PCDHA4 (protocadherin alpha 4)

Gene

• Entrez ID: 56144
• Gene name: Protocadherin alpha 4
• Gene symbol: PCDHA4
• Synonyms: CNR1, CNRN1, CRNR1, PCDH-ALPHA4
• Chromosome: 5
• Chromosome location: 5q31.3
• Summary: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha ge

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019262	hsa-miR-148b-3p	Microarray	17612493
MIRT028998	hsa-miR-26b-5p	Microarray	19088304
MIRT053674	hsa-miR-181a-5p	Microarray	22942087
MIRT053722	hsa-miR-221-3p	Microarray	22942087
MIRT619218	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT659438	hsa-miR-5008-3p	HITS-CLIP	23824327
MIRT659437	hsa-miR-6737-3p	HITS-CLIP	23824327
MIRT659436	hsa-miR-7157-3p	HITS-CLIP	23824327
MIRT619217	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT659435	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT619215	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT619214	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT619218	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT619217	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT619216	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT619215	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT619214	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT619218	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT659438	hsa-miR-5008-3p	HITS-CLIP	23824327
MIRT659437	hsa-miR-6737-3p	HITS-CLIP	23824327
MIRT659436	hsa-miR-7157-3p	HITS-CLIP	23824327
MIRT619217	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT659435	hsa-miR-6882-3p	HITS-CLIP	23824327
MIRT619215	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT619214	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT619218	hsa-miR-1914-5p	HITS-CLIP	23824327
MIRT619217	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT619216	hsa-miR-27b-5p	HITS-CLIP	23824327
MIRT619215	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT619214	hsa-miR-7152-5p	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	ISS
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0007155	Process	Cell adhesion	IBA	21873635
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0007399	Process	Nervous system development	TAS	10380929
GO:0042802	Function	Identical protein binding	ISS

Other IDs

• MIM: 606310
• HGNC: 8670
• e!Ensembl: ENSG00000204967

Protein

• UniProt ID: Q9UN74
• Protein name: Protocadherin alpha-4 (PCDH-alpha-4)
• Protein function: Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08266	Cadherin_2	30 → 112	Cadherin-like	Domain
  PF00028	Cadherin	138 → 233	Cadherin domain	Domain
  PF00028	Cadherin	247 → 341	Cadherin domain	Domain
  PF00028	Cadherin	355 → 446	Cadherin domain	Domain
  PF00028	Cadherin	460 → 556	Cadherin domain	Domain
  PF00028	Cadherin	577 → 670	Cadherin domain	Domain
  PF15974	Cadherin_tail	797 → 930	Cadherin C-terminal cytoplasmic tail, catenin-binding region	Family

• Sequence:

  MEFSWGSGQESRRLLLLLLLLAAWEAGNGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV
  PRLFRVASKGRGGLLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVIVDRPLQVFHVD
  VEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSL
  EKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAP
  AFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITG
  QIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIR
  EDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDRESVSA
  YELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAW
  DADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDA
  GVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDAD
  SGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPALT
  ATATVLVSLVESGQAPKASSRALVGAVGPDAALVDVNVYLIIAICAVSSLLVLTLLLYTA
  LRCSALPTEGACAPGKPTLVCSSAVGSWSYSQQRRPRVCSGEGPPKTDLMAFSPSLPDSR
  DREDQLQTTEESFAKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVS
  SATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEP
  TNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ

• Sequence length: 947

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	24185611

Unknown
Disease name	Disease term	dbSNP ID	References
Mental depression	Major Depressive Disorder	rs587778876, rs587778877	29942085, 27479909