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UBAP2 (ubiquitin associated protein 2)

Gene

Ubiquitin associated protein 2

UBAP2

UBAP-2

9

9p13.3

The protein encoded by this gene contains a UBA (ubiquitin associated) domain, which is characteristic of proteins that function in the ubiquitination pathway. This gene may show increased expression in the adrenal gland and lymphatic tissues. Alternative

Show/Hide all(209)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003091	hsa-miR-122-5p	Luciferase reporter assay, qRT-PCR	19296470
MIRT025365	hsa-miR-34a-5p	Proteomics	21566225
MIRT052395	hsa-let-7a-5p	CLASH	23622248
MIRT051355	hsa-let-7f-5p	CLASH	23622248
MIRT044443	hsa-miR-320a	CLASH	23622248
MIRT610236	hsa-miR-6801-5p	HITS-CLIP	23824327
MIRT610235	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT610236	hsa-miR-6801-5p	HITS-CLIP	23824327
MIRT610235	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT610236	hsa-miR-6801-5p	HITS-CLIP	23824327
MIRT610235	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT610236	hsa-miR-6801-5p	HITS-CLIP	23824327
MIRT610235	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT439368	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439368	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT737363	hsa-miR-148a-3p	Luciferase reporter assay, Western blotting, qRT-PCR	32425115
MIRT610236	hsa-miR-6801-5p	HITS-CLIP	23824327
MIRT610235	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT610236	hsa-miR-6801-5p	HITS-CLIP	23824327
MIRT610235	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT610236	hsa-miR-6801-5p	HITS-CLIP	23824327
MIRT610235	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT610236	hsa-miR-6801-5p	HITS-CLIP	23824327
MIRT610235	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT1466740	hsa-miR-150	CLIP-seq
MIRT1466741	hsa-miR-3064-5p	CLIP-seq
MIRT1466742	hsa-miR-3157-5p	CLIP-seq
MIRT1466743	hsa-miR-3160-3p	CLIP-seq
MIRT1466744	hsa-miR-3187-3p	CLIP-seq
MIRT1466745	hsa-miR-378g	CLIP-seq
MIRT1466746	hsa-miR-4300	CLIP-seq
MIRT1466747	hsa-miR-4427	CLIP-seq
MIRT1466748	hsa-miR-4437	CLIP-seq
MIRT1466749	hsa-miR-4496	CLIP-seq
MIRT1466750	hsa-miR-4529-5p	CLIP-seq
MIRT1466751	hsa-miR-4643	CLIP-seq
MIRT1466752	hsa-miR-4674	CLIP-seq
MIRT1466753	hsa-miR-4676-5p	CLIP-seq
MIRT1466754	hsa-miR-4691-3p	CLIP-seq
MIRT1466755	hsa-miR-4760-5p	CLIP-seq
MIRT1466756	hsa-miR-552	CLIP-seq
MIRT1466757	hsa-miR-575	CLIP-seq
MIRT1466758	hsa-miR-642b	CLIP-seq
MIRT1466759	hsa-miR-892b	CLIP-seq
MIRT1466760	hsa-miR-920	CLIP-seq
MIRT1466761	hsa-miR-939	CLIP-seq
MIRT1466740	hsa-miR-150	CLIP-seq
MIRT2140297	hsa-miR-23a	CLIP-seq
MIRT2140298	hsa-miR-23b	CLIP-seq
MIRT2140299	hsa-miR-23c	CLIP-seq
MIRT1466745	hsa-miR-378g	CLIP-seq
MIRT1466748	hsa-miR-4437	CLIP-seq
MIRT1466749	hsa-miR-4496	CLIP-seq
MIRT1466751	hsa-miR-4643	CLIP-seq
MIRT1466752	hsa-miR-4674	CLIP-seq
MIRT2140300	hsa-miR-520d-5p	CLIP-seq
MIRT2140301	hsa-miR-524-5p	CLIP-seq
