EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2)

Gene

• Entrez ID: 5610
• Gene name: Eukaryotic translation initiation factor 2 alpha kinase 2
• Gene symbol: EIF2AK2
• Synonyms: DYT33, EIF2AK1, LEUDEN, PKR, PPP1R83, PRKR
• Chromosome: 2
• Chromosome location: 2p22.2
• Summary: The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1573010519	C>T	Likely-pathogenic	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019974	hsa-miR-375	qRT-PCR;Microarray	20584986
MIRT022755	hsa-miR-124-3p	Proteomics	18668037
MIRT046386	hsa-miR-15b-5p	CLASH	23622248
MIRT037216	hsa-miR-877-5p	CLASH	23622248
MIRT706575	hsa-miR-495-5p	HITS-CLIP	22927820
MIRT706574	hsa-miR-34b-3p	HITS-CLIP	22927820
MIRT706573	hsa-miR-510-5p	HITS-CLIP	22927820
MIRT706572	hsa-miR-4695-5p	HITS-CLIP	22927820
MIRT706571	hsa-miR-6808-5p	HITS-CLIP	22927820
MIRT706570	hsa-miR-6893-5p	HITS-CLIP	22927820
MIRT706569	hsa-miR-940	HITS-CLIP	22927820
MIRT706568	hsa-miR-3929	HITS-CLIP	22927820
MIRT706567	hsa-miR-4419b	HITS-CLIP	22927820
MIRT706566	hsa-miR-4478	HITS-CLIP	22927820
MIRT706565	hsa-miR-3614-5p	HITS-CLIP	22927820
MIRT706564	hsa-miR-6500-3p	HITS-CLIP	22927820
MIRT706563	hsa-miR-4768-3p	HITS-CLIP	22927820
MIRT706562	hsa-miR-4459	HITS-CLIP	22927820
MIRT706561	hsa-miR-4433a-3p	HITS-CLIP	22927820
MIRT706560	hsa-miR-3664-3p	HITS-CLIP	22927820
MIRT706559	hsa-miR-4649-3p	HITS-CLIP	22927820
MIRT706558	hsa-miR-485-5p	HITS-CLIP	22927820
MIRT706557	hsa-miR-6884-5p	HITS-CLIP	22927820
MIRT706556	hsa-miR-298	HITS-CLIP	22927820
MIRT706555	hsa-miR-4722-5p	HITS-CLIP	22927820
MIRT706554	hsa-miR-7160-5p	HITS-CLIP	22927820
MIRT706553	hsa-miR-665	HITS-CLIP	22927820
MIRT668600	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT668599	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT668598	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT668597	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT668596	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT668595	hsa-miR-202-5p	HITS-CLIP	23824327
MIRT395635	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT668594	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT668593	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT668592	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT668591	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT668591	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT668591	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT668591	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT668591	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT668591	hsa-miR-4652-3p	HITS-CLIP	27418678
MIRT668592	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT668592	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT668592	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT668592	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT668592	hsa-miR-4743-3p	HITS-CLIP	27418678
MIRT668594	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT668594	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT668594	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT668594	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT668594	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT668593	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT668593	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT668593	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT668593	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT668593	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT706575	hsa-miR-495-5p	HITS-CLIP	22927820
MIRT706574	hsa-miR-34b-3p	HITS-CLIP	22927820
MIRT706573	hsa-miR-510-5p	HITS-CLIP	22927820
MIRT706572	hsa-miR-4695-5p	HITS-CLIP	22927820
MIRT706571	hsa-miR-6808-5p	HITS-CLIP	22927820
