MAP2K7 (mitogen-activated protein kinase kinase 7)

Gene

• Entrez ID: 5609
• Gene name: Mitogen-activated protein kinase kinase 7
• Gene symbol: MAP2K7
• Synonyms: JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4
• Chromosome: 19
• Chromosome location: 19p13.2
• Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase k

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT045769	hsa-miR-125a-5p	CLASH	23622248
MIRT054426	hsa-miR-493-3p	Immunohistochemistry, Luciferase reporter assay, Western blot	24533778
MIRT054426	hsa-miR-493-3p	Immunohistochemistry, Luciferase reporter assay, Western blot	24533778
MIRT502019	hsa-miR-4311	PAR-CLIP	24398324
MIRT473843	hsa-miR-8080	PAR-CLIP	23592263
MIRT473842	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT473841	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT473840	hsa-miR-2278	PAR-CLIP	23592263
MIRT473839	hsa-miR-3125	PAR-CLIP	23592263
MIRT473838	hsa-miR-3916	PAR-CLIP	23592263
MIRT473837	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT473836	hsa-miR-6510-5p	PAR-CLIP	23592263
MIRT473835	hsa-miR-3927-3p	PAR-CLIP	23592263
MIRT473834	hsa-miR-6831-5p	PAR-CLIP	23592263
MIRT473833	hsa-miR-3928-3p	PAR-CLIP	23592263
MIRT473832	hsa-let-7a-5p	PAR-CLIP	23592263
MIRT473831	hsa-let-7b-5p	PAR-CLIP	23592263
MIRT473830	hsa-let-7c-5p	PAR-CLIP	23592263
MIRT473829	hsa-let-7d-5p	PAR-CLIP	23592263
MIRT473828	hsa-let-7e-5p	PAR-CLIP	23592263
MIRT473827	hsa-let-7f-5p	PAR-CLIP	23592263
MIRT473826	hsa-let-7g-5p	PAR-CLIP	23592263
MIRT473825	hsa-let-7i-5p	PAR-CLIP	23592263
MIRT473823	hsa-miR-4458	PAR-CLIP	23592263
MIRT473824	hsa-miR-4500	PAR-CLIP	23592263
MIRT473822	hsa-miR-98-5p	PAR-CLIP	23592263
MIRT473821	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT473819	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT473820	hsa-miR-6077	PAR-CLIP	23592263
MIRT473818	hsa-miR-4451	PAR-CLIP	23592263
MIRT473817	hsa-miR-4732-5p	PAR-CLIP	23592263
MIRT440290	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440290	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT473832	hsa-let-7a-5p	PAR-CLIP	26701625
MIRT473832	hsa-let-7a-5p	PAR-CLIP	26701625
MIRT473832	hsa-let-7a-5p	PAR-CLIP	26701625
MIRT473832	hsa-let-7a-5p	PAR-CLIP	26701625
MIRT473831	hsa-let-7b-5p	PAR-CLIP	26701625
MIRT473831	hsa-let-7b-5p	PAR-CLIP	26701625
MIRT473831	hsa-let-7b-5p	PAR-CLIP	26701625
MIRT473831	hsa-let-7b-5p	PAR-CLIP	26701625
MIRT473830	hsa-let-7c-5p	PAR-CLIP	26701625
MIRT473830	hsa-let-7c-5p	PAR-CLIP	26701625
MIRT473830	hsa-let-7c-5p	PAR-CLIP	26701625
MIRT473830	hsa-let-7c-5p	PAR-CLIP	26701625
MIRT473829	hsa-let-7d-5p	PAR-CLIP	26701625
MIRT473829	hsa-let-7d-5p	PAR-CLIP	26701625
MIRT473829	hsa-let-7d-5p	PAR-CLIP	26701625
MIRT473829	hsa-let-7d-5p	PAR-CLIP	26701625
MIRT473828	hsa-let-7e-5p	PAR-CLIP	26701625
MIRT473828	hsa-let-7e-5p	PAR-CLIP	26701625
MIRT473828	hsa-let-7e-5p	PAR-CLIP	26701625
MIRT473828	hsa-let-7e-5p	PAR-CLIP	26701625
MIRT473827	hsa-let-7f-5p	PAR-CLIP	26701625
MIRT473827	hsa-let-7f-5p	PAR-CLIP	26701625
MIRT473827	hsa-let-7f-5p	PAR-CLIP	26701625
MIRT473827	hsa-let-7f-5p	PAR-CLIP	26701625
MIRT473826	hsa-let-7g-5p	PAR-CLIP	26701625
MIRT473826	hsa-let-7g-5p	PAR-CLIP	26701625
MIRT473826	hsa-let-7g-5p	PAR-CLIP	26701625
MIRT473826	hsa-let-7g-5p	PAR-CLIP	26701625
MIRT473825	hsa-let-7i-5p	PAR-CLIP	26701625
MIRT473825	hsa-let-7i-5p	PAR-CLIP	26701625
MIRT473825	hsa-let-7i-5p	PAR-CLIP	26701625
MIRT473825	hsa-let-7i-5p	PAR-CLIP	26701625
MIRT473821	hsa-miR-1909-3p	PAR-CLIP	26701625
MIRT473821	hsa-miR-1909-3p	PAR-CLIP	26701625
MIRT473821	hsa-miR-1909-3p	PAR-CLIP	26701625
MIRT473821	hsa-miR-1909-3p	PAR-CLIP	26701625
MIRT473840	hsa-miR-2278	PAR-CLIP	26701625
MIRT473840	hsa-miR-2278	PAR-CLIP	26701625
MIRT473840	hsa-miR-2278	PAR-CLIP	26701625
MIRT473840	hsa-miR-2278	PAR-CLIP	26701625
