CRTAM (cytotoxic and regulatory T cell molecule)

Gene

• Entrez ID: 56253
• Gene name: Cytotoxic and regulatory T cell molecule
• Gene symbol: CRTAM
• Synonyms: CD355
• Chromosome: 11
• Chromosome location: 11q24.1
• Summary: The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018919	hsa-miR-335-5p	Microarray	18185580
MIRT030104	hsa-miR-26b-5p	Microarray	19088304
MIRT910565	hsa-miR-122	CLIP-seq
MIRT910566	hsa-miR-1245	CLIP-seq
MIRT910567	hsa-miR-129-5p	CLIP-seq
MIRT910568	hsa-miR-2113	CLIP-seq
MIRT910569	hsa-miR-3135b	CLIP-seq
MIRT910570	hsa-miR-3180-5p	CLIP-seq
MIRT910571	hsa-miR-3187-3p	CLIP-seq
MIRT910572	hsa-miR-3189-3p	CLIP-seq
MIRT910573	hsa-miR-3622b-5p	CLIP-seq
MIRT910574	hsa-miR-3652	CLIP-seq
MIRT910575	hsa-miR-3663-5p	CLIP-seq
MIRT910576	hsa-miR-4253	CLIP-seq
MIRT910577	hsa-miR-4260	CLIP-seq
MIRT910578	hsa-miR-4268	CLIP-seq
MIRT910579	hsa-miR-4312	CLIP-seq
MIRT910580	hsa-miR-4423-5p	CLIP-seq
MIRT910581	hsa-miR-4430	CLIP-seq
MIRT910582	hsa-miR-4435	CLIP-seq
MIRT910583	hsa-miR-4701-5p	CLIP-seq
MIRT910584	hsa-miR-4710	CLIP-seq
MIRT910585	hsa-miR-4755-3p	CLIP-seq
MIRT910586	hsa-miR-4781-3p	CLIP-seq
MIRT910587	hsa-miR-4792	CLIP-seq
MIRT910588	hsa-miR-486-3p	CLIP-seq
MIRT910589	hsa-miR-490-5p	CLIP-seq
MIRT910590	hsa-miR-515-5p	CLIP-seq
MIRT910591	hsa-miR-548c-3p	CLIP-seq
MIRT910592	hsa-miR-548s	CLIP-seq
MIRT910593	hsa-miR-550a	CLIP-seq
MIRT910594	hsa-miR-588	CLIP-seq
MIRT910565	hsa-miR-122	CLIP-seq
MIRT1969930	hsa-miR-1267	CLIP-seq
MIRT910567	hsa-miR-129-5p	CLIP-seq
MIRT910569	hsa-miR-3135b	CLIP-seq
MIRT910571	hsa-miR-3187-3p	CLIP-seq
MIRT910574	hsa-miR-3652	CLIP-seq
MIRT910575	hsa-miR-3663-5p	CLIP-seq
MIRT1969931	hsa-miR-3672	CLIP-seq
MIRT1969932	hsa-miR-411	CLIP-seq
MIRT1969933	hsa-miR-4287	CLIP-seq
MIRT910580	hsa-miR-4423-5p	CLIP-seq
MIRT910581	hsa-miR-4430	CLIP-seq
MIRT910582	hsa-miR-4435	CLIP-seq
MIRT1969934	hsa-miR-4469	CLIP-seq
MIRT1969935	hsa-miR-4685-3p	CLIP-seq
MIRT910583	hsa-miR-4701-5p	CLIP-seq
MIRT910584	hsa-miR-4710	CLIP-seq
MIRT910585	hsa-miR-4755-3p	CLIP-seq
MIRT910586	hsa-miR-4781-3p	CLIP-seq
MIRT910587	hsa-miR-4792	CLIP-seq
MIRT1969936	hsa-miR-4797-5p	CLIP-seq
MIRT1969937	hsa-miR-483-5p	CLIP-seq
MIRT910592	hsa-miR-548s	CLIP-seq
MIRT910594	hsa-miR-588	CLIP-seq
MIRT1969938	hsa-miR-642a	CLIP-seq
MIRT2205936	hsa-miR-106a	CLIP-seq
MIRT2205937	hsa-miR-106b	CLIP-seq
MIRT910565	hsa-miR-122	CLIP-seq
MIRT1969930	hsa-miR-1267	CLIP-seq
MIRT2205938	hsa-miR-150	CLIP-seq
MIRT2205939	hsa-miR-17	CLIP-seq
MIRT2205940	hsa-miR-20a	CLIP-seq
MIRT2205941	hsa-miR-20b	CLIP-seq
MIRT2205942	hsa-miR-302a	CLIP-seq
MIRT2205943	hsa-miR-302b	CLIP-seq
MIRT2205944	hsa-miR-302c	CLIP-seq
MIRT2205945	hsa-miR-302d	CLIP-seq
MIRT2205946	hsa-miR-302e	CLIP-seq
MIRT910569	hsa-miR-3135b	CLIP-seq
MIRT2205947	hsa-miR-3159	CLIP-seq
MIRT2205948	hsa-miR-33a	CLIP-seq
MIRT2205949	hsa-miR-33b	CLIP-seq
MIRT910574	hsa-miR-3652	CLIP-seq
MIRT2205950	hsa-miR-372	CLIP-seq
MIRT2205951	hsa-miR-373	CLIP-seq
MIRT1969932	hsa-miR-411	CLIP-seq
MIRT1969933	hsa-miR-4287	CLIP-seq
MIRT910580	hsa-miR-4423-5p	CLIP-seq
MIRT910581	hsa-miR-4430	CLIP-seq
MIRT910582	hsa-miR-4435	CLIP-seq
MIRT2205952	hsa-miR-4438	CLIP-seq
MIRT1969934	hsa-miR-4469	CLIP-seq
MIRT1969935	hsa-miR-4685-3p	CLIP-seq
MIRT910584	hsa-miR-4710	CLIP-seq
MIRT2205953	hsa-miR-4777-3p	CLIP-seq