MIRT706570	hsa-miR-6893-5p	HITS-CLIP	22927820
MIRT706569	hsa-miR-940	HITS-CLIP	22927820
MIRT706568	hsa-miR-3929	HITS-CLIP	22927820
MIRT706567	hsa-miR-4419b	HITS-CLIP	22927820
MIRT706566	hsa-miR-4478	HITS-CLIP	22927820
MIRT706565	hsa-miR-3614-5p	HITS-CLIP	22927820
MIRT706564	hsa-miR-6500-3p	HITS-CLIP	22927820
MIRT706563	hsa-miR-4768-3p	HITS-CLIP	22927820
MIRT706562	hsa-miR-4459	HITS-CLIP	22927820
MIRT706561	hsa-miR-4433a-3p	HITS-CLIP	22927820
MIRT706560	hsa-miR-3664-3p	HITS-CLIP	22927820
MIRT706559	hsa-miR-4649-3p	HITS-CLIP	22927820
MIRT706558	hsa-miR-485-5p	HITS-CLIP	22927820
MIRT706557	hsa-miR-6884-5p	HITS-CLIP	22927820
MIRT706556	hsa-miR-298	HITS-CLIP	22927820
MIRT706555	hsa-miR-4722-5p	HITS-CLIP	22927820
MIRT706554	hsa-miR-7160-5p	HITS-CLIP	22927820
MIRT706553	hsa-miR-665	HITS-CLIP	22927820
MIRT668600	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT668599	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT668598	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT668597	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT668596	hsa-miR-7158-5p	HITS-CLIP	23824327
MIRT668595	hsa-miR-202-5p	HITS-CLIP	23824327
MIRT395635	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT668594	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT668593	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT668592	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT668591	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT956547	hsa-miR-1827	CLIP-seq
MIRT956548	hsa-miR-3122	CLIP-seq
MIRT956549	hsa-miR-3165	CLIP-seq
MIRT956550	hsa-miR-3665	CLIP-seq
MIRT956551	hsa-miR-3689a-3p	CLIP-seq
MIRT956552	hsa-miR-3689c	CLIP-seq
MIRT956553	hsa-miR-3913-5p	CLIP-seq
MIRT956554	hsa-miR-4433	CLIP-seq
MIRT956555	hsa-miR-4728-5p	CLIP-seq
MIRT956556	hsa-miR-4736	CLIP-seq
MIRT956557	hsa-miR-1207-3p	CLIP-seq
MIRT956558	hsa-miR-1262	CLIP-seq
MIRT956559	hsa-miR-1293	CLIP-seq
MIRT956560	hsa-miR-1294	CLIP-seq
MIRT956547	hsa-miR-1827	CLIP-seq
MIRT956561	hsa-miR-3074-3p	CLIP-seq
MIRT956562	hsa-miR-3120-5p	CLIP-seq
MIRT956563	hsa-miR-361-5p	CLIP-seq
MIRT956564	hsa-miR-3664-5p	CLIP-seq
MIRT956565	hsa-miR-3919	CLIP-seq
MIRT956566	hsa-miR-3925-3p	CLIP-seq
MIRT956567	hsa-miR-3925-5p	CLIP-seq
MIRT956568	hsa-miR-4259	CLIP-seq
MIRT956569	hsa-miR-4267	CLIP-seq
MIRT956570	hsa-miR-4316	CLIP-seq
MIRT956554	hsa-miR-4433	CLIP-seq
MIRT956571	hsa-miR-448	CLIP-seq
MIRT956572	hsa-miR-4483	CLIP-seq
MIRT956573	hsa-miR-4501	CLIP-seq
MIRT956574	hsa-miR-4522	CLIP-seq
MIRT956575	hsa-miR-4701-3p	CLIP-seq
MIRT956576	hsa-miR-4715-5p	CLIP-seq
MIRT956577	hsa-miR-510	CLIP-seq
MIRT956578	hsa-miR-511	CLIP-seq
MIRT956579	hsa-miR-512-5p	CLIP-seq
MIRT956580	hsa-miR-515-5p	CLIP-seq
MIRT956581	hsa-miR-766	CLIP-seq
MIRT1920405	hsa-miR-4773	CLIP-seq
MIRT1920406	hsa-miR-587	CLIP-seq
MIRT1920407	hsa-miR-876-3p	CLIP-seq
MIRT1983267	hsa-miR-1285	CLIP-seq
MIRT956560	hsa-miR-1294	CLIP-seq
MIRT1983268	hsa-miR-129-5p	CLIP-seq
MIRT1983269	hsa-miR-143	CLIP-seq
MIRT956547	hsa-miR-1827	CLIP-seq
MIRT1983270	hsa-miR-24	CLIP-seq
MIRT1983271	hsa-miR-2467-5p	CLIP-seq
MIRT1983272	hsa-miR-25	CLIP-seq
MIRT956549	hsa-miR-3165	CLIP-seq
MIRT1983273	hsa-miR-3178	CLIP-seq
MIRT1983274	hsa-miR-3187-5p	CLIP-seq
MIRT1983275	hsa-miR-3188	CLIP-seq
MIRT1983276	hsa-miR-32	CLIP-seq
MIRT1983277	hsa-miR-34b	CLIP-seq
MIRT1983278	hsa-miR-363	CLIP-seq
MIRT1983279	hsa-miR-367	CLIP-seq
MIRT956565	hsa-miR-3919	CLIP-seq
MIRT956567	hsa-miR-3925-5p	CLIP-seq
MIRT1983280	hsa-miR-3975	CLIP-seq
MIRT956569	hsa-miR-4267	CLIP-seq
MIRT1983281	hsa-miR-4284	CLIP-seq
MIRT956570	hsa-miR-4316	CLIP-seq
MIRT1983282	hsa-miR-4317	CLIP-seq
MIRT1983283	hsa-miR-4325	CLIP-seq
MIRT956554	hsa-miR-4433	CLIP-seq
