ASF1B (anti-silencing function 1B histone chaperone)

Gene

• Entrez ID: 55723
• Gene name: Anti-silencing function 1B histone chaperone
• Gene symbol: ASF1B
• Synonyms: CIA-II
• Chromosome: 19
• Chromosome location: 19p13.12
• Summary: This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may pla

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016454	hsa-miR-193b-3p	Microarray	20304954
MIRT029781	hsa-miR-26b-5p	Microarray	19088304
MIRT035546	hsa-miR-214-3p	Luciferase reporter assay	23100276
MIRT043037	hsa-miR-324-5p	CLASH	23622248
MIRT040934	hsa-miR-18a-3p	CLASH	23622248
MIRT040666	hsa-miR-92b-3p	CLASH	23622248
MIRT038280	hsa-miR-130b-5p	CLASH	23622248
MIRT559422	hsa-miR-3133	PAR-CLIP	21572407
MIRT559421	hsa-miR-3677-5p	PAR-CLIP	21572407
MIRT559422	hsa-miR-3133	PAR-CLIP	21572407
MIRT559421	hsa-miR-3677-5p	PAR-CLIP	21572407
MIRT802752	hsa-miR-1245b-3p	CLIP-seq
MIRT802753	hsa-miR-1286	CLIP-seq
MIRT802754	hsa-miR-1287	CLIP-seq
MIRT802755	hsa-miR-1301	CLIP-seq
MIRT802756	hsa-miR-1321	CLIP-seq
MIRT802757	hsa-miR-1343	CLIP-seq
MIRT802758	hsa-miR-2116	CLIP-seq
MIRT802759	hsa-miR-214	CLIP-seq
MIRT802760	hsa-miR-24	CLIP-seq
MIRT802761	hsa-miR-300	CLIP-seq
MIRT802762	hsa-miR-3120-3p	CLIP-seq
MIRT802763	hsa-miR-3124-3p	CLIP-seq
MIRT802764	hsa-miR-3126-5p	CLIP-seq
MIRT802765	hsa-miR-3135b	CLIP-seq
MIRT802766	hsa-miR-3144-5p	CLIP-seq
MIRT802767	hsa-miR-3150a-3p	CLIP-seq
MIRT802768	hsa-miR-3153	CLIP-seq
MIRT802769	hsa-miR-3169	CLIP-seq
MIRT802770	hsa-miR-3175	CLIP-seq
MIRT802771	hsa-miR-3184	CLIP-seq
MIRT802772	hsa-miR-3192	CLIP-seq
MIRT802773	hsa-miR-3619-5p	CLIP-seq
MIRT802774	hsa-miR-3661	CLIP-seq
MIRT802775	hsa-miR-3685	CLIP-seq
MIRT802776	hsa-miR-3689a-3p	CLIP-seq
MIRT802777	hsa-miR-3689c	CLIP-seq
MIRT802778	hsa-miR-381	CLIP-seq
MIRT802779	hsa-miR-384	CLIP-seq
MIRT802780	hsa-miR-423-5p	CLIP-seq
MIRT802781	hsa-miR-4266	CLIP-seq
MIRT802782	hsa-miR-4270	CLIP-seq
MIRT802783	hsa-miR-4284	CLIP-seq
MIRT802784	hsa-miR-4291	CLIP-seq
MIRT802785	hsa-miR-4300	CLIP-seq
MIRT802786	hsa-miR-4314	CLIP-seq
MIRT802787	hsa-miR-4328	CLIP-seq
MIRT802788	hsa-miR-4330	CLIP-seq
MIRT802789	hsa-miR-4436a	CLIP-seq
MIRT802790	hsa-miR-4441	CLIP-seq
MIRT802791	hsa-miR-4476	CLIP-seq
MIRT802792	hsa-miR-4492	CLIP-seq
MIRT802793	hsa-miR-4498	CLIP-seq
MIRT802794	hsa-miR-4505	CLIP-seq
MIRT802795	hsa-miR-4514	CLIP-seq
MIRT802796	hsa-miR-4515	CLIP-seq
MIRT802797	hsa-miR-4640-5p	CLIP-seq