MIRT910586	hsa-miR-4781-3p	CLIP-seq
MIRT910587	hsa-miR-4792	CLIP-seq
MIRT1969936	hsa-miR-4797-5p	CLIP-seq
MIRT1969937	hsa-miR-483-5p	CLIP-seq
MIRT2205954	hsa-miR-5095	CLIP-seq
MIRT2205955	hsa-miR-519d	CLIP-seq
MIRT2205956	hsa-miR-520a-3p	CLIP-seq
MIRT2205957	hsa-miR-520b	CLIP-seq
MIRT2205958	hsa-miR-520c-3p	CLIP-seq
MIRT2205959	hsa-miR-520d-3p	CLIP-seq
MIRT2205960	hsa-miR-520e	CLIP-seq
MIRT2205961	hsa-miR-520g	CLIP-seq
MIRT2205962	hsa-miR-520h	CLIP-seq
MIRT1969938	hsa-miR-642a	CLIP-seq
MIRT2205963	hsa-miR-885-5p	CLIP-seq
MIRT2205964	hsa-miR-93	CLIP-seq
MIRT1969930	hsa-miR-1267	CLIP-seq
MIRT1969933	hsa-miR-4287	CLIP-seq
MIRT910580	hsa-miR-4423-5p	CLIP-seq
MIRT1969934	hsa-miR-4469	CLIP-seq
MIRT1969935	hsa-miR-4685-3p	CLIP-seq
MIRT1969936	hsa-miR-4797-5p	CLIP-seq
MIRT1969938	hsa-miR-642a	CLIP-seq
MIRT910565	hsa-miR-122	CLIP-seq
MIRT1969930	hsa-miR-1267	CLIP-seq
MIRT910567	hsa-miR-129-5p	CLIP-seq
MIRT910569	hsa-miR-3135b	CLIP-seq
MIRT2205948	hsa-miR-33a	CLIP-seq
MIRT2205949	hsa-miR-33b	CLIP-seq
MIRT910574	hsa-miR-3652	CLIP-seq
MIRT1969933	hsa-miR-4287	CLIP-seq
MIRT910580	hsa-miR-4423-5p	CLIP-seq
MIRT910581	hsa-miR-4430	CLIP-seq
MIRT1969934	hsa-miR-4469	CLIP-seq
MIRT2509184	hsa-miR-450b-5p	CLIP-seq
MIRT1969935	hsa-miR-4685-3p	CLIP-seq
MIRT910584	hsa-miR-4710	CLIP-seq
MIRT2509185	hsa-miR-4735-5p	CLIP-seq
MIRT2509186	hsa-miR-4775	CLIP-seq
MIRT910587	hsa-miR-4792	CLIP-seq
MIRT2509187	hsa-miR-4794	CLIP-seq
MIRT1969936	hsa-miR-4797-5p	CLIP-seq
MIRT2509188	hsa-miR-507	CLIP-seq
MIRT2509189	hsa-miR-557	CLIP-seq
MIRT2509190	hsa-miR-561	CLIP-seq
MIRT2509191	hsa-miR-590-3p	CLIP-seq
MIRT1969938	hsa-miR-642a	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001768	Process	Establishment of T cell polarity	ISS
GO:0001772	Component	Immunological synapse	ISS
GO:0001819	Process	Positive regulation of cytokine production	IDA	15811952
GO:0001913	Process	T cell mediated cytotoxicity	IDA	15811952
GO:0002355	Process	Detection of tumor cell	IBA	21873635
GO:0002355	Process	Detection of tumor cell	IDA	15811952
GO:0002860	Process	Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IBA	21873635
GO:0002860	Process	Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IDA	15811952
GO:0005102	Function	Signaling receptor binding	IBA	21873635
GO:0005102	Function	Signaling receptor binding	IPI	15811952
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	15811952
GO:0005886	Component	Plasma membrane	TAS
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISS
GO:0008037	Process	Cell recognition	IBA	21873635
GO:0008037	Process	Cell recognition	IDA	15811952
GO:0016021	Component	Integral component of membrane	IEA
GO:0032729	Process	Positive regulation of interferon-gamma production	ISS
GO:0045580	Process	Regulation of T cell differentiation	ISS
GO:0045954	Process	Positive regulation of natural killer cell mediated cytotoxicity	IDA	15811952
GO:0046007	Process	Negative regulation of activated T cell proliferation	ISS
GO:0050776	Process	Regulation of immune response	TAS
GO:0050798	Process	Activated T cell proliferation	IDA	15811952
GO:0050863	Process	Regulation of T cell activation	ISS
GO:0051606	Process	Detection of stimulus	IDA	15811952
GO:0097021	Process	Lymphocyte migration into lymphoid organs	ISS
GO:2001185	Process	Regulation of CD8-positive, alpha-beta T cell activation	ISS