MIRT1983284	hsa-miR-4486	CLIP-seq
MIRT956573	hsa-miR-4501	CLIP-seq
MIRT1983285	hsa-miR-4505	CLIP-seq
MIRT1983286	hsa-miR-4770	CLIP-seq
MIRT1983287	hsa-miR-508-5p	CLIP-seq
MIRT956577	hsa-miR-510	CLIP-seq
MIRT956579	hsa-miR-512-5p	CLIP-seq
MIRT1983288	hsa-miR-592	CLIP-seq
MIRT1983289	hsa-miR-597	CLIP-seq
MIRT1983290	hsa-miR-600	CLIP-seq
MIRT1983291	hsa-miR-612	CLIP-seq
MIRT1983292	hsa-miR-616	CLIP-seq
MIRT1983293	hsa-miR-661	CLIP-seq
MIRT956581	hsa-miR-766	CLIP-seq
MIRT1983294	hsa-miR-892a	CLIP-seq
MIRT1983295	hsa-miR-92a	CLIP-seq
MIRT1983296	hsa-miR-92b	CLIP-seq
MIRT1983267	hsa-miR-1285	CLIP-seq
MIRT956560	hsa-miR-1294	CLIP-seq
MIRT1983269	hsa-miR-143	CLIP-seq
MIRT956547	hsa-miR-1827	CLIP-seq
MIRT1983271	hsa-miR-2467-5p	CLIP-seq
MIRT1983272	hsa-miR-25	CLIP-seq
MIRT1983273	hsa-miR-3178	CLIP-seq
MIRT1983274	hsa-miR-3187-5p	CLIP-seq
MIRT1983275	hsa-miR-3188	CLIP-seq
MIRT1983276	hsa-miR-32	CLIP-seq
MIRT1983277	hsa-miR-34b	CLIP-seq
MIRT1983278	hsa-miR-363	CLIP-seq
MIRT1983279	hsa-miR-367	CLIP-seq
MIRT956565	hsa-miR-3919	CLIP-seq
MIRT956567	hsa-miR-3925-5p	CLIP-seq
MIRT1983280	hsa-miR-3975	CLIP-seq
MIRT956569	hsa-miR-4267	CLIP-seq
MIRT956570	hsa-miR-4316	CLIP-seq
MIRT1983282	hsa-miR-4317	CLIP-seq
MIRT1983283	hsa-miR-4325	CLIP-seq
MIRT956554	hsa-miR-4433	CLIP-seq
MIRT1983284	hsa-miR-4486	CLIP-seq
MIRT956573	hsa-miR-4501	CLIP-seq
MIRT1983285	hsa-miR-4505	CLIP-seq
MIRT1983286	hsa-miR-4770	CLIP-seq
MIRT1983287	hsa-miR-508-5p	CLIP-seq
MIRT956577	hsa-miR-510	CLIP-seq
MIRT956579	hsa-miR-512-5p	CLIP-seq
MIRT1983288	hsa-miR-592	CLIP-seq
MIRT1983289	hsa-miR-597	CLIP-seq
MIRT1983291	hsa-miR-612	CLIP-seq
MIRT1983292	hsa-miR-616	CLIP-seq
MIRT1983293	hsa-miR-661	CLIP-seq
MIRT956581	hsa-miR-766	CLIP-seq
MIRT1983294	hsa-miR-892a	CLIP-seq
MIRT1983295	hsa-miR-92a	CLIP-seq
MIRT1983296	hsa-miR-92b	CLIP-seq
MIRT1983267	hsa-miR-1285	CLIP-seq
MIRT956547	hsa-miR-1827	CLIP-seq
MIRT1983272	hsa-miR-25	CLIP-seq
MIRT956562	hsa-miR-3120-5p	CLIP-seq
MIRT1983274	hsa-miR-3187-5p	CLIP-seq
MIRT1983276	hsa-miR-32	CLIP-seq
MIRT1983278	hsa-miR-363	CLIP-seq
MIRT956564	hsa-miR-3664-5p	CLIP-seq
MIRT1983279	hsa-miR-367	CLIP-seq
MIRT1983282	hsa-miR-4317	CLIP-seq
MIRT1983283	hsa-miR-4325	CLIP-seq
MIRT956554	hsa-miR-4433	CLIP-seq
MIRT956574	hsa-miR-4522	CLIP-seq
MIRT1983287	hsa-miR-508-5p	CLIP-seq
MIRT956578	hsa-miR-511	CLIP-seq
MIRT1983291	hsa-miR-612	CLIP-seq
MIRT1983292	hsa-miR-616	CLIP-seq
MIRT1983293	hsa-miR-661	CLIP-seq
MIRT956581	hsa-miR-766	CLIP-seq
MIRT1983295	hsa-miR-92a	CLIP-seq
MIRT1983296	hsa-miR-92b	CLIP-seq
MIRT1983267	hsa-miR-1285	CLIP-seq
MIRT956547	hsa-miR-1827	CLIP-seq
MIRT1983272	hsa-miR-25	CLIP-seq
MIRT956562	hsa-miR-3120-5p	CLIP-seq
MIRT956548	hsa-miR-3122	CLIP-seq
MIRT956549	hsa-miR-3165	CLIP-seq
MIRT1983274	hsa-miR-3187-5p	CLIP-seq
MIRT1983276	hsa-miR-32	CLIP-seq
MIRT2679870	hsa-miR-339-5p	CLIP-seq
MIRT1983278	hsa-miR-363	CLIP-seq
MIRT956564	hsa-miR-3664-5p	CLIP-seq
MIRT956550	hsa-miR-3665	CLIP-seq
MIRT1983279	hsa-miR-367	CLIP-seq
MIRT956551	hsa-miR-3689a-3p	CLIP-seq
MIRT956552	hsa-miR-3689c	CLIP-seq
MIRT956553	hsa-miR-3913-5p	CLIP-seq
MIRT956569	hsa-miR-4267	CLIP-seq
MIRT1983282	hsa-miR-4317	CLIP-seq
MIRT1983283	hsa-miR-4325	CLIP-seq
MIRT956554	hsa-miR-4433	CLIP-seq
MIRT956574	hsa-miR-4522	CLIP-seq
MIRT956555	hsa-miR-4728-5p	CLIP-seq
MIRT956556	hsa-miR-4736	CLIP-seq
MIRT1983287	hsa-miR-508-5p	CLIP-seq
MIRT956577	hsa-miR-510	CLIP-seq
MIRT956578	hsa-miR-511	CLIP-seq
MIRT956579	hsa-miR-512-5p	CLIP-seq
MIRT1983291	hsa-miR-612	CLIP-seq
MIRT1983292	hsa-miR-616	CLIP-seq
MIRT1983293	hsa-miR-661	CLIP-seq
MIRT956581	hsa-miR-766	CLIP-seq
MIRT1983295	hsa-miR-92a	CLIP-seq
MIRT1983296	hsa-miR-92b	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
IRF1	Activation	8622878