MIRT473839	hsa-miR-3125	PAR-CLIP	26701625
MIRT473839	hsa-miR-3125	PAR-CLIP	26701625
MIRT473838	hsa-miR-3916	PAR-CLIP	26701625
MIRT473838	hsa-miR-3916	PAR-CLIP	26701625
MIRT473835	hsa-miR-3927-3p	PAR-CLIP	26701625
MIRT473835	hsa-miR-3927-3p	PAR-CLIP	26701625
MIRT473835	hsa-miR-3927-3p	PAR-CLIP	26701625
MIRT473835	hsa-miR-3927-3p	PAR-CLIP	26701625
MIRT473833	hsa-miR-3928-3p	PAR-CLIP	26701625
MIRT473833	hsa-miR-3928-3p	PAR-CLIP	26701625
MIRT473818	hsa-miR-4451	PAR-CLIP	26701625
MIRT473818	hsa-miR-4451	PAR-CLIP	26701625
MIRT473818	hsa-miR-4451	PAR-CLIP	26701625
MIRT473818	hsa-miR-4451	PAR-CLIP	26701625
MIRT473823	hsa-miR-4458	PAR-CLIP	26701625
MIRT473823	hsa-miR-4458	PAR-CLIP	26701625
MIRT473823	hsa-miR-4458	PAR-CLIP	26701625
MIRT473823	hsa-miR-4458	PAR-CLIP	26701625
MIRT473824	hsa-miR-4500	PAR-CLIP	26701625
MIRT473824	hsa-miR-4500	PAR-CLIP	26701625
MIRT473824	hsa-miR-4500	PAR-CLIP	26701625
MIRT473824	hsa-miR-4500	PAR-CLIP	26701625
MIRT473817	hsa-miR-4732-5p	PAR-CLIP	26701625
MIRT473817	hsa-miR-4732-5p	PAR-CLIP	26701625
MIRT473817	hsa-miR-4732-5p	PAR-CLIP	26701625
MIRT473817	hsa-miR-4732-5p	PAR-CLIP	26701625
MIRT473820	hsa-miR-6077	PAR-CLIP	26701625
MIRT473820	hsa-miR-6077	PAR-CLIP	26701625
MIRT473836	hsa-miR-6510-5p	PAR-CLIP	26701625
MIRT473836	hsa-miR-6510-5p	PAR-CLIP	26701625
MIRT473836	hsa-miR-6510-5p	PAR-CLIP	26701625
MIRT473836	hsa-miR-6510-5p	PAR-CLIP	26701625
MIRT473819	hsa-miR-6722-3p	PAR-CLIP	26701625
MIRT473819	hsa-miR-6722-3p	PAR-CLIP	26701625
MIRT473819	hsa-miR-6722-3p	PAR-CLIP	26701625
MIRT473819	hsa-miR-6722-3p	PAR-CLIP	26701625
MIRT473842	hsa-miR-6758-5p	PAR-CLIP	26701625
MIRT473842	hsa-miR-6758-5p	PAR-CLIP	26701625
MIRT473842	hsa-miR-6758-5p	PAR-CLIP	26701625
MIRT473842	hsa-miR-6758-5p	PAR-CLIP	26701625
MIRT473834	hsa-miR-6831-5p	PAR-CLIP	26701625
MIRT473834	hsa-miR-6831-5p	PAR-CLIP	26701625
MIRT473834	hsa-miR-6831-5p	PAR-CLIP	26701625
MIRT473834	hsa-miR-6831-5p	PAR-CLIP	26701625
MIRT473841	hsa-miR-6856-5p	PAR-CLIP	26701625
MIRT473841	hsa-miR-6856-5p	PAR-CLIP	26701625
MIRT473841	hsa-miR-6856-5p	PAR-CLIP	26701625
MIRT473841	hsa-miR-6856-5p	PAR-CLIP	26701625
MIRT473837	hsa-miR-6859-5p	PAR-CLIP	26701625
MIRT473837	hsa-miR-6859-5p	PAR-CLIP	26701625
MIRT473843	hsa-miR-8080	PAR-CLIP	26701625
MIRT473843	hsa-miR-8080	PAR-CLIP	26701625
MIRT473822	hsa-miR-98-5p	PAR-CLIP	26701625
MIRT473822	hsa-miR-98-5p	PAR-CLIP	26701625
MIRT473822	hsa-miR-98-5p	PAR-CLIP	26701625
MIRT473822	hsa-miR-98-5p	PAR-CLIP	26701625
MIRT502019	hsa-miR-4311	PAR-CLIP	27292025
MIRT734747	hsa-miR-125b-5p	Luciferase reporter assay, qRT-PCR	33921710
MIRT736015	hsa-miR-331-3p	Luciferase reporter assay, Western blotting, qRT-PCR	32776229
MIRT502019	hsa-miR-4311	PAR-CLIP	24398324
MIRT473843	hsa-miR-8080	PAR-CLIP	23592263
MIRT473842	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT473841	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT473840	hsa-miR-2278	PAR-CLIP	23592263
MIRT473839	hsa-miR-3125	PAR-CLIP	23592263
MIRT473838	hsa-miR-3916	PAR-CLIP	23592263
MIRT473837	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT473836	hsa-miR-6510-5p	PAR-CLIP	23592263
MIRT473835	hsa-miR-3927-3p	PAR-CLIP	23592263
MIRT473834	hsa-miR-6831-5p	PAR-CLIP	23592263
MIRT473833	hsa-miR-3928-3p	PAR-CLIP	23592263
MIRT473832	hsa-let-7a-5p	PAR-CLIP	23592263
MIRT473831	hsa-let-7b-5p	PAR-CLIP	23592263
MIRT473830	hsa-let-7c-5p	PAR-CLIP	23592263
MIRT473829	hsa-let-7d-5p	PAR-CLIP	23592263
MIRT473828	hsa-let-7e-5p	PAR-CLIP	23592263
MIRT473827	hsa-let-7f-5p	PAR-CLIP	23592263
MIRT473826	hsa-let-7g-5p	PAR-CLIP	23592263
MIRT473825	hsa-let-7i-5p	PAR-CLIP	23592263
MIRT473823	hsa-miR-4458	PAR-CLIP	23592263
MIRT473824	hsa-miR-4500	PAR-CLIP	23592263
MIRT473822	hsa-miR-98-5p	PAR-CLIP	23592263
