitation, In situ hybridization, Luciferase assay, Microarray, Northern blot, QRTPCR, Western blot	23505378
MIRT569276	hsa-miR-4694-3p	PAR-CLIP	20371350
MIRT569275	hsa-miR-4719	PAR-CLIP	20371350
MIRT569274	hsa-miR-184	PAR-CLIP	20371350
MIRT569273	hsa-miR-4804-5p	PAR-CLIP	20371350
MIRT536217	hsa-miR-208a-5p	PAR-CLIP	22012620
MIRT536216	hsa-miR-208b-5p	PAR-CLIP	22012620
MIRT536215	hsa-miR-6715a-3p	PAR-CLIP	22012620
MIRT536214	hsa-miR-330-3p	PAR-CLIP	22012620
MIRT536213	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT536212	hsa-miR-607	PAR-CLIP	22012620
MIRT536211	hsa-miR-1305	PAR-CLIP	22012620
MIRT569276	hsa-miR-4694-3p	PAR-CLIP	20371350
MIRT569275	hsa-miR-4719	PAR-CLIP	20371350
MIRT569274	hsa-miR-184	PAR-CLIP	20371350
MIRT569273	hsa-miR-4804-5p	PAR-CLIP	20371350
MIRT536217	hsa-miR-208a-5p	PAR-CLIP	22012620
MIRT536216	hsa-miR-208b-5p	PAR-CLIP	22012620
MIRT536215	hsa-miR-6715a-3p	PAR-CLIP	22012620
MIRT536214	hsa-miR-330-3p	PAR-CLIP	22012620
MIRT536213	hsa-miR-1250-3p	PAR-CLIP	22012620
MIRT536212	hsa-miR-607	PAR-CLIP	22012620
MIRT536211	hsa-miR-1305	PAR-CLIP	22012620
MIRT1120476	hsa-miR-1185	CLIP-seq
MIRT1120477	hsa-miR-1224-3p	CLIP-seq
MIRT1120478	hsa-miR-125a-5p	CLIP-seq
MIRT1120479	hsa-miR-125b	CLIP-seq
MIRT1120480	hsa-miR-1290	CLIP-seq
MIRT1120481	hsa-miR-129-5p	CLIP-seq
MIRT1120482	hsa-miR-191	CLIP-seq
MIRT1120483	hsa-miR-3159	CLIP-seq
MIRT1120484	hsa-miR-323b-5p	CLIP-seq
MIRT1120485	hsa-miR-331-3p	CLIP-seq
MIRT1120486	hsa-miR-3605-5p	CLIP-seq
MIRT1120487	hsa-miR-3679-5p	CLIP-seq
MIRT1120488	hsa-miR-3975	CLIP-seq
MIRT1120489	hsa-miR-3977	CLIP-seq
MIRT1120490	hsa-miR-4257	CLIP-seq
MIRT1120491	hsa-miR-4292	CLIP-seq
MIRT1120492	hsa-miR-4303	CLIP-seq
MIRT1120493	hsa-miR-4319	CLIP-seq
MIRT1120494	hsa-miR-4446-5p	CLIP-seq
MIRT1120495	hsa-miR-4480	CLIP-seq
MIRT1120496	hsa-miR-4487	CLIP-seq
MIRT1120497	hsa-miR-4643	CLIP-seq
MIRT1120498	hsa-miR-4649-3p	CLIP-seq
MIRT1120499	hsa-miR-4690-3p	CLIP-seq
MIRT1120500	hsa-miR-4717-3p	CLIP-seq
MIRT1120501	hsa-miR-4722-3p	CLIP-seq
MIRT1120502	hsa-miR-4732-3p	CLIP-seq
MIRT1120503	hsa-miR-4755-5p	CLIP-seq
MIRT1120504	hsa-miR-4762-3p	CLIP-seq
MIRT1120505	hsa-miR-4763-5p	CLIP-seq
MIRT1120506	hsa-miR-4802-3p	CLIP-seq
MIRT1120507	hsa-miR-486-3p	CLIP-seq
MIRT1120508	hsa-miR-515-3p	CLIP-seq
MIRT1120509	hsa-miR-519e	CLIP-seq
MIRT1120510	hsa-miR-550a	CLIP-seq
MIRT1120511	hsa-miR-642b	CLIP-seq
MIRT1120512	hsa-miR-648	CLIP-seq
MIRT1120513	hsa-miR-670	CLIP-seq
MIRT1120476	hsa-miR-1185	CLIP-seq
MIRT1120480	hsa-miR-1290	CLIP-seq
MIRT1120481	hsa-miR-129-5p	CLIP-seq
MIRT1120482	hsa-miR-191	CLIP-seq
MIRT1120483	hsa-miR-3159	CLIP-seq
MIRT1120484	hsa-miR-323b-5p	CLIP-seq
