TRIM36 (tripartite motif containing 36)

Gene

• Entrez ID: 55521
• Gene name: Tripartite motif containing 36
• Gene symbol: TRIM36
• Synonyms: ANPH, ANPH1, HAPRIN, RBCC728, RNF98
• Chromosome: 5
• Chromosome location: 5q22.3
• Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs773607884	G>T	Pathogenic	Coding sequence variant, non coding transcript variant, missense variant, genic downstream transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021589	hsa-miR-142-3p	Microarray	17612493
MIRT021747	hsa-miR-132-3p	Microarray	17612493
MIRT021969	hsa-miR-128-3p	Microarray	17612493
MIRT028267	hsa-miR-32-5p	Sequencing	20371350
MIRT050046	hsa-miR-26b-5p	CLASH	23622248
MIRT545267	hsa-miR-624-3p	PAR-CLIP	20371350
MIRT545266	hsa-miR-7849-3p	PAR-CLIP	20371350
MIRT545265	hsa-miR-4464	PAR-CLIP	20371350
MIRT545264	hsa-miR-4748	PAR-CLIP	20371350
MIRT545263	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT028267	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT545262	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT545261	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT545260	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT545259	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT545258	hsa-miR-4699-3p	PAR-CLIP	20371350
MIRT545257	hsa-miR-4457	PAR-CLIP	20371350
MIRT545256	hsa-miR-494-3p	PAR-CLIP	20371350
MIRT545255	hsa-miR-510-3p	PAR-CLIP	20371350
MIRT545267	hsa-miR-624-3p	PAR-CLIP	21572407
MIRT545266	hsa-miR-7849-3p	PAR-CLIP	21572407
MIRT545265	hsa-miR-4464	PAR-CLIP	21572407
MIRT545264	hsa-miR-4748	PAR-CLIP	21572407
MIRT545263	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT028267	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT545262	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT545261	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT545260	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT545259	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT545258	hsa-miR-4699-3p	PAR-CLIP	21572407
MIRT545257	hsa-miR-4457	PAR-CLIP	21572407
MIRT545256	hsa-miR-494-3p	PAR-CLIP	21572407
MIRT545255	hsa-miR-510-3p	PAR-CLIP	21572407
MIRT545267	hsa-miR-624-3p	PAR-CLIP	20371350
MIRT545266	hsa-miR-7849-3p	PAR-CLIP	20371350
MIRT545265	hsa-miR-4464	PAR-CLIP	20371350
MIRT545264	hsa-miR-4748	PAR-CLIP	20371350
MIRT545263	hsa-miR-25-3p	PAR-CLIP	20371350
MIRT028267	hsa-miR-32-5p	PAR-CLIP	20371350
MIRT545262	hsa-miR-363-3p	PAR-CLIP	20371350
MIRT545261	hsa-miR-367-3p	PAR-CLIP	20371350
MIRT545260	hsa-miR-92a-3p	PAR-CLIP	20371350
MIRT545259	hsa-miR-92b-3p	PAR-CLIP	20371350
MIRT545258	hsa-miR-4699-3p	PAR-CLIP	20371350