MIRT473821	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT473819	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT473820	hsa-miR-6077	PAR-CLIP	23592263
MIRT473818	hsa-miR-4451	PAR-CLIP	23592263
MIRT473817	hsa-miR-4732-5p	PAR-CLIP	23592263
MIRT1128094	hsa-let-7a	CLIP-seq
MIRT1128095	hsa-let-7b	CLIP-seq
MIRT1128096	hsa-let-7c	CLIP-seq
MIRT1128097	hsa-let-7d	CLIP-seq
MIRT1128098	hsa-let-7e	CLIP-seq
MIRT1128099	hsa-let-7f	CLIP-seq
MIRT1128100	hsa-let-7g	CLIP-seq
MIRT1128101	hsa-let-7i	CLIP-seq
MIRT1128102	hsa-miR-1287	CLIP-seq
MIRT1128103	hsa-miR-1538	CLIP-seq
MIRT1128104	hsa-miR-1908	CLIP-seq
MIRT1128105	hsa-miR-1909	CLIP-seq
MIRT1128106	hsa-miR-2861	CLIP-seq
MIRT1128107	hsa-miR-3150a-3p	CLIP-seq
MIRT1128108	hsa-miR-3175	CLIP-seq
MIRT1128109	hsa-miR-3180	CLIP-seq
MIRT1128110	hsa-miR-3180-3p	CLIP-seq
MIRT1128111	hsa-miR-3187-3p	CLIP-seq
MIRT1128112	hsa-miR-3196	CLIP-seq
MIRT1128113	hsa-miR-3689a-3p	CLIP-seq
MIRT1128114	hsa-miR-3689c	CLIP-seq
MIRT1128115	hsa-miR-3927	CLIP-seq
MIRT1128116	hsa-miR-4529-5p	CLIP-seq
MIRT1128117	hsa-miR-4532	CLIP-seq
MIRT1128118	hsa-miR-4640-5p	CLIP-seq
MIRT1128119	hsa-miR-4651	CLIP-seq
MIRT1128120	hsa-miR-4726-5p	CLIP-seq
MIRT1128121	hsa-miR-4745-3p	CLIP-seq
MIRT1128122	hsa-miR-4747-3p	CLIP-seq
MIRT1128123	hsa-miR-491-5p	CLIP-seq
MIRT1128124	hsa-miR-603	CLIP-seq
MIRT1128125	hsa-miR-608	CLIP-seq
MIRT1128126	hsa-miR-663	CLIP-seq
MIRT1128127	hsa-miR-663b	CLIP-seq
MIRT1128128	hsa-miR-939	CLIP-seq
MIRT1128129	hsa-miR-98	CLIP-seq
MIRT1551118	hsa-miR-1197	CLIP-seq
MIRT2036417	hsa-miR-1913	CLIP-seq
MIRT2036418	hsa-miR-3130-3p	CLIP-seq
MIRT1128111	hsa-miR-3187-3p	CLIP-seq
MIRT2036419	hsa-miR-3189-5p	CLIP-seq
MIRT2036420	hsa-miR-3191	CLIP-seq
MIRT2036421	hsa-miR-3194-3p	CLIP-seq
MIRT2036422	hsa-miR-324-3p	CLIP-seq
MIRT2036423	hsa-miR-328	CLIP-seq
MIRT2036424	hsa-miR-3622a-3p	CLIP-seq
MIRT2036425	hsa-miR-3622b-3p	CLIP-seq
MIRT2036426	hsa-miR-370	CLIP-seq
MIRT2036427	hsa-miR-4287	CLIP-seq
MIRT2036428	hsa-miR-4292	CLIP-seq
MIRT2036429	hsa-miR-4313	CLIP-seq
MIRT2036430	hsa-miR-4447	CLIP-seq
MIRT2036431	hsa-miR-4472	CLIP-seq
MIRT1128116	hsa-miR-4529-5p	CLIP-seq
MIRT1128119	hsa-miR-4651	CLIP-seq
MIRT2036432	hsa-miR-4685-3p	CLIP-seq
MIRT2036433	hsa-miR-4758-3p	CLIP-seq
MIRT2036434	hsa-miR-4780	CLIP-seq
MIRT2036435	hsa-miR-4793-3p	CLIP-seq
MIRT2036436	hsa-miR-541	CLIP-seq
MIRT1128124	hsa-miR-603	CLIP-seq
MIRT1128125	hsa-miR-608	CLIP-seq
MIRT2036437	hsa-miR-623	CLIP-seq
MIRT2036438	hsa-miR-654-5p	CLIP-seq
MIRT1128127	hsa-miR-663b	CLIP-seq
MIRT2036439	hsa-miR-670	CLIP-seq
MIRT2036440	hsa-miR-767-5p	CLIP-seq
MIRT1128094	hsa-let-7a	CLIP-seq
MIRT1128095	hsa-let-7b	CLIP-seq
MIRT1128096	hsa-let-7c	CLIP-seq
MIRT1128097	hsa-let-7d	CLIP-seq
MIRT1128098	hsa-let-7e	CLIP-seq
MIRT1128099	hsa-let-7f	CLIP-seq
MIRT1128100	hsa-let-7g	CLIP-seq
MIRT1128101	hsa-let-7i	CLIP-seq
MIRT2266663	hsa-miR-1234	CLIP-seq
MIRT2266664	hsa-miR-125b	CLIP-seq
MIRT2266665	hsa-miR-128	CLIP-seq
MIRT1128102	hsa-miR-1287	CLIP-seq
MIRT2266666	hsa-miR-141	CLIP-seq
MIRT2266667	hsa-miR-1468	CLIP-seq
MIRT1128105	hsa-miR-1909	CLIP-seq
MIRT2266668	hsa-miR-1976	CLIP-seq
MIRT2266669	hsa-miR-200a	CLIP-seq
MIRT2266670	hsa-miR-27a	CLIP-seq
MIRT2266671	hsa-miR-27b	CLIP-seq
MIRT2036418	hsa-miR-3130-3p	CLIP-seq
MIRT2266672	hsa-miR-3150b-3p	CLIP-seq
MIRT2266673	hsa-miR-3179	CLIP-seq
MIRT2036419	hsa-miR-3189-5p	CLIP-seq
MIRT2036420	hsa-miR-3191	CLIP-seq
MIRT2036421	hsa-miR-3194-3p	CLIP-seq
MIRT2266674	hsa-miR-329	CLIP-seq
MIRT2036424	hsa-miR-3622a-3p	CLIP-seq
MIRT2036425	hsa-miR-3622b-3p	CLIP-seq
MIRT2266675	hsa-miR-362-3p	CLIP-seq
MIRT1128113	hsa-miR-3689a-3p	CLIP-seq
MIRT1128114	hsa-miR-3689c	CLIP-seq
MIRT2036426	hsa-miR-370	CLIP-seq
MIRT1128115	hsa-miR-3927	CLIP-seq
MIRT2266676	hsa-miR-421	CLIP-seq
MIRT2266677	hsa-miR-4319	CLIP-seq