MIRT1120486	hsa-miR-3605-5p	CLIP-seq
MIRT1120487	hsa-miR-3679-5p	CLIP-seq
MIRT1120514	hsa-miR-374c	CLIP-seq
MIRT1120488	hsa-miR-3975	CLIP-seq
MIRT1120489	hsa-miR-3977	CLIP-seq
MIRT1120515	hsa-miR-425	CLIP-seq
MIRT1120490	hsa-miR-4257	CLIP-seq
MIRT1120492	hsa-miR-4303	CLIP-seq
MIRT1120516	hsa-miR-4462	CLIP-seq
MIRT1120495	hsa-miR-4480	CLIP-seq
MIRT1120497	hsa-miR-4643	CLIP-seq
MIRT1120498	hsa-miR-4649-3p	CLIP-seq
MIRT1120500	hsa-miR-4717-3p	CLIP-seq
MIRT1120501	hsa-miR-4722-3p	CLIP-seq
MIRT1120504	hsa-miR-4762-3p	CLIP-seq
MIRT1120505	hsa-miR-4763-5p	CLIP-seq
MIRT1120506	hsa-miR-4802-3p	CLIP-seq
MIRT1120508	hsa-miR-515-3p	CLIP-seq
MIRT1120509	hsa-miR-519e	CLIP-seq
MIRT1120510	hsa-miR-550a	CLIP-seq
MIRT1120511	hsa-miR-642b	CLIP-seq
MIRT1120512	hsa-miR-648	CLIP-seq
MIRT1120517	hsa-miR-655	CLIP-seq
MIRT1120478	hsa-miR-125a-5p	CLIP-seq
MIRT1120479	hsa-miR-125b	CLIP-seq
MIRT1120518	hsa-miR-1283	CLIP-seq
MIRT1120519	hsa-miR-146b-3p	CLIP-seq
MIRT1120520	hsa-miR-1539	CLIP-seq
MIRT1120482	hsa-miR-191	CLIP-seq
MIRT1120521	hsa-miR-1915	CLIP-seq
MIRT1120522	hsa-miR-193a-3p	CLIP-seq
MIRT1120523	hsa-miR-193b	CLIP-seq
MIRT1120524	hsa-miR-200b	CLIP-seq
MIRT1120525	hsa-miR-200c	CLIP-seq
MIRT1120526	hsa-miR-3130-3p	CLIP-seq
MIRT1120527	hsa-miR-3145-5p	CLIP-seq
MIRT1120528	hsa-miR-3153	CLIP-seq
MIRT1120529	hsa-miR-3173-5p	CLIP-seq
MIRT1120484	hsa-miR-323b-5p	CLIP-seq
MIRT1120530	hsa-miR-3591-5p	CLIP-seq
MIRT1120531	hsa-miR-3618	CLIP-seq
MIRT1120532	hsa-miR-3620	CLIP-seq
MIRT1120533	hsa-miR-3672	CLIP-seq
MIRT1120534	hsa-miR-3680	CLIP-seq
MIRT1120514	hsa-miR-374c	CLIP-seq
MIRT1120488	hsa-miR-3975	CLIP-seq
MIRT1120489	hsa-miR-3977	CLIP-seq
MIRT1120490	hsa-miR-4257	CLIP-seq
MIRT1120535	hsa-miR-4261	CLIP-seq
MIRT1120536	hsa-miR-429	CLIP-seq
MIRT1120537	hsa-miR-4318	CLIP-seq
MIRT1120493	hsa-miR-4319	CLIP-seq
MIRT1120538	hsa-miR-4324	CLIP-seq
MIRT1120539	hsa-miR-4329	CLIP-seq
MIRT1120540	hsa-miR-4496	CLIP-seq
MIRT1120541	hsa-miR-4681	CLIP-seq
MIRT1120542	hsa-miR-4693-5p	CLIP-seq
MIRT1120543	hsa-miR-4709-3p	CLIP-seq
MIRT1120544	hsa-miR-4711-3p	CLIP-seq
MIRT1120545	hsa-miR-4715-3p	CLIP-seq
MIRT1120546	hsa-miR-4724-5p	CLIP-seq
MIRT1120547	hsa-miR-511	CLIP-seq
MIRT1120512	hsa-miR-648	CLIP-seq
MIRT1120517	hsa-miR-655	CLIP-seq
MIRT1120548	hsa-miR-7	CLIP-seq
MIRT1120549	hsa-miR-874	CLIP-seq
MIRT1120550	hsa-miR-892a	CLIP-seq
MIRT1120551	hsa-miR-95	CLIP-seq
MIRT1120476	hsa-miR-1185	CLIP-seq
MIRT1120483	hsa-miR-3159	CLIP-seq
MIRT1120484	hsa-miR-323b-5p	CLIP-seq
MIRT1120486	hsa-miR-3605-5p	CLIP-seq
MIRT1120487	hsa-miR-3679-5p	CLIP-seq
MIRT1120488	hsa-miR-3975	CLIP-seq
MIRT1120490	hsa-miR-4257	CLIP-seq
MIRT1120492	hsa-miR-4303	CLIP-seq