MIRT545257	hsa-miR-4457	PAR-CLIP	20371350
MIRT545256	hsa-miR-494-3p	PAR-CLIP	20371350
MIRT545255	hsa-miR-510-3p	PAR-CLIP	20371350
MIRT545267	hsa-miR-624-3p	PAR-CLIP	21572407
MIRT545266	hsa-miR-7849-3p	PAR-CLIP	21572407
MIRT545265	hsa-miR-4464	PAR-CLIP	21572407
MIRT545264	hsa-miR-4748	PAR-CLIP	21572407
MIRT545263	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT028267	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT545262	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT545261	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT545260	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT545259	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT545258	hsa-miR-4699-3p	PAR-CLIP	21572407
MIRT545257	hsa-miR-4457	PAR-CLIP	21572407
MIRT545256	hsa-miR-494-3p	PAR-CLIP	21572407
MIRT545255	hsa-miR-510-3p	PAR-CLIP	21572407
MIRT1454367	hsa-miR-1908	CLIP-seq
MIRT1454368	hsa-miR-3180	CLIP-seq
MIRT1454369	hsa-miR-3180-3p	CLIP-seq
MIRT1454370	hsa-miR-3196	CLIP-seq
MIRT1454371	hsa-miR-4706	CLIP-seq
MIRT1454372	hsa-miR-4734	CLIP-seq
MIRT1454373	hsa-miR-4749-5p	CLIP-seq
MIRT1454374	hsa-miR-486-3p	CLIP-seq
MIRT1454375	hsa-miR-604	CLIP-seq
MIRT1454376	hsa-miR-663	CLIP-seq
MIRT1454377	hsa-miR-744	CLIP-seq
MIRT1454378	hsa-miR-105	CLIP-seq
MIRT1454379	hsa-miR-106a	CLIP-seq
MIRT1454380	hsa-miR-106b	CLIP-seq
MIRT1454381	hsa-miR-124	CLIP-seq
MIRT1454382	hsa-miR-1253	CLIP-seq
MIRT1454383	hsa-miR-1278	CLIP-seq
MIRT1454384	hsa-miR-134	CLIP-seq
MIRT1454385	hsa-miR-137	CLIP-seq
MIRT1454386	hsa-miR-142-5p	CLIP-seq
MIRT1454387	hsa-miR-153	CLIP-seq
MIRT1454388	hsa-miR-15a	CLIP-seq
MIRT1454389	hsa-miR-15b	CLIP-seq
MIRT1454390	hsa-miR-16	CLIP-seq
MIRT1454391	hsa-miR-17	CLIP-seq
MIRT1454392	hsa-miR-194	CLIP-seq
MIRT1454393	hsa-miR-195	CLIP-seq
MIRT1454394	hsa-miR-20a	CLIP-seq
MIRT1454395	hsa-miR-20b	CLIP-seq
MIRT1454396	hsa-miR-23a	CLIP-seq
MIRT1454397	hsa-miR-23b	CLIP-seq
MIRT1454398	hsa-miR-23c	CLIP-seq
MIRT1454399	hsa-miR-25	CLIP-seq
MIRT1454400	hsa-miR-302a	CLIP-seq
MIRT1454401	hsa-miR-302b	CLIP-seq
MIRT1454402	hsa-miR-302c	CLIP-seq
MIRT1454403	hsa-miR-302d	CLIP-seq
MIRT1454404	hsa-miR-302e	CLIP-seq
MIRT1454405	hsa-miR-3118	CLIP-seq
MIRT1454406	hsa-miR-3153	CLIP-seq
MIRT1454407	hsa-miR-3164	CLIP-seq
MIRT1454408	hsa-miR-32	CLIP-seq
MIRT1454409	hsa-miR-320a	CLIP-seq
MIRT1454410	hsa-miR-320b	CLIP-seq
MIRT1454411	hsa-miR-320c	CLIP-seq
MIRT1454412	hsa-miR-320d	CLIP-seq
MIRT1454413	hsa-miR-337-3p	CLIP-seq
MIRT1454414	hsa-miR-340	CLIP-seq
MIRT1454415	hsa-miR-3609	CLIP-seq
MIRT1454416	hsa-miR-363	CLIP-seq
MIRT1454417	hsa-miR-3646	CLIP-seq
MIRT1454418	hsa-miR-3662	CLIP-seq
MIRT1454419	hsa-miR-367	CLIP-seq