MIRT2266678	hsa-miR-4431	CLIP-seq
MIRT2266679	hsa-miR-4438	CLIP-seq
MIRT2036430	hsa-miR-4447	CLIP-seq
MIRT2036431	hsa-miR-4472	CLIP-seq
MIRT2266680	hsa-miR-4493	CLIP-seq
MIRT2266681	hsa-miR-4522	CLIP-seq
MIRT1128116	hsa-miR-4529-5p	CLIP-seq
MIRT2266682	hsa-miR-4640-3p	CLIP-seq
MIRT1128118	hsa-miR-4640-5p	CLIP-seq
MIRT1128119	hsa-miR-4651	CLIP-seq
MIRT2266683	hsa-miR-4667-3p	CLIP-seq
MIRT2266684	hsa-miR-4709-5p	CLIP-seq
MIRT2266685	hsa-miR-4714-5p	CLIP-seq
MIRT1128120	hsa-miR-4726-5p	CLIP-seq
MIRT2266686	hsa-miR-4732-3p	CLIP-seq
MIRT2266687	hsa-miR-4753-5p	CLIP-seq
MIRT2266688	hsa-miR-4755-3p	CLIP-seq
MIRT2036433	hsa-miR-4758-3p	CLIP-seq
MIRT2266689	hsa-miR-4762-3p	CLIP-seq
MIRT2266690	hsa-miR-4784	CLIP-seq
MIRT2036435	hsa-miR-4793-3p	CLIP-seq
MIRT2266691	hsa-miR-4793-5p	CLIP-seq
MIRT2266692	hsa-miR-485-5p	CLIP-seq
MIRT2266693	hsa-miR-493	CLIP-seq
MIRT2266694	hsa-miR-505	CLIP-seq
MIRT2266695	hsa-miR-513a-5p	CLIP-seq
MIRT2036436	hsa-miR-541	CLIP-seq
MIRT2266696	hsa-miR-548n	CLIP-seq
MIRT2266697	hsa-miR-548t	CLIP-seq
MIRT2266698	hsa-miR-561	CLIP-seq
MIRT1128124	hsa-miR-603	CLIP-seq
MIRT2266699	hsa-miR-604	CLIP-seq
MIRT1128125	hsa-miR-608	CLIP-seq
MIRT2266700	hsa-miR-626	CLIP-seq
MIRT2036438	hsa-miR-654-5p	CLIP-seq
MIRT2036439	hsa-miR-670	CLIP-seq
MIRT2036440	hsa-miR-767-5p	CLIP-seq
MIRT1128129	hsa-miR-98	CLIP-seq
MIRT2390556	hsa-miR-1291	CLIP-seq
MIRT2390557	hsa-miR-1914	CLIP-seq
MIRT2036423	hsa-miR-328	CLIP-seq
MIRT2390558	hsa-miR-3649	CLIP-seq
MIRT2036428	hsa-miR-4292	CLIP-seq
MIRT2566310	hsa-miR-1470	CLIP-seq
MIRT2036418	hsa-miR-3130-3p	CLIP-seq
MIRT2036421	hsa-miR-3194-3p	CLIP-seq
MIRT2036424	hsa-miR-3622a-3p	CLIP-seq
MIRT2036425	hsa-miR-3622b-3p	CLIP-seq
MIRT2266683	hsa-miR-4667-3p	CLIP-seq
MIRT2036435	hsa-miR-4793-3p	CLIP-seq
MIRT2036440	hsa-miR-767-5p	CLIP-seq
MIRT2566310	hsa-miR-1470	CLIP-seq
MIRT2036418	hsa-miR-3130-3p	CLIP-seq
MIRT2036421	hsa-miR-3194-3p	CLIP-seq
MIRT2036424	hsa-miR-3622a-3p	CLIP-seq
MIRT2036425	hsa-miR-3622b-3p	CLIP-seq
MIRT2266683	hsa-miR-4667-3p	CLIP-seq
MIRT2036435	hsa-miR-4793-3p	CLIP-seq
MIRT2036440	hsa-miR-767-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000187	Process	Activation of MAPK activity	IBA	21873635
GO:0000287	Function	Magnesium ion binding	IDA	9535930
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004708	Function	MAP kinase kinase activity	IBA	21873635
GO:0004708	Function	MAP kinase kinase activity	IDA	9535930
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	15299019, 16840345, 17110930, 17709393, 18286207, 20067578, 25241761, 25284480, 25314077
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0006970	Process	Response to osmotic stress	IDA	9535930
GO:0007165	Process	Signal transduction	TAS	9535930
GO:0007254	Process	JNK cascade	TAS
GO:0007257	Process	Activation of JUN kinase activity	IBA	21873635
GO:0007257	Process	Activation of JUN kinase activity	ISS
GO:0008545	Function	JUN kinase kinase activity	IBA	21873635
GO:0009408	Process	Response to heat	IDA	9535930
GO:0009411	Process	Response to UV	IDA	9535930
GO:0018108	Process	Peptidyl-tyrosine phosphorylation	IEA
GO:0019899	Function	Enzyme binding	IPI	14615289
GO:0019901	Function	Protein kinase binding	IPI	14697235
GO:0019903	Function	Protein phosphatase binding	ISS
GO:0032212	Process	Positive regulation of telomere maintenance via telomerase	IMP	21531765
GO:0034612	Process	Response to tumor necrosis factor	IDA	9535930
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IMP	28111074
GO:0051403	Process	Stress-activated MAPK cascade	IDA	9535930
GO:0051973	Process	Positive regulation of telomerase activity	IMP	21531765
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IMP	28111074
GO:1904355	Process	Positive regulation of telomere capping	IMP	21531765

