PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1)
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Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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5562 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Protein kinase AMP-activated catalytic subunit alpha 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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PRKAA1 |
SynonymsGene synonyms aliases
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AMPK, AMPK alpha 1, AMPKa1 |
ChromosomeChromosome number
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5 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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5p13.1 |
SummarySummary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5`-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000187 |
Process |
Activation of MAPK activity |
NAS |
11546797 |
GO:0001666 |
Process |
Response to hypoxia |
NAS |
8557660 |
GO:0003682 |
Function |
Chromatin binding |
ISS |
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GO:0004672 |
Function |
Protein kinase activity |
IDA |
17028174 |
GO:0004674 |
Function |
Protein serine/threonine kinase activity |
IBA |
21873635 |
GO:0004679 |
Function |
AMP-activated protein kinase activity |
IDA |
18439900 |
GO:0004679 |
Function |
AMP-activated protein kinase activity |
ISS |
|
GO:0004679 |
Function |
AMP-activated protein kinase activity |
TAS |
21768291 |
GO:0004691 |
Function |
CAMP-dependent protein kinase activity |
NAS |
8557660 |
GO:0005515 |
Function |
Protein binding |
IPI |
16306228, 17028174, 18403135, 18439900, 18480843, 18663353, 19914239, 20562859, 21988832, 22363791, 22939624, 23455922, 24722188, 25416956, 25751139, 25751140, 25852190, 28561066, 29892012, 31515488 |
GO:0005524 |
Function |
ATP binding |
IEA |
|
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005634 |
Component |
Nucleus |
ISS |
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GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005737 |
Component |
Cytoplasm |
IBA |
21873635 |
GO:0005737 |
Component |
Cytoplasm |
IDA |
21768291 |
GO:0005829 |
Component |
Cytosol |
IDA |
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GO:0005829 |
Component |
Cytosol |
TAS |
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GO:0006006 |
Process |
Glucose metabolic process |
IEA |
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GO:0006468 |
Process |
Protein phosphorylation |
IBA |
21873635 |
GO:0006468 |
Process |
Protein phosphorylation |
IDA |
17028174 |
GO:0006633 |
Process |
Fatty acid biosynthetic process |
IEA |
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GO:0006695 |
Process |
Cholesterol biosynthetic process |
IEA |
|
GO:0007050 |
Process |
Cell cycle arrest |
TAS |
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GO:0007165 |
Process |
Signal transduction |
TAS |
8557660 |
GO:0008022 |
Function |
Protein C-terminus binding |
IEA |
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GO:0008284 |
Process |
Positive regulation of cell population proliferation |
IEA |
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GO:0008610 |
Process |
Lipid biosynthetic process |
ISS |
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GO:0009411 |
Process |
Response to UV |
IEA |
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GO:0009631 |
Process |
Cold acclimation |
IEA |
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GO:0010332 |
Process |
Response to gamma radiation |
ISS |
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GO:0010508 |
Process |
Positive regulation of autophagy |
IDA |
22012985 |
GO:0010508 |
Process |
Positive regulation of autophagy |
IMP |
26103054 |
GO:0010508 |
Process |
Positive regulation of autophagy |
ISS |
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GO:0010628 |
Process |
Positive regulation of gene expression |
IDA |
17028174 |
GO:0010629 |
Process |
Negative regulation of gene expression |
ISS |
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GO:0014823 |
Process |
Response to activity |
IEA |
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GO:0015721 |
Process |
Bile acid and bile salt transport |
IEA |
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GO:0016055 |
Process |
Wnt signaling pathway |
IEA |
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GO:0016236 |
Process |
Macroautophagy |
TAS |
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GO:0016241 |
Process |
Regulation of macroautophagy |
TAS |
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GO:0016324 |
Component |
Apical plasma membrane |
IEA |
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GO:0016607 |
Component |
Nuclear speck |
IDA |
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GO:0019395 |
Process |
Fatty acid oxidation |
IEA |
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GO:0030424 |
Component |
Axon |
ISS |
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GO:0030425 |
Component |
Dendrite |
ISS |
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GO:0031000 |
Process |
Response to caffeine |
IEA |
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GO:0031588 |
Component |
Nucleotide-activated protein kinase complex |
ISS |
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GO:0031588 |
Component |
Nucleotide-activated protein kinase complex |
TAS |
21768291 |
GO:0031669 |
Process |
Cellular response to nutrient levels |
ISS |
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GO:0032007 |
Process |
Negative regulation of TOR signaling |
ISS |
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GO:0033135 |
Process |
Regulation of peptidyl-serine phosphorylation |
IEA |
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GO:0034599 |
Process |
Cellular response to oxidative stress |
ISS |
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GO:0035174 |
Function |
Histone serine kinase activity |
ISS |
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GO:0035404 |
Process |
Histone-serine phosphorylation |
IEA |
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GO:0035556 |
Process |
Intracellular signal transduction |
IBA |
21873635 |
GO:0035690 |
Process |
Cellular response to drug |
IEA |
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GO:0038183 |