MIRT1120498	hsa-miR-4649-3p	CLIP-seq
MIRT1120504	hsa-miR-4762-3p	CLIP-seq
MIRT1120512	hsa-miR-648	CLIP-seq
MIRT2034130	hsa-miR-4457	CLIP-seq
MIRT1120501	hsa-miR-4722-3p	CLIP-seq
MIRT2034131	hsa-miR-513b	CLIP-seq
MIRT2034132	hsa-miR-671-5p	CLIP-seq
MIRT1120478	hsa-miR-125a-5p	CLIP-seq
MIRT1120479	hsa-miR-125b	CLIP-seq
MIRT1120524	hsa-miR-200b	CLIP-seq
MIRT1120525	hsa-miR-200c	CLIP-seq
MIRT1120536	hsa-miR-429	CLIP-seq
MIRT1120493	hsa-miR-4319	CLIP-seq
MIRT2264478	hsa-miR-4521	CLIP-seq
MIRT1120518	hsa-miR-1283	CLIP-seq
MIRT1120531	hsa-miR-3618	CLIP-seq
MIRT1120516	hsa-miR-4462	CLIP-seq
MIRT2430853	hsa-miR-570	CLIP-seq
MIRT1120478	hsa-miR-125a-5p	CLIP-seq
MIRT1120479	hsa-miR-125b	CLIP-seq
MIRT1120519	hsa-miR-146b-3p	CLIP-seq
MIRT1120522	hsa-miR-193a-3p	CLIP-seq
MIRT1120523	hsa-miR-193b	CLIP-seq
MIRT1120527	hsa-miR-3145-5p	CLIP-seq
MIRT1120529	hsa-miR-3173-5p	CLIP-seq
MIRT1120530	hsa-miR-3591-5p	CLIP-seq
MIRT1120532	hsa-miR-3620	CLIP-seq
MIRT1120533	hsa-miR-3672	CLIP-seq
MIRT1120534	hsa-miR-3680	CLIP-seq
MIRT1120493	hsa-miR-4319	CLIP-seq
MIRT1120538	hsa-miR-4324	CLIP-seq
MIRT1120539	hsa-miR-4329	CLIP-seq
MIRT1120544	hsa-miR-4711-3p	CLIP-seq
MIRT1120545	hsa-miR-4715-3p	CLIP-seq
MIRT1120547	hsa-miR-511	CLIP-seq
MIRT1120549	hsa-miR-874	CLIP-seq
MIRT2453394	hsa-miR-1252	CLIP-seq
MIRT2453395	hsa-miR-1255a	CLIP-seq
MIRT2453396	hsa-miR-1255b	CLIP-seq
MIRT2453397	hsa-miR-3126-3p	CLIP-seq
MIRT2453398	hsa-miR-3173-3p	CLIP-seq
MIRT2453399	hsa-miR-3689d	CLIP-seq
MIRT2453400	hsa-miR-4782-5p	CLIP-seq
MIRT2264478	hsa-miR-4521	CLIP-seq
MIRT2563451	hsa-miR-1228	CLIP-seq
MIRT2563452	hsa-miR-1245	CLIP-seq
MIRT1120478	hsa-miR-125a-5p	CLIP-seq
MIRT1120479	hsa-miR-125b	CLIP-seq
MIRT2563453	hsa-miR-1285	CLIP-seq
MIRT1120519	hsa-miR-146b-3p	CLIP-seq
MIRT2563454	hsa-miR-1470	CLIP-seq
MIRT2563455	hsa-miR-18a	CLIP-seq
MIRT2563456	hsa-miR-18b	CLIP-seq
MIRT2563457	hsa-miR-1908	CLIP-seq
MIRT1120522	hsa-miR-193a-3p	CLIP-seq
MIRT1120523	hsa-miR-193b	CLIP-seq
MIRT2563458	hsa-miR-208a	CLIP-seq
MIRT2563459	hsa-miR-208b	CLIP-seq
MIRT2563460	hsa-miR-2115	CLIP-seq
MIRT2563461	hsa-miR-2355-5p	CLIP-seq
MIRT2563462	hsa-miR-3121-3p	CLIP-seq
MIRT1120526	hsa-miR-3130-3p	CLIP-seq
MIRT2563463	hsa-miR-3144-5p	CLIP-seq
MIRT1120527	hsa-miR-3145-5p	CLIP-seq
MIRT2563464	hsa-miR-3150b-3p	CLIP-seq
MIRT1120529	hsa-miR-3173-5p	CLIP-seq
MIRT2563465	hsa-miR-3187-5p	CLIP-seq
MIRT2563466	hsa-miR-3191	CLIP-seq
MIRT2563467	hsa-miR-3192	CLIP-seq
MIRT1120530	hsa-miR-3591-5p	CLIP-seq
MIRT2563468	hsa-miR-3613-3p	CLIP-seq
MIRT2563469	hsa-miR-3617	CLIP-seq
MIRT2563470	hsa-miR-3619-3p	CLIP-seq
MIRT1120532	hsa-miR-3620	CLIP-seq
MIRT1120533	hsa-miR-3672	CLIP-seq