MIRT1454420	hsa-miR-3714	CLIP-seq
MIRT1454421	hsa-miR-372	CLIP-seq
MIRT1454422	hsa-miR-373	CLIP-seq
MIRT1454423	hsa-miR-376a	CLIP-seq
MIRT1454424	hsa-miR-376b	CLIP-seq
MIRT1454425	hsa-miR-3910	CLIP-seq
MIRT1454426	hsa-miR-410	CLIP-seq
MIRT1454427	hsa-miR-424	CLIP-seq
MIRT1454428	hsa-miR-4293	CLIP-seq
MIRT1454429	hsa-miR-4429	CLIP-seq
MIRT1454430	hsa-miR-448	CLIP-seq
MIRT1454431	hsa-miR-4501	CLIP-seq
MIRT1454432	hsa-miR-4524	CLIP-seq
MIRT1454433	hsa-miR-4668-5p	CLIP-seq
MIRT1454434	hsa-miR-4696	CLIP-seq
MIRT1454435	hsa-miR-4719	CLIP-seq
MIRT1454436	hsa-miR-4796-3p	CLIP-seq
MIRT1454437	hsa-miR-494	CLIP-seq
MIRT1454438	hsa-miR-496	CLIP-seq
MIRT1454439	hsa-miR-497	CLIP-seq
MIRT1454440	hsa-miR-499-3p	CLIP-seq
MIRT1454441	hsa-miR-499a-3p	CLIP-seq
MIRT1454442	hsa-miR-503	CLIP-seq
MIRT1454443	hsa-miR-506	CLIP-seq
MIRT1454444	hsa-miR-519d	CLIP-seq
MIRT1454445	hsa-miR-520a-3p	CLIP-seq
MIRT1454446	hsa-miR-520b	CLIP-seq
MIRT1454447	hsa-miR-520c-3p	CLIP-seq
MIRT1454448	hsa-miR-520d-3p	CLIP-seq
MIRT1454449	hsa-miR-520e	CLIP-seq
MIRT1454450	hsa-miR-548ah	CLIP-seq
MIRT1454451	hsa-miR-548l	CLIP-seq
MIRT1454452	hsa-miR-548n	CLIP-seq
MIRT1454453	hsa-miR-570	CLIP-seq
MIRT1454454	hsa-miR-596	CLIP-seq
MIRT1454455	hsa-miR-624	CLIP-seq
MIRT1454456	hsa-miR-634	CLIP-seq
MIRT1454457	hsa-miR-640	CLIP-seq
MIRT1454458	hsa-miR-642b	CLIP-seq
MIRT1454459	hsa-miR-646	CLIP-seq
MIRT1454460	hsa-miR-664	CLIP-seq
MIRT1454461	hsa-miR-802	CLIP-seq
MIRT1454462	hsa-miR-92a	CLIP-seq
MIRT1454463	hsa-miR-92b	CLIP-seq
MIRT1454464	hsa-miR-93	CLIP-seq
MIRT1454379	hsa-miR-106a	CLIP-seq
MIRT1454380	hsa-miR-106b	CLIP-seq
MIRT1454384	hsa-miR-134	CLIP-seq
MIRT1454385	hsa-miR-137	CLIP-seq
MIRT1454386	hsa-miR-142-5p	CLIP-seq
MIRT1454387	hsa-miR-153	CLIP-seq
MIRT1454388	hsa-miR-15a	CLIP-seq
MIRT1454389	hsa-miR-15b	CLIP-seq
MIRT1454390	hsa-miR-16	CLIP-seq
MIRT1454391	hsa-miR-17	CLIP-seq
MIRT1454393	hsa-miR-195	CLIP-seq
MIRT1454394	hsa-miR-20a	CLIP-seq
MIRT1454395	hsa-miR-20b	CLIP-seq
MIRT1454399	hsa-miR-25	CLIP-seq
MIRT1454405	hsa-miR-3118	CLIP-seq
MIRT1454407	hsa-miR-3164	CLIP-seq
MIRT1454408	hsa-miR-32	CLIP-seq
MIRT1454415	hsa-miR-3609	CLIP-seq
MIRT1454416	hsa-miR-363	CLIP-seq
MIRT1454419	hsa-miR-367	CLIP-seq
MIRT1454427	hsa-miR-424	CLIP-seq
MIRT1454430	hsa-miR-448	CLIP-seq
MIRT1454431	hsa-miR-4501	CLIP-seq
MIRT1454432	hsa-miR-4524	CLIP-seq
MIRT1454436	hsa-miR-4796-3p	CLIP-seq
MIRT1454439	hsa-miR-497	CLIP-seq
MIRT1454440	hsa-miR-499-3p	CLIP-seq
MIRT1454441	hsa-miR-499a-3p	CLIP-seq
MIRT1454442	hsa-miR-503	CLIP-seq
MIRT1454444	hsa-miR-519d	CLIP-seq
MIRT1454450	hsa-miR-548ah	CLIP-seq
MIRT2136169	hsa-miR-582-5p	CLIP-seq