MIRT802798	hsa-miR-4645-5p	CLIP-seq
MIRT802799	hsa-miR-4646-5p	CLIP-seq
MIRT802800	hsa-miR-4648	CLIP-seq
MIRT802801	hsa-miR-4654	CLIP-seq
MIRT802802	hsa-miR-4656	CLIP-seq
MIRT802803	hsa-miR-4660	CLIP-seq
MIRT802804	hsa-miR-4666-3p	CLIP-seq
MIRT802805	hsa-miR-4667-5p	CLIP-seq
MIRT802806	hsa-miR-4668-5p	CLIP-seq
MIRT802807	hsa-miR-4673	CLIP-seq
MIRT802808	hsa-miR-4677-5p	CLIP-seq
MIRT802809	hsa-miR-4679	CLIP-seq
MIRT802810	hsa-miR-4682	CLIP-seq
MIRT802811	hsa-miR-4685-5p	CLIP-seq
MIRT802812	hsa-miR-4687-3p	CLIP-seq
MIRT802813	hsa-miR-4688	CLIP-seq
MIRT802814	hsa-miR-4692	CLIP-seq
MIRT802815	hsa-miR-4700-3p	CLIP-seq
MIRT802816	hsa-miR-4700-5p	CLIP-seq
MIRT802817	hsa-miR-4705	CLIP-seq
MIRT802818	hsa-miR-4709-3p	CLIP-seq
MIRT802819	hsa-miR-4716-3p	CLIP-seq
MIRT802820	hsa-miR-4717-3p	CLIP-seq
MIRT802821	hsa-miR-4723-5p	CLIP-seq
MIRT802822	hsa-miR-4726-5p	CLIP-seq
MIRT802823	hsa-miR-4728-5p	CLIP-seq
MIRT802824	hsa-miR-4731-3p	CLIP-seq
MIRT802825	hsa-miR-4731-5p	CLIP-seq
MIRT802826	hsa-miR-4739	CLIP-seq
MIRT802827	hsa-miR-4751	CLIP-seq
MIRT802828	hsa-miR-4756-5p	CLIP-seq
MIRT802829	hsa-miR-4769-5p	CLIP-seq
MIRT802830	hsa-miR-4801	CLIP-seq
MIRT802831	hsa-miR-5047	CLIP-seq
MIRT802832	hsa-miR-514	CLIP-seq
MIRT802833	hsa-miR-514b-3p	CLIP-seq
MIRT802834	hsa-miR-541	CLIP-seq
MIRT802835	hsa-miR-619	CLIP-seq
MIRT802836	hsa-miR-631	CLIP-seq
MIRT802837	hsa-miR-651	CLIP-seq
MIRT802838	hsa-miR-654-5p	CLIP-seq
MIRT802839	hsa-miR-665	CLIP-seq
MIRT802840	hsa-miR-761	CLIP-seq
MIRT802841	hsa-miR-762	CLIP-seq
MIRT802842	hsa-miR-767-3p	CLIP-seq
MIRT802843	hsa-miR-885-3p	CLIP-seq
MIRT802844	hsa-miR-920	CLIP-seq
MIRT802845	hsa-miR-922	CLIP-seq
MIRT802846	hsa-miR-939	CLIP-seq
MIRT802847	hsa-miR-940	CLIP-seq
MIRT1937038	hsa-miR-122	CLIP-seq
MIRT802752	hsa-miR-1245b-3p	CLIP-seq
MIRT1937039	hsa-miR-1245b-5p	CLIP-seq
MIRT1937040	hsa-miR-128	CLIP-seq
MIRT802753	hsa-miR-1286	CLIP-seq
MIRT802756	hsa-miR-1321	CLIP-seq
MIRT802757	hsa-miR-1343	CLIP-seq
MIRT1937041	hsa-miR-193a-5p	CLIP-seq
MIRT1937042	hsa-miR-203	CLIP-seq
MIRT1937043	hsa-miR-2115	CLIP-seq
MIRT802758	hsa-miR-2116	CLIP-seq
MIRT802763	hsa-miR-3124-3p	CLIP-seq
MIRT802764	hsa-miR-3126-5p	CLIP-seq
MIRT1937044	hsa-miR-3127-5p	CLIP-seq
MIRT802765	hsa-miR-3135b	CLIP-seq
MIRT1937045	hsa-miR-3142	CLIP-seq
MIRT802766	hsa-miR-3144-5p	CLIP-seq
MIRT802767	hsa-miR-3150a-3p	CLIP-seq
MIRT802768	hsa-miR-3153	CLIP-seq
MIRT802770	hsa-miR-3175	CLIP-seq