MIRT1120534	hsa-miR-3680	CLIP-seq
MIRT2563471	hsa-miR-3690	CLIP-seq
MIRT2563472	hsa-miR-378g	CLIP-seq
MIRT2563473	hsa-miR-3940-3p	CLIP-seq
MIRT2563474	hsa-miR-3974	CLIP-seq
MIRT2563475	hsa-miR-4254	CLIP-seq
MIRT2563476	hsa-miR-4263	CLIP-seq
MIRT2563477	hsa-miR-4314	CLIP-seq
MIRT1120493	hsa-miR-4319	CLIP-seq
MIRT1120538	hsa-miR-4324	CLIP-seq
MIRT1120539	hsa-miR-4329	CLIP-seq
MIRT2563478	hsa-miR-4422	CLIP-seq
MIRT2563479	hsa-miR-4434	CLIP-seq
MIRT1120516	hsa-miR-4462	CLIP-seq
MIRT2563480	hsa-miR-4469	CLIP-seq
MIRT1120495	hsa-miR-4480	CLIP-seq
MIRT2563481	hsa-miR-4497	CLIP-seq
MIRT2563482	hsa-miR-4509	CLIP-seq
MIRT2563483	hsa-miR-4516	CLIP-seq
MIRT2264478	hsa-miR-4521	CLIP-seq
MIRT1120497	hsa-miR-4643	CLIP-seq
MIRT2563484	hsa-miR-4646-5p	CLIP-seq
MIRT2563485	hsa-miR-4652-5p	CLIP-seq
MIRT2563486	hsa-miR-4667-3p	CLIP-seq
MIRT2563487	hsa-miR-4691-3p	CLIP-seq
MIRT2563488	hsa-miR-4706	CLIP-seq
MIRT1120544	hsa-miR-4711-3p	CLIP-seq
MIRT1120545	hsa-miR-4715-3p	CLIP-seq
MIRT1120500	hsa-miR-4717-3p	CLIP-seq
MIRT2563489	hsa-miR-4733-3p	CLIP-seq
MIRT2563490	hsa-miR-4735-3p	CLIP-seq
MIRT2563491	hsa-miR-4744	CLIP-seq
MIRT2563492	hsa-miR-4749-5p	CLIP-seq
MIRT2563493	hsa-miR-4765	CLIP-seq
MIRT2563494	hsa-miR-4776-5p	CLIP-seq
MIRT2563495	hsa-miR-4784	CLIP-seq
MIRT1120506	hsa-miR-4802-3p	CLIP-seq
MIRT2563496	hsa-miR-4802-5p	CLIP-seq
MIRT2563497	hsa-miR-491-5p	CLIP-seq
MIRT2563498	hsa-miR-495	CLIP-seq
MIRT2563499	hsa-miR-499-5p	CLIP-seq
MIRT1120547	hsa-miR-511	CLIP-seq
MIRT2563500	hsa-miR-524-3p	CLIP-seq
MIRT2563501	hsa-miR-525-3p	CLIP-seq
MIRT2563502	hsa-miR-548ac	CLIP-seq
MIRT2563503	hsa-miR-548ad	CLIP-seq
MIRT2563504	hsa-miR-548d-3p	CLIP-seq
MIRT2563505	hsa-miR-548z	CLIP-seq
MIRT2430853	hsa-miR-570	CLIP-seq
MIRT2563506	hsa-miR-612	CLIP-seq
MIRT2563507	hsa-miR-641	CLIP-seq
MIRT1120511	hsa-miR-642b	CLIP-seq
MIRT2563508	hsa-miR-663	CLIP-seq
MIRT1120548	hsa-miR-7	CLIP-seq
MIRT2563509	hsa-miR-764	CLIP-seq
MIRT2563510	hsa-miR-765	CLIP-seq
MIRT2563511	hsa-miR-873	CLIP-seq
MIRT1120549	hsa-miR-874	CLIP-seq
MIRT2264478	hsa-miR-4521	CLIP-seq
MIRT1120476	hsa-miR-1185	CLIP-seq
MIRT2563451	hsa-miR-1228	CLIP-seq
MIRT2563452	hsa-miR-1245	CLIP-seq
MIRT1120478	hsa-miR-125a-5p	CLIP-seq
MIRT1120479	hsa-miR-125b	CLIP-seq
MIRT1120519	hsa-miR-146b-3p	CLIP-seq
MIRT2563454	hsa-miR-1470	CLIP-seq
MIRT2563455	hsa-miR-18a	CLIP-seq
MIRT2563456	hsa-miR-18b	CLIP-seq
MIRT2563457	hsa-miR-1908	CLIP-seq
MIRT1120522	hsa-miR-193a-3p	CLIP-seq
MIRT1120523	hsa-miR-193b	CLIP-seq
MIRT2684220	hsa-miR-1976	CLIP-seq
MIRT2563458	hsa-miR-208a	CLIP-seq
MIRT2563459	hsa-miR-208b	CLIP-seq
MIRT2563460	hsa-miR-2115	CLIP-seq
MIRT2563461	hsa-miR-2355-5p	CLIP-seq