Other IDs

• MIM: 603014
• HGNC: 6847
• e!Ensembl: ENSG00000076984

Protein

• UniProt ID: O14733
• Protein name: Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal
• Protein function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4,
• PDB: 2DYL, 3WZU, 4UX9, 5B2K, 5B2L, 5B2M, 5Y8U, 5Y90, 5Z1D, 5Z1E, 6IB0, 6IB2, 6QFL, 6QFR, 6QFT, 6QG4, 6QG7, 6QHO, 6QHR, 6YFZ, 6YG0, 6YG1, 6YG2, 6YG3, 6YG4, 6YG5, 6YG6, 6YG7, 6YZ4, 7CBX, 7OVI, 7OVJ, 7OVK, 7OVL, 7OVM, 7OVN
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	120 → 380	Protein kinase domain	Domain

• Sequence:

  MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
  SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
  ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
  QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
  HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
  IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC
  LTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR

• Sequence length: 419

Pathways

KEGG:

MAPK signaling pathway
ErbB signaling pathway
Protein processing in endoplasmic reticulum
Osteoclast differentiation
Tight junction
Toll-like receptor signaling pathway
T cell receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
GnRH signaling pathway
Relaxin signaling pathway
Alcoholic liver disease
Alzheimer disease
Huntington disease
Pathways of neurodegeneration - multiple diseases
Salmonella infection
Yersinia infection
Hepatitis B
Kaposi sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Human immunodeficiency virus 1 infection
Chemical carcinogenesis - reactive oxygen species
Lipid and atherosclerosis
Fluid shear stress and atherosclerosis

Reactome:

Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Uptake and function of anthrax toxins