MIRT802772	hsa-miR-3192	CLIP-seq
MIRT1937046	hsa-miR-320a	CLIP-seq
MIRT1937047	hsa-miR-320b	CLIP-seq
MIRT1937048	hsa-miR-320c	CLIP-seq
MIRT1937049	hsa-miR-320d	CLIP-seq
MIRT1937050	hsa-miR-320e	CLIP-seq
MIRT802775	hsa-miR-3685	CLIP-seq
MIRT802779	hsa-miR-384	CLIP-seq
MIRT1937051	hsa-miR-3922-5p	CLIP-seq
MIRT1937052	hsa-miR-3977	CLIP-seq
MIRT802782	hsa-miR-4270	CLIP-seq
MIRT1937053	hsa-miR-4292	CLIP-seq
MIRT802785	hsa-miR-4300	CLIP-seq
MIRT1937054	hsa-miR-4308	CLIP-seq
MIRT802787	hsa-miR-4328	CLIP-seq
MIRT802788	hsa-miR-4330	CLIP-seq
MIRT1937055	hsa-miR-4429	CLIP-seq
MIRT802789	hsa-miR-4436a	CLIP-seq
MIRT802790	hsa-miR-4441	CLIP-seq
MIRT1937056	hsa-miR-4481	CLIP-seq
MIRT802792	hsa-miR-4492	CLIP-seq
MIRT802793	hsa-miR-4498	CLIP-seq
MIRT802794	hsa-miR-4505	CLIP-seq
MIRT1937057	hsa-miR-4527	CLIP-seq
MIRT802797	hsa-miR-4640-5p	CLIP-seq
MIRT802800	hsa-miR-4648	CLIP-seq
MIRT802801	hsa-miR-4654	CLIP-seq
MIRT802805	hsa-miR-4667-5p	CLIP-seq
MIRT802806	hsa-miR-4668-5p	CLIP-seq
MIRT802808	hsa-miR-4677-5p	CLIP-seq
MIRT802810	hsa-miR-4682	CLIP-seq
MIRT802811	hsa-miR-4685-5p	CLIP-seq
MIRT802813	hsa-miR-4688	CLIP-seq
MIRT802816	hsa-miR-4700-5p	CLIP-seq
MIRT802819	hsa-miR-4716-3p	CLIP-seq
MIRT802821	hsa-miR-4723-5p	CLIP-seq
MIRT802822	hsa-miR-4726-5p	CLIP-seq
MIRT802823	hsa-miR-4728-5p	CLIP-seq
MIRT802824	hsa-miR-4731-3p	CLIP-seq
MIRT802825	hsa-miR-4731-5p	CLIP-seq
MIRT802826	hsa-miR-4739	CLIP-seq
MIRT1937058	hsa-miR-4745-5p	CLIP-seq
MIRT802828	hsa-miR-4756-5p	CLIP-seq
MIRT1937059	hsa-miR-4759	CLIP-seq
MIRT802829	hsa-miR-4769-5p	CLIP-seq
MIRT802830	hsa-miR-4801	CLIP-seq
MIRT1937060	hsa-miR-516a-3p	CLIP-seq
MIRT802834	hsa-miR-541	CLIP-seq
MIRT802838	hsa-miR-654-5p	CLIP-seq
MIRT1937061	hsa-miR-670	CLIP-seq
MIRT802841	hsa-miR-762	CLIP-seq
MIRT802842	hsa-miR-767-3p	CLIP-seq
MIRT802843	hsa-miR-885-3p	CLIP-seq
MIRT1937062	hsa-miR-888	CLIP-seq
MIRT802844	hsa-miR-920	CLIP-seq
MIRT802846	hsa-miR-939	CLIP-seq
MIRT1937038	hsa-miR-122	CLIP-seq
MIRT802752	hsa-miR-1245b-3p	CLIP-seq
MIRT802753	hsa-miR-1286	CLIP-seq
MIRT802757	hsa-miR-1343	CLIP-seq
MIRT1937041	hsa-miR-193a-5p	CLIP-seq
MIRT802758	hsa-miR-2116	CLIP-seq
MIRT802761	hsa-miR-300	CLIP-seq
MIRT802762	hsa-miR-3120-3p	CLIP-seq
MIRT802763	hsa-miR-3124-3p	CLIP-seq
MIRT802764	hsa-miR-3126-5p	CLIP-seq
MIRT1937044	hsa-miR-3127-5p	CLIP-seq
MIRT802765	hsa-miR-3135b	CLIP-seq
MIRT802766	hsa-miR-3144-5p	CLIP-seq
MIRT802767	hsa-miR-3150a-3p	CLIP-seq