MIRT2563462	hsa-miR-3121-3p	CLIP-seq
MIRT2563463	hsa-miR-3144-5p	CLIP-seq
MIRT1120527	hsa-miR-3145-5p	CLIP-seq
MIRT2563464	hsa-miR-3150b-3p	CLIP-seq
MIRT2684221	hsa-miR-3155	CLIP-seq
MIRT2684222	hsa-miR-3155b	CLIP-seq
MIRT1120483	hsa-miR-3159	CLIP-seq
MIRT1120529	hsa-miR-3173-5p	CLIP-seq
MIRT2563466	hsa-miR-3191	CLIP-seq
MIRT1120530	hsa-miR-3591-5p	CLIP-seq
MIRT1120486	hsa-miR-3605-5p	CLIP-seq
MIRT2563468	hsa-miR-3613-3p	CLIP-seq
MIRT2563469	hsa-miR-3617	CLIP-seq
MIRT2563470	hsa-miR-3619-3p	CLIP-seq
MIRT1120532	hsa-miR-3620	CLIP-seq
MIRT1120533	hsa-miR-3672	CLIP-seq
MIRT1120487	hsa-miR-3679-5p	CLIP-seq
MIRT1120534	hsa-miR-3680	CLIP-seq
MIRT2563471	hsa-miR-3690	CLIP-seq
MIRT2563472	hsa-miR-378g	CLIP-seq
MIRT2563474	hsa-miR-3974	CLIP-seq
MIRT2563475	hsa-miR-4254	CLIP-seq
MIRT2563476	hsa-miR-4263	CLIP-seq
MIRT1120492	hsa-miR-4303	CLIP-seq
MIRT1120493	hsa-miR-4319	CLIP-seq
MIRT1120538	hsa-miR-4324	CLIP-seq
MIRT1120539	hsa-miR-4329	CLIP-seq
MIRT2563478	hsa-miR-4422	CLIP-seq
MIRT2034130	hsa-miR-4457	CLIP-seq
MIRT1120516	hsa-miR-4462	CLIP-seq
MIRT2563480	hsa-miR-4469	CLIP-seq
MIRT1120495	hsa-miR-4480	CLIP-seq
MIRT2563482	hsa-miR-4509	CLIP-seq
MIRT2264478	hsa-miR-4521	CLIP-seq
MIRT1120497	hsa-miR-4643	CLIP-seq
MIRT1120498	hsa-miR-4649-3p	CLIP-seq
MIRT2563485	hsa-miR-4652-5p	CLIP-seq
MIRT2563486	hsa-miR-4667-3p	CLIP-seq
MIRT2563487	hsa-miR-4691-3p	CLIP-seq
MIRT2563488	hsa-miR-4706	CLIP-seq
MIRT1120544	hsa-miR-4711-3p	CLIP-seq
MIRT1120545	hsa-miR-4715-3p	CLIP-seq
MIRT1120500	hsa-miR-4717-3p	CLIP-seq
MIRT1120501	hsa-miR-4722-3p	CLIP-seq
MIRT2563489	hsa-miR-4733-3p	CLIP-seq
MIRT2563490	hsa-miR-4735-3p	CLIP-seq
MIRT2563491	hsa-miR-4744	CLIP-seq
MIRT2563492	hsa-miR-4749-5p	CLIP-seq
MIRT1120504	hsa-miR-4762-3p	CLIP-seq
MIRT2563493	hsa-miR-4765	CLIP-seq
MIRT2563494	hsa-miR-4776-5p	CLIP-seq
MIRT2563495	hsa-miR-4784	CLIP-seq
MIRT1120506	hsa-miR-4802-3p	CLIP-seq
MIRT2563496	hsa-miR-4802-5p	CLIP-seq
MIRT2684223	hsa-miR-484	CLIP-seq
MIRT2684224	hsa-miR-485-5p	CLIP-seq
MIRT2563497	hsa-miR-491-5p	CLIP-seq
MIRT2563498	hsa-miR-495	CLIP-seq
MIRT2563499	hsa-miR-499-5p	CLIP-seq
MIRT1120547	hsa-miR-511	CLIP-seq
MIRT2034131	hsa-miR-513b	CLIP-seq
MIRT2563500	hsa-miR-524-3p	CLIP-seq
MIRT2563501	hsa-miR-525-3p	CLIP-seq
MIRT2563502	hsa-miR-548ac	CLIP-seq
MIRT2563503	hsa-miR-548ad	CLIP-seq
MIRT2563504	hsa-miR-548d-3p	CLIP-seq
MIRT2563505	hsa-miR-548z	CLIP-seq
MIRT2430853	hsa-miR-570	CLIP-seq
MIRT2563507	hsa-miR-641	CLIP-seq
MIRT1120511	hsa-miR-642b	CLIP-seq
MIRT2563508	hsa-miR-663	CLIP-seq
MIRT1120548	hsa-miR-7	CLIP-seq
MIRT2563510	hsa-miR-765	CLIP-seq
MIRT2563511	hsa-miR-873	CLIP-seq
MIRT1120549	hsa-miR-874	CLIP-seq

