FGD6 (FYVE, RhoGEF and PH domain containing 6)

Gene

• Entrez ID: 55785
• Gene name: FYVE, RhoGEF and PH domain containing 6
• Gene symbol: FGD6
• Synonyms: ZFYVE24
• Chromosome: 12
• Chromosome location: 12q22

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018984	hsa-miR-335-5p	Microarray	18185580
MIRT027861	hsa-miR-98-5p	Microarray	19088304
MIRT509369	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT509369	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT509370	hsa-miR-135b-3p	PAR-CLIP	23446348
MIRT509370	hsa-miR-135b-3p	PAR-CLIP	20371350
MIRT509371	hsa-miR-8077	PAR-CLIP	23446348
MIRT509371	hsa-miR-8077	PAR-CLIP	20371350
MIRT509372	hsa-miR-7160-5p	PAR-CLIP	23446348
MIRT509372	hsa-miR-7160-5p	PAR-CLIP	20371350
MIRT509373	hsa-miR-4663	PAR-CLIP	23446348
MIRT509373	hsa-miR-4663	PAR-CLIP	20371350
MIRT509374	hsa-miR-508-3p	PAR-CLIP	23446348
MIRT509374	hsa-miR-508-3p	PAR-CLIP	20371350
MIRT509375	hsa-miR-5186	PAR-CLIP	23446348
MIRT509375	hsa-miR-5186	PAR-CLIP	20371350
MIRT509376	hsa-miR-186-3p	PAR-CLIP	23446348
MIRT509376	hsa-miR-186-3p	PAR-CLIP	20371350
MIRT509377	hsa-miR-4698	PAR-CLIP	23446348
MIRT509377	hsa-miR-4698	PAR-CLIP	20371350
MIRT517038	hsa-miR-150-5p	PAR-CLIP	23446348
MIRT537388	hsa-miR-8059	PAR-CLIP	22012620
MIRT537390	hsa-miR-4471	PAR-CLIP	22012620
MIRT537391	hsa-miR-1292-5p	PAR-CLIP	22012620
MIRT537392	hsa-miR-6837-5p	PAR-CLIP	22012620
MIRT537393	hsa-miR-4685-5p	PAR-CLIP	22012620
MIRT537394	hsa-miR-3918	PAR-CLIP	22012620
MIRT537395	hsa-miR-802	PAR-CLIP	22012620
MIRT537396	hsa-miR-8083	PAR-CLIP	22012620
MIRT537397	hsa-miR-6753-5p	PAR-CLIP	22012620
MIRT675057	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT675058	hsa-miR-8055	HITS-CLIP	23824327
MIRT675059	hsa-miR-4309	HITS-CLIP	23824327
MIRT675060	hsa-miR-3198	HITS-CLIP	23824327
MIRT675061	hsa-miR-4294	HITS-CLIP	23824327
MIRT675062	hsa-miR-1289	HITS-CLIP	23824327
MIRT675063	hsa-miR-8082	HITS-CLIP	23824327
MIRT675064	hsa-miR-4534	HITS-CLIP	23824327
MIRT675065	hsa-miR-1273f	HITS-CLIP	23824327
MIRT675066	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT675067	hsa-miR-6088	HITS-CLIP	23824327
MIRT675068	hsa-miR-4770	HITS-CLIP	23824327
MIRT675069	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT675070	hsa-miR-6514-5p	HITS-CLIP	23824327
MIRT723056	hsa-miR-3692-3p	HITS-CLIP	19536157
MIRT723057	hsa-miR-524-5p	HITS-CLIP	19536157
MIRT723058	hsa-miR-520d-5p	HITS-CLIP	19536157
MIRT723059	hsa-miR-8087	HITS-CLIP	19536157
MIRT723060	hsa-miR-7161-5p	HITS-CLIP	19536157
MIRT723061	hsa-miR-548u	HITS-CLIP	19536157