MIRT1466758	hsa-miR-642b	CLIP-seq
MIRT1466740	hsa-miR-150	CLIP-seq
MIRT1466745	hsa-miR-378g	CLIP-seq
MIRT2361042	hsa-miR-4286	CLIP-seq
MIRT1466748	hsa-miR-4437	CLIP-seq
MIRT1466749	hsa-miR-4496	CLIP-seq
MIRT1466751	hsa-miR-4643	CLIP-seq
MIRT1466752	hsa-miR-4674	CLIP-seq
MIRT2361043	hsa-miR-4728-5p	CLIP-seq
MIRT2361044	hsa-miR-4771	CLIP-seq
MIRT1466758	hsa-miR-642b	CLIP-seq
MIRT1466749	hsa-miR-4496	CLIP-seq
MIRT1466751	hsa-miR-4643	CLIP-seq
MIRT1466758	hsa-miR-642b	CLIP-seq
MIRT2654723	hsa-miR-1236	CLIP-seq
MIRT2654724	hsa-miR-1270	CLIP-seq
MIRT2654725	hsa-miR-1273e	CLIP-seq
MIRT2654726	hsa-miR-1285	CLIP-seq
MIRT2654727	hsa-miR-139-5p	CLIP-seq
MIRT2654728	hsa-miR-148a	CLIP-seq
MIRT2654729	hsa-miR-148b	CLIP-seq
MIRT1466740	hsa-miR-150	CLIP-seq
MIRT2654730	hsa-miR-152	CLIP-seq
MIRT2654731	hsa-miR-191	CLIP-seq
MIRT2654732	hsa-miR-1976	CLIP-seq
MIRT2654733	hsa-miR-2117	CLIP-seq
MIRT2654734	hsa-miR-221	CLIP-seq
MIRT2654735	hsa-miR-222	CLIP-seq
MIRT2654736	hsa-miR-3136-3p	CLIP-seq
MIRT2654737	hsa-miR-3150a-3p	CLIP-seq
MIRT2654738	hsa-miR-3154	CLIP-seq
MIRT2654739	hsa-miR-3175	CLIP-seq
MIRT2654740	hsa-miR-3179	CLIP-seq
MIRT2654741	hsa-miR-3182	CLIP-seq
MIRT2654742	hsa-miR-3183	CLIP-seq
MIRT2654743	hsa-miR-3185	CLIP-seq
MIRT2654744	hsa-miR-3187-5p	CLIP-seq
MIRT2654745	hsa-miR-3189-5p	CLIP-seq
MIRT2654746	hsa-miR-342-5p	CLIP-seq
MIRT2654747	hsa-miR-34a	CLIP-seq
MIRT2654748	hsa-miR-34c-5p	CLIP-seq
MIRT2654749	hsa-miR-3611	CLIP-seq
MIRT2654750	hsa-miR-3613-3p	CLIP-seq
MIRT2654751	hsa-miR-3616-3p	CLIP-seq
MIRT2654752	hsa-miR-3677-5p	CLIP-seq
MIRT2654753	hsa-miR-3714	CLIP-seq
MIRT2654754	hsa-miR-371-5p	CLIP-seq
MIRT2654755	hsa-miR-371b-5p	CLIP-seq
MIRT1466745	hsa-miR-378g	CLIP-seq
MIRT2654756	hsa-miR-4273	CLIP-seq
MIRT2654757	hsa-miR-432	CLIP-seq
MIRT2654758	hsa-miR-4434	CLIP-seq
MIRT2654759	hsa-miR-4436b-3p	CLIP-seq
MIRT1466748	hsa-miR-4437	CLIP-seq
MIRT2654760	hsa-miR-4447	CLIP-seq
MIRT2654761	hsa-miR-4472	CLIP-seq
MIRT2654762	hsa-miR-4493	CLIP-seq
MIRT1466749	hsa-miR-4496	CLIP-seq
MIRT2654763	hsa-miR-449a	CLIP-seq
MIRT2654764	hsa-miR-449b	CLIP-seq
MIRT2654765	hsa-miR-4516	CLIP-seq
MIRT2654766	hsa-miR-4531	CLIP-seq
MIRT1466751	hsa-miR-4643	CLIP-seq
MIRT2654767	hsa-miR-4651	CLIP-seq
MIRT2654768	hsa-miR-4664-5p	CLIP-seq
MIRT1466752	hsa-miR-4674	CLIP-seq
MIRT2654769	hsa-miR-4683	CLIP-seq
MIRT2654770	hsa-miR-4690-3p	CLIP-seq
MIRT2654771	hsa-miR-4722-3p	CLIP-seq
MIRT2654772	hsa-miR-4723-3p	CLIP-seq
MIRT2361043	hsa-miR-4728-5p	CLIP-seq
MIRT2654773	hsa-miR-4749-3p	CLIP-seq
MIRT2654774	hsa-miR-4758-3p	CLIP-seq
MIRT2654775	hsa-miR-4768-5p	CLIP-seq
MIRT2654776	hsa-miR-4790-3p	CLIP-seq
MIRT2654777	hsa-miR-494	CLIP-seq
MIRT2654778	hsa-miR-513c	CLIP-seq
MIRT2654779	hsa-miR-514b-5p	CLIP-seq
MIRT2654780	hsa-miR-548v	CLIP-seq
MIRT2654781	hsa-miR-549	CLIP-seq
MIRT2654782	hsa-miR-576-3p	CLIP-seq
MIRT2654783	hsa-miR-608	CLIP-seq
MIRT2654784	hsa-miR-612	CLIP-seq