MIRT2176833	hsa-miR-3161	CLIP-seq
MIRT802770	hsa-miR-3175	CLIP-seq
MIRT802772	hsa-miR-3192	CLIP-seq
MIRT1937046	hsa-miR-320a	CLIP-seq
MIRT1937047	hsa-miR-320b	CLIP-seq
MIRT1937048	hsa-miR-320c	CLIP-seq
MIRT1937049	hsa-miR-320d	CLIP-seq
MIRT1937050	hsa-miR-320e	CLIP-seq
MIRT802775	hsa-miR-3685	CLIP-seq
MIRT802778	hsa-miR-381	CLIP-seq
MIRT802779	hsa-miR-384	CLIP-seq
MIRT1937051	hsa-miR-3922-5p	CLIP-seq
MIRT802785	hsa-miR-4300	CLIP-seq
MIRT802787	hsa-miR-4328	CLIP-seq
MIRT802788	hsa-miR-4330	CLIP-seq
MIRT1937055	hsa-miR-4429	CLIP-seq
MIRT802789	hsa-miR-4436a	CLIP-seq
MIRT1937056	hsa-miR-4481	CLIP-seq
MIRT802792	hsa-miR-4492	CLIP-seq
MIRT802793	hsa-miR-4498	CLIP-seq
MIRT802794	hsa-miR-4505	CLIP-seq
MIRT1937057	hsa-miR-4527	CLIP-seq
MIRT802802	hsa-miR-4656	CLIP-seq
MIRT802804	hsa-miR-4666-3p	CLIP-seq
MIRT802805	hsa-miR-4667-5p	CLIP-seq
MIRT802808	hsa-miR-4677-5p	CLIP-seq
MIRT802810	hsa-miR-4682	CLIP-seq
MIRT802811	hsa-miR-4685-5p	CLIP-seq
MIRT802813	hsa-miR-4688	CLIP-seq
MIRT802816	hsa-miR-4700-5p	CLIP-seq
MIRT802817	hsa-miR-4705	CLIP-seq
MIRT802819	hsa-miR-4716-3p	CLIP-seq
MIRT802820	hsa-miR-4717-3p	CLIP-seq
MIRT802821	hsa-miR-4723-5p	CLIP-seq
MIRT802823	hsa-miR-4728-5p	CLIP-seq
MIRT802825	hsa-miR-4731-5p	CLIP-seq
MIRT1937058	hsa-miR-4745-5p	CLIP-seq
MIRT1937059	hsa-miR-4759	CLIP-seq
MIRT802841	hsa-miR-762	CLIP-seq
MIRT802842	hsa-miR-767-3p	CLIP-seq
MIRT802843	hsa-miR-885-3p	CLIP-seq
MIRT802844	hsa-miR-920	CLIP-seq
MIRT802846	hsa-miR-939	CLIP-seq
MIRT802762	hsa-miR-3120-3p	CLIP-seq
MIRT802766	hsa-miR-3144-5p	CLIP-seq
MIRT802817	hsa-miR-4705	CLIP-seq
MIRT802843	hsa-miR-885-3p	CLIP-seq
MIRT2464864	hsa-miR-302a	CLIP-seq
MIRT2464865	hsa-miR-302b	CLIP-seq
MIRT2464866	hsa-miR-302c	CLIP-seq
MIRT2464867	hsa-miR-302d	CLIP-seq
MIRT2464868	hsa-miR-302e	CLIP-seq
MIRT2464869	hsa-miR-3140-3p	CLIP-seq
MIRT2464870	hsa-miR-3616-5p	CLIP-seq
MIRT2464871	hsa-miR-3646	CLIP-seq
MIRT2464872	hsa-miR-3647-5p	CLIP-seq
MIRT2464873	hsa-miR-372	CLIP-seq
MIRT2464874	hsa-miR-373	CLIP-seq
MIRT2464875	hsa-miR-4795-5p	CLIP-seq
MIRT2464876	hsa-miR-4799-5p	CLIP-seq
MIRT2464877	hsa-miR-520a-3p	CLIP-seq
MIRT2464878	hsa-miR-520b	CLIP-seq
MIRT2464879	hsa-miR-520c-3p	CLIP-seq
MIRT2464880	hsa-miR-520d-3p	CLIP-seq
MIRT2464881	hsa-miR-520e	CLIP-seq
MIRT2464882	hsa-miR-520f	CLIP-seq
MIRT2464883	hsa-miR-573	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
E2F1	Activation	17328667