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000186	Process	Activation of MAPKK activity	IMP	15229216
GO:0001819	Process	Positive regulation of cytokine production	ISS
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003725	Function	Double-stranded RNA binding	IDA	21266579
GO:0004672	Function	Protein kinase activity	IBA	21873635
GO:0004672	Function	Protein kinase activity	IDA	12882984, 15229216, 18835251
GO:0004672	Function	Protein kinase activity	IMP	21123651
GO:0004674	Function	Protein serine/threonine kinase activity	TAS	1695551
GO:0004694	Function	Eukaryotic translation initiation factor 2alpha kinase activity	IBA	21873635
GO:0004694	Function	Eukaryotic translation initiation factor 2alpha kinase activity	IMP	25329545
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	8576172, 9143277, 9431994, 10390359, 10488152, 11160738, 11773402, 11836380, 12610133, 12882984, 15121867, 15229216, 16288713, 16785445, 16957780, 18096616, 18362360, 18835251, 18971339, 20395957, 21903422, 22801494, 23455922, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	15121867
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	TAS	10390359
GO:0006468	Process	Protein phosphorylation	IDA	19189853
GO:0008285	Process	Negative regulation of cell population proliferation	TAS	1351683
GO:0009615	Process	Response to virus	IMP	19189853
GO:0010998	Process	Regulation of translational initiation by eIF2 alpha phosphorylation	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0017148	Process	Negative regulation of translation	IDA	12882984
GO:0017148	Process	Negative regulation of translation	IMP	12610133, 19189853
GO:0018108	Process	Peptidyl-tyrosine phosphorylation	IEA
GO:0019888	Function	Protein phosphatase regulator activity	TAS	10866685
GO:0030683	Process	Mitigation of host immune response by virus	TAS
GO:0032722	Process	Positive regulation of chemokine production	ISS
GO:0032874	Process	Positive regulation of stress-activated MAPK cascade	ISS
GO:0033689	Process	Negative regulation of osteoblast proliferation	IMP	16216244
GO:0034198	Process	Cellular response to amino acid starvation	IMP	25329545
GO:0035455	Process	Response to interferon-alpha	IDA	19840259
GO:0042802	Function	Identical protein binding	IPI	16373505
GO:0043666	Process	Regulation of phosphoprotein phosphatase activity	IEA
GO:0045071	Process	Negative regulation of viral genome replication	IMP	19189853, 19840259
GO:0045087	Process	Innate immune response	IEA
GO:0046777	Process	Protein autophosphorylation	IDA	22801494
GO:0046777	Process	Protein autophosphorylation	IMP	16216244
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	15121867
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IDA	15121867
GO:0051607	Process	Defense response to virus	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA
GO:1900225	Process	Regulation of NLRP3 inflammasome complex assembly	ISS
GO:1901224	Process	Positive regulation of NIK/NF-kappaB signaling	ISS
GO:1901532	Process	Regulation of hematopoietic progenitor cell differentiation	ISS
GO:1902033	Process	Regulation of hematopoietic stem cell proliferation	ISS
GO:1902036	Process	Regulation of hematopoietic stem cell differentiation	ISS