Process |
Bile acid signaling pathway |
IEA |
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GO:0042149 |
Process |
Cellular response to glucose starvation |
ISS |
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GO:0042593 |
Process |
Glucose homeostasis |
ISS |
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GO:0042752 |
Process |
Regulation of circadian rhythm |
ISS |
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GO:0043025 |
Component |
Neuronal cell body |
ISS |
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GO:0043066 |
Process |
Negative regulation of apoptotic process |
ISS |
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GO:0044877 |
Function |
Protein-containing complex binding |
IEA |
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GO:0045542 |
Process |
Positive regulation of cholesterol biosynthetic process |
NAS |
8557660 |
GO:0045821 |
Process |
Positive regulation of glycolytic process |
ISS |
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GO:0046318 |
Process |
Negative regulation of glucosylceramide biosynthetic process |
NAS |
11165240 |
GO:0046627 |
Process |
Negative regulation of insulin receptor signaling pathway |
IEA |
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GO:0046872 |
Function |
Metal ion binding |
IEA |
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GO:0047322 |
Function |
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity |
IEA |
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GO:0048156 |
Function |
Tau protein binding |
NAS |
28386764 |
GO:0048511 |
Process |
Rhythmic process |
IEA |
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GO:0048643 |
Process |
Positive regulation of skeletal muscle tissue development |
IEA |
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GO:0050321 |
Function |
Tau-protein kinase activity |
NAS |
28386764 |
GO:0050405 |
Function |
[acetyl-CoA carboxylase] kinase activity |
IEA |
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GO:0050995 |
Process |
Negative regulation of lipid catabolic process |
ISS |
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GO:0055089 |
Process |
Fatty acid homeostasis |
ISS |
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GO:0060627 |
Process |
Regulation of vesicle-mediated transport |
IEA |
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GO:0061744 |
Process |
Motor behavior |
IGI |
21768291 |
GO:0061762 |
Process |
CAMKK-AMPK signaling cascade |
IC |
22012985 |
GO:0061762 |
Process |
CAMKK-AMPK signaling cascade |
IMP |
26103054 |
GO:0061762 |
Process |
CAMKK-AMPK signaling cascade |
TAS |
21768291 |
GO:0062028 |
Process |
Regulation of stress granule assembly |
IEA |
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GO:0070050 |
Process |
Neuron cellular homeostasis |
IGI |
21768291 |
GO:0070301 |
Process |
Cellular response to hydrogen peroxide |
IEA |
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GO:0070507 |
Process |
Regulation of microtubule cytoskeleton organization |
ISS |
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GO:0071277 |
Process |
Cellular response to calcium ion |
ISS |
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GO:0071333 |
Process |
Cellular response to glucose stimulus |
ISS |
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GO:0071361 |
Process |
Cellular response to ethanol |
IEA |
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GO:0071380 |
Process |
Cellular response to prostaglandin E stimulus |
IEA |
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GO:0071417 |
Process |
Cellular response to organonitrogen compound |
IEA |
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GO:0071456 |
Process |
Cellular response to hypoxia |
IEA |
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GO:0097009 |
Process |
Energy homeostasis |
ISS |
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GO:0097009 |
Process |
Energy homeostasis |
TAS |
21768291 |
GO:0106310 |
Function |
Protein serine kinase activity |
IEA |
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GO:0106311 |
Function |
Protein threonine kinase activity |
IEA |
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GO:0120188 |
Process |
Regulation of bile acid secretion |
IEA |
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GO:1901563 |
Process |
Response to camptothecin |
IEA |
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GO:1901796 |
Process |
Regulation of signal transduction by p53 class mediator |
TAS |
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GO:1903109 |
Process |
Positive regulation of mitochondrial transcription |
IEA |
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GO:1903829 |
Process |
Positive regulation of cellular protein localization |
ISS |
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GO:1903955 |
Process |
Positive regulation of protein targeting to mitochondrion |
IEA |
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GO:1904428 |
Process |
Negative regulation of tubulin deacetylation |
ISS |
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GO:1904486 |
Process |
Response to 17alpha-ethynylestradiol |
IEA |
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GO:2000758 |
Process |
Positive regulation of peptidyl-lysine acetylation |
ISS |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
Q13131 |
Protein name |
5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11 |
Protein function |
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reducti |
PDB |
4RED
,
4RER
,
4REW
,
5EZV
,
6C9F
,
6C9G
,
6C9H
,
6C9J
,
7JHG
,
7JHH
,
7JIJ
,
7M74
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00069 |
Pkinase |
27 → 279 |
Protein kinase domain |
Domain |
PF16579 |
AdenylateSensor |
406 → 503 |
Adenylate sensor of SNF1-like protein kinase |
Domain |
|
Sequence |
|
Sequence length |
559 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Breast cancer |
Malignant neoplasm of breast |
rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243 |
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Gastric cancer |
Hereditary Diffuse Gastric Cancer |
rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208 |
26098866 |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
22037555 |
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