BMP2K (BMP2 inducible kinase)

Gene

• Entrez ID: 55589
• Gene name: BMP2 inducible kinase
• Gene symbol: BMP2K
• Synonyms: BIKE, HRIHFB2017
• Chromosome: 4
• Chromosome location: 4q21.21
• Summary: This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT026511	hsa-miR-192-5p	Microarray	19074876
MIRT027518	hsa-miR-98-5p	Microarray	19088304
MIRT051629	hsa-let-7e-5p	CLASH	23622248
MIRT054907	hsa-miR-1228-3p	qRT-PCR	23362149
MIRT512220	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT512219	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT512218	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT524746	hsa-miR-6885-3p	HITS-CLIP	21572407
MIRT524747	hsa-miR-6771-3p	HITS-CLIP	21572407
MIRT512220	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT512219	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT512218	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT524747	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT512220	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT512219	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT512218	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT512220	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT512219	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT512218	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT524746	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT538948	hsa-miR-606	PAR-CLIP	20371350
MIRT568265	hsa-miR-1245a	PAR-CLIP	20371350
MIRT568264	hsa-miR-8079	PAR-CLIP	20371350
MIRT568263	hsa-miR-8062	PAR-CLIP	20371350
MIRT568262	hsa-miR-101-5p	PAR-CLIP	20371350
MIRT568261	hsa-miR-5697	PAR-CLIP	20371350
MIRT568260	hsa-miR-1297	PAR-CLIP	20371350
MIRT568259	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT568258	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT568257	hsa-miR-4465	PAR-CLIP	20371350
MIRT512220	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT512219	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT512218	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT524747	hsa-miR-6771-3p	PAR-CLIP	21572407
MIRT512220	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT512219	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT512218	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT538960	hsa-miR-4789-3p	PAR-CLIP	22012620
MIRT538959	hsa-miR-4643	PAR-CLIP	22012620
MIRT538958	hsa-miR-610	PAR-CLIP	22012620
MIRT538957	hsa-miR-3941	PAR-CLIP	22012620
MIRT538955	hsa-miR-4672	PAR-CLIP	22012620
MIRT538956	hsa-miR-466	PAR-CLIP	22012620
MIRT538954	hsa-miR-548a-3p	PAR-CLIP	22012620
MIRT538953	hsa-miR-548ar-3p	PAR-CLIP	22012620
MIRT538952	hsa-miR-548az-3p	PAR-CLIP	22012620
MIRT538951	hsa-miR-548e-3p	PAR-CLIP	22012620
MIRT538950	hsa-miR-548f-3p	PAR-CLIP	22012620
MIRT538949	hsa-miR-5582-3p	PAR-CLIP	22012620
MIRT538948	hsa-miR-606	PAR-CLIP	22012620
MIRT538947	hsa-miR-3145-5p	PAR-CLIP	22012620
MIRT538946	hsa-miR-508-5p	PAR-CLIP	22012620
MIRT538945	hsa-miR-4477a	PAR-CLIP	22012620
MIRT538944	hsa-miR-548c-3p	PAR-CLIP	22012620
MIRT538943	hsa-miR-4311	PAR-CLIP	22012620
MIRT538942	hsa-miR-551b-5p	PAR-CLIP	22012620
MIRT538941	hsa-miR-4693-3p	PAR-CLIP	22012620
MIRT538940	hsa-miR-1909-5p	PAR-CLIP	22012620
MIRT524747	hsa-miR-6771-3p	PAR-CLIP	23446348
MIRT512220	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT512219	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT512218	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT524746	hsa-miR-6885-3p	PAR-CLIP	23446348
MIRT512220	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT512219	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT512218	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT512220	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT512219	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT512218	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT524746	hsa-miR-6885-3p	HITS-CLIP	21572407
MIRT524747	hsa-miR-6771-3p	HITS-CLIP	21572407
MIRT512220	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT512219	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT512218	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT524747	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT512220	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT512219	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT512218	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT512220	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT512219	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT512218	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT524746	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT538948	hsa-miR-606	PAR-CLIP	20371350
MIRT568265	hsa-miR-1245a	PAR-CLIP	20371350
MIRT568264	hsa-miR-8079	PAR-CLIP	20371350
MIRT568263	hsa-miR-8062	PAR-CLIP	20371350
MIRT568262	hsa-miR-101-5p	PAR-CLIP	20371350
MIRT568261	hsa-miR-5697	PAR-CLIP	20371350
MIRT568260	hsa-miR-1297	PAR-CLIP	20371350