MIRT1454457	hsa-miR-640	CLIP-seq
MIRT1454459	hsa-miR-646	CLIP-seq
MIRT1454462	hsa-miR-92a	CLIP-seq
MIRT1454463	hsa-miR-92b	CLIP-seq
MIRT1454464	hsa-miR-93	CLIP-seq
MIRT1454379	hsa-miR-106a	CLIP-seq
MIRT1454380	hsa-miR-106b	CLIP-seq
MIRT2357142	hsa-miR-1200	CLIP-seq
MIRT1454384	hsa-miR-134	CLIP-seq
MIRT2357143	hsa-miR-135a	CLIP-seq
MIRT2357144	hsa-miR-135b	CLIP-seq
MIRT1454385	hsa-miR-137	CLIP-seq
MIRT1454386	hsa-miR-142-5p	CLIP-seq
MIRT2357145	hsa-miR-145	CLIP-seq
MIRT1454387	hsa-miR-153	CLIP-seq
MIRT2357146	hsa-miR-155	CLIP-seq
MIRT1454388	hsa-miR-15a	CLIP-seq
MIRT1454389	hsa-miR-15b	CLIP-seq
MIRT1454390	hsa-miR-16	CLIP-seq
MIRT1454391	hsa-miR-17	CLIP-seq
MIRT2357147	hsa-miR-190	CLIP-seq
MIRT2357148	hsa-miR-190b	CLIP-seq
MIRT2357149	hsa-miR-1910	CLIP-seq
MIRT1454393	hsa-miR-195	CLIP-seq
MIRT1454394	hsa-miR-20a	CLIP-seq
MIRT1454395	hsa-miR-20b	CLIP-seq
MIRT2357150	hsa-miR-218	CLIP-seq
MIRT1454396	hsa-miR-23a	CLIP-seq
MIRT1454397	hsa-miR-23b	CLIP-seq
MIRT1454398	hsa-miR-23c	CLIP-seq
MIRT1454399	hsa-miR-25	CLIP-seq
MIRT2357151	hsa-miR-3074-3p	CLIP-seq
MIRT1454405	hsa-miR-3118	CLIP-seq
MIRT1454407	hsa-miR-3164	CLIP-seq
MIRT1454408	hsa-miR-32	CLIP-seq
MIRT2357152	hsa-miR-3200-5p	CLIP-seq
MIRT1454409	hsa-miR-320a	CLIP-seq
MIRT1454410	hsa-miR-320b	CLIP-seq
MIRT1454411	hsa-miR-320c	CLIP-seq
MIRT1454412	hsa-miR-320d	CLIP-seq
MIRT1454415	hsa-miR-3609	CLIP-seq
MIRT2357153	hsa-miR-3611	CLIP-seq
MIRT2357154	hsa-miR-3618	CLIP-seq
MIRT1454416	hsa-miR-363	CLIP-seq
MIRT1454417	hsa-miR-3646	CLIP-seq
MIRT2357155	hsa-miR-3659	CLIP-seq
MIRT1454419	hsa-miR-367	CLIP-seq
MIRT1454420	hsa-miR-3714	CLIP-seq
MIRT2357156	hsa-miR-380	CLIP-seq
MIRT1454427	hsa-miR-424	CLIP-seq
MIRT1454428	hsa-miR-4293	CLIP-seq
MIRT2357157	hsa-miR-4324	CLIP-seq
MIRT2357158	hsa-miR-4328	CLIP-seq
MIRT1454429	hsa-miR-4429	CLIP-seq
MIRT1454430	hsa-miR-448	CLIP-seq
MIRT2357159	hsa-miR-4495	CLIP-seq
MIRT1454431	hsa-miR-4501	CLIP-seq
MIRT1454432	hsa-miR-4524	CLIP-seq
MIRT2357160	hsa-miR-455-3p	CLIP-seq
MIRT2357161	hsa-miR-4658	CLIP-seq
MIRT2357162	hsa-miR-4684-3p	CLIP-seq
MIRT1454435	hsa-miR-4719	CLIP-seq
MIRT2357163	hsa-miR-4771	CLIP-seq
MIRT1454436	hsa-miR-4796-3p	CLIP-seq
MIRT2357164	hsa-miR-488	CLIP-seq
MIRT1454437	hsa-miR-494	CLIP-seq
MIRT1454438	hsa-miR-496	CLIP-seq
MIRT1454439	hsa-miR-497	CLIP-seq
MIRT1454440	hsa-miR-499-3p	CLIP-seq
MIRT1454441	hsa-miR-499a-3p	CLIP-seq
MIRT1454442	hsa-miR-503	CLIP-seq
MIRT2357165	hsa-miR-512-5p	CLIP-seq
MIRT2357166	hsa-miR-518a-5p	CLIP-seq
MIRT1454444	hsa-miR-519d	CLIP-seq
MIRT2357167	hsa-miR-527	CLIP-seq
MIRT2357168	hsa-miR-544b	CLIP-seq
MIRT2357169	hsa-miR-548a-5p	CLIP-seq