MIRT2654785	hsa-miR-620	CLIP-seq
MIRT1466758	hsa-miR-642b	CLIP-seq
MIRT2654786	hsa-miR-662	CLIP-seq
MIRT2654787	hsa-miR-663b	CLIP-seq
MIRT1466761	hsa-miR-939	CLIP-seq
MIRT2654726	hsa-miR-1285	CLIP-seq
MIRT2694582	hsa-miR-129-3p	CLIP-seq
MIRT2654727	hsa-miR-139-5p	CLIP-seq
MIRT2654728	hsa-miR-148a	CLIP-seq
MIRT2654729	hsa-miR-148b	CLIP-seq
MIRT1466740	hsa-miR-150	CLIP-seq
MIRT2654730	hsa-miR-152	CLIP-seq
MIRT2654731	hsa-miR-191	CLIP-seq
MIRT2654732	hsa-miR-1976	CLIP-seq
MIRT2654733	hsa-miR-2117	CLIP-seq
MIRT2654734	hsa-miR-221	CLIP-seq
MIRT2654735	hsa-miR-222	CLIP-seq
MIRT2654736	hsa-miR-3136-3p	CLIP-seq
MIRT2654737	hsa-miR-3150a-3p	CLIP-seq
MIRT2654738	hsa-miR-3154	CLIP-seq
MIRT2654739	hsa-miR-3175	CLIP-seq
MIRT2654740	hsa-miR-3179	CLIP-seq
MIRT2654743	hsa-miR-3185	CLIP-seq
MIRT2654744	hsa-miR-3187-5p	CLIP-seq
MIRT2654745	hsa-miR-3189-5p	CLIP-seq
MIRT2654746	hsa-miR-342-5p	CLIP-seq
MIRT2654747	hsa-miR-34a	CLIP-seq
MIRT2654748	hsa-miR-34c-5p	CLIP-seq
MIRT2654749	hsa-miR-3611	CLIP-seq
MIRT2654750	hsa-miR-3613-3p	CLIP-seq
MIRT2654751	hsa-miR-3616-3p	CLIP-seq
MIRT2694583	hsa-miR-3661	CLIP-seq
MIRT2654752	hsa-miR-3677-5p	CLIP-seq
MIRT2654753	hsa-miR-3714	CLIP-seq
MIRT2654754	hsa-miR-371-5p	CLIP-seq
MIRT2654755	hsa-miR-371b-5p	CLIP-seq
MIRT1466745	hsa-miR-378g	CLIP-seq
MIRT2654756	hsa-miR-4273	CLIP-seq
MIRT2654758	hsa-miR-4434	CLIP-seq
MIRT2654759	hsa-miR-4436b-3p	CLIP-seq
MIRT1466748	hsa-miR-4437	CLIP-seq
MIRT2654760	hsa-miR-4447	CLIP-seq
MIRT2654761	hsa-miR-4472	CLIP-seq
MIRT2654762	hsa-miR-4493	CLIP-seq
MIRT1466749	hsa-miR-4496	CLIP-seq
MIRT2654763	hsa-miR-449a	CLIP-seq
MIRT2654764	hsa-miR-449b	CLIP-seq
MIRT2654765	hsa-miR-4516	CLIP-seq
MIRT2654766	hsa-miR-4531	CLIP-seq
MIRT1466751	hsa-miR-4643	CLIP-seq
MIRT2654767	hsa-miR-4651	CLIP-seq
MIRT2654768	hsa-miR-4664-5p	CLIP-seq
MIRT1466752	hsa-miR-4674	CLIP-seq
MIRT2654770	hsa-miR-4690-3p	CLIP-seq
MIRT2654771	hsa-miR-4722-3p	CLIP-seq
MIRT2361043	hsa-miR-4728-5p	CLIP-seq
MIRT2654773	hsa-miR-4749-3p	CLIP-seq
MIRT2654774	hsa-miR-4758-3p	CLIP-seq
MIRT2654775	hsa-miR-4768-5p	CLIP-seq
MIRT2654776	hsa-miR-4790-3p	CLIP-seq
MIRT2654778	hsa-miR-513c	CLIP-seq
MIRT2654779	hsa-miR-514b-5p	CLIP-seq
MIRT2654780	hsa-miR-548v	CLIP-seq
MIRT2654783	hsa-miR-608	CLIP-seq
MIRT2654784	hsa-miR-612	CLIP-seq
MIRT2694584	hsa-miR-631	CLIP-seq
MIRT1466758	hsa-miR-642b	CLIP-seq
MIRT2654787	hsa-miR-663b	CLIP-seq
MIRT1466761	hsa-miR-939	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000932	Component	P-body	ISS
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0010629	Process	Negative regulation of gene expression	ISS
GO:0043065	Process	Positive regulation of apoptotic process	ISS
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0045893	Process	Positive regulation of transcription, DNA-templated	ISS
GO:0045926	Process	Negative regulation of growth	ISS
GO:0046426	Process	Negative regulation of receptor signaling pathway via JAK-STAT	ISS