MIRT568259	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT568258	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT568257	hsa-miR-4465	PAR-CLIP	20371350
MIRT512220	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT512219	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT512218	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT524747	hsa-miR-6771-3p	PAR-CLIP	21572407
MIRT512220	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT512219	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT512218	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT538960	hsa-miR-4789-3p	PAR-CLIP	22012620
MIRT538959	hsa-miR-4643	PAR-CLIP	22012620
MIRT538958	hsa-miR-610	PAR-CLIP	22012620
MIRT538957	hsa-miR-3941	PAR-CLIP	22012620
MIRT538955	hsa-miR-4672	PAR-CLIP	22012620
MIRT538956	hsa-miR-466	PAR-CLIP	22012620
MIRT538954	hsa-miR-548a-3p	PAR-CLIP	22012620
MIRT538953	hsa-miR-548ar-3p	PAR-CLIP	22012620
MIRT538952	hsa-miR-548az-3p	PAR-CLIP	22012620
MIRT538951	hsa-miR-548e-3p	PAR-CLIP	22012620
MIRT538950	hsa-miR-548f-3p	PAR-CLIP	22012620
MIRT538949	hsa-miR-5582-3p	PAR-CLIP	22012620
MIRT538948	hsa-miR-606	PAR-CLIP	22012620
MIRT538947	hsa-miR-3145-5p	PAR-CLIP	22012620
MIRT538946	hsa-miR-508-5p	PAR-CLIP	22012620
MIRT538945	hsa-miR-4477a	PAR-CLIP	22012620
MIRT538944	hsa-miR-548c-3p	PAR-CLIP	22012620
MIRT538943	hsa-miR-4311	PAR-CLIP	22012620
MIRT538942	hsa-miR-551b-5p	PAR-CLIP	22012620
MIRT538941	hsa-miR-4693-3p	PAR-CLIP	22012620
MIRT538940	hsa-miR-1909-5p	PAR-CLIP	22012620
MIRT524747	hsa-miR-6771-3p	PAR-CLIP	23446348
MIRT512220	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT512219	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT512218	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT524746	hsa-miR-6885-3p	PAR-CLIP	23446348
MIRT512220	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT512219	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT512218	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT822378	hsa-miR-1305	CLIP-seq
MIRT822379	hsa-miR-181a	CLIP-seq
MIRT822380	hsa-miR-181b	CLIP-seq
MIRT822381	hsa-miR-181c	CLIP-seq
MIRT822382	hsa-miR-181d	CLIP-seq
MIRT822383	hsa-miR-298	CLIP-seq
MIRT822384	hsa-miR-3065-5p	CLIP-seq
MIRT822385	hsa-miR-3074-3p	CLIP-seq
MIRT822386	hsa-miR-3143	CLIP-seq
MIRT822387	hsa-miR-330-3p	CLIP-seq
MIRT822388	hsa-miR-3659	CLIP-seq
MIRT822389	hsa-miR-376a	CLIP-seq
MIRT822390	hsa-miR-376b	CLIP-seq
MIRT822391	hsa-miR-3944-5p	CLIP-seq
MIRT822392	hsa-miR-4262	CLIP-seq
MIRT822393	hsa-miR-4330	CLIP-seq
MIRT822394	hsa-miR-4427	CLIP-seq
MIRT822395	hsa-miR-4436a	CLIP-seq
MIRT822396	hsa-miR-4461	CLIP-seq
MIRT822397	hsa-miR-4658	CLIP-seq
MIRT822398	hsa-miR-4680-3p	CLIP-seq
MIRT822399	hsa-miR-4758-5p	CLIP-seq
MIRT822400	hsa-miR-4761-3p	CLIP-seq
MIRT822401	hsa-miR-543	CLIP-seq
MIRT822402	hsa-miR-558	CLIP-seq
MIRT822403	hsa-miR-574-5p	CLIP-seq
MIRT822404	hsa-miR-607	CLIP-seq
MIRT822405	hsa-miR-648	CLIP-seq
MIRT822406	hsa-miR-155	CLIP-seq
MIRT822407	hsa-miR-365	CLIP-seq
MIRT822408	hsa-miR-4424	CLIP-seq
MIRT822409	hsa-miR-4433	CLIP-seq
MIRT822410	hsa-miR-4653-3p	CLIP-seq
MIRT822411	hsa-miR-494	CLIP-seq
MIRT822412	hsa-miR-569	CLIP-seq
MIRT1943045	hsa-miR-129-5p	CLIP-seq
MIRT1943046	hsa-miR-377	CLIP-seq
MIRT822411	hsa-miR-494	CLIP-seq
MIRT1943047	hsa-miR-548e	CLIP-seq
MIRT1943048	hsa-miR-548f	CLIP-seq
MIRT1943049	hsa-miR-548g	CLIP-seq
MIRT822378	hsa-miR-1305	CLIP-seq
MIRT822393	hsa-miR-4330	CLIP-seq
MIRT822400	hsa-miR-4761-3p	CLIP-seq
MIRT822404	hsa-miR-607	CLIP-seq
MIRT822378	hsa-miR-1305	CLIP-seq
MIRT822393	hsa-miR-4330	CLIP-seq
MIRT822400	hsa-miR-4761-3p	CLIP-seq
MIRT822404	hsa-miR-607	CLIP-seq
MIRT2442013	hsa-miR-1264	CLIP-seq
MIRT2442014	hsa-miR-371-5p	CLIP-seq
MIRT2442015	hsa-miR-371b-5p	CLIP-seq
MIRT2442016	hsa-miR-513c	CLIP-seq
MIRT2442017	hsa-miR-514b-5p	CLIP-seq
MIRT2442018	hsa-miR-628-5p	CLIP-seq
MIRT2442019	hsa-miR-9	CLIP-seq
MIRT1943046	hsa-miR-377	CLIP-seq
MIRT2444812	hsa-miR-4760-3p	CLIP-seq
MIRT1943047	hsa-miR-548e	CLIP-seq
MIRT1943048	hsa-miR-548f	CLIP-seq
MIRT1943049	hsa-miR-548g	CLIP-seq
MIRT1943046	hsa-miR-377	CLIP-seq
MIRT2444812	hsa-miR-4760-3p	CLIP-seq
MIRT1943047	hsa-miR-548e	CLIP-seq
MIRT1943048	hsa-miR-548f	CLIP-seq
MIRT1943049	hsa-miR-548g	CLIP-seq
MIRT1943046	hsa-miR-377	CLIP-seq
MIRT2444812	hsa-miR-4760-3p	CLIP-seq
MIRT1943047	hsa-miR-548e	CLIP-seq
MIRT1943048	hsa-miR-548f	CLIP-seq
MIRT1943049	hsa-miR-548g	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0006468	Process	Protein phosphorylation	IBA	21873635
GO:0016607	Component	Nuclear speck	IDA
GO:0019208	Function	Phosphatase regulator activity	IBA	21873635
GO:0030500	Process	Regulation of bone mineralization	IBA	21873635
GO:0035612	Function	AP-2 adaptor complex binding	IBA	21873635
GO:0045747	Process	Positive regulation of Notch signaling pathway	IBA	21873635
GO:0050790	Process	Regulation of catalytic activity	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA
GO:2000369	Process	Regulation of clathrin-dependent endocytosis	IBA	21873635