MIRT2357170	hsa-miR-548ab	CLIP-seq
MIRT2357171	hsa-miR-548ae	CLIP-seq
MIRT1454450	hsa-miR-548ah	CLIP-seq
MIRT2357172	hsa-miR-548aj	CLIP-seq
MIRT2357173	hsa-miR-548ak	CLIP-seq
MIRT2357174	hsa-miR-548am	CLIP-seq
MIRT2357175	hsa-miR-548an	CLIP-seq
MIRT2357176	hsa-miR-548b-5p	CLIP-seq
MIRT2357177	hsa-miR-548c-3p	CLIP-seq
MIRT2357178	hsa-miR-548c-5p	CLIP-seq
MIRT2357179	hsa-miR-548d-5p	CLIP-seq
MIRT2357180	hsa-miR-548h	CLIP-seq
MIRT2357181	hsa-miR-548i	CLIP-seq
MIRT2357182	hsa-miR-548j	CLIP-seq
MIRT2357183	hsa-miR-548k	CLIP-seq
MIRT1454451	hsa-miR-548l	CLIP-seq
MIRT2357184	hsa-miR-548w	CLIP-seq
MIRT2357185	hsa-miR-548x	CLIP-seq
MIRT2357186	hsa-miR-548y	CLIP-seq
MIRT2357187	hsa-miR-559	CLIP-seq
MIRT2357188	hsa-miR-574-5p	CLIP-seq
MIRT2357189	hsa-miR-579	CLIP-seq
MIRT2136169	hsa-miR-582-5p	CLIP-seq
MIRT1454455	hsa-miR-624	CLIP-seq
MIRT1454456	hsa-miR-634	CLIP-seq
MIRT2357190	hsa-miR-636	CLIP-seq
MIRT1454457	hsa-miR-640	CLIP-seq
MIRT1454459	hsa-miR-646	CLIP-seq
MIRT2357191	hsa-miR-660	CLIP-seq
MIRT2357192	hsa-miR-758	CLIP-seq
MIRT2357193	hsa-miR-889	CLIP-seq
MIRT1454462	hsa-miR-92a	CLIP-seq
MIRT1454463	hsa-miR-92b	CLIP-seq
MIRT1454464	hsa-miR-93	CLIP-seq
MIRT2357194	hsa-miR-934	CLIP-seq
MIRT1454384	hsa-miR-134	CLIP-seq
MIRT1454385	hsa-miR-137	CLIP-seq
MIRT1454387	hsa-miR-153	CLIP-seq
MIRT1454388	hsa-miR-15a	CLIP-seq
MIRT1454389	hsa-miR-15b	CLIP-seq
MIRT1454390	hsa-miR-16	CLIP-seq
MIRT1454393	hsa-miR-195	CLIP-seq
MIRT1454399	hsa-miR-25	CLIP-seq
MIRT1454405	hsa-miR-3118	CLIP-seq
MIRT1454407	hsa-miR-3164	CLIP-seq
MIRT1454408	hsa-miR-32	CLIP-seq
MIRT1454416	hsa-miR-363	CLIP-seq
MIRT1454419	hsa-miR-367	CLIP-seq
MIRT1454427	hsa-miR-424	CLIP-seq
MIRT1454430	hsa-miR-448	CLIP-seq
MIRT1454431	hsa-miR-4501	CLIP-seq
MIRT1454432	hsa-miR-4524	CLIP-seq
MIRT1454439	hsa-miR-497	CLIP-seq
MIRT1454442	hsa-miR-503	CLIP-seq
MIRT1454459	hsa-miR-646	CLIP-seq
MIRT1454462	hsa-miR-92a	CLIP-seq
MIRT1454463	hsa-miR-92b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	TAS
GO:0000281	Process	Mitotic cytokinesis	IMP	28087737
GO:0001669	Component	Acrosomal vesicle	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	ISS
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005737	Component	Cytoplasm	IDA	28087737
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0007051	Process	Spindle organization	IMP	28087737
GO:0007340	Process	Acrosome reaction	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0043014	Function	Alpha-tubulin binding	ISS
GO:0051726	Process	Regulation of cell cycle	IEA
GO:0070507	Process	Regulation of microtubule cytoskeleton organization	IMP	28087737