Show/Hide all(22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002329	Process	Pre-B cell differentiation	ISS
GO:0005225	Function	Volume-sensitive anion channel activity	IMP	26824658, 29769723
GO:0005225	Function	Volume-sensitive anion channel activity	ISS
GO:0005253	Function	Anion channel activity	IMP	24725410, 24790029
GO:0005515	Function	Protein binding	IPI	24790029, 28514442
GO:0005886	Component	Plasma membrane	IDA	24725410, 24790029
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	ISS
GO:0006820	Process	Anion transport	IMP	24725410, 24790029
GO:0006884	Process	Cell volume homeostasis	IMP	24725410, 24790029
GO:0006970	Process	Response to osmotic stress	IMP	24725410, 24790029
GO:0009986	Component	Cell surface	IDA	14660746
GO:0015698	Process	Inorganic anion transport	IEA
GO:0015734	Process	Taurine transport	IEA
GO:0015810	Process	Aspartate transmembrane transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0034214	Process	Protein hexamerization	ISS
GO:0034702	Component	Ion channel complex	IDA	24790029
GO:0042802	Function	Identical protein binding	IPI	24790029, 30127360
GO:0055085	Process	Transmembrane transport	TAS
GO:0098656	Process	Anion transmembrane transport	IMP	29769723
GO:0098656	Process	Anion transmembrane transport	ISS