Other IDs

• MIM: 617648
• HGNC: 18041
• e!Ensembl: ENSG00000138756

Protein

• UniProt ID: Q9NSY1
• Protein name: BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1)
• Protein function: May be involved in osteoblast differentiation.
• PDB: 4W9W, 4W9X, 5I3O, 5I3R, 5IKW
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	51 → 314	Protein kinase domain	Domain
  PF15282	BMP2K_C	893 → 1161	BMP-2-inducible protein kinase C-terminus	Family

• Sequence:

  MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG
  GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS
  DNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRD
  LKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGG
  KPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEP
  DPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDT
  IGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPE
  ILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQ
  QQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQY
  QQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSV
  ADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNRLEERASSD
  KNVDSLSAPHNHPPEDPFGSVPFISHSGSPEKKAEHSSINQENGTANPIKNGKTSPASKD
  QRTGKKTSVQGQVQKGNDESESDFESDPPSPKSSEEEEQDDEEVLQGEQGDFNDDDTEPE
  NLGHRPLLMDSEDEEEEEKHSSDSDYEQAKAKYSDMSSVYRDRSGSGPTQDLNTILLTSA
  QLSSDVAVETPKQEFDVFGAVPFFAVRAQQPQQEKNEKNLPQHRFPAAGLEQEEFDVFTK
  APFSKKVNVQECHAVGPEAHTIPGYPKSVDVFGSTPFQPFLTSTSKSESNEDLFGLVPFD
  EITGSQQQKVKQRSLQKLSSRQRRTKQDMSKSNGKRHHGTPTSTKKTLKPTYRTPERARR
  HKKVGRRDSQSSNEFLTISDSKENISVALTDGKDRGNVLQPEESLLDPFGAKPFHSPDLS
  WHPPHQGLSDIRADHNTVLPGRPRQNSLHGSFHSADVLKMDDFGAVPFTELVVQSITPHQ
  SQQSQPVELDPFGAAPFPSKQ

• Sequence length: 1161

Pathways

KEGG:

Transcriptional misregulation in cancer

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Lung carcinoma	Squamous cell carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193