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243	21317887
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs10520699, rs11852999, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038	21317887
Colorectal cancer	Adenocarcinoma of large intestine	rs137854568, rs137854573, rs137854575, rs387906234, rs1801155, rs121908380, rs121908702, rs267606674, rs4939827, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553149467, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	30595370
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	21317887
Marfan syndrome	Mammary Carcinoma, Human	rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465, rs137854466, rs137854467, rs387906547, rs387906548, rs137854469, rs137854473, rs1131692050, rs112989722, rs137854474, rs137854476, rs140593, rs1555395819, rs137854478, rs137854479, rs137854480, rs137854481, rs137854482, rs137854483, rs137854484, rs137854485, rs112289537, rs193922181, rs193922182, rs193922185, rs140603, rs193922187, rs193922188, rs193921256, rs112660651, rs193922193, rs193922194, rs193922197, rs193922198, rs193922199, rs193922203, rs193922204, rs193922205, rs193922206, rs111401431, rs193922207, rs113871094, rs111671429, rs193922216, rs193922219, rs193922220, rs193922223, rs193922224, rs193922225, rs193922226, rs193922227, rs193922228, rs193922230, rs193922235, rs147195031, rs193922236, rs193922239, rs193922240, rs193922241, rs193922246, rs397514558, rs398122934, rs397515753, rs397515754, rs397515755, rs397515756, rs397515757, rs113812345, rs397515758, rs397515759, rs397515762, rs25403, rs397515765, rs397515766, rs397515767, rs397515768, rs397515769, rs397515770, rs397515771, rs25404, rs397515773, rs397515774, rs397515775, rs397515776, rs397515778, rs397515779, rs397515781, rs112202622, rs397515782, rs397515784, rs397515785, rs397515786, rs397515788, rs397515789, rs397515790, rs397515791, rs397515792, rs397515793, rs397515794, rs397515797, rs397515798, rs397515799, rs397515801, rs397515802, rs397515803, rs397515804, rs397515805, rs397515808, rs397515810, rs397515811, rs397515812, rs111231312, rs267606798, rs397515814, rs113905529, rs397515816, rs397515817, rs397515818, rs397515819, rs397515820, rs363853, rs113249837, rs397515821, rs111929350, rs397515823, rs397515824, rs113086760, rs397515825, rs397515826, rs397515827, rs363807, rs397515828, rs397515829, rs397515830, rs397515831, rs397515833, rs111687884, rs113080385, rs397515834, rs397515836, rs113001196, rs397515840, rs397515845, rs397515846, rs397515847, rs397515848, rs397515851, rs397515852, rs397515853, rs397515854, rs111856492, rs397515859, rs397515861, rs397515863, rs397515864, rs397515865, rs397515866, rs397515867, rs137854855, rs199474693, rs587782944, rs587782947, rs587782948, rs672601352, rs876658120, rs727504651, rs727503054, rs727504315, rs727504411, rs727503057, rs727504454, rs200309328, rs363811, rs727504410, rs363821, rs727504347, rs727505006, rs727505110, rs730880356, rs727505269, rs727503058, rs727504421, rs730880107, rs730880104, rs730880103, rs730880102, rs730880101, rs730880106, rs730880100, rs730880105, rs730880099, rs112645512, rs730880108, rs730880098, rs730880097, rs794728321, rs794728283, rs794728280, rs794728336, rs794728272, rs794728160, rs794728271, rs794728270, rs794728319, rs794728262, rs794728251, rs76702162, rs794728335, rs794728334, rs794728246, rs763091520, rs794728333, rs794728237, rs761857514, rs794728234, rs140630, rs794728231, rs794728228, rs794728225, rs794728308, rs794728216, rs794728221, rs763449629, rs201058219, rs794728210, rs794728208, rs794728206, rs794728199, rs794728195, rs794728194, rs794728193, rs794728190, rs1555399381, rs794728176, rs1555399968, rs113422242, rs794728326, rs794728166, rs794728325, rs794728165, rs794728162, rs794728213, rs869025417, rs112642323, rs869025416, rs869025415, rs869025424, rs869025423, rs869025414, rs869025422, rs869025413, rs869025412, rs869025411, rs869025418, rs869025426, rs869025406, rs869025421, rs869025425, rs869025404, rs869025420, rs869025403, rs398122833, rs876657645, rs878853686, rs878853676, rs886038919, rs886038795, rs187553035, rs886038869, rs886038949, rs886038967, rs886038976, rs886038848, rs886038940, rs886038877, rs886039038, rs886038817, rs886038963, rs886039036, rs886038797, rs886039550, rs886041482, rs1057517855, rs1057518912, rs1057518973, rs1057519502, rs1057521100, rs1057521102, rs1057518881, rs1057520617, rs1057521101, rs1555394445, rs369058466, rs1060501069, rs1060501031, rs778966916, rs1060501043, rs1555397663, rs1060501017, rs1060501094, rs1060501065, rs1555393848, rs1555394151, rs1060501051, rs1060501013, rs1060501054, rs1060501048, rs1060501089, rs1060501039, rs1555398160, rs1060501022, rs1060501024, rs1060501086, rs1060501058, rs1060501036, rs1060501100, rs1060501042, rs1060501059