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TNFRSF19 (TNF receptor superfamily member 19)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55504
Gene nameGene Name - the full gene name approved by the HGNC.
TNF receptor superfamily member 19
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
TNFRSF19
SynonymsGene synonyms aliases
TAJ, TAJ-alpha, TRADE, TROY
ChromosomeChromosome number
13
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q12.12
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT1442980 hsa-miR-1206 CLIP-seq
MIRT1442981 hsa-miR-3656 CLIP-seq
MIRT1442982 hsa-miR-433 CLIP-seq
MIRT1442983 hsa-miR-4786-5p CLIP-seq
MIRT1442984 hsa-miR-609 CLIP-seq
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001942 Process Hair follicle development IEA
GO:0005031 Function Tumor necrosis factor-activated receptor activity NAS 10809768
GO:0005515 Function Protein binding IPI 30337686
GO:0005886 Component Plasma membrane IBA 21873635
GO:0006915 Process Apoptotic process NAS 10809768
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q9NS68
Protein name Tumor necrosis factor receptor superfamily member 19 (TRADE) (Toxicity and JNK inducer)
Protein function Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00020 TNFR_c6
34 72
TNFR/NGFR cysteine-rich region
Domain
PF00020 TNFR_c6
75 114
TNFR/NGFR cysteine-rich region
Domain
Sequence
MALKVLLEQEKTFFTLLVLLGYLSCKVTCESGDCRQQEFRDRSGNCVPCNQCGPGMELSK
ECGFGYGEDAQC
VTCRLHRFKEDWGFQKCKPCLDCAVVNRFQKANCSATSDAICGDCLPG
FYRKTKLVGFQDMECVPCGDPPPPYEPHCASKVNLVKIASTASSPRDTALAAVICSALAT
VLLALLILCVIYCKRQFMEKKPSWSLRSQDIQYNGSELSCFDRPQLHEYAHRACCQCRRD
SVQTCGPVRLLPSMCCEEACSPNPATLGCGVHSAASLQARNAGPAGEMVPTFFGSLTQSI
CGEFSDAWPLMQNPMGGDNISFCDSYPELTGEDIHSLNPELESSTSLDSNSSQDLVGGAV
PVQSHSENFTAATDLSRYNNTLVESASTQDALTMRSQLDQESGAVIHPATQTSLQVRQRL
GSL
Sequence length 423
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
  Cytokine-cytokine receptor interaction  
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Melanoma melanoma rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050 17187358
Nasopharyngeal carcinoma Nasopharyngeal carcinoma rs200046052 20512145
Unknown
Disease name Disease term dbSNP ID References
Nasopharyngeal neoplasms Nasopharyngeal Neoplasms 20512145, 26545403
Nasopharyngeal cancer Cancer of Nasopharynx 20512145

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