MIM	HGNC	e!Ensembl
608360	19027	ENSG00000136802

Protein

UniProt ID

Q8IWT6

Protein name

Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A) (HsLRRC8A) (Swelling protein 1)

Protein function

Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24725410, PubMed:24790

PDB

5ZSU , 6DJB , 7XZH , 8DXN , 8DXO , 8DXP , 8DXQ , 8DXR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12534	Pannexin_like	1 → 340	Pannexin-like TM region of LRRC8	Family
PF13855	LRR_8	591 → 651	Leucine rich repeat	Repeat
PF13855	LRR_8	659 → 706	Leucine rich repeat	Repeat
PF13855	LRR_8	708 → 766	Leucine rich repeat	Repeat

Sequence

MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCKWV
TKDSCNDSFRGWAAPGPEPTYPNSTILPTPDTGPTGIKYDLDRHQYNYVDAVCYENRLHW
FAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRALSETVVEE
SDPKPAFSKMNGSMDKKSSTVSEDVEATVPMLQRTKSRIEQGIVDRSETGVLDKKEGEQA
KALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILIICYTVYYVHNIKFDVDCTVDIE
SLTGYRTYRCAHPLATLFKILASFYISLVIFYGLICMYTLWWMLRRSLKKYSFESIREES
SYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRL
TKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTA
AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGL
RELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIR
CDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGN
LTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRI
ETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK
RSGLVVEEDLFNTLPPEVKERLWRADKEQA

Sequence length

810

Interactions

View interactions

	Reactome
			Miscellaneous transport and binding events

Associated diseases

Show/Hide Causal Diseases (6)