, rs1555397743, rs1060501021, rs1060501027, rs1060501096, rs1060501038, rs1060501050, rs1064794130, rs112118237, rs1064793980, rs1064793118, rs1064793636, rs1064794282, rs1064793559, rs1085307921, rs1085308004, rs1085307468, rs112907302, rs1131691479, rs1131691373, rs1131691467, rs1131691938, rs1131691311, rs1131691806, rs1131691317, rs1555393827, rs363804, rs1555397738, rs1555399144, rs1555400274, rs1555394195, rs1555398836, rs113543334, rs1555399825, rs1555394626, rs1555395256, rs1555395257, rs1555396427, rs1555397548, rs1555398173, rs1555404803, rs1232880706, rs1555393825, rs1555394567, rs1555396998, rs1555394928, rs1555397203, rs112375043, rs1555397720, rs140599, rs1555399150, rs1555400373, rs1555405041, rs1555395229, rs1555397671, rs775417975, rs1555398774, rs1555399368, rs1555394904, rs1555395987, rs1555397424, rs1555398377, rs1555398835, rs1555401011, rs1555405043, rs1555394580, rs1555397404, rs1555398511, rs1555395826, rs1555399372, rs1555399821, rs1555399836, rs1555400063, rs363810, rs1555397655, rs1555395756, rs1555395742, rs1555393844, rs112550005, rs1555395002, rs1555395658, rs765387131, rs1555396429, rs1555396835, rs1555397014, rs1555397016, rs778710767, rs1555397557, rs1555397704, rs140648, rs1555398406, rs1555398681, rs1555399257, rs1555399361, rs1555399764, rs1555405056, rs1555393510, rs1555395980, rs1555396789, rs1555399094, rs1555399378, rs1555399816, rs1555395645, rs371097218, rs1555398278, rs1555394238, rs1555396418, rs1206813753, rs1555399271, rs1555405044, rs113544411, rs1555395663, rs1555397216, rs1555398989, rs1555399149, rs1555401670, rs1555395001, rs1445085747, rs1555393538, rs1555393565, rs1404133653, rs1555394450, rs1555394581, rs1555394633, rs1555394900, rs1555395189, rs1555395261, rs1052480459, rs1555395480, rs1555395670, rs363806, rs1555395820, rs1555396419, rs1555396765, rs1296209846, rs794728233, rs1555396853, rs1555396863, rs1555397197, rs1555397204, rs1555397212, rs1555397713, rs1555397736, rs1555398139, rs1555398144, rs1555398409, rs1555398510, rs1555398520, rs1555398524, rs1555398667, rs1555399089, rs1555399482, rs1555399763, rs1555401002, rs794728323, rs1555393508, rs1555393514, rs1555393525, rs1555393532, rs1555393653, rs1555393657, rs1555393824, rs1555393831, rs112196241, rs1555393847, rs1555393862, rs1555393863, rs1555393866, rs113935744, rs1555393882, rs1555393886, rs1555393889, rs1555394138, rs1555394144, rs1555394146, rs1555394148, rs1555394149, rs1555394152, rs1555394153, rs1555394189, rs1555394197, rs1555394206, rs1555394212, rs1555394218, rs1555394220, rs1555394235, rs1555394245, rs1555394246, rs1057520728, rs1555394390, rs1555394391, rs537570299, rs1555394397, rs1555394398, rs1555394399, rs1555394402, rs1555394407, rs1555394412, rs1555394435, rs1555394436, rs1555394441, rs1555394556, rs1555394557, rs1555394559, rs1555394561, rs1555394570, rs397515844, rs1555394571, rs1555394574, rs1555394579, rs1555394582, rs534811966, rs111588631, rs1555394628, rs1555394629, rs1555394630, rs1555394631, rs1555394641, rs1555394644, rs1555394647, rs1555394756, rs886051245, rs1555394775, rs1555394776, rs1555394777, rs1555394779, rs1555394780, rs1555394783, rs1555394901, rs1555394906, rs1555394925, rs794728253, rs886039158, rs1555395013, rs1555395187, rs1555395188, rs1555395203, rs1555395205, rs363815, rs1246984265, rs794728245, rs1555395263, rs1555395267, rs1555395456, rs1555395475, rs1555395482, rs1555395638, rs1555395641, rs1555395648, rs1555395653, rs1555395659, rs111239111, rs1555395745, rs1555395747, rs1555395753, rs1555395757, rs1555395766, rs1555395767, rs1555395843, rs1555395846, rs1555395849, rs1555395978, rs1555395981, rs1555395984, rs1555395989, rs1555395990, rs1260109901, rs1555396186, rs1555396188, rs1555396198, rs1555396199, rs1555396201, rs1555396202, rs1555396205, rs1555396213, rs1555396424, rs1555396426, rs1555396428, rs1555396435, rs1555396630, rs1555396635, rs1555396636, rs1555396639, rs1555396757, rs1555396769, rs1555396838, rs1555396844, rs140627, rs1555396858, rs1555396990, rs1555396991, rs1555396993, rs769588424, rs1555397022, rs1555397024, rs1555397160, rs1555397174, rs1555397176, rs1555397193, rs1555397209, rs1555397210, rs1555397214, rs1060501076, rs113082854, rs113693945, rs111978932, rs1555397403, rs1555397419, rs1555397420, rs1555397421, rs1555397536, rs1555397537, rs1555397540, rs1555397542, rs1555397543, rs1555397545, rs1555397546, rs1555397670, rs1555397692, rs1555397718, rs1555397723, rs1555397744, rs113393517, rs1555398148, rs1555398152, rs1555398174, rs1555398176, rs1555398179, rs1555398282, rs1555398287, rs1555398380, rs1555398394, rs1555398397, rs1555398401, rs1555398404, rs1555398407, rs1555398413, rs1555398501, rs1555398508, rs1555398512, rs1555398513, rs1555398515, rs1555398521, rs794728205, rs1555398527, rs1555398551, rs1060501075