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IDA	14718166
GO:0001835	Process	Blastocyst hatching	IEA
GO:0005515	Function	Protein binding	IPI	16980972, 22407294, 23075851, 24981860, 26167883, 27705803, 28514442
GO:0005654	Component	Nucleoplasm	IDA
GO:0006335	Process	DNA replication-dependent nucleosome assembly	IBA	21873635
GO:0006335	Process	DNA replication-dependent nucleosome assembly	IDA	14718166
GO:0006336	Process	DNA replication-independent nucleosome assembly	IBA	21873635
GO:0006336	Process	DNA replication-independent nucleosome assembly	IDA	14718166
GO:0007283	Process	Spermatogenesis	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0032991	Component	Protein-containing complex	IDA	14718166
GO:0042393	Function	Histone binding	IBA	21873635

Other IDs

• MIM: 609190
• HGNC: 20996
• e!Ensembl: ENSG00000105011

Protein

• UniProt ID: Q9NVP2
• Protein name: Histone chaperone ASF1B (Anti-silencing function protein 1 homolog B) (hAsf1) (hAsf1b) (CCG1-interacting factor A-II) (CIA-II) (hCIA-II)
• Protein function: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524, PubMed:26527279). Cooperates
• PDB: 5BNX, 5BO0, 7V1M, 7VCQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04729	ASF1_hist_chap	1 → 154	ASF1 like histone chaperone	Family

• Sequence:

  MAKVSVLNVAVLENPSPFHSPFRFEISFECSEALADDLEWKIIYVGSAESEEFDQILDSV
  LVGPVPAGRHMFVFQADAPNPSLIPETDAVGVTVVLITCTYHGQEFIRVGYYVNNEYLNP
  ELRENPPMKPDFSQLQRNILASNPRVTRFHINWDNNMDRLEAIETQDPSLGCGLPLNCTP
  IKGLGLPGCIPGLLPENSMDCI

• Sequence length: 202

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560
Prostatic cancer, castration-resistant	Prostatic Cancer, Castration-Resistant		29581250
Prostatic neoplasms, castration-resistant	Prostatic Neoplasms, Castration-Resistant		29581250