MIM	HGNC	e!Ensembl
HGNC		HGNC

Protein

UniProt ID

Protein name

Ubiquitin-associated protein 2 (UBAP-2) (RNA polymerase II degradation factor UBAP2)

Protein function

Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled nucleotide excision repair (TC-NER) machinery fails to resolve DNA damage (PubMed:35633597). May promote t

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12478	DUF3697	512 → 544	Ubiquitin-associated protein 2	Family

Sequence

MMTSVSSDHCRGAREKPQISAAQSTQPQKQVVQATAEQMRLAQVIFDKNDSDFEAKVKQL
MEVTGKNQDECIVALHDCNGDVNKAINILLEGNSDTTSWETVGCKKKNFAKENSENKENR
EKKSEKESSRGRGNNNRKGRGGNRGREFRGEENGIDCNQVDKPSDRGKRARGRGFGRGRG
RGAGRFSTQGMGTFNPADYSDSTSTDVCGTKLVVWEAAQNGADEGTELASNTHNIAQDLS
NKSSYGLKGAWKNSVEEWTTEDWTEDLSETKVFTASSAPAENHILPGQSIDLVALLQKPV
PHSQASEANSFETSQQQGFGQALVFTNSQHNNQMAPGTGSSTAVNSCSPQSLSSVLGSGF
GELAPPKMANITSSQILDQLKAPSLGQFTTTPSTQQNSTSHPTTTTSWDLKPPTSQSSVL
SHLDFKSQPEPSPVLSQLSQRQQHQSQAVTVPPPGLESFPSQAKLRESTPGDSPSTVNKL
LQLPSTTIENISVSVHQPQPKHIKLAKRRIPPASKIPASAVEMPGSADVTGLNVQFGALE
FGSEPSLSEFGSAPSSENSNQIPISLYSKSLSEPLNTSLSMTSAVQNSTYTTSVITSCSL
TSSSLNSASPVAMSSSYDQSSVHNRIPYQSPVSSSESAPGTIMNGHGGGRSQQTLDTPKT
TGPPSALPSVSSLPSTTSCTALLPSTSQHTGDLTSSPLSQLSSSLSSHQSSLSAHAALSS
STSHTHASVESASSHQSSATFSTAATSVSSSASSGASLSSSMNTANSLCLGGTPASASSS
SSRAAPLVTSGKAPPNLPQGVPPLLHNQYLVGPGGLLPAYPIYGYDELQMLQSRLPVDYY
GIPFAAPTALASRDGSLANNPYPGDVTKFGRGDSASPAPATTPAQPQQSQSQTHHTAQQP
FVNPALPPGYSYTGLPYYTGMPSAFQYGPTMFVPPASAKQHGVNLSTPTPPFQQASGYGQ
HGYSTGYDDLTQGTAAGDYSKGGYAGSSQAPNKSAGSGPGKGVSVSSSTTGLPDMTGSVY
NKTQTFDKQGFHAGTPPPFSLPSVLGSTGPLASGAAPGYAPPPFLHILPAHQQPHSQLLH
HHLPQDAQSGSGQRSQPSSLQPKSQASKPAYGNSPYWTN

Sequence length

1119

Interactions

View interactions

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	30054458

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