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PRLR (prolactin receptor)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5618
Gene nameGene Name - the full gene name approved by the HGNC.
Prolactin receptor
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
PRLR
SynonymsGene synonyms aliases
HPRL, MFAB, RI-PRLR, hPRLrI
ChromosomeChromosome number
5
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5p13.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternativ
SNPsSNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs72478580 T>G Conflicting-interpretations-of-pathogenicity Coding sequence variant, missense variant, non coding transcript variant
rs376188691 G>A,T Pathogenic Non coding transcript variant, coding sequence variant, synonymous variant, stop gained
rs398122522 T>C Pathogenic Non coding transcript variant, coding sequence variant, missense variant
rs754974807 G>A Pathogenic Non coding transcript variant, missense variant, coding sequence variant, intron variant
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025183 hsa-miR-181a-5p Microarray 17612493
MIRT666815 hsa-miR-5680 HITS-CLIP 23824327
MIRT666814 hsa-miR-5579-5p HITS-CLIP 23824327
MIRT666813 hsa-miR-6832-3p HITS-CLIP 23824327
MIRT666812 hsa-miR-1249-3p HITS-CLIP 23824327
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004896 Function Cytokine receptor activity IBA 21873635
GO:0004923 Function Leukemia inhibitory factor receptor activity IBA 21873635
GO:0004924 Function Oncostatin-M receptor activity IBA 21873635
GO:0004925 Function Prolactin receptor activity IBA 21873635
GO:0004925 Function Prolactin receptor activity IDA 10585417
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID P16471
Protein name Prolactin receptor (PRL-R)
Protein function This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to tran
PDB 1BP3 , 2LFG , 2N7I , 3D48 , 3MZG , 3N06 , 3N0P , 3NCB , 3NCC , 3NCE , 3NCF , 4I18
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09067 EpoR_lig-bind
22 120
Erythropoietin receptor, ligand binding
Domain
Sequence
MKENVASATVFTLLLFLNTCLLNGQLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNY
SLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVD

VTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEW
EIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDTTVWIS
VAVLSAVICLIIVWAVALKGYSMVTCIFPPVPGPKIKGFDAHLLEKGKSEELLSALGCQD
FPPTSDYEDLLVEYLEVDDSEDQHLMSVHSKEHPSQGMKPTYLDPDTDSGRGSCDSPSLL
SEKCEEPQANPSTFYDPEVIEKPENPETTHTWDPQCISMEGKIPYFHAGGSKCSTWPLPQ
PSQHNPRSSYHNITDVCELAVGPAGAPATLLNEAGKDALKSSQTIKSREEGKATQQREVE
SFHSETDQDTPWLLPQEKTPFGSAKPLDYVEIHKVNKDGALSLLPKQRENSGKPKKPGTP
ENNKEYAKVSGVMDNNILVLVPDPHAKNVACFEESAKEAPPSLEQNQAEKALANFTATSS
KCRLQLGGLDYLDPACFTHSFH
Sequence length 622
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Cytokine-cytokine receptor interaction
Neuroactive ligand-receptor interaction
Hormone signaling
PI3K-Akt signaling pathway
JAK-STAT signaling pathway
Prolactin signaling pathway
  Prolactin receptor signaling
Growth hormone receptor signaling
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Autism Autistic Disorder rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634 18207134
Carcinoma Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 17173897, 16316942, 16316942, 17173897
Hyperprolactinemia Hyperprolactinemia, Familial hyperprolactinemia rs398122522, rs376188691, rs754974807 24195502
Osteoporosis Osteoporosis rs72658152, rs72667023, rs587776916, rs72656370, rs768615287
Unknown
Disease name Disease term dbSNP ID References
Anaplastic carcinoma Anaplastic carcinoma 17173897, 16316942
Endometrioma Endometrioma 20864642
Endometriosis Endometriosis rs1800629, rs1143634 20864642
Female hypogonadism syndrome Female hypogonadism syndrome

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