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001726	Component	Ruffle	ISS
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	ISS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	ISS
GO:0005794	Component	Golgi apparatus	ISS
GO:0005856	Component	Cytoskeleton	IEA
GO:0007010	Process	Cytoskeleton organization	ISS
GO:0008360	Process	Regulation of cell shape	ISS
GO:0030027	Component	Lamellipodium	ISS
GO:0030036	Process	Actin cytoskeleton organization	ISS
GO:0031267	Function	Small GTPase binding	ISS
GO:0043087	Process	Regulation of GTPase activity	ISS
GO:0046847	Process	Filopodium assembly	ISS
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 613520
• HGNC: 21740
• e!Ensembl: ENSG00000180263

Protein

• UniProt ID: Q6ZV73
• Protein name: FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24)
• Protein function: May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00621	RhoGEF	875 → 1058	RhoGEF domain	Domain
  PF00169	PH	1090 → 1183	PH domain	Domain
  PF01363	FYVE	1217 → 1282	FYVE zinc finger	Domain
  PF00169	PH	1334 → 1428	PH domain	Domain

• Sequence:

  MTSAAEIKKPPVAPKPKFVVANNKPAPPPIAPKPDIVISSVPQSTKKMKPAIAPKPKVLK
  TSPVREIGQSPSRKIMLNLEGHKQELAESTDNFNCKYEGNQSNDYISPMCSCSSECIHKL
  GHRENLCVKQLVLEPLEMNENLENSKIDETLTIKTRSKCDLYGEKAKNQGGVVLKASVLE
  EELKDALIHQMPPFISAQKHRPTDSPEMNGGCNSNGQFRIEFADLSPSPSSFEKVPDHHS
  CHLQLPSDECEHFETCQDDSEKSNNCFQSSELEALENGKRSTLISSDGVSKKSEVKDLGP
  LEIHLVPYTPKFPTPKPRKTRTARLLRQKCVDTPSESTEEPGNSDSSSSCLTENSLKINK
  ISVLHQNVLCKQEQVDKMKLGNKSELNMESNSDAQDLVNSQKAMCNETTSFEKMAPSFDK
  DSNLSSDSTTVDGSSMSLAVDEGTGFIRCTVSMSLPKQLKLTCNEHLQSGRNLGVSAPQM
  QKESVIKEENSLRIVPKKPQRHSLPATGVLKKAASEELLEKSSYPSSEEKSSEKSLERNH
  LQHLCAQNRGVSSSFDMPKRASEKPVWKLPHPILPFSGNPEFLKSVTVSSNSEPSTALTK
  PRAKSLSAMDVEKCTKPCKDSTKKNSFKKLLSMKLSICFMKSDFQKFWSKSSQLGDTTTG
  HLSSGEQKGIESDWQGLLVGEEKRSKPIKAYSTENYSLESQKKRKKSRGQTSAANGLRAE
  SLDDQMLSRESSSQAPYKSVTSLCAPEYENIRHYEEIPEYENLPFIMAIRKTQELEWQNS
  SSMEDADANVYEVEEPYEAPDGQLQLGPRHQHSSSGASQEEQNDLGLGDLPSDEEEIINS
  SDEDDVSSESSKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRDA
  VAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLLKELEERMLHWTEQQRIADIFVKKG
  PYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIP
  QYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGH
  HEIVQPGRVFLKEGILMKLSRKVMQPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKV
  RKPTQEAYQNELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDE
  ADSENKEEVSPLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKY
  GLDYLKNQPARVCEHCFQELQKLDHQHSPRIGSPGNHKSPSSALSSVLHSIPSGRKQKKI
  PAALKEVSANTEDSSMSGYLYRSKGNKKPWKHFWFVIKNKVLYTYAASEDVAALESQPLL
  GFTVIQVKDENSESKVFQLLHKNMLFYVFKAEDAHSAQKWIEAFQEGTIL

• Sequence length: 1430

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs-1, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	29212778
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs-1	30804561

Unknown
Disease name	Disease term	dbSNP ID	References
Endometriosis	Endometriosis	rs1800629, rs-1, rs1143634	23104006
Exudative macular degeneration	Exudative age-related macular degeneration, exudative macular degeneration		25629512, 27089177
Malignant mesothelioma	Malignant mesothelioma		25756049