Other IDs

• MIM: 609317
• HGNC: 16280
• e!Ensembl: ENSG00000152503

Protein

• UniProt ID: Q9NQ86
• Protein name: E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728)
• Protein function: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation (PubMed:28087737). May play a role in the acrosome reaction and fer
• PDB: 7QS4
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13445	zf-RING_UBOX	33 → 86	RING-type zinc-finger	Domain
  PF00643	zf-B_box	207 → 249	B-box zinc finger	Domain
  PF18568	COS	359 → 408	TRIM C-terminal subgroup One Signature domain	Domain
  PF00041	fn3	426 → 500	Fibronectin type III domain	Domain

• Sequence:

  MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL
  LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPGWKRNSLTPRTTVFPCPGCEH
  DVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPPPQESTKSCMDCSASYCN
  ECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMYCELCRRPVCHLCKLGGN
  HANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNLLMKETECNGERAKEEAI
  THFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLLENNGLVGYAQEVLKETD
  QSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQTELLGELSFFSSGIDVP
  EINEEQSKVYNNALINWHHPEKDKADSYVLEYRKINRDDEMSWNEIEVCGTSKIIQDLEN
  SSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFDEKCGYNNEHLLLNLKRDRVESR
  AGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAFRVEPYSYLVKVGVASSDKLQEW
  LRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTIGMQKFFIPKSPTSSNEPENRVL
  PMPTSIGIFLDCDKGKVDFYDMDQMKCLYERQVDCSHTLYPAFALMGSGGIQLEEPITAK
  YLEYQEDM

• Sequence length: 728

Pathways

Reactome:

Antigen processing: Ubiquitination & Proteasome degradation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Anencephaly	Anencephaly	rs773607884	28087737

Unknown
Disease name	Disease term	dbSNP ID	References
Aprosencephaly	Aprosencephaly
Incomplete anencephaly, hemicrania	incomplete anencephaly, hemicrania
Spina bifida	Spina Bifida