Other IDs

• MIM: 176871
• HGNC: 9437
• e!Ensembl: ENSG00000055332

Protein

• UniProt ID: P19525
• Protein name: Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein ki
• Protein function: IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection (PubMed:18
• PDB: 1QU6, 2A19, 2A1A, 3UIU, 6D3K, 6D3L, 7OBK, 7OBL, 8BI7, 8I9J, 8IZN
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00035	dsrm	10 → 75	Double-stranded RNA binding motif	Domain
  PF00035	dsrm	101 → 165	Double-stranded RNA binding motif	Domain
  PF00069	Pkinase	267 → 537	Protein kinase domain	Domain

• Sequence:

  MAGDLSAGFFMEELNTYRQKQGVVLKYQELPNSGPPHDRRFTFQVIIDGREFPEGEGRSK
  KEAKNAAAKLAVEILNKEKKAVSPLLLTTTNSSEGLSMGNYIGLINRIAQKKRLTVNYEQ
  CASGVHGPEGFHYKCKMGQKEYSIGTGSTKQEAKQLAAKLAYLQILSEETSVKSDYLSSG
  SFATTCESQSNSLVTSTLASESSSEGDFSADTSEINSNSDSLNSSSLLMNGLRNNQRKAK
  RSLAPRFDLPDMKETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKY
  NNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTK
  CLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNI
  FLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAE
  LLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWK
  KSPEKNERHTC

• Sequence length: 551

Pathways

KEGG:

Necroptosis
Alzheimer disease
Hepatitis C
Measles
Influenza A
Human papillomavirus infection
Kaposi sarcoma-associated herpesvirus infection
Herpes simplex virus 1 infection
Epstein-Barr virus infection
Coronavirus disease - COVID-19
Viral carcinogenesis

Reactome:

ISG15 antiviral mechanism
Inhibition of PKR

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17199135

Unknown
Disease name	Disease term	dbSNP ID	References
Grand mal status epilepticus	Grand Mal Status Epilepticus		16492139
Nonconvulsive status epilepticus	Non-Convulsive Status Epilepticus		16492139
Petit mal status	Petit mal status		16492139
Prostatic neoplasms	Prostatic Neoplasms		17199135
Status epilepticus	Status Epilepticus, Complex Partial Status Epilepticus, Status Epilepticus, Subclinical		16492139