, rs1555398566, rs1555398572, rs1555398580, rs1555398582, rs140597, rs1555398622, rs1555398624, rs1555398625, rs112547596, rs1555398627, rs1555398633, rs1555398637, rs1555398642, rs778867355, rs1555398648, rs1555398659, rs1293095681, rs1060501040, rs987202268, rs1555398672, rs1555398673, rs1555398677, rs1555398793, rs1555398803, rs1555398811, rs1555398826, rs1555398833, rs1555398974, rs1555398981, rs778900586, rs1555398988, rs1555398994, rs1555398995, rs1555398996, rs1555399093, rs869025405, rs1555399101, rs1555399146, rs1555399160, rs1555399162, rs1555399164, rs1555399165, rs1555399193, rs1555399195, rs1555399202, rs1555399204, rs1555399206, rs201778577, rs1555399210, rs1555399214, rs1555399270, rs1555399273, rs1555399281, rs1555399371, rs1555399385, rs1555399477, rs1555399484, rs1555399761, rs1555399775, rs1555399802, rs1555399804, rs1555399837, rs1555399840, rs1555399940, rs1555399944, rs1555399949, rs1555399953, rs1555399954, rs1555399955, rs1555399959, rs1555399962, rs1555399963, rs1060501041, rs1555399974, rs1555399976, rs1555399977, rs1555400049, rs794728172, rs1555400062, rs1555400064, rs1555400066, rs1555400267, rs1555400268, rs1555400278, rs794728168, rs1555400279, rs1156747241, rs1555400288, rs1555400371, rs1555400372, rs1555400379, rs1555400385, rs587782943, rs1555400387, rs1555400406, rs1439533354, rs746201757, rs1555400595, rs1555400603, rs1555400604, rs1555400606, rs1555400609, rs752010116, rs1555400612, rs1555400616, rs1555401004, rs1555401005, rs146348130, rs1555401667, rs1555401671, rs1555401676, rs1555401679, rs1555401687, rs1555401689, rs1555401695, rs1555401697, rs1555401701, rs1555404799, rs1555404800, rs200295020, rs1555404810, rs1555404820, rs1555405031, rs1555405039, rs1555405045, rs1555405530, rs794728292, rs1555405533, rs1555405536, rs1555405537, rs111764111, rs1555405658, rs1555405664, rs774371494, rs1555405673, rs1555407399, rs1555407414, rs1555407423, rs1555407429, rs886041536, rs1555404806, rs1566911709, rs1566913974, rs1566894226, rs1566895223, rs1566897376, rs1566902526, rs1566915277, rs1566897374, rs1566897420, rs1566891655, rs1346043320, rs1566922396, rs1566891706, rs1566894783, rs1566913670, rs1555394196, rs1566891454, rs1566891406, rs1566891404, rs1566895262, rs1566891645, rs1566895225, rs1566896114, rs1566898399, rs1566904011, rs1566906537, rs1566908956, rs1566909766, rs1566919599, rs1566937712, rs1566915335, rs1566891675, rs1566904526, rs1566906506, rs1566900540, rs1566894230, rs1555395206, rs1566891797, rs1597512576, rs1597523873, rs1597581001, rs1597516325, rs1057524757, rs1597506641, rs1597520781, rs1597593695, rs1597529829, rs1597520625, rs1597579923, rs1597531796, rs1008275504, rs1597567249, rs1597569265, rs1597652471, rs1597516347, rs1597577114, rs1597633163, rs1597519658, rs1597593852, rs1597516501, rs1566913982, rs1555393859, rs1597513708, rs368978109, rs1480832655, rs1597520683, rs1597522390, rs1597522553, rs1597529748, rs1597533707, rs1597537815, rs1597545309, rs1597545836, rs1597563234, rs1597563280, rs1597564359, rs772108557, rs1597568968, rs1597574236, rs1597574308, rs1597577975, rs193922179, rs1597581005, rs1597593736, rs1597623670, rs1597625734, rs1597631662, rs113604459, rs1597633183, rs1597633219, rs1597518951, rs1555394781, rs1597525871, rs1597526073, rs1597569159, rs1597569536, rs1597563934, rs1597545199, rs1364210063, rs1597552583, rs1597520619, rs1597540854, rs1597591602, rs1597569551, rs1597548716, rs1597553721, rs112728248, rs1597537858, rs1597517935, rs1597540907, rs1597552388, rs1597591643, rs1597529841, rs1597506547, rs1597509836, rs1597529686, rs1566897404, rs1597533713, rs1597543486, rs1597545257, rs1597545345, rs1597548672, rs1597562812, rs1597563287, rs1597571391, rs1555400052, rs1597583989, rs363852, rs1597547226, rs363808, rs974604498, rs2043595650, rs2043526284, rs2042997306, rs1555397195, rs886039054, rs1555397213, rs2042873946	21317887
Myocardial infarction	Myocardial Failure	rs12316150, rs41303970, rs909253, rs7291467, rs2234693	21284947
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	22899651

Unknown
Disease name	Disease term	dbSNP ID	References
Mammary neoplasms	Mammary Neoplasms, Human, Mammary Neoplasms		21317887
Cirrhosis	Cirrhosis	rs119465999, rs144369314, rs8056684, rs112053857, rs75998507	21284947
Congestive heart failure	Congestive heart failure	rs2301610, rs3833910, rs12301951, rs201674674, rs186741807, rs150140412, rs786205727, rs757840030, rs552050895, rs759465783, rs201978086, rs572757800, rs1572143354, rs749160569	21284947
Heart failure	Heart failure, Left-Sided Heart Failure, Heart Failure, Right-Sided	rs121918074, rs142027794, rs148791216, rs72648927, rs71578935, rs142416150, rs199830512, rs755445214, rs150102469, rs779568205, rs907992794, rs1202130741	21284947
Lung neoplasms	Lung Neoplasms		21317887