Other IDs

• MIM: 612597
• HGNC: 24313
• e!Ensembl: ENSG00000109943

Protein

• UniProt ID: O95727
• Protein name: Cytotoxic and regulatory T-cell molecule (Class-I MHC-restricted T-cell-associated molecule) (CD antigen CD355)
• Protein function: Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (By similarity). Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-ga
• PDB: 3RBG, 4H5S
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	21 → 115	Immunoglobulin V-set domain	Domain
  PF08205	C2-set_2	121 → 207	CD80-like C2-set immunoglobulin domain	Domain

• Sequence:

  MWWRVLSLLAWFPLQEASLTNHTETITVEEGQTLTLKCVTSLRKNSSLQWLTPSGFTIFL
  NEYPALKNSKYQLLHHSANQLSITVPNVTLQDEGVYKCLHYSDSVSTKEVKVIVLATPFK
  PILEASVIRKQNGEEHVVLMCSTMRSKPPPQITWLLGNSMEVSGGTLHEFETDGKKCNTT
  STLIIHTYGKNSTVDCIIRHRGLQGRKLVAPFRFEDLVTDEETASDALERNSLSSQDPQQ
  PTSTVSVTEDSSTSEIDKEEKEQTTQDPDLTTEANPQYLGLARKKSGILLLTLVSFLIFI
  LFIIVQLFIMKLRKAHVIWKKENEVSEHTLESYRSRSNNEETSSEEKNGQSSHPMRCMNY
  ITKLYSEAKTKRKENVQHSKLEEKHIQVPESIV

• Sequence length: 393

Pathways

Reactome:

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Malignant mesothelioma	Malignant mesothelioma		23827383