Causal
Disease name	Disease term	dbSNP ID	References
Agammaglobulinemia	Agammaglobulinemia, Agammaglobulinemia, non-Bruton type, AGAMMAGLOBULINEMIA 5, AUTOSOMAL DOMINANT, Autosomal agammaglobulinemia	rs2134166251, rs128620183, rs128620185, rs128621193, rs128621201, rs128621204, rs121912424, rs267606711, rs376256147, rs281865422, rs1600631593, rs1555843601, rs267606871, rs879255271, rs2142904392, rs1555976766, rs1555977461, rs1555977580, rs1555977592, rs1555977598, rs1555978024, rs1555978197, rs1555978277, rs1555978891, rs1555980049, rs1555980799, rs1555980866, rs1554906579, rs1568801716, rs1565638431, rs2095906547, rs2095906404	14660746
Arthritis	Arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470
Bronchiectasis	Bronchiectasis	rs121908758, rs121908811, rs76649725, rs267606722, rs121909008, rs387906360, rs387906361, rs80034486, rs74767530, rs121908776, rs121909012, rs77646904, rs121908754, rs121909015, rs121909016, rs387906365, rs80055610, rs75528968, rs121908748, rs77932196, rs121909026, rs121908751, rs121908750, rs746418935, rs79282516, rs77409459, rs121909031, rs76554633, rs75115087, rs79633941, rs387906375, rs75389940, rs121909043, rs387906379, rs121908784, rs121909047, rs137852709, rs1596894031, rs137852710, rs61759860, rs121908805, rs193922501, rs193922503, rs193922504, rs1554389296, rs121908812, rs74467662, rs193922510, rs193922514, rs121908797, rs193922515, rs76151804, rs78984783, rs77035409, rs193922532, rs121908767, rs77188391, rs121908789, rs121908779, rs36210737, rs121908763, rs121908794, rs121908796, rs121908772, rs79031340, rs397508137, rs397508139, rs121908774, rs397508150, rs397508152, rs397508158, rs397508165, rs397508168, rs397508173, rs397508192, rs397508196, rs397508200, rs397508205, rs397508208, rs397508211, rs397508222, rs397508225, rs397508231, rs397508243, rs397508251, rs397508261, rs397508272, rs397508273, rs397508276, rs397508295, rs397508296, rs397508298, rs397508300, rs77284892, rs397508310, rs201978662, rs201124247, rs121908780, rs397508331, rs397508333, rs397508339, rs397508341, rs121908760, rs397508350, rs397508353, rs121908810, rs397508360, rs374946172, rs145449046, rs397508377, rs397508379, rs397508380, rs397508386, rs397508387, rs397508393, rs397508399, rs397508400, rs397508412, rs397508413, rs121909034, rs149790377, rs121908792, rs397508426, rs397508431, rs397508441, rs397508451, rs397508461, rs397508479, rs397508482, rs397508496, rs397508498, rs397508506, rs397508510, rs142394380, rs121909036, rs139304906, rs121908798, rs397508532, rs397508535, rs146521846, rs139729994, rs397508570, rs397508572, rs77834169, rs78655421, rs121908765, rs397508595, rs397508596, rs397508600, rs397508604, rs397508609, rs397508616, rs397508620, rs397508624, rs121908808, rs397508635, rs397508636, rs397508637, rs397508658, rs397508673, rs397508680, rs397508686, rs76371115, rs397508702, rs397508706, rs397508712, rs397508715, rs397508721, rs397508732, rs397508734, rs397508740, rs121908771, rs397508761, rs78440224, rs121908793, rs397508767, rs121908803, rs397508777, rs397508784, rs397508791, rs397508796, rs397508799, rs397508805, rs397508808, rs397508809, rs397508824, rs786204693, rs755416052, rs397508263, rs1057516619, rs397508176, rs1057516415, rs1057516970, rs754392413, rs1057516457, rs397508709, rs1060503164, rs775663783, rs397508294, rs1554380497, rs397508163, rs121908785, rs1235397597, rs397508405, rs1554392800, rs375661578, rs397508693, rs766063304, rs141482808, rs1290078234, rs756219310, rs1554390958, rs1555112332, rs750559671, rs533959068, rs1554389062, rs1554389486, rs1330431481, rs193922730, rs779177972, rs1562928997, rs1562908997, rs1562876459, rs1584785196, rs1584786454, rs1299250440, rs1584837090, rs1584764596, rs1584812425
Hypothyroidism	Hypothyroidism	rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912, rs121917847, rs104893655, rs104893657, rs104893658, rs104893659, rs104893660, rs104893656, rs121917719, rs786204790, rs189261858, rs879255608, rs868197660, rs879255609, rs1586744173, rs1586182837, rs771222349, rs1587618417, rs1601844140, rs760832986, rs780982673, rs1603336347, rs1691155605	30595370
Neutropenia	Neutropenia	rs879253882
Osteomyelitis	Osteomyelitis	rs11125529, rs10936599, rs7675998, rs398652, rs755017

Show/Hide Unknown Diseases (8)

Unknown
Disease name	Disease term	dbSNP ID	References
Congenital epicanthus	Congenital Epicanthus
Conjunctivitis	Conjunctivitis
High palate	Byzanthine arch palate
Hypogammaglobulinemia	Hypogammaglobulinemia
Immunologic deficiency syndromes	Immunologic Deficiency Syndromes
Malabsorption syndrome	Malabsorption Syndrome
Otitis media	Chronic otitis media	rs601338, rs1047781, rs1800028
Sinusitis	Sinusitis

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