CTNNBL1 (catenin beta like 1)

Gene

• Entrez ID: 56259
• Gene name: Catenin beta like 1
• Gene symbol: CTNNBL1
• Synonyms: C20orf33, IMD99, NAP, P14L, PP8304, dJ633O20.1
• Chromosome: 20
• Chromosome location: 20q11.23
• Summary: The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nucl

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020731	hsa-miR-155-5p	Proteomics	18668040
MIRT050320	hsa-miR-25-3p	CLASH	23622248
MIRT049224	hsa-miR-92a-3p	CLASH	23622248
MIRT045603	hsa-miR-149-5p	CLASH	23622248
MIRT044639	hsa-miR-320a	CLASH	23622248
MIRT036306	hsa-miR-1229-3p	CLASH	23622248
MIRT639456	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT639455	hsa-miR-6872-3p	HITS-CLIP	23824327
MIRT639454	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT639453	hsa-miR-138-2-3p	HITS-CLIP	23824327
MIRT639452	hsa-miR-4794	HITS-CLIP	23824327
MIRT639451	hsa-miR-664a-5p	HITS-CLIP	23824327
MIRT639450	hsa-miR-1254	HITS-CLIP	23824327
MIRT639449	hsa-miR-3116	HITS-CLIP	23824327
MIRT639448	hsa-miR-661	HITS-CLIP	23824327
MIRT639447	hsa-miR-4775	HITS-CLIP	23824327
MIRT639446	hsa-miR-4715-3p	HITS-CLIP	23824327
MIRT639445	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT639444	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT639443	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT639456	hsa-miR-590-3p	HITS-CLIP	23824327
MIRT639455	hsa-miR-6872-3p	HITS-CLIP	23824327
MIRT639454	hsa-miR-4735-5p	HITS-CLIP	23824327
MIRT639453	hsa-miR-138-2-3p	HITS-CLIP	23824327
MIRT639452	hsa-miR-4794	HITS-CLIP	23824327
MIRT639451	hsa-miR-664a-5p	HITS-CLIP	23824327
MIRT639450	hsa-miR-1254	HITS-CLIP	23824327
MIRT639449	hsa-miR-3116	HITS-CLIP	23824327
MIRT639448	hsa-miR-661	HITS-CLIP	23824327
MIRT639447	hsa-miR-4775	HITS-CLIP	23824327
MIRT639446	hsa-miR-4715-3p	HITS-CLIP	23824327
MIRT639445	hsa-miR-7159-3p	HITS-CLIP	23824327
MIRT639444	hsa-miR-4482-3p	HITS-CLIP	23824327
MIRT639443	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT915042	hsa-miR-1322	CLIP-seq
MIRT915043	hsa-miR-18a	CLIP-seq
MIRT915044	hsa-miR-18b	CLIP-seq
MIRT915045	hsa-miR-3918	CLIP-seq
MIRT915046	hsa-miR-4735-3p	CLIP-seq
MIRT915047	hsa-miR-4761-5p	CLIP-seq
MIRT1971438	hsa-miR-4797-5p	CLIP-seq
MIRT915042	hsa-miR-1322	CLIP-seq
MIRT2510207	hsa-miR-1343	CLIP-seq
MIRT2510208	hsa-miR-3192	CLIP-seq
MIRT2510209	hsa-miR-3689a-3p	CLIP-seq
MIRT2510210	hsa-miR-3689c	CLIP-seq
MIRT915045	hsa-miR-3918	CLIP-seq
MIRT2510211	hsa-miR-4728-5p	CLIP-seq
MIRT915042	hsa-miR-1322	CLIP-seq
MIRT2510207	hsa-miR-1343	CLIP-seq
MIRT2510208	hsa-miR-3192	CLIP-seq
MIRT2510209	hsa-miR-3689a-3p	CLIP-seq
MIRT2510210	hsa-miR-3689c	CLIP-seq
MIRT2510211	hsa-miR-4728-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000398	Process	MRNA splicing, via spliceosome	TAS
GO:0000974	Component	Prp19 complex	IDA	15175653
GO:0005515	Function	Protein binding	IPI	18722174, 20176811, 21385873, 22365833, 24269683, 25416956, 29892012, 31515488
GO:0005634	Component	Nucleus	IDA	12659813, 18722174, 20176811
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005681	Component	Spliceosomal complex	IBA	21873635
GO:0005681	Component	Spliceosomal complex	IDA	20176811
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006915	Process	Apoptotic process	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016445	Process	Somatic diversification of immunoglobulins	IMP	18722174
GO:0019899	Function	Enzyme binding	IPI	18722174
GO:0043065	Process	Positive regulation of apoptotic process	IDA	12659813

Other IDs

• MIM: 611537
• HGNC: 15879
• e!Ensembl: ENSG00000132792

Protein

• UniProt ID: Q8WYA6
• Protein name: Beta-catenin-like protein 1 (Nuclear-associated protein) (NAP) (Testis development protein NYD-SP19)
• Protein function: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processe
• PDB: 4CB8, 4CB9, 4CBA, 4HM9, 4HNM, 4MFU, 4MFV, 7ABI
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08216	CTNNBL	57 → 162	Catenin-beta-like, Arm-motif containing nuclear	Domain

• Sequence:

  MDVGELLSYQPNRGTKRPRDDEEEEQKMRRKQTGTRERGRYREEEMTVVEEADDDKKRLL
  QIIDRDGEEEEEEEEPLDESSVKKMILTFEKRSYKNQELRIKFPDNPEKFMESELDLNDI
  IQEMHVVATMPDLYHLLVELNAVQSLLGLLGHDNTDVSIAVVDLLQELTDIDTLHESEEG
  AEVLIDALVDGQVVALLVQNLERLDESVKEEADGVHNTLAIVENMAEFRPEMCTEGAQQG
  LLQWLLKRLKAKMPFDANKLYCSEVLAILLQDNDENRELLGELDGIDVLLQQLSVFKRHN
  PSTAEEQEMMENLFDSLCSCLMLSSNRERFLKGEGLQLMNLMLREKKISRSSALKVLDHA
  MIGPEGTDNCHKFVDILGLRTIFPLFMKSPRKIKKVGTTEKEHEEHVCSILASLLRNLRG
  QQRTRLLNKFTENDSEKVDRLMELHFKYLGAMQVADKKIEGEKHDMVRRGEIIDNDTEEE
  FYLRRLDAGLFVLQHICYIMAEICNANVPQIRQRVHQILNMRGSSIKIVRHIIKEYAENI
  GDGRSPEFRENEQKRILGLLENF

• Sequence length: 563

Pathways

KEGG:

Spliceosome

Reactome:

mRNA Splicing - Major Pathway

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	18264096