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PAG1 (phosphoprotein membrane anchor with glycosphingolipid microdomains 1)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55824
Gene nameGene Name - the full gene name approved by the HGNC.
Phosphoprotein membrane anchor with glycosphingolipid microdomains 1
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
PAG1
SynonymsGene synonyms aliases
CBP, PAG
ChromosomeChromosome number
8
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q21.13
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT027134 hsa-miR-103a-3p Sequencing 20371350
MIRT030922 hsa-miR-21-5p Microarray 18591254
MIRT031726 hsa-miR-16-5p Sequencing 20371350
MIRT393570 hsa-miR-6867-5p HITS-CLIP 23706177
MIRT570563 hsa-miR-574-5p HITS-CLIP 23706177
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002250 Process Adaptive immune response IEA
GO:0005515 Function Protein binding IPI 10790433, 17911601, 18056706, 18070987, 23866081, 28514442
GO:0005886 Component Plasma membrane IDA 10790433
GO:0005886 Component Plasma membrane TAS
GO:0007165 Process Signal transduction TAS 10790433
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9NWQ8
Protein name Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp)
Protein function Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15347 PAG
2 432
Phosphoprotein associated with glycosphingolipid-enriched
Family
Sequence
Sequence length 432
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    GAB1 signalosome
Phosphorylation of CD3 and TCR zeta chains
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Lymphoblastic leukemia Childhood Acute Lymphoblastic Leukemia, L2 Acute Lymphoblastic Leukemia, Precursor Cell Lymphoblastic Leukemia Lymphoma rs387906351, rs104894562, rs398122513, rs398122840, rs398123063, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699, rs1597567692, rs1597567985, rs1438890364, rs1288977950, rs1597552140, rs1597566356, rs1597566726, rs1597568117, rs2069719445, rs2069729948, rs2070018439, rs745708044, rs1169577591 23334668
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 21822266
Unknown
Disease name Disease term dbSNP ID References
Urinary bladder cancer Malignant neoplasm of urinary bladder 24163127
Bladder carcinoma Carcinoma